Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | proteasome subunit alpha type-5, putative | proteasome (prosome, macropain) subunit, beta type, 5 | 160 aa | 148 aa | 23.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0086 | 0.299 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0086 | 0.299 | 0.5 |
Echinococcus granulosus | proteasome prosome macropain | 0.0086 | 0.299 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0086 | 0.299 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0086 | 0.299 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0086 | 0.299 | 1 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0086 | 0.299 | 0.299 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.085 | 0.085 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0086 | 0.299 | 0.5 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0086 | 0.299 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0269 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0086 | 0.299 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0086 | 0.299 | 0.299 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0086 | 0.299 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0086 | 0.299 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0086 | 0.299 | 0.5 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0086 | 0.299 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.085 | 0.085 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0086 | 0.299 | 0.5 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0086 | 0.299 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0086 | 0.299 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 47 nM | Inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit using Suc-LLVY-AMC as substrate after 60 mins by fluorescence assay | ChEMBL. | 23547757 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.