TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 425.54 | Formula: C24H27NO4S
H donors: 0 H acceptors: 1 LogP: 4.41 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(/C=C/c2ccc(cc2)OC)c(c(c1)OC)/C=C/C(=O)N1CCSCC1
InChi: 1S/C24H27NO4S/c1-27-20-8-5-18(6-9-20)4-7-19-16-21(28-2)17-23(29-3)22(19)10-11-24(26)25-12-14-30-15-13-25/h4-11,16-17H,12-15H2,1-3H3/b7-4+,11-10+
InChiKey: KLFIASJIUCZZHS-QPABKMLOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	prostaglandin-endoperoxide synthase 2	Starlite/ChEMBL	References
Homo sapiens	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK/Met protein kinase	0.0054	0.2178	0.218
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0104	0.5255	0.5261
Echinococcus granulosus	tyrosine protein kinase csk	0.0054	0.2178	0.2178
Giardia lamblia	Kinase	0.0054	0.2178	1
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Echinococcus granulosus	tensin	0.005	0.1899	0.1899
Echinococcus multilocularis	protein jagged 1	0.0021	0.0094	0.0094
Onchocerca volvulus		0.0104	0.5255	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.2178	0.0654
Giardia lamblia	Kinase, NEK	0.0054	0.2178	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2759	0.2763
Schistosoma mansoni	ephrin receptor	0.0054	0.2178	0.218
Onchocerca volvulus	Peroxidasin homolog	0.0063	0.2759	0.5251
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.2179	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.005	0.1899	0.1902
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Onchocerca volvulus	Neurogenic locus notch homolog	0.0021	0.0094	0.0179
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.2178	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0552	0.0553
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2759	0.2763
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Schistosoma mansoni	peroxidasin	0.0063	0.2759	0.2763
Onchocerca volvulus		0.0054	0.2178	0.4144
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0114	0.588	0.5888
Schistosoma mansoni	tyrosine kinase	0.0104	0.5255	0.5261
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0054	0.2178	0.4144
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2759	0.2763
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.005	0.1899	0.1902
Brugia malayi	integrin-linked kinase	0.0054	0.2178	0.218
Onchocerca volvulus		0.0054	0.2178	0.4144
Schistosoma mansoni	tensin	0.005	0.1899	0.1902
Trypanosoma brucei	protein kinase, putative	0.0054	0.219	1
Loa Loa (eye worm)	TK protein kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	TK/RYK protein kinase	0.0054	0.2178	0.218
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Echinococcus granulosus	growth factor receptor bound protein 2	0.0062	0.2651	0.2651
Schistosoma mansoni	tensin-related	0.005	0.1899	0.1902
Schistosoma mansoni	cell polarity protein	0.0021	0.0094	0.0094
Onchocerca volvulus	Tyrosine kinase homolog	0.0054	0.2178	0.4144
Echinococcus granulosus	tyrosine protein kinase shark	0.0104	0.5255	0.5255
Brugia malayi	Animal haem peroxidase family protein	0.0063	0.2759	0.2763
Entamoeba histolytica	hypothetical protein, conserved	0.0054	0.2178	0.0654
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0054	0.2178	0.2178
Loa Loa (eye worm)	hypothetical protein	0.005	0.1899	0.1902
Entamoeba histolytica	protein kinase, putative	0.0054	0.2179	0.0656
Brugia malayi	protein-tyrosine kinase	0.0168	0.9236	0.9247
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Echinococcus multilocularis	neural cadherin	0.0021	0.0094	0.0094
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0021	0.0094	0.0094
Entamoeba histolytica	protein kinase, putative	0.0054	0.2178	0.0654
Brugia malayi	SH2 domain containing protein	0.005	0.1899	0.1902
Echinococcus granulosus	suppressor of cytokine signaling 6	0.005	0.1899	0.1899
Brugia malayi	hypothetical protein	0.0104	0.5255	0.5261
Schistosoma mansoni	SH2A	0.005	0.1899	0.1902
Schistosoma mansoni	protein kinase	0.0054	0.2178	0.218
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.2178	0.0654
Loa Loa (eye worm)	hypothetical protein	0.005	0.1899	0.1902
Entamoeba histolytica	protein kinase, putative	0.0054	0.2178	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2759	0.2763
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.2178	0.0654
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0104	0.5255	0.5261
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.2178	0.0654
Loa Loa (eye worm)	TK/CSK protein kinase	0.0054	0.2178	0.218
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.2178	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.018	0.9987	1
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Echinococcus multilocularis	integrin linked protein kinase	0.0054	0.2178	0.218
Schistosoma mansoni	notch	0.0021	0.0094	0.0094
Echinococcus granulosus	protein jagged 2	0.0021	0.0094	0.0094
Onchocerca volvulus	Chorion peroxidase homolog	0.0063	0.2759	0.5251
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Brugia malayi	Guanylyl cyclase protein 23	0.0054	0.2178	0.218
Echinococcus multilocularis	tyrosine protein kinase csk	0.0054	0.2178	0.218
Entamoeba histolytica	protein kinase, putative	0.0054	0.2178	0.0654
Loa Loa (eye worm)	animal heme peroxidase	0.0063	0.2759	0.2763
Schistosoma mansoni	tyrosine kinase	0.018	0.9987	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0054	0.2178	0.2178
Brugia malayi	EGF-like domain containing protein	0.0021	0.0094	0.0094
