Detailed information for compound 173054

Basic information

Technical information
  • TDR Targets ID: 173054
  • Name: 2-hydroxyethyl(dimethyl)sulfanium
  • MW: 107.195 | Formula: C4H11OS+
  • H donors: 1 H acceptors: 1 LogP: 0.21 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC[S+](C)C
  • InChi: 1S/C4H11OS/c1-6(2)4-3-5/h5H,3-4H2,1-2H3/q+1
  • InChiKey: DPYMRUOGINZSQM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-hydroxyethyl(dimethyl)sulfonium
  • 2-hydroxyethyl-dimethylsulfanium
  • 2-hydroxyethyl-dimethyl-sulfonium
  • 2-hydroxyethyl-dimethylsulfonium
  • 2-hydroxyethyl-dimethyl-sulfanium

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0524 0.0665
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0055 0.0521 0.0963
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0524 0.0524
Brugia malayi EGF-like domain containing protein 0.0028 0.0077 0.0077
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0623 0.1151
Echinococcus granulosus ecdysone induced protein 78C 0.0055 0.0521 0.0963
Echinococcus multilocularis hypothetical protein 0.011 0.1425 0.2634
Brugia malayi hypothetical protein 0.0035 0.0193 0.0193
Trypanosoma cruzi epsilon tubulin, putative 0.0084 0.0988 0.6933
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.7881 1
Brugia malayi Calcium binding EGF domain containing protein 0.0028 0.0077 0.0077
Leishmania major alpha tubulin 0.011 0.1425 1
Echinococcus multilocularis tubulin delta chain 0.0036 0.0212 0.0392
Loa Loa (eye worm) hypothetical protein 0.0055 0.0521 0.0521
Echinococcus multilocularis Tubulin alpha 1 chain 0.011 0.1425 0.2634
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0521 0.0521
Echinococcus granulosus tubulin alpha 0.0084 0.0988 0.1826
Trichomonas vaginalis tubulin alpha chain, putative 0.0084 0.0988 0.1254
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Echinococcus multilocularis tubulin alpha 1C chain 0.011 0.1425 0.2634
Echinococcus multilocularis beta tubulin 0.011 0.1419 0.2623
Toxoplasma gondii beta tubulin 0.011 0.1419 0.996
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0524 0.0629
Toxoplasma gondii alpha tubulin TUBA1 0.011 0.1425 1
Giardia lamblia Beta tubulin 0.011 0.1419 0.1801
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0055 0.0521 0.0963
Loa Loa (eye worm) BEN-1 protein 0.011 0.1419 0.1419
Loa Loa (eye worm) tubulin beta-1 chain 0.011 0.1419 0.1419
Leishmania major hypothetical protein, conserved 0.0028 0.007 0.049
Echinococcus multilocularis peroxisome assembly protein 26 0.011 0.1425 0.2634
Brugia malayi hypothetical protein 0.0028 0.007 0.007
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0524 0.0665
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0201 0.1408
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0055 0.0521 0.0625
Leishmania major beta tubulin 0.011 0.1419 0.996
Brugia malayi Blistered cuticle protein 3 0.0087 0.1041 0.1041
Loa Loa (eye worm) tubulin alpha chain 0.011 0.1425 0.1425
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Echinococcus multilocularis neurogenic locus notch protein 0.0028 0.0077 0.0142
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0026 0.0043 0.0043
Trypanosoma cruzi alpha tubulin, putative 0.011 0.1425 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0623 0.0747
Echinococcus multilocularis tubulin alpha chain 0.011 0.1425 0.2634
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0055 0.0521 0.0625
Schistosoma mansoni alpha tubulin 0.011 0.1425 0.1709
Brugia malayi hypothetical protein 0.0029 0.0094 0.0094
Trypanosoma brucei alpha tubulin 0.011 0.1425 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0115 0.1498 0.2768
Trichomonas vaginalis tubulin epsilon chain, putative 0.011 0.1425 0.1808
Loa Loa (eye worm) hypothetical protein 0.0087 0.1041 0.1041
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0201 0.0255
Toxoplasma gondii ABC1 family protein 0.0036 0.0201 0.1408
Giardia lamblia NADPH oxidoreductase, putative 0.0504 0.7881 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Loa Loa (eye worm) animal heme peroxidase 0.0087 0.1041 0.1041
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0524 0.368
Giardia lamblia NADPH oxidoreductase, putative 0.0504 0.7881 1
Leishmania major alpha tubulin 0.011 0.1425 1
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0028 0.0077 0.0092
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.3403 0.6289
Echinococcus multilocularis protein jagged 2 0.0028 0.0077 0.0142
Loa Loa (eye worm) beta-tubulin 0.011 0.1419 0.1419
Trichomonas vaginalis tubulin beta chain, putative 0.011 0.1425 0.1808
Entamoeba histolytica tubulin family protein 0.011 0.1419 0.8441
Echinococcus granulosus neurogenic locus protein delta 0.0028 0.0077 0.0142
Leishmania major alpha tubulin 0.011 0.1425 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0524 0.368
Echinococcus granulosus alpha tubulin 0.011 0.1425 0.2634
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1682 0.2134
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0521 0.0521
Leishmania major beta tubulin 0.011 0.1419 0.996
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Onchocerca volvulus 0.0487 0.7599 1
Schistosoma mansoni tubulin subunit delta 0.0036 0.0212 0.0254
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0513 0.0513
Echinococcus granulosus thyroid hormone receptor alpha 0.0026 0.0043 0.008
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0513 0.0513
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0586 0.1082
Leishmania major alpha tubulin 0.011 0.1425 1
Echinococcus granulosus beta tubulin 0.011 0.1419 0.2623
Leishmania major alpha tubulin 0.011 0.1425 1
