Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutathione reductase | 0.0172 | 0.9911 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0172 | 0.9911 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0043 | 0.1223 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0043 | 0.1223 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0172 | 0.9911 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0043 | 0.1223 | 0.5 |
Leishmania major | trypanothione reductase | 0.0172 | 0.9911 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0043 | 0.1223 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0043 | 0.1223 | 0.5 |
Brugia malayi | glutathione reductase | 0.0172 | 0.9911 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0172 | 0.9911 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0172 | 0.9911 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0172 | 0.9911 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0043 | 0.1223 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0172 | 0.9911 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0043 | 0.1223 | 0.1234 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0043 | 0.1223 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0172 | 0.9911 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0043 | 0.1223 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0172 | 0.9911 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0043 | 0.1223 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0043 | 0.1223 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0043 | 0.1223 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0172 | 0.9911 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0172 | 0.9911 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 20.34 % | Inhibition of alpha-1G calcium channel in human HEK293 cells at 10 uM by whole-cell patch-clamp method | ChEMBL. | 23395659 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.