Schistosoma mansoni	hypothetical protein	0.0021	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0062	0.2651	0.2654
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.2178	0.0654
Schistosoma mansoni	tyrosine protein kinase	0.0054	0.2178	0.218
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Echinococcus multilocularis	tyrosine protein kinase csk	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Brugia malayi	Blistered cuticle protein 3	0.0063	0.2759	0.2763
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2759	0.2763
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0118	0.6159	0.6166
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0054	0.2178	0.218
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0054	0.2178	0.2178
Echinococcus granulosus	expressed conserved protein	0.005	0.1899	0.1899
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0054	0.2178	0.218
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2178	0.218
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.005	0.1899	0.1902
Schistosoma mansoni	tyrosine kinase	0.018	0.9987	1
Entamoeba histolytica	hypothetical protein	0.0054	0.2178	0.0654
Brugia malayi	Animal haem peroxidase family protein	0.0063	0.2759	0.2763
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0054	0.219	1
Entamoeba histolytica	hypothetical protein	0.0054	0.2178	0.0654
Loa Loa (eye worm)	TK/FAK protein kinase	0.0054	0.2178	0.218
Echinococcus granulosus	protein jagged 1	0.0021	0.0094	0.0094
Echinococcus multilocularis	protein tyrosine kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0054	0.2178	0.218
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.2178	0.0654
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0054	0.2178	0.218
Schistosoma mansoni	septate junction protein	0.0021	0.0094	0.0094
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0116	0.6006	0.6014
Echinococcus granulosus	activin receptor type	0.0054	0.219	0.219
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Echinococcus multilocularis	peroxidasin	0.0063	0.2759	0.2763
Echinococcus granulosus	neurogenic locus notch protein	0.0021	0.0094	0.0094
Echinococcus multilocularis	tensin	0.005	0.1899	0.1902
Entamoeba histolytica	protein kinase, putative	0.0054	0.2178	0.0654
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.2178	0.0654
Schistosoma mansoni	protein kinase	0.0054	0.2178	0.218
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.2178	0.218
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0168	0.9236	0.9247
Onchocerca volvulus		0.0054	0.2178	0.4144
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.2178	0.0654
Echinococcus multilocularis	insulin receptor	0.0054	0.2178	0.218
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Plasmodium falciparum	protein kinase, putative	0.0054	0.219	1
Brugia malayi	SH2 domain containing protein	0.0104	0.5255	0.5261
Schistosoma mansoni	hypothetical protein	0.0021	0.0094	0.0094
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0062	0.2651	0.2654
Echinococcus granulosus	raf serine:threonine protein kinase	0.0054	0.2178	0.2178
Onchocerca volvulus		0.0063	0.2759	0.5251
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.005	0.1899	0.1902
Echinococcus granulosus	NCK adaptor protein	0.0062	0.2651	0.2651
Brugia malayi	Delta serrate ligand family protein	0.0021	0.0094	0.0094
Brugia malayi	SH2 domain containing protein	0.0104	0.5255	0.5261
Echinococcus multilocularis	tyrosine protein kinase shark	0.0104	0.5255	0.5261
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0054	0.2178	0.218
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.2929	0.2933
Loa Loa (eye worm)	hypothetical protein	0.005	0.1899	0.1902
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.005	0.1899	0.1902
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0054	0.2178	0.2178
Entamoeba histolytica	hypothetical protein	0.0054	0.2178	0.0654
Entamoeba histolytica	tyrosin kinase, putative	0.0054	0.2178	0.0654
Loa Loa (eye worm)	TK protein kinase	0.0054	0.2178	0.218
Entamoeba histolytica	ankyrin repeat protein	0.0054	0.2179	0.0656
Brugia malayi	SRC-1	0.018	0.9987	1
Entamoeba histolytica	hypothetical protein	0.0054	0.2178	0.0654
Brugia malayi	Protein kinase domain containing protein	0.0047	0.1742	0.1745
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0054	0.2178	0.218
Onchocerca volvulus	Peroxidase homolog	0.0063	0.2759	0.5251
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2178	0.218
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.2178	0.0654
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.005	0.1899	0.3614
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Echinococcus granulosus	tyrosine protein kinase Fyn	0.018	0.9987	0.9987
Onchocerca volvulus		0.0104	0.5255	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5255	0.5261
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0019	0.000000068286	0.000000068372
Echinococcus granulosus	tyrosine protein kinase Fyn	0.018	0.9987	0.9987
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Schistosoma mansoni	ankyrin 23/unc44	0.0019	0.0001	0.0001
Entamoeba histolytica	hypothetical protein	0.0054	0.2178	0.0654
Onchocerca volvulus		0.0104	0.5255	1
Schistosoma mansoni	notch	0.0021	0.0094	0.0094
Loa Loa (eye worm)	SRC-1	0.018	0.9987	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0054	0.2178	0.2178
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.2178	0.0654