Mycobacterium ulcerans cell division protein FtsZ 0.0036 0.0212 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Loa Loa (eye worm) tubulin alpha-3 chain 0.0063 0.0649 0.0649
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0055 0.0521 0.0963
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Schistosoma mansoni tubulin subunit beta 0.011 0.1419 0.1703
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0521 0.0521
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0229 0.0229
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0055 0.0521 0.0625
Brugia malayi hypothetical protein 0.0486 0.7579 0.7579
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Plasmodium vivax SET domain protein, putative 0.0061 0.0623 0.4079
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Onchocerca volvulus Dual oxidase homolog 0.0087 0.1041 0.137
Onchocerca volvulus Peroxidasin homolog 0.0087 0.1041 0.137
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0201 0.0599
Onchocerca volvulus Putative cubilin 0.0028 0.0077 0.0101
Brugia malayi beta-lactamase family protein 0.0036 0.0201 0.0201
Echinococcus granulosus tubulin beta 4A class IVa 0.011 0.1419 0.2623
Loa Loa (eye worm) blistered cuticle protein 3 0.0087 0.1041 0.1041
Echinococcus granulosus neurogenic locus notch protein 0.0028 0.0077 0.0142
Trichomonas vaginalis tubulin epsilon chain, putative 0.0036 0.0212 0.0269
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Toxoplasma gondii beta-tubulin, putative 0.011 0.1419 0.996
Brugia malayi beta-tubulin, identical 0.011 0.1419 0.1419
Entamoeba histolytica tubulin alpha-1 chain 0.011 0.1425 0.8475
Loa Loa (eye worm) hypothetical protein 0.0087 0.1041 0.1041
Brugia malayi steroid hormone receptor 0.0055 0.0521 0.0521
Trichomonas vaginalis tubulin gamma chain, putative 0.0036 0.0212 0.0269
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0029 0.0094 0.0094
Leishmania major alpha tubulin 0.011 0.1425 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0524 0.368
Brugia malayi nuclear hormone receptor family member odr-7 0.0026 0.0043 0.0043
Echinococcus granulosus slit 2 protein 0.0028 0.0077 0.0142
Trypanosoma brucei alpha tubulin, putative 0.0047 0.0393 0.2755
Loa Loa (eye worm) hypothetical protein 0.0486 0.7579 0.7579
Leishmania major epsilon tubulin, putative 0.0084 0.0988 0.6933
Leishmania major beta tubulin 0.011 0.1419 0.996
Loa Loa (eye worm) steroid hormone receptor 0.0055 0.0521 0.0521
Trypanosoma brucei tubulin gamma chain 0.0084 0.0988 0.6933
Loa Loa (eye worm) hypothetical protein 0.0029 0.0094 0.0094
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0623 0.4369
Brugia malayi EGF-like domain containing protein 0.0028 0.0077 0.0077
Loa Loa (eye worm) tubulin beta chain 0.0036 0.0212 0.0212
Plasmodium falciparum alpha tubulin 2 0.011 0.1425 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0055 0.0521 0.0521
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0623 0.1151
Trichomonas vaginalis tubulin, putative 0.0036 0.0212 0.0269
Loa Loa (eye worm) tubulin gamma chain 0.0084 0.0988 0.0988
Mycobacterium tuberculosis Cell division protein FtsZ 0.0036 0.0212 0.0634
Plasmodium vivax tubulin gamma chain, putative 0.0084 0.0988 0.6775
Trichomonas vaginalis conserved hypothetical protein 0.0378 0.5816 0.738
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1682 0.2134
Loa Loa (eye worm) hypothetical protein 0.0121 0.1592 0.1592
Trypanosoma brucei beta tubulin 0.011 0.1419 0.996
Brugia malayi Steroid receptor seven-up type 2 0.0055 0.0521 0.0521
Trichomonas vaginalis tubulin beta chain, putative 0.011 0.1425 0.1808
Trypanosoma brucei tubulin delta chain 0.0036 0.0212 0.1488
Leishmania major beta tubulin 0.011 0.1419 0.996
Trypanosoma brucei alpha tubulin 0.011 0.1425 1
Leishmania major beta tubulin 0.011 0.1419 0.996
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0055 0.0521 0.0521
Entamoeba histolytica tubulin alpha chain, putative 0.011 0.1425 0.8475
Echinococcus granulosus tubulin subunit TubB 0.011 0.1425 0.2634
Echinococcus granulosus peroxidasin 0.0087 0.1041 0.1923
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0043 0.0043
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0524 0.0665
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1682 0.2134
Echinococcus multilocularis caspase 2 0.0121 0.1592 0.2943
Schistosoma mansoni notch 0.0028 0.0077 0.0092
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0115 0.1498 0.1498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0055 0.0521 0.0521
Schistosoma mansoni serine-type protease inhibitor 0.0532 0.8336 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0201 0.0371
Loa Loa (eye worm) Notch2 0.0028 0.0077 0.0077
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0055 0.0521 0.0521
Trypanosoma brucei beta tubulin 0.011 0.1419 0.996
Entamoeba histolytica hypothetical protein 0.0035 0.0193 0.1146
Brugia malayi tailless protein 0.0026 0.0043 0.0043
Plasmodium vivax tubulin alpha chain, putative 0.011 0.1425 1
Brugia malayi Tubulin gamma chain 0.0084 0.0988 0.0988
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0115 0.1498 0.2768
Loa Loa (eye worm) hypothetical protein 0.0087 0.1041 0.1041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0055 0.0521 0.0521
Schistosoma mansoni hypothetical protein 0.0028 0.0077 0.0092
Mycobacterium ulcerans hypothetical protein 0.0036 0.0201 0.9458
Trypanosoma cruzi beta tubulin, putative 0.011 0.1419 0.996
Plasmodium vivax tubulin epsilon chain, putative 0.0084 0.0988 0.6775
Echinococcus granulosus nuclear receptor nhr 48 0.0026 0.0043 0.008
Schistosoma mansoni notch 0.0028 0.0077 0.0092
Schistosoma mansoni peroxidasin 0.0087 0.1041 0.1248
