Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0088 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0088 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0088 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0088 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0088 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0088 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0088 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0088 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0088 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.5 | 0.5 | |
Brugia malayi | SH2 domain containing protein | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0088 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0088 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0088 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0088 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0088 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0088 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0088 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0088 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0088 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0088 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0088 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0088 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 125 uM | Inhibition of human recombinant LSD1 (157 to 852 aa) expressed in Escherichia coli BL21(DE) using H3K4me2 as substrate by fluorescence assay | ChEMBL. | 24131029 |
IC50 (functional) | > 128 uM | Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTT assay | ChEMBL. | 23353743 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.