Echinococcus granulosus	tyrosine protein kinase Blk	0.0168	0.9236	0.9236
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.2178	0.0654
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Echinococcus granulosus	activated cdc42 kinase 1	0.0054	0.2178	0.2178
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Onchocerca volvulus		0.0021	0.0094	0.0179
Brugia malayi	Tyrosine-protein kinase PR2	0.0054	0.2178	0.218
Brugia malayi	Calcium binding EGF domain containing protein	0.0021	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2759	0.2763
Schistosoma mansoni	notch	0.0021	0.0094	0.0094
Toxoplasma gondii	STE kinase	0.0054	0.2178	0.994
Onchocerca volvulus		0.0054	0.2178	0.4144
Echinococcus granulosus	protein jagged 1	0.0021	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2759	0.2763
Onchocerca volvulus	Dual oxidase homolog	0.0063	0.2759	0.5251
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Schistosoma mansoni	shc transforming protein	0.005	0.1899	0.1902
Entamoeba histolytica	protein kinase, putative	0.0054	0.2178	0.0654
Brugia malayi	Animal haem peroxidase family protein	0.0063	0.2759	0.2763
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0552	0.0553
Entamoeba histolytica	tyrosin kinase, putative	0.0054	0.2178	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2759	0.2763
Schistosoma mansoni	hypothetical protein	0.005	0.1899	0.1902
Onchocerca volvulus		0.0021	0.0094	0.0179
Echinococcus multilocularis	tyrosine kinase	0.0104	0.5255	0.5261
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Echinococcus multilocularis	NCK adaptor protein	0.0062	0.2651	0.2654
Echinococcus granulosus	signal transduction protein lnk realted	0.005	0.1899	0.1899
Onchocerca volvulus		0.0104	0.5255	1
Loa Loa (eye worm)	TK protein kinase	0.0054	0.2178	0.218
Echinococcus multilocularis	SH2 motif	0.005	0.1899	0.1902
Brugia malayi	hypothetical protein	0.0054	0.2178	0.218
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.018	0.9987	0.9987
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.005	0.1899	0.1902
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0054	0.219	1
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Schistosoma mansoni	tensin	0.005	0.1899	0.1902
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0104	0.5255	0.5255
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0054	0.2178	0.218
Entamoeba histolytica	protein kinase, putative	0.0054	0.2178	0.0654
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0021	0.0094	0.0094
Schistosoma mansoni	notch	0.0021	0.0094	0.0094
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Loa Loa (eye worm)	TK/ACK protein kinase	0.0054	0.2178	0.218
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.2178	0.0654
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0054	0.2178	0.2178
Schistosoma mansoni	slit	0.0021	0.0094	0.0094
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.005	0.1899	0.1902
Loa Loa (eye worm)	TK/DDR protein kinase	0.0054	0.2178	0.218
Leishmania major	protein kinase, putative	0.0054	0.219	1
Echinococcus multilocularis	transfer RNA-Thr	0.0054	0.2178	0.218
Brugia malayi	notch-like transmembrane receptor	0.0021	0.0094	0.0094
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.005	0.1899	0.1899
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0054	0.2178	0.218
Echinococcus granulosus	Ankyrin	0.0019	0.000000068286	0.000000068286
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0054	0.2178	0.994
Echinococcus granulosus	SH2 motif	0.005	0.1899	0.1899
Brugia malayi	Raf kinase	0.0054	0.2178	0.218
Brugia malayi	Variant SH3 domain containing protein	0.005	0.1899	0.1902
Brugia malayi	SH2 domain containing protein	0.005	0.1899	0.1902
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.2179	0.9993
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Onchocerca volvulus		0.0104	0.5255	1
Entamoeba histolytica	ankyrin repeat protein	0.0054	0.2178	0.0654
Echinococcus granulosus	tyrosine kinase	0.0168	0.9236	0.9236
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Brugia malayi	Animal haem peroxidase family protein	0.0063	0.2759	0.2763
Echinococcus multilocularis	signal transduction protein lnk realted	0.005	0.1899	0.1902
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2759	0.2763
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.018	0.9987	1
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Echinococcus multilocularis	Ankyrin	0.0019	0.0001	0.0001
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0054	0.2178	0.218
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0054	0.2178	0.218
Echinococcus granulosus	insulin receptor	0.0054	0.2178	0.2178
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.005	0.1899	0.1899
Brugia malayi	C-terminal src kinase protein 1	0.0054	0.2178	0.218
Loa Loa (eye worm)	SH2 domain-containing protein	0.005	0.1899	0.1902
Brugia malayi	RhoGAP domain containing protein	0.005	0.1899	0.1902
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Schistosoma mansoni	protein kinase	0.0054	0.2178	0.218
Brugia malayi	Protein kinase domain containing protein	0.0104	0.5255	0.5261
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.018	0.9987	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0054	0.2178	0.218
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.1899	0.1902
Onchocerca volvulus		0.0021	0.0094	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0104	0.5255	0.5261
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5255	0.5261