Mycobacterium tuberculosis Conserved protein 0.0036 0.0201 0.0599
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0036 0.0212 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0115 0.1498 0.2768
Echinococcus multilocularis ecdysone induced protein 78C 0.0055 0.0521 0.0963
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0115 0.1498 0.1498
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Schistosoma mansoni tubulin subunit beta 0.011 0.1419 0.1703
Leishmania major alpha tubulin 0.011 0.1425 1
Echinococcus multilocularis tubulin beta 1 chain 0.011 0.1419 0.2623
Echinococcus granulosus Tubulin beta 2C chain 0.011 0.1419 0.2623
Brugia malayi nuclear receptor NHR-88 0.0026 0.0043 0.0043
Brugia malayi hypothetical protein 0.0121 0.1592 0.1592
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0029 0.0094 0.0174
Brugia malayi Animal haem peroxidase family protein 0.0087 0.1041 0.1041
Onchocerca volvulus 0.0028 0.0077 0.0101
Loa Loa (eye worm) DR-78 0.0026 0.0043 0.0043
Echinococcus granulosus tubulin gamma 1 chain 0.0084 0.0988 0.1826
Onchocerca volvulus 0.0036 0.0201 0.0264
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0043 0.0043
Echinococcus granulosus neural cadherin 0.0028 0.0077 0.0142
Schistosoma mansoni hypothetical protein 0.0037 0.0229 0.0275
Loa Loa (eye worm) tubulin beta-4 chain 0.011 0.1419 0.1419
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0055 0.0521 0.0521
Loa Loa (eye worm) tubulin beta chain 0.011 0.1419 0.1419
Loa Loa (eye worm) hypothetical protein 0.0055 0.0521 0.0521
Echinococcus granulosus tubulin alpha chain 0.011 0.1425 0.2634
Brugia malayi Cadherin domain containing protein 0.0028 0.0077 0.0077
Trypanosoma brucei epsilon tubulin 0.0084 0.0988 0.6933
Echinococcus multilocularis tubulin alpha chain 0.011 0.1425 0.2634
Plasmodium falciparum tubulin beta chain 0.011 0.1419 0.9958
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0087 0.1041 0.1041
Loa Loa (eye worm) tubulin alpha 2 0.0074 0.083 0.083
Schistosoma mansoni notch 0.0028 0.0077 0.0092
Echinococcus multilocularis tubulin alpha chain 0.011 0.1425 0.2634
Brugia malayi ecdysteroid receptor 0.0055 0.0521 0.0521
Trichomonas vaginalis tubulin gamma chain, putative 0.011 0.1419 0.1801
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0201 0.0201
Loa Loa (eye worm) animal heme peroxidase 0.0087 0.1041 0.1041
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0201 0.0241
Loa Loa (eye worm) tubulin alpha-2 chain 0.011 0.1425 0.1425
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0055 0.0521 0.0963
Brugia malayi hypothetical protein 0.0087 0.1041 0.1041
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0126 0.1682 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Schistosoma mansoni tubulin subunit alpha 0.011 0.1425 0.1709
Schistosoma mansoni steroid hormone receptor ad4bp 0.0055 0.0521 0.0625
Echinococcus granulosus protein jagged 2 0.0028 0.0077 0.0142
Brugia malayi EGF-like domain containing protein 0.0028 0.0077 0.0077
Echinococcus multilocularis tubulin alpha chain 0.011 0.1425 0.2634
Onchocerca volvulus 0.0087 0.1041 0.137
Loa Loa (eye worm) hypothetical protein 0.0087 0.1041 0.1041
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.7881 1
Schistosoma mansoni zinc finger protein 0.0026 0.0043 0.0052
Echinococcus granulosus tubulin alpha chain 0.011 0.1425 0.2634
Schistosoma mansoni coup transcription factor 0.0055 0.0521 0.0625
Brugia malayi hypothetical protein 0.0026 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Leishmania major beta tubulin 0.011 0.1419 0.996
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1682 0.2134
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0055 0.0521 0.0685
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0073 0.0073
Brugia malayi Tubulin beta chain 0.0036 0.0212 0.0212
Mycobacterium tuberculosis Conserved protein 0.0036 0.0201 0.0599
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0201 0.0255
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0193 0.0356
Brugia malayi nuclear receptor RXR 0.0029 0.0094 0.0094
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0201 0.9458
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0055 0.0521 0.0963
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0521 0.0963
Entamoeba histolytica hypothetical protein 0.0035 0.0193 0.1146
Echinococcus multilocularis tubulin alpha 3 chain 0.011 0.1425 0.2634
Loa Loa (eye worm) hypothetical protein 0.0087 0.1041 0.1041
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0521 0.0625
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1682 0.2134
Plasmodium vivax tubulin alpha chain, putative 0.011 0.1425 1
Brugia malayi ecdysone receptor 0.0026 0.0043 0.0043
Echinococcus multilocularis peroxidasin 0.0087 0.1041 0.1923
Loa Loa (eye worm) hypothetical protein 0.0055 0.0513 0.0513
Brugia malayi Tubulin alpha chain 0.011 0.1425 0.1425
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Brugia malayi notch-like transmembrane receptor 0.0028 0.0077 0.0077
Echinococcus multilocularis geminin 0.0354 0.5411 1
Trypanosoma brucei epsilon tubulin 0.0084 0.0988 0.6933
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Onchocerca volvulus Cell death protein 3 homolog 0.0121 0.1592 0.2096
Echinococcus multilocularis FTZ F1 alpha 0.0055 0.0521 0.0963
Schistosoma mansoni hypothetical protein 0.0028 0.0077 0.0092
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0036 0.0212 0.0269
Trypanosoma brucei beta tubulin 0.0084 0.0988 0.6933
Echinococcus multilocularis thyroid hormone receptor alpha 0.0055 0.0521 0.0963
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0521 0.0521
Echinococcus granulosus caspase 2 0.0121 0.1592 0.2943
