Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Gallus gallus | Melatonin receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Melatonin receptor | 346 aa | 298 aa | 20.5 % | |
Onchocerca volvulus | Melatonin receptor | 346 aa | 279 aa | 23.7 % | |
Onchocerca volvulus | Melatonin receptor | 346 aa | 343 aa | 22.4 % | |
Loa Loa (eye worm) | hypothetical protein | Melatonin receptor | 346 aa | 292 aa | 25.3 % |
Schistosoma mansoni | neuropeptide receptor | Melatonin receptor | 346 aa | 284 aa | 21.1 % |
Loa Loa (eye worm) | hypothetical protein | Melatonin receptor | 346 aa | 325 aa | 25.8 % |
Brugia malayi | putative neuropeptide receptor NPR1 | Melatonin receptor | 346 aa | 295 aa | 25.8 % |
Echinococcus granulosus | neuropeptide receptor | Melatonin receptor | 346 aa | 303 aa | 29.7 % |
Onchocerca volvulus | Phospholipase d-related homolog | Melatonin receptor | 346 aa | 295 aa | 19.7 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Melatonin receptor | 346 aa | 307 aa | 21.2 % |
Echinococcus multilocularis | neuropeptide receptor | Melatonin receptor | 346 aa | 303 aa | 28.7 % |
Echinococcus granulosus | allatostatin A receptor | Melatonin receptor | 346 aa | 325 aa | 20.9 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Melatonin receptor | 346 aa | 315 aa | 24.8 % |
Schistosoma japonicum | Rhodopsin, putative | Melatonin receptor | 346 aa | 285 aa | 27.0 % |
Onchocerca volvulus | Melatonin receptor | 346 aa | 302 aa | 19.2 % | |
Loa Loa (eye worm) | neuropeptide F receptor | Melatonin receptor | 346 aa | 299 aa | 20.1 % |
Onchocerca volvulus | Melatonin receptor | 346 aa | 307 aa | 21.5 % | |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Melatonin receptor | 346 aa | 323 aa | 22.0 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Melatonin receptor | 346 aa | 349 aa | 23.2 % |
Echinococcus multilocularis | allatostatin A receptor | Melatonin receptor | 346 aa | 325 aa | 21.2 % |
Onchocerca volvulus | E3 ubiquitin-protein ligase rpm-1 homolog | Melatonin receptor | 346 aa | 307 aa | 22.1 % |
Schistosoma mansoni | neuropeptide receptor | Melatonin receptor | 346 aa | 290 aa | 27.6 % |
Onchocerca volvulus | Melatonin receptor | 346 aa | 285 aa | 26.7 % | |
Onchocerca volvulus | Melatonin receptor | 346 aa | 308 aa | 22.1 % | |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Melatonin receptor | 346 aa | 288 aa | 28.8 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Melatonin receptor | 346 aa | 298 aa | 21.5 % |
Onchocerca volvulus | Putative beta-1,3-glucuronyltransferase | Melatonin receptor | 346 aa | 363 aa | 22.9 % |
Onchocerca volvulus | Melatonin receptor | 346 aa | 300 aa | 23.0 % | |
Candida albicans | similar to S. cerevisiae a-factor receptor STE3 (YKL178C) | Melatonin receptor | 346 aa | 291 aa | 24.4 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Melatonin receptor | 346 aa | 323 aa | 22.0 % |
Candida albicans | similar to S. cerevisiae a-factor receptor STE3 (YKL178C) | Melatonin receptor | 346 aa | 291 aa | 24.4 % |
Onchocerca volvulus | Melatonin receptor | 346 aa | 330 aa | 21.8 % | |
Schistosoma mansoni | adenoreceptor | Melatonin receptor | 346 aa | 309 aa | 24.3 % |
Schistosoma mansoni | opsin-like receptor | Melatonin receptor | 346 aa | 327 aa | 23.5 % |
Schistosoma japonicum | Alpha-1A adrenergic receptor, putative | Melatonin receptor | 346 aa | 325 aa | 22.8 % |
Onchocerca volvulus | Melatonin receptor | 346 aa | 297 aa | 23.9 % | |
Schistosoma mansoni | biogenic amine (5HT) receptor | Melatonin receptor | 346 aa | 350 aa | 23.4 % |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | Melatonin receptor | 346 aa | 340 aa | 22.6 % |
Onchocerca volvulus | Melatonin receptor | 346 aa | 309 aa | 18.8 % | |
Echinococcus granulosus | tachykinin peptides receptor 99D | Melatonin receptor | 346 aa | 308 aa | 23.1 % |
Echinococcus multilocularis | G-protein coupled receptor, putative | Melatonin receptor | 346 aa | 295 aa | 20.0 % |
Brugia malayi | G-protein coupled receptor | Melatonin receptor | 346 aa | 313 aa | 24.0 % |
Brugia malayi | GnHR receptor homolog | Melatonin receptor | 346 aa | 310 aa | 21.3 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.7 nM | In vitro binding affinity against melatonin receptor using 2-[125I]-iodomelatonin (0.05 nM) and chiken brain membranes | ChEMBL. | 8759629 |
Ki (binding) | = 0.7 nM | In vitro binding affinity against melatonin receptor using 2-[125I]-iodomelatonin (0.05 nM) and chiken brain membranes | ChEMBL. | 8759629 |
pRA (binding) | = -0.18 | Negative logarithm of relative affinity (pRA) towards melatonin receptor (relative to N-actyl-5-methoxytryptamine (aMT)) | ChEMBL. | 9748358 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.