Echinococcus granulosus	tyrosine protein kinase csk	0.0054	0.2178	0.2178
Loa Loa (eye worm)	hypothetical protein	0.0047	0.173	0.1732
Echinococcus granulosus	kinase suppressor of Ras 1	0.0054	0.2178	0.2178
Onchocerca volvulus		0.0054	0.2178	0.4144
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0054	0.2178	0.218
Loa Loa (eye worm)	SH2 domain-containing protein	0.005	0.1899	0.1902
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0116	0.6006	0.6014
Entamoeba histolytica	receptor protein kinase, putative	0.0054	0.2178	0.0654
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.2178	0.0654
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Echinococcus multilocularis	c src tyrosine kinase	0.0116	0.6006	0.6014
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2178	0.218
Loa Loa (eye worm)	TK protein kinase	0.0054	0.2178	0.218
Schistosoma mansoni	protein kinase	0.0054	0.219	0.2193
Echinococcus multilocularis	SH2 motif	0.005	0.1899	0.1902
Echinococcus granulosus	protein jagged 2	0.0021	0.0094	0.0094
Echinococcus granulosus	peroxidasin	0.0063	0.2759	0.2759
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0054	0.2178	0.0007
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0054	0.2178	0.5
Echinococcus granulosus	notch	0.0021	0.0094	0.0094
Echinococcus granulosus	protein tyrosine kinase	0.0054	0.2178	0.2178
Echinococcus multilocularis	SH2 motif	0.005	0.1899	0.1902
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Echinococcus granulosus	hypothetical protein	0.005	0.1899	0.1899
Brugia malayi	Protein kinase domain containing protein	0.0104	0.5255	0.5261
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2759	0.2763
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Loa Loa (eye worm)	hypothetical protein	0.005	0.1899	0.1902
Echinococcus multilocularis	neurogenic locus protein delta	0.0021	0.0094	0.0094
Echinococcus multilocularis		0.005	0.1899	0.1902
Brugia malayi	Protein kinase domain containing protein	0.0104	0.5255	0.5261
Schistosoma mansoni	protein kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2178	0.218
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0054	0.2178	0.2178
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.2178	0.0654
Brugia malayi	Peroxidasin	0.0063	0.2759	0.2763
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.2178	0.0654
Echinococcus granulosus	SH2 domain containing adapter protein F	0.005	0.1899	0.1899
Echinococcus granulosus	tyrosine protein kinase pr2	0.0054	0.2178	0.2178
Schistosoma mansoni	hypothetical protein	0.0021	0.0094	0.0094
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.2178	0.0654
Brugia malayi	Death domain containing protein	0.0019	0.000000068286	0.000000068372
Schistosoma mansoni	protein kinase	0.0054	0.219	0.2193
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.005	0.1899	0.3614
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.018	0.9987	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.018	0.9987	0.9987
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.2178	0.0654
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	CAMK/DAPK/DAPK protein kinase	0.0028	0.0565	0.0565
Brugia malayi	Protein kinase domain containing protein	0.0104	0.5255	0.5261
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0054	0.2178	0.2178
Brugia malayi	Calcium binding EGF domain containing protein	0.0021	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2759	0.2763
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.005	0.1899	0.1902
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Schistosoma mansoni	hypothetical protein	0.0021	0.0094	0.0094
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.018	0.9987	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.2178	0.0654
Schistosoma mansoni	suppressor of cytokine signaling	0.005	0.1899	0.1902
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0116	0.6006	0.6006
Onchocerca volvulus		0.0063	0.2759	0.5251
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0054	0.2178	0.218
Schistosoma mansoni	notch	0.0021	0.0094	0.0094
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Brugia malayi	Calcium binding EGF domain containing protein	0.0021	0.0094	0.0094
Echinococcus granulosus	slit 2 protein	0.0021	0.0094	0.0094
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2178	0.218
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2178	0.218
Echinococcus granulosus	neurogenic locus notch protein 4	0.0021	0.0094	0.0094
Schistosoma mansoni	tensin-related	0.005	0.1899	0.1902
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0054	0.2178	0.218
Brugia malayi	hypothetical protein	0.005	0.1899	0.1902
Onchocerca volvulus		0.0054	0.2178	0.4144
Brugia malayi	SH2 domain containing protein	0.005	0.1899	0.1902
Echinococcus multilocularis	tyrosine protein kinase	0.0054	0.2178	0.218
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0021	0.0094	0.0094
Brugia malayi	Uncoordinated protein 44	0.0019	0.0001	0.0001
Echinococcus granulosus	ephrin type A receptor 4 A	0.0054	0.2178	0.2178
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.2178	0.0654
Echinococcus multilocularis	notch	0.0021	0.0094	0.0094
Echinococcus granulosus	integrin linked protein kinase	0.0054	0.2178	0.2178
Schistosoma mansoni	ephrin receptor	0.0054	0.2178	0.218
Entamoeba histolytica	tyrosin kinase, putative	0.0054	0.2178	0.0654
Brugia malayi	EGF-like domain containing protein	0.0021	0.0095	0.0095