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0521 0.0521
Trypanosoma brucei zeta tubulin 0.0036 0.0212 0.1488
Trichomonas vaginalis tubulin, putative 0.011 0.1419 0.1801
Echinococcus multilocularis tubulin alpha 3 chain 0.011 0.1425 0.2634
Loa Loa (eye worm) alpha-tubulin 0.011 0.1425 0.1425
Echinococcus multilocularis tubulin alpha chain 0.011 0.1425 0.2634
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0504 0.7881 1
Onchocerca volvulus 0.0087 0.1041 0.137
Echinococcus granulosus tubulin delta chain 0.0036 0.0212 0.0392
Echinococcus granulosus Tubulin beta 2C chain 0.011 0.1419 0.2623
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0524 0.0969
Brugia malayi nuclear receptor NHR-88 0.0055 0.0521 0.0521
Plasmodium falciparum alpha tubulin 1 0.011 0.1425 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0084 0.0988 0.1254
Trichomonas vaginalis tubulin epsilon chain, putative 0.011 0.1425 0.1808
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0201 0.0599
Onchocerca volvulus Chorion peroxidase homolog 0.0087 0.1041 0.137
Loa Loa (eye worm) hypothetical protein 0.0087 0.1041 0.1041
Echinococcus multilocularis tubulin subunit beta 0.011 0.1419 0.2623
Schistosoma mansoni nuclear receptor nhr-48 0.0026 0.0043 0.0052
Brugia malayi Animal haem peroxidase family protein 0.0087 0.1041 0.1041
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0126 0.1682 1
Entamoeba histolytica hypothetical protein 0.0035 0.0193 0.1146
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0043 0.008
Schistosoma mansoni retinoic acid receptor RXR 0.0055 0.0521 0.0625
Loa Loa (eye worm) hypothetical protein 0.011 0.1425 0.1425
Mycobacterium leprae cell division protein FtsZ 0.0036 0.0212 1
Echinococcus granulosus neurogenic locus notch protein 4 0.0028 0.0077 0.0142
Leishmania major beta tubulin 0.011 0.1419 0.996
Brugia malayi EGF-like domain containing protein 0.0028 0.0077 0.0077
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0043 0.008
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.011 0.1425 0.1808
Echinococcus granulosus tubulin alpha 1C chain 0.011 0.1425 0.2634
Trichomonas vaginalis tubulin gamma chain, putative 0.0084 0.0988 0.1254
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0029 0.0094 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0055 0.0521 0.0521
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0094 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0055 0.0521 0.0521
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0055 0.0521 0.0521
Trichomonas vaginalis tubulin beta chain, putative 0.011 0.1425 0.1808
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0201 0.0599
Schistosoma mansoni tubulin subunit beta 0.011 0.1419 0.1703
Brugia malayi hypothetical protein 0.0029 0.0094 0.0094
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0126 0.1682 0.2134
Leishmania major cytochrome p450-like protein 0.0028 0.0073 0.051
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Echinococcus multilocularis protein jagged 1 0.0028 0.0077 0.0142
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0193 0.0231
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0524 0.0969
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1682 0.2134
Leishmania major alpha tubulin 0.011 0.1425 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Schistosoma mansoni alpha tubulin 0.011 0.1425 0.1709
Schistosoma mansoni serine-type protease inhibitor 0.0532 0.8336 1
Trichomonas vaginalis tubulin beta chain, putative 0.011 0.1419 0.1801
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.7881 1
Echinococcus granulosus protein jagged 2 0.0028 0.0077 0.0142
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0524 0.0969
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Leishmania major beta tubulin 0.011 0.1419 0.996
Trichomonas vaginalis tubulin alpha chain, putative 0.0047 0.0393 0.0498
Schistosoma mansoni hypothetical protein 0.0028 0.0077 0.0092
Giardia lamblia Alpha-tubulin 0.011 0.1425 0.1808
Giardia lamblia High cysteine protein 0.0028 0.0077 0.0097
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Leishmania major alpha tubulin 0.011 0.1425 1
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0201 0.9458
Brugia malayi Animal haem peroxidase family protein 0.0087 0.1041 0.1041
Loa Loa (eye worm) tubulin alpha 2 0.0074 0.083 0.083
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Trichomonas vaginalis tubulin alpha chain, putative 0.011 0.1419 0.1801
Echinococcus multilocularis Tubulin beta 2C chain 0.011 0.1419 0.2623
Echinococcus granulosus fibropellin Ia 0.0028 0.0077 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1682 0.2134
Trichomonas vaginalis set domain proteins, putative 0.0487 0.7599 0.9642
Loa Loa (eye worm) hypothetical protein 0.0087 0.1041 0.1041
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0074 0.083 0.1053
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0428 0.663 0.663
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0043 0.008
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0504 0.7881 1
Brugia malayi Tubulin beta-1 chain 0.011 0.1419 0.1419
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0055 0.0521 0.0521
Leishmania major beta tubulin 0.011 0.1419 0.996
Trichomonas vaginalis tubulin, putative 0.0047 0.0393 0.0498
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Echinococcus multilocularis neurogenic locus protein delta 0.0028 0.0077 0.0142
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0115 0.1498 0.2768
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0087 0.1041 0.1041
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0047 0.0393 0.0498
