Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0048 | 0.0009 | 0.0002 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0048 | 0.0009 | 0.0002 |
Echinococcus multilocularis | adenine phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2164 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0048 | 0.0009 | 0.0002 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0281 | 0.1189 | 0.1182 |
Onchocerca volvulus | 0.0281 | 0.1189 | 0.1181 | |
Onchocerca volvulus | Adenine phosphoribosyltransferase homolog | 0.0474 | 0.2164 | 0.2156 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.0166 | 0.0159 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0281 | 0.1189 | 0.2781 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0048 | 0.0009 | 0.0004 |
Mycobacterium leprae | Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho | 0.155 | 0.7604 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0048 | 0.0009 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.1189 | 0.2781 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.008 | 0.0171 | 0.0163 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0281 | 0.1189 | 0.1182 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0048 | 0.0009 | 0.0002 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0888 | 0.4255 | 0.4251 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0148 | 0.0517 | 0.0517 |
Loa Loa (eye worm) | adenine phosphoribosyltransferase | 0.0474 | 0.2164 | 0.5076 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0048 | 0.0009 | 0.0002 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0281 | 0.1189 | 0.2781 |
Wolbachia endosymbiont of Brugia malayi | amidophosphoribosyltransferase | 0.0474 | 0.2164 | 0.5 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0048 | 0.0009 | 0.0009 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0148 | 0.0517 | 0.051 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0048 | 0.0009 | 0.0002 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0048 | 0.0009 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0009 | 0.0004 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0048 | 0.0009 | 0.0009 |
Schistosoma mansoni | tyrosine kinase | 0.0148 | 0.0517 | 0.051 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0048 | 0.0009 | 0.0002 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0048 | 0.0009 | 0.0009 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0048 | 0.0009 | 0.0002 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0048 | 0.0009 | 0.0009 |
Echinococcus granulosus | epidermal growth factor receptor | 0.008 | 0.0171 | 0.0163 |
Treponema pallidum | phosphoribosylpyrophosphate synthetase | 0.0474 | 0.2164 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.1189 | 0.2781 |
Echinococcus granulosus | serotonin transporter | 0.0281 | 0.1189 | 0.1182 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0171 | 0.0163 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0009 | 0.0004 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.0166 | 0.0159 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0048 | 0.0009 | 0.0004 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0048 | 0.0009 | 0.0002 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0048 | 0.0009 | 0.0009 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0048 | 0.0009 | 0.0002 |
Wolbachia endosymbiont of Brugia malayi | orotate phosphoribosyltransferase | 0.0474 | 0.2164 | 0.5 |
Toxoplasma gondii | orotate phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2156 |
Echinococcus multilocularis | serotonin transporter | 0.0281 | 0.1189 | 0.1189 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2158 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0148 | 0.0517 | 0.12 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.1189 | 0.2781 |
Schistosoma mansoni | orotidine 5'-phosphate decarboxylase | 0.0474 | 0.2164 | 0.2158 |
Brugia malayi | Protein kinase domain containing protein | 0.0888 | 0.4255 | 0.4251 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0048 | 0.0009 | 0.0002 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0888 | 0.4255 | 1 |
Loa Loa (eye worm) | orotate phosphoribosyltransferase | 0.0474 | 0.2164 | 0.5076 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0048 | 0.0009 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0009 | 0.0004 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0048 | 0.0009 | 0.0002 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0281 | 0.1189 | 0.1182 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0048 | 0.0009 | 0.0002 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0048 | 0.0009 | 0.0002 |
Schistosoma mansoni | Adenine phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2158 |
Echinococcus granulosus | adenine phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2158 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0009 | 0.0004 |
Schistosoma mansoni | uracil phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2158 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0148 | 0.0517 | 0.051 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.008 | 0.0171 | 0.0171 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0048 | 0.0009 | 0.0002 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0048 | 0.0009 | 0.5 |
Plasmodium falciparum | orotate phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2156 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0009 | 0.0004 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.005 | 0.0022 | 0.0014 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.0166 | 0.0159 |
Mycobacterium tuberculosis | Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor | 0.155 | 0.7604 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0009 | 0.0004 |
Schistosoma mansoni | Adenine phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2158 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0048 | 0.0009 | 0.0002 |
Treponema pallidum | hypothetical protein | 0.0474 | 0.2164 | 1 |
Echinococcus multilocularis | uridine 5' monophosphate synthase | 0.0474 | 0.2164 | 0.2164 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2158 |
Brugia malayi | orotate phosphoribosyltransferase family protein | 0.0474 | 0.2164 | 0.2158 |
Brugia malayi | Adenine phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2158 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0009 | 0.0004 |
Plasmodium vivax | orotate phosphoribosyltransferase, putative | 0.0474 | 0.2164 | 0.2156 |
Echinococcus multilocularis | insulin receptor | 0.0047 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | serotonin transporter b | 0.0281 | 0.1189 | 0.2781 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0048 | 0.0009 | 0.0002 |
Echinococcus granulosus | uridine 5' monophosphate synthase | 0.0474 | 0.2164 | 0.2158 |
Treponema pallidum | adenine phosphoribosyltransferase | 0.0474 | 0.2164 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0048 | 0.0009 | 0.0002 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0047 | 0.0008 | 0.0008 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0171 | 0.0163 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.