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0054	0.2178	0.4144
Entamoeba histolytica	receptor protein kinase, putative	0.0054	0.2178	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Echinococcus granulosus	epidermal growth factor receptor	0.0054	0.2178	0.2178
Entamoeba histolytica	protein kinase, putative	0.0054	0.2178	0.0654
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Echinococcus multilocularis	epidermal growth factor receptor	0.0054	0.2178	0.218
Entamoeba histolytica	hypothetical protein	0.0054	0.2178	0.0654
Brugia malayi	Receptor family ligand binding region containing protein	0.0054	0.2178	0.218
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.2178	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2759	0.2763
Schistosoma mansoni	tyrosine kinase	0.0116	0.6006	0.6014
Echinococcus multilocularis	protein kinase	0.0054	0.2178	0.218
Schistosoma mansoni	tyrosine kinase	0.0116	0.6006	0.6014
Entamoeba histolytica	hypothetical protein	0.0054	0.2178	0.0654
Schistosoma mansoni	protein kinase	0.0054	0.219	0.2193
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.018	0.9987	1
Brugia malayi	SH2 domain containing protein	0.005	0.1899	0.1902
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	CAMK/DAPK/DAPK protein kinase	0.0028	0.0565	0.0565
Brugia malayi	EGF-like domain containing protein	0.0021	0.0094	0.0094
Brugia malayi	Variant SH3 domain containing protein	0.005	0.1899	0.1902
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.005	0.1899	0.1899
Echinococcus multilocularis	SHC transforming protein 3	0.005	0.1899	0.1902
Loa Loa (eye worm)	notch protein	0.0021	0.0094	0.0094
Onchocerca volvulus	Putative cubilin	0.0021	0.0094	0.0179
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0021	0.0094	0.0094
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.2178	0.218
Echinococcus granulosus	tyrosine protein kinase	0.0054	0.2178	0.2178
Brugia malayi	EGF-like domain containing protein	0.0021	0.0094	0.0094
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0104	0.5255	0.5255
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Echinococcus granulosus	tyrosine protein kinase HCK	0.0118	0.6159	0.6159
Echinococcus granulosus	SHC transforming protein 3	0.005	0.1899	0.1899
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5255	0.5261
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.005	0.1899	0.1902
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0054	0.2178	0.218
Toxoplasma gondii	protein kinase domain-containing protein	0.0054	0.2178	0.994
Echinococcus granulosus	delta-like protein 1	0.0021	0.0094	0.0094
Brugia malayi	SH2 domain containing protein	0.005	0.1899	0.1902
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.005	0.1899	0.1902
Entamoeba histolytica	cysteine surface protein, putative	0.0054	0.2178	0.0654
Loa Loa (eye worm)	Notch2	0.0021	0.0095	0.0095
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.018	0.9987	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5255	0.5261
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0054	0.2178	0.218
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0054	0.2178	0.218
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.2178	0.0654
Schistosoma mansoni	notch	0.0021	0.0094	0.0094
Echinococcus multilocularis	tyrosine protein kinase csk	0.0054	0.2178	0.218
Loa Loa (eye worm)	TK/ALK protein kinase	0.0054	0.2178	0.218
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0168	0.9236	0.9247
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0054	0.2178	0.218
Onchocerca volvulus		0.005	0.1899	0.3614
Echinococcus granulosus	tyrosine protein kinase Srms	0.0104	0.5255	0.5255
Brugia malayi	tRNA modification GTPase TrmE family protein	0.005	0.1899	0.1902
Entamoeba histolytica	protein kinase, putative	0.0054	0.2178	0.0654
Echinococcus granulosus	epidermal growth factor receptor	0.0054	0.2178	0.2178
Loa Loa (eye worm)	hypothetical protein	0.005	0.1899	0.1902
Onchocerca volvulus		0.005	0.1899	0.3614
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.005	0.1899	0.1902
Schistosoma mansoni	vav2	0.005	0.1899	0.1902
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Entamoeba histolytica	hypothetical protein	0.0054	0.2178	0.0654
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.005	0.1899	0.1902
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.2178	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Onchocerca volvulus	Slit protein homolog	0.0021	0.0094	0.0179
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0565	0.0565
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0054	0.2178	0.0654
Loa Loa (eye worm)	TK protein kinase	0.0054	0.2178	0.218
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2178	0.218
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0054	0.2178	0.0654
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0054	0.2178	0.2178
Brugia malayi	hypothetical protein	0.0054	0.2178	0.218
Echinococcus granulosus	N chimaerin	0.005	0.1899	0.1899
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0054	0.2178	0.218
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0054	0.2178	0.2178
Brugia malayi	GCC2 and GCC3 family protein	0.0021	0.0094	0.0094
Brugia malayi	Cadherin domain containing protein	0.0021	0.0094	0.0094
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.018	0.9987	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.005	0.1899	0.1902
Echinococcus multilocularis	neurogenic locus notch protein	0.0021	0.0094	0.0094