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0055 0.0521 0.0963
Leishmania major beta tubulin 0.011 0.1419 0.996
Onchocerca volvulus 0.0028 0.0077 0.0101
Echinococcus granulosus FTZ F1 alpha 0.0055 0.0521 0.0963
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0504 0.7881 1
Schistosoma mansoni tubulin subunit alpha 0.0036 0.0212 0.0254
Leishmania major beta tubulin 0.011 0.1419 0.996
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0029 0.0094 0.0174
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0115 0.1498 0.1796
Trypanosoma cruzi epsilon tubulin, putative 0.0084 0.0988 0.6933
Trypanosoma brucei zeta tubulin, putative 0.0036 0.0212 0.1488
Schistosoma mansoni laminin gamma-3 chain 0.0028 0.0077 0.0092
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0524 0.0665
Loa Loa (eye worm) hypothetical protein 0.0055 0.0521 0.0521
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0074 0.083 0.083
Echinococcus granulosus notch 0.0028 0.0077 0.0142
Schistosoma mansoni tubulin subunit beta 0.011 0.1419 0.1703
Leishmania major delta tubulin, putative 0.0036 0.0212 0.1488
Loa Loa (eye worm) hypothetical protein 0.0037 0.0229 0.0229
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0193 0.0356
Onchocerca volvulus 0.0028 0.0077 0.0101
Schistosoma mansoni tubulin subunit beta 0.011 0.1419 0.1703
Loa Loa (eye worm) nuclear hormone receptor 0.0026 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0029 0.0094 0.0094
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0029 0.0094 0.0094
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0055 0.0521 0.0963
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.007 0.049
Echinococcus multilocularis notch 0.0028 0.0077 0.0142
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0126 0.1682 0.2134
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.3347 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.1041 0.1041
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0028 0.0077 0.0101
Giardia lamblia NADPH oxidoreductase, putative 0.0504 0.7881 1
Echinococcus granulosus tubulin alpha chain 0.011 0.1425 0.2634
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.007 0.049
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0073 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.7881 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0026 0.0043 0.0043
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Echinococcus granulosus neurogenic locus notch protein 0.0028 0.0077 0.0142
Schistosoma mansoni hypothetical protein 0.0028 0.0077 0.0092
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0063 0.0649 0.0824
Trichomonas vaginalis tubulin beta chain, putative 0.0047 0.0393 0.0498
Leishmania major alpha tubulin 0.011 0.1425 1
Echinococcus granulosus tubulin subunit beta 0.011 0.1419 0.2623
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Onchocerca volvulus 0.0028 0.0077 0.0101
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Schistosoma mansoni tubulin subunit gamma 0.0084 0.0988 0.1185
Onchocerca volvulus Peroxidase homolog 0.0087 0.1041 0.137
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0121 0.1592 0.191
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0043 0.0052
Mycobacterium leprae Probable lipase LipE 0.0036 0.0201 0.9458
Leishmania major beta tubulin 0.011 0.1419 0.996
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0521 0.0521
Trypanosoma brucei alpha tubulin 0.011 0.1425 1
Echinococcus multilocularis tubulin epsilon chain 0.0084 0.0988 0.1826
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Leishmania major alpha tubulin 0.011 0.1425 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Brugia malayi tubulin alpha chain - mouse 0.011 0.1425 0.1425
Loa Loa (eye worm) hypothetical protein 0.0087 0.1041 0.1041
Leishmania major beta tubulin 0.011 0.1419 0.996
Brugia malayi EGF-like domain containing protein 0.0028 0.0077 0.0077
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0028 0.0077 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.7881 1
Brugia malayi nuclear receptor RXR 0.0026 0.0043 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0055 0.0521 0.0521
Echinococcus multilocularis fibropellin Ia 0.0028 0.0077 0.0142
Leishmania major beta tubulin 0.011 0.1419 0.996
Loa Loa (eye worm) alpha-tubulin 0.011 0.1425 0.1425
Schistosoma mansoni tubulin subunit alpha 0.011 0.1425 0.1709
Trypanosoma cruzi tubulin delta chain 0.0036 0.0212 0.1488
Brugia malayi Tubulin alpha-2 chain 0.011 0.1425 0.1425
Schistosoma mansoni nuclear receptor 0.0026 0.0043 0.0052
Schistosoma mansoni lozenge 0.0061 0.0616 0.0738
Brugia malayi nuclear receptor NHR-67 0.0026 0.0043 0.0043
Mycobacterium ulcerans lipase LipD 0.0036 0.0201 0.9458
Onchocerca volvulus 0.0026 0.0043 0.0057
Plasmodium vivax delta tubulin, putative 0.0036 0.0212 0.105
Brugia malayi Calcium binding EGF domain containing protein 0.0028 0.0077 0.0077
Trypanosoma brucei alpha tubulin 0.011 0.1425 1
Schistosoma mansoni RAR-like nuclear receptor 0.0055 0.0521 0.0625
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0201 0.0965
Brugia malayi Cell death protein 3 precursor 0.0121 0.1592 0.1592
Loa Loa (eye worm) hypothetical protein 0.0055 0.0521 0.0521
Entamoeba histolytica hypothetical protein 0.0126 0.1682 1
Echinococcus multilocularis neural cadherin 0.0028 0.0077 0.0142
Brugia malayi Pre-SET motif family protein 0.0428 0.663 0.663
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0026 0.0043 0.0052
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0201 0.0599
Loa Loa (eye worm) nuclear receptor NHR-67 0.0026 0.0043 0.0043
Onchocerca volvulus Peroxidasin homolog 0.0087 0.1041 0.137
Onchocerca volvulus 0.0486 0.7579 0.9974
