Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0064 | 0.0019 | 0.5 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0168 | 0.0363 | 0.0344 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.145 | 0.459 | 1 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0122 | 0.0209 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.309 | 1 | 1 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0064 | 0.0019 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1272 | 0.4004 | 0.3992 |
Echinococcus multilocularis | protein patched | 0.1272 | 0.4004 | 0.3992 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1272 | 0.4004 | 0.3992 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0168 | 0.0363 | 1 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0168 | 0.0363 | 0.0344 |
Echinococcus multilocularis | protein dispatched 1 | 0.1272 | 0.4004 | 0.3992 |
Chlamydia trachomatis | biotin carboxylase | 0.0058 | 0 | 0.5 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0104 | 0.0151 | 0.0132 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1272 | 0.4004 | 0.3992 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.145 | 0.459 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.309 | 1 | 1 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0064 | 0.0019 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.309 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.309 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0064 | 0.0019 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1272 | 0.4004 | 0.3791 |
Schistosoma mansoni | patched 1 | 0.1272 | 0.4004 | 0.3992 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1272 | 0.4004 | 0.3992 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0168 | 0.0363 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.145 | 0.459 | 1 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.0168 | 0.0363 | 0.0344 |
Loa Loa (eye worm) | hypothetical protein | 0.309 | 1 | 1 |
Brugia malayi | CHE-14 protein | 0.1272 | 0.4004 | 0.3791 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.309 | 1 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1272 | 0.4004 | 0.3791 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0122 | 0.0209 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.309 | 1 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.145 | 0.459 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.309 | 1 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0168 | 0.0363 | 0.0344 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.309 | 1 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1272 | 0.4004 | 0.3992 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1272 | 0.4004 | 0.3992 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0168 | 0.0363 | 0.0344 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 30 uM | Inhibition of Kv1.3 ion channel. Measured in the Rb_Kv assay: [86Rb+] efflux from CHO cells stably transfected with Kv1.3 channel. | ChEMBL. | 12643934 |
IC50 (functional) | > 30 uM | Inhibition of Kv1.3 ion channel. Measured in the Rb_Kv assay: [86Rb+] efflux from CHO cells stably transfected with Kv1.3 channel. | ChEMBL. | 12643934 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.