Schistosoma mansoni	protein kinase	0.0054	0.2178	0.218
Brugia malayi	SH2 domain containing protein	0.005	0.1899	0.1902
Schistosoma mansoni	nck2/grb4	0.0062	0.2651	0.2654
Echinococcus multilocularis	fibropellin Ia	0.0021	0.0094	0.0094
Echinococcus granulosus	tyrosine protein kinase Fyn	0.018	0.9987	0.9987
Echinococcus granulosus	neural cadherin	0.0021	0.0094	0.0094
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0054	0.2178	0.218
Onchocerca volvulus		0.005	0.1899	0.3614
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Entamoeba histolytica	protein kinase, putative	0.0054	0.2178	0.0654
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0054	0.2178	0.2178
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2759	0.2763
Brugia malayi	Variant SH3 domain containing protein	0.0062	0.2651	0.2654
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0054	0.2178	0.2178
Echinococcus granulosus	tyrosine kinase	0.0054	0.2178	0.2178
Entamoeba histolytica	protein kinase, putative	0.0054	0.2178	0.0654
Echinococcus granulosus	protein kinase	0.0054	0.2178	0.2178
Loa Loa (eye worm)	TK/EPH protein kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	TK protein kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5255	0.5261
Schistosoma mansoni	hypothetical protein	0.0021	0.0094	0.0094
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.005	0.1899	0.1902
Brugia malayi	Tensin	0.005	0.1899	0.1902
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0054	0.2178	0.2178
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.005	0.1899	0.1902
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.2178	0.0654
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0054	0.2178	0.218
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0054	0.2178	0.218
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0054	0.2178	0.2178
Schistosoma mansoni	protein kinase	0.0054	0.2178	0.218
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.2178	0.0007
Loa Loa (eye worm)	TK protein kinase	0.0118	0.6159	0.6166
Brugia malayi	Sex muscle abnormal protein 5	0.0062	0.2651	0.2654
Brugia malayi	Animal haem peroxidase family protein	0.0063	0.2759	0.2763
Loa Loa (eye worm)	hypothetical protein	0.005	0.1899	0.1902
Echinococcus multilocularis	protein jagged 1	0.0021	0.0094	0.0094
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0054	0.2178	0.218
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0054	0.2178	0.218
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0104	0.5255	0.7878
Echinococcus multilocularis	epidermal growth factor receptor	0.0054	0.2178	0.218
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Echinococcus granulosus	c src tyrosine kinase	0.0116	0.6006	0.6006
Brugia malayi	Tyrosine-protein kinase abl-1	0.0116	0.6006	0.6014
Schistosoma mansoni	growth factor receptor-bound protein	0.0062	0.2651	0.2654
Loa Loa (eye worm)	animal heme peroxidase	0.0063	0.2759	0.2763
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0001	0.0001
Schistosoma mansoni	tyrosine kinase	0.0104	0.5255	0.5261
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0062	0.2651	0.2654
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0054	0.2178	0.2178
Brugia malayi	EGF-like domain containing protein	0.0021	0.0094	0.0094
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0054	0.2178	0.994
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.2178	0.0654
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.2178	0.0654
Entamoeba histolytica	protein kinase, putative	0.0054	0.2178	0.0654
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Entamoeba histolytica	protein kinase, putative	0.0054	0.2178	0.0654
Echinococcus granulosus	SH2 domain containing protein 7	0.005	0.1899	0.1899
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0054	0.2178	0.218
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Loa Loa (eye worm)	TK protein kinase	0.0054	0.2178	0.218
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.2178	0.0654
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0168	0.9236	0.9247
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0565	0.0565
Loa Loa (eye worm)	hypothetical protein	0.005	0.1899	0.1902
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0054	0.2178	0.218
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0054	0.2178	0.218
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0019	0.000000068286	0.000000068286
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0054	0.2178	0.218
Giardia lamblia	Protein 21.1	0.0054	0.2178	1
Onchocerca volvulus		0.0054	0.2178	0.4144
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.005	0.1899	0.1902
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2178	0.218
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Onchocerca volvulus	Peroxidasin homolog	0.0063	0.2759	0.5251
Brugia malayi	hypothetical protein	0.0063	0.2759	0.2763
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0054	0.2178	0.218
Schistosoma mansoni	protein tyrosine kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.005	0.1899	0.1902
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0054	0.2178	0.218
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Onchocerca volvulus		0.0021	0.0094	0.0179
Entamoeba histolytica	hypothetical protein	0.0054	0.2178	0.0654
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0054	0.2178	0.218
Onchocerca volvulus		0.0063	0.2759	0.5251