Echinococcus multilocularis apoptotic protease activating factor 1 0.0121 0.1592 0.2943
Loa Loa (eye worm) tubulin alpha chain 0.011 0.1425 0.1425
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0524 0.368
Brugia malayi Cytochrome P450 family protein 0.0028 0.0073 0.0073
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0073 0.3424
Loa Loa (eye worm) runx1 0.0061 0.0616 0.0616
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0201 0.0599
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1682 0.2134
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0623 0.0747
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Echinococcus granulosus tubulin alpha 3 chain 0.011 0.1425 0.2634
Plasmodium falciparum tubulin delta chain, putative 0.0036 0.0212 0.105
Echinococcus multilocularis Tubulin beta 2C chain 0.011 0.1419 0.2623
Schistosoma mansoni hypothetical protein 0.0028 0.0077 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.7881 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0521 0.0521
Echinococcus multilocularis protein jagged 1 0.0028 0.0077 0.0142
Loa Loa (eye worm) notch protein 0.0028 0.0077 0.0077
Mycobacterium ulcerans beta-lactamase 0.0036 0.0201 0.9458
Loa Loa (eye worm) hypothetical protein 0.0029 0.0094 0.0094
Brugia malayi hypothetical protein 0.0026 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.7881 1
Brugia malayi conserved hypotetical protein 0.0026 0.0043 0.0043
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0036 0.0212 0.1488
Brugia malayi EGF-like domain containing protein 0.0028 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0047 0.0389 0.0467
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.3403 0.6289
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Trichomonas vaginalis tubulin, putative 0.0047 0.0393 0.0498
Loa Loa (eye worm) hypothetical protein 0.0063 0.0649 0.0649
Brugia malayi beta-lactamase 0.0036 0.0201 0.0201
Schistosoma mansoni nuclear receptor 0.0026 0.0043 0.0052
Giardia lamblia Epsilon tubulin 0.0036 0.0212 0.0269
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0201 0.0599
Trypanosoma brucei epsilon tubulin 0.0084 0.0988 0.6933
Brugia malayi Cytochrome P450 family protein 0.006 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Trichomonas vaginalis tubulin alpha chain, putative 0.0047 0.0393 0.0498
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.7881 1
Schistosoma mansoni hypothetical protein 0.0035 0.0193 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.7881 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.1592 0.1592
Echinococcus multilocularis Protein lozenge 0.0061 0.0616 0.1138
Echinococcus granulosus geminin 0.0354 0.5411 1
Entamoeba histolytica tubulin family protein 0.011 0.1419 0.8441
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.7881 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0389 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0212 0.0269
Onchocerca volvulus 0.0087 0.1041 0.137
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0073 0.051
Echinococcus granulosus protein jagged 1 0.0028 0.0077 0.0142
Loa Loa (eye worm) hypothetical protein 0.0087 0.1041 0.1041
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0212 0.0269
Echinococcus granulosus Tubulin beta 2C chain 0.011 0.1419 0.2623
Brugia malayi Muscle positioning protein 4 0.0028 0.0077 0.0077
Echinococcus multilocularis neurogenic locus notch protein 4 0.0028 0.0077 0.0142
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0201 0.0599
Giardia lamblia Gamma tubulin 0.0084 0.0988 0.1254
Echinococcus granulosus protein jagged 1 0.0028 0.0077 0.0142
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0029 0.0094 0.0113
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0201 0.0371
Brugia malayi Cytochrome P450 family protein 0.0028 0.0073 0.0073
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Onchocerca volvulus 0.0061 0.0623 0.0819
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0524 0.0969
Echinococcus granulosus delta-like protein 1 0.0028 0.0077 0.0142
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0601 0.0601
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0524 0.368
Giardia lamblia Alpha-tubulin 0.011 0.1425 0.1808
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0084 0.0988 0.6933
Trypanosoma cruzi tubulin delta chain 0.0036 0.0212 0.1488
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0043 0.0052
Trichomonas vaginalis esterase, putative 0.0036 0.0201 0.0255
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0055 0.0521 0.0625
Echinococcus multilocularis slit 2 protein 0.0028 0.0077 0.0142
Schistosoma mansoni hypothetical protein 0.0095 0.1178 0.1413
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.7881 1
Brugia malayi Cell division protein ftsZ 0.0036 0.0212 0.0212
Brugia malayi EGF-like domain containing protein 0.0028 0.0077 0.0077
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0524 0.368
Echinococcus multilocularis beta tubulin 0.011 0.1419 0.2623
Trichomonas vaginalis tubulin epsilon chain, putative 0.011 0.1419 0.1801
Brugia malayi orphan nuclear receptor NR2E1 0.0026 0.0043 0.0043
Echinococcus multilocularis Tubulin beta 2C chain 0.011 0.1419 0.2623
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.007 0.049
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.7881 1
Echinococcus granulosus Tubulin alpha 1 chain 0.011 0.1425 0.2634
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0055 0.0521 0.0521
Brugia malayi beta-lactamase family protein 0.0036 0.0201 0.0201
Echinococcus multilocularis tubulin gamma 1 chain 0.0084 0.0988 0.1826
Entamoeba histolytica tubulin gamma chain 0.0084 0.0988 0.5875