Echinococcus granulosus	suppressor of cytokine signaling 7	0.005	0.1899	0.1899
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5255	0.5261
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Brugia malayi	SH2 domain containing protein	0.005	0.1899	0.1902
Brugia malayi	STAT protein, DNA binding domain containing protein	0.005	0.1899	0.1902
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0054	0.2178	0.2178
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Brugia malayi	ephrin receptor 1 precursor	0.0054	0.2178	0.218
Echinococcus granulosus	neurogenic locus protein delta	0.0021	0.0094	0.0094
Echinococcus granulosus	tyrosine kinase	0.0104	0.5255	0.5255
Echinococcus multilocularis	protein kinase	0.0054	0.2178	0.218
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0054	0.2178	0.218
Echinococcus multilocularis	tyrosine protein kinase csk	0.0054	0.2178	0.218
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0054	0.2178	0.218
Loa Loa (eye worm)	animal heme peroxidase	0.0063	0.2759	0.2763
Onchocerca volvulus		0.0104	0.5255	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5255	0.5261
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.2178	0.218
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0054	0.2178	0.218
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.2178	0.0654
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.219	0.0683
Onchocerca volvulus		0.0054	0.2178	0.4144
Brugia malayi	Furin-like cysteine rich region family protein	0.0054	0.2178	0.218
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.005	0.1899	0.1902
Loa Loa (eye worm)	TK/ROR protein kinase	0.0054	0.2178	0.218
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0054	0.219	0.219
Loa Loa (eye worm)	animal heme peroxidase	0.0063	0.2759	0.2763
Schistosoma mansoni	hypothetical protein	0.0021	0.0094	0.0094
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0054	0.219	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.018	0.9987	0.9987
Onchocerca volvulus		0.005	0.1899	0.3614
Entamoeba histolytica	protein kinase, putative	0.0054	0.2178	0.0654
Entamoeba histolytica	protein kinase, putative	0.0054	0.2178	0.0654
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0054	0.2178	0.218
Entamoeba histolytica	tyrosin kinase, putative	0.0054	0.2178	0.0654
Onchocerca volvulus		0.0054	0.2178	0.4144
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0054	0.2178	0.218
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.2178	0.0654
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0054	0.2178	0.218
Echinococcus multilocularis	activated cdc42 kinase 1	0.0054	0.2178	0.218
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0168	0.9236	0.9236
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.2178	0.0654
Schistosoma mansoni	protein kinase	0.0054	0.2178	0.218
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Schistosoma mansoni	GTPase activating protein	0.005	0.1899	0.1902
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.2178	0.0007
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0116	0.6006	0.6014
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0054	0.2178	0.2178
Brugia malayi	EGF-like domain containing protein	0.0021	0.0094	0.0094
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.2178	0.218
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.018	0.9987	1
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Schistosoma mansoni	adapter molecule crk	0.0062	0.2651	0.2654
Echinococcus multilocularis	protein jagged 2	0.0021	0.0094	0.0094
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.2178	0.0654
Echinococcus granulosus	activated cdc42 kinase 1	0.0054	0.2178	0.2178
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.005	0.1899	0.1899
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.2178	0.218
Schistosoma mansoni	signal transduction protein lnk-related	0.005	0.1899	0.1902
Loa Loa (eye worm)	blistered cuticle protein 3	0.0063	0.2759	0.2763
Loa Loa (eye worm)	hypothetical protein	0.005	0.1899	0.1902
Entamoeba histolytica	protein kinase, putative	0.0054	0.2178	0.0654
Brugia malayi	Protein kinase domain containing protein	0.0104	0.5255	0.5261
Echinococcus granulosus	natriuretic peptide receptor 1	0.0054	0.2178	0.2178
Schistosoma mansoni	protein kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.2178	0.218
Echinococcus multilocularis	heat shock protein 70	0.0054	0.2178	0.218
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0054	0.219	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Echinococcus multilocularis	N chimaerin	0.005	0.1899	0.1902
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.2178	0.0654
Schistosoma mansoni	hypothetical protein	0.0054	0.2178	0.218
Entamoeba histolytica	hypothetical protein	0.0054	0.2178	0.0654
Onchocerca volvulus		0.005	0.1899	0.3614
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0054	0.2178	0.218
Schistosoma mansoni	hypothetical protein	0.005	0.1899	0.1902
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.005	0.1899	0.1902
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2178	0.218
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.005	0.1899	0.1902
Echinococcus multilocularis	neurogenic locus notch protein	0.0021	0.0094	0.0094
Echinococcus granulosus	fibropellin Ia	0.0021	0.0094	0.0094
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0054	0.219	0.2193
Brugia malayi	Variant SH3 domain containing protein	0.0062	0.2651	0.2654