Loa Loa (eye worm) tubulin alpha 2 0.0027 0.0054 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.7881 1
Schistosoma mansoni hypothetical protein 0.0354 0.5411 0.6491
Trypanosoma brucei beta tubulin 0.011 0.1419 0.996
Echinococcus granulosus apoptotic protease activating factor 1 0.0121 0.1592 0.2943
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Toxoplasma gondii alpha-tubulin I, putative 0.011 0.1425 1
Plasmodium falciparum tubulin gamma chain 0.0084 0.0988 0.6775
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1682 0.2134
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0513 0.0513
Loa Loa (eye worm) hypothetical protein 0.0061 0.0623 0.0623
Schistosoma mansoni peroxidasin 0.0087 0.1041 0.1248
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0201 0.9458
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0026 0.0043 0.0043
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0043 0.008
Echinococcus multilocularis Tubulin beta 2C chain 0.011 0.1419 0.2623
Trypanosoma cruzi zeta tubulin, putative 0.0036 0.0212 0.1488
Brugia malayi MAP kinase sur-1 0.0055 0.0524 0.0524
Schistosoma mansoni tubulin subunit epsilon 0.0084 0.0988 0.1185
Brugia malayi GCC2 and GCC3 family protein 0.0028 0.0077 0.0077
Echinococcus multilocularis nuclear receptor nhr 48 0.0026 0.0043 0.008
Giardia lamblia Beta tubulin 0.011 0.1419 0.1801
Brugia malayi Cadherin domain containing protein 0.0028 0.0077 0.0077
Echinococcus granulosus tubulin epsilon chain 0.0084 0.0988 0.1826
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.007 0.049
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0055 0.0521 0.0963
Brugia malayi Tubulin alpha-2 chain 0.011 0.1425 0.1425
Onchocerca volvulus Bile acid receptor homolog 0.0055 0.0521 0.0685
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0201 0.0255
Onchocerca volvulus 0.0028 0.0077 0.0101
Leishmania major beta tubulin 0.011 0.1419 0.996
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Onchocerca volvulus 0.0036 0.0201 0.0264
Loa Loa (eye worm) tubulin beta-2A chain 0.011 0.1419 0.1419
Schistosoma mansoni caspase-7 (C14 family) 0.0121 0.1592 0.191
Schistosoma mansoni hypothetical protein 0.0354 0.5411 0.6491
Leishmania major zeta tubulin, putative 0.0036 0.0212 0.1488
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0043 0.008
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0026 0.0043 0.0052
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0126 0.1682 0.2134
Echinococcus multilocularis tubulin, beta 4A class IVa 0.011 0.1419 0.2623
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0521 0.0625
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0043 0.008
Plasmodium vivax tubulin beta chain, putative 0.011 0.1419 0.9958
Echinococcus granulosus tubulin alpha chain 0.011 0.1425 0.2634
Echinococcus granulosus Tubulin beta 2C chain 0.011 0.1419 0.2623
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0521 0.0521
Onchocerca volvulus 0.0121 0.1592 0.2096
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0043 0.0057
Echinococcus multilocularis tubulin alpha 1C chain 0.011 0.1425 0.2634
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0094 0.0113
Echinococcus granulosus peroxisome assembly protein 26 0.011 0.1425 0.2634
Schistosoma mansoni hypothetical protein 0.0028 0.0077 0.0092
Echinococcus granulosus tubulin alpha chain 0.011 0.1425 0.2634
Echinococcus multilocularis neurogenic locus notch protein 0.0028 0.0077 0.0142
Brugia malayi Tubulin alpha chain 0.0036 0.0212 0.0212
Schistosoma mansoni hypothetical protein 0.0028 0.0077 0.0092
Brugia malayi alpha-tubulin 0.011 0.1425 0.1425
Trichomonas vaginalis tubulin beta chain, putative 0.011 0.1425 0.1808
Loa Loa (eye worm) hypothetical protein 0.0055 0.0521 0.0521
Giardia lamblia Beta tubulin 0.011 0.1419 0.1801
Echinococcus multilocularis tubulin alpha 0.0084 0.0988 0.1826
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0055 0.0521 0.0521
Schistosoma mansoni notch 0.0028 0.0077 0.0092
Loa Loa (eye worm) hypothetical protein 0.0055 0.0521 0.0521
Schistosoma mansoni alpha tubulin 0.011 0.1425 0.1709
Schistosoma mansoni tubulin subunit beta 0.011 0.1419 0.1703
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0524 0.368
Schistosoma mansoni septate junction protein 0.0028 0.0077 0.0092
Loa Loa (eye worm) hypothetical protein 0.0087 0.1041 0.1041
Loa Loa (eye worm) hypothetical protein 0.0486 0.7579 0.7579
Echinococcus multilocularis fat cadherin tumor suppressor 0.0028 0.0077 0.0142
Trypanosoma brucei protein kinase, putative 0.0055 0.0524 0.368
Brugia malayi Calcium binding EGF domain containing protein 0.0028 0.0077 0.0077
Trypanosoma brucei beta tubulin 0.011 0.1419 0.996
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0521 0.0963
Trichomonas vaginalis tubulin beta chain, putative 0.011 0.1425 0.1808
Echinococcus multilocularis Tubulin beta 2C chain 0.011 0.1419 0.2623
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0055 0.0521 0.0521
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0524 0.0665
Entamoeba histolytica hypothetical protein 0.0035 0.0193 0.1146
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Leishmania major beta tubulin 0.011 0.1419 0.996
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0521 0.0625
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0623 0.0747
Giardia lamblia Delta tubulin 0.0036 0.0212 0.0269
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0043 0.0057
Echinococcus granulosus tubulin alpha 3 chain 0.011 0.1425 0.2634
Trypanosoma cruzi tubulin gamma chain 0.0084 0.0988 0.6933
Schistosoma mansoni tubulin subunit alpha 0.011 0.1425 0.1709
Trichomonas vaginalis tubulin beta chain, putative 0.011 0.1425 0.1808
Schistosoma mansoni cell polarity protein 0.0028 0.0077 0.0092
Loa Loa (eye worm) BEN-1 protein 0.011 0.1419 0.1419
Loa Loa (eye worm) hypothetical protein 0.0074 0.083 0.083
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0201 0.1408
Toxoplasma gondii beta-1 tubulin, putative 0.011 0.1419 0.996
Schistosoma mansoni notch 0.0028 0.0077 0.0092
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Leishmania major beta tubulin 0.011 0.1419 0.996
Onchocerca volvulus Protein ultraspiracle homolog 0.0055 0.0521 0.0685
Brugia malayi Animal haem peroxidase family protein 0.0087 0.1041 0.1041
Onchocerca volvulus 0.0055 0.0521 0.0685
Brugia malayi photoreceptor-specific nuclear receptor 0.0055 0.0521 0.0521
Echinococcus granulosus tubulin alpha 1C chain 0.011 0.1425 0.2634
Loa Loa (eye worm) hypothetical protein 0.0634 1 1
Echinococcus multilocularis neurogenic locus protein delta 0.0028 0.0077 0.0142
Onchocerca volvulus Peroxidase homolog 0.0087 0.1041 0.137
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0055 0.0521 0.0625
Brugia malayi Tubulin beta chain 0.0047 0.0393 0.0393
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0201 0.0241
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Brugia malayi Peroxidasin 0.0087 0.1041 0.1041
Onchocerca volvulus 0.0047 0.0389 0.0512
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0521 0.0963
Leishmania major hypothetical protein, conserved 0.0036 0.0201 0.1408
Echinococcus multilocularis Tubulin alpha 1 chain 0.011 0.1425 0.2634
Treponema pallidum cell division protein FtsZ 0.0036 0.0212 0.5
Onchocerca volvulus Neurogenic locus notch homolog 0.0028 0.0077 0.0101
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Brugia malayi Pre-SET motif family protein 0.0061 0.0623 0.0623
Plasmodium falciparum tubulin epsilon chain, putative 0.0084 0.0988 0.6775
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0026 0.0043 0.008
Echinococcus multilocularis tubulin subunit TubB 0.011 0.1425 0.2634
Schistosoma mansoni notch 0.0028 0.0077 0.0092
Loa Loa (eye worm) animal heme peroxidase 0.0087 0.1041 0.1041
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0201 0.0255
Schistosoma mansoni slit 0.0028 0.0077 0.0092
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0073 0.051
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Toxoplasma gondii EGF family domain-containing protein 0.0028 0.0077 0.0539
Trypanosoma cruzi zeta tubulin, putative 0.0036 0.0212 0.1488
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0036 0.0212 0.1488
Brugia malayi Animal haem peroxidase family protein 0.0087 0.1041 0.1041
Echinococcus multilocularis Tubulin alpha 1 chain 0.011 0.1425 0.2634
Leishmania major alpha tubulin 0.011 0.1425 1
Loa Loa (eye worm) hypothetical protein 0.0231 0.3403 0.3403
Brugia malayi nuclear hormone receptor 0.0026 0.0043 0.0043
Onchocerca volvulus 0.0036 0.0201 0.0264
Onchocerca volvulus 0.0026 0.0043 0.0057
Mycobacterium tuberculosis Conserved protein 0.0036 0.0201 0.0599
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0623 0.0747
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0026 0.0043 0.008
Brugia malayi nuclear hormone receptor 0.0055 0.0521 0.0521
Leishmania major beta tubulin 0.011 0.1419 0.996
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0055 0.0521 0.0963
Echinococcus granulosus Tubulin alpha 1 chain 0.011 0.1425 0.2634
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0201 0.0255
Trichomonas vaginalis tubulin alpha chain, putative 0.0047 0.0393 0.0498
Loa Loa (eye worm) hypothetical protein 0.0087 0.1041 0.1041
Trichomonas vaginalis tubulin epsilon chain, putative 0.011 0.1419 0.1801
Loa Loa (eye worm) beta-lactamase 0.0036 0.0201 0.0201
Echinococcus granulosus Tubulin alpha 1 chain 0.011 0.1425 0.2634
Loa Loa (eye worm) hypothetical protein 0.0028 0.007 0.007
Brugia malayi Delta serrate ligand family protein 0.0028 0.0077 0.0077
Echinococcus granulosus Tubulin beta 2C chain 0.011 0.1419 0.2623
Echinococcus granulosus tubulin beta 1 chain 0.011 0.1419 0.2623
Leishmania major gamma-tubulin 0.0084 0.0988 0.6933
Echinococcus granulosus beta tubulin 0.011 0.1419 0.2623
Brugia malayi hypothetical protein 0.0231 0.3403 0.3403
Loa Loa (eye worm) hypothetical protein 0.0055 0.0521 0.0521
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0026 0.0043 0.008
Brugia malayi tubulin alpha-2 chain 0.011 0.1425 0.1425
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0201 0.1408
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0524 0.368
Onchocerca volvulus Slit protein homolog 0.0028 0.0077 0.0101
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.0521 0.0625
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0623 0.1151
Loa Loa (eye worm) animal heme peroxidase 0.0087 0.1041 0.1041
Onchocerca volvulus 0.0047 0.0393 0.0517
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0094 0.0094
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0073 0.051
Trichomonas vaginalis modulator of drug activity B, putative 0.0126 0.1682 0.2134
Schistosoma mansoni tubulin subunit beta 0.0036 0.0212 0.0254
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0521 0.0963
Schistosoma mansoni survival motor neuron protein 0.0047 0.0389 0.0467

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 117 uM Inhibition of [3H]-choline brain uptake was determined by in situ brain perfusion studies in male rats ChEMBL. 15149650
Ki (binding) = 117 uM Inhibition of [3H]-choline brain uptake was determined by in situ brain perfusion studies in male rats ChEMBL. 15149650

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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