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Schistosoma mansoni	peroxidasin	0.0063	0.2759	0.2763
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5255	0.5261
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0054	0.2178	0.218
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.005	0.1899	0.1899
Toxoplasma gondii	protein kinase	0.0054	0.2178	0.994
Onchocerca volvulus	Peroxidase homolog	0.0063	0.2759	0.5251
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0054	0.2178	0.218
Loa Loa (eye worm)	TK/INSR protein kinase	0.0054	0.2178	0.218
Brugia malayi	EGF-like domain containing protein	0.0021	0.0094	0.0094
Onchocerca volvulus		0.0021	0.0094	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2178	0.218
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0062	0.2651	0.2654
Schistosoma mansoni	growth factor receptor-bound protein	0.0062	0.2651	0.2654
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0553	0.0554
Brugia malayi	Muscle positioning protein 4	0.0021	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.005	0.1899	0.1902
Loa Loa (eye worm)	TK protein kinase	0.0054	0.2178	0.218
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0054	0.2178	0.218
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.2178	0.218
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0054	0.2178	0.0654
Loa Loa (eye worm)	hypothetical protein	0.005	0.1899	0.1902
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0062	0.2651	0.2654
Echinococcus multilocularis	activin receptor type	0.0054	0.219	0.2193
Loa Loa (eye worm)	TK/ABL protein kinase	0.0104	0.5255	0.5261
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0054	0.2178	0.218
Echinococcus multilocularis	SH2 domain containing protein 7	0.005	0.1899	0.1902
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Entamoeba histolytica	hypothetical protein	0.0054	0.2178	0.0654
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.018	0.9987	0.9987
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0114	0.588	0.588
Schistosoma mansoni	laminin gamma-3 chain	0.0021	0.0094	0.0094
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.2178	0.0654
Loa Loa (eye worm)	SH2 domain-containing protein	0.005	0.1899	0.1902
Trichomonas vaginalis	TKL family protein kinase	0.0054	0.2178	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0094
Echinococcus multilocularis	neurogenic locus protein delta	0.0021	0.0094	0.0094
Brugia malayi	Cadherin domain containing protein	0.0021	0.0094	0.0094
Schistosoma mansoni	tyrosine kinase	0.0054	0.2178	0.218
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5255	0.5261
Schistosoma mansoni	tensin	0.005	0.1899	0.1902
Onchocerca volvulus		0.005	0.1899	0.3614
Loa Loa (eye worm)	serine/threonine protein kinase	0.0054	0.2178	0.218
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.1899	0.1902
Loa Loa (eye worm)	STAT protein	0.005	0.1899	0.1902
Echinococcus multilocularis	FL cytokine receptor	0.0054	0.2178	0.218
Schistosoma mansoni	suppressor of cytokine signaling	0.005	0.1899	0.1902
Echinococcus multilocularis	slit 2 protein	0.0021	0.0094	0.0094
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0054	0.2178	0.5
Entamoeba histolytica	protein kinase, putative	0.0054	0.2178	0.0654
Echinococcus multilocularis	tensin	0.005	0.1899	0.1902
Entamoeba histolytica	protein kinase, putative	0.005	0.1912	0.003
Echinococcus granulosus	neurogenic locus notch protein	0.0021	0.0094	0.0094
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5255	0.5261
Giardia lamblia	Kinase, NEK	0.0054	0.2178	1
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0021	0.0094	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2759	0.2763
Plasmodium vivax	protein kinase, putative	0.0054	0.2178	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.005	0.1912	0.003
Loa Loa (eye worm)	TK protein kinase	0.0168	0.9236	0.9247
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.2178	0.0654
Brugia malayi	Protein kinase domain containing protein	0.0054	0.2178	0.218
Echinococcus granulosus	SH2 motif	0.005	0.1899	0.1899
Entamoeba histolytica	protein kinase, putative	0.0118	0.6159	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.2178	0.0654
Schistosoma mansoni	hypothetical protein	0.0021	0.0094	0.0094
Entamoeba histolytica	protein kinase, putative	0.0054	0.2178	0.0654
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.2178	0.0654
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0054	0.2178	0.2178
Echinococcus multilocularis	tyrosine kinase	0.0054	0.2178	0.218
Schistosoma mansoni	serine/threonine RGC	0.0054	0.2178	0.218

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3.18 uM	Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production	ChEMBL.	23353741
IC50 (functional)	= 5.4 uM	Antitumor activity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	ChEMBL.	23353741
IC50 (binding)	= 8.01 uM	Inhibition of COX-2 (unknown origin) by chemiluminescence assay	ChEMBL.	23353741
IC50 (functional)	= 8.1 uM	Antitumor activity against mouse B16F10 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	ChEMBL.	23353741
IC50 (binding)	= 45.19 uM	Inhibition of COX-1 (unknown origin) by chemiluminescence assay	ChEMBL.	23353741

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mus musculus	ChEMBL23	23353741
Homo sapiens	ChEMBL23	23353741

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2333739

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1730513