Detailed information for compound 1730877

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 611.217 | Formula: C40H39ClN4
  • H donors: 1 H acceptors: 2 LogP: 10.17 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(cc1)c1nc(c(n1CCCCCCNc1c2CCCCc2nc2c1cccc2)c1ccccc1)c1ccccc1
  • InChi: 1S/C40H39ClN4/c41-32-25-23-31(24-26-32)40-44-37(29-15-5-3-6-16-29)39(30-17-7-4-8-18-30)45(40)28-14-2-1-13-27-42-38-33-19-9-11-21-35(33)43-36-22-12-10-20-34(36)38/h3-9,11,15-19,21,23-26H,1-2,10,12-14,20,22,27-28H2,(H,42,43)
  • InChiKey: ZBOYECSUZSRATG-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens butyrylcholinesterase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Carboxylesterase family protein butyrylcholinesterase 602 aa 546 aa 30.2 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0115 0.3216 0.3418
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0035 0.0665 0.0588
Loa Loa (eye worm) acetylcholinesterase 1 0.0082 0.2164 0.2232
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0144 0.4166 0.4428
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0018 0.0119 0.0037
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0125 0.3552 0.3721
Toxoplasma gondii proteasome subunit 0.0125 0.3552 0.3707
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0115 0.3216 0.3345
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0118 0.3326 0.327
Echinococcus granulosus adhesion regulating molecule 1 0.0085 0.2256 0.2191
Trypanosoma brucei protease regulatory ATPase subunit 4 0.0018 0.0103 0.0022
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0126 0.3587 0.3812
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0039 0.0784 0.0688
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0144 0.4166 0.4428
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0033 0.0586 0.0508
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0027 0.0408 0.0433
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0035 0.0665 0.0588
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0119 0.0127
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0152 0.0071
Leishmania major proteasome beta 7 subunit, putative 0.0118 0.3326 0.3535
Giardia lamblia Proteasome subunit beta type 3 0.012 0.3374 0.3529
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0124 0.3526 0.3678
Echinococcus multilocularis proteasome subunit alpha type 6 0.0136 0.3895 0.3844
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0169 0.4957 0.4915
Giardia lamblia 20S proteasome alpha subunit 1 0.0136 0.3895 0.4088
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0033 0.0586 0.0623
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0412 0.0438
Leishmania major proteasome beta 3 subunit, putative 0.012 0.3374 0.3586
Schistosoma mansoni hypothetical protein 0.0078 0.2055 0.1972
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0017 0.0082 0.0088
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0026 0.0368 0.0306
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0039 0.0784 0.0753
Entamoeba histolytica proteasome regulatory subunit, putative 0.0035 0.0665 0.0604
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0129 0.3683 0.3861
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0115 0.3216 0.336
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0125 0.3552 0.3721
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.012 0.3374 0.3586
Onchocerca volvulus 0.0018 0.0119 0.0047
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0308 0.9408 1
Onchocerca volvulus Notchless protein homolog 0.0126 0.3587 1
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0115 0.3216 0.3345
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.003 0.049 0.0411
Toxoplasma gondii proteasome beta subunit 0.012 0.3374 0.3515
Toxoplasma gondii PCI domain-containing protein 0.0027 0.0408 0.0327
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0103 0.011
Brugia malayi Carboxylesterase family protein 0.0082 0.2164 0.2082
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0026 0.0368 0.0268
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.003 0.0486 0.0412
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0039 0.0784 0.0732
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0026 0.0368 0.0288
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0033 0.0586 0.0519
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0018 0.0119 0.0018
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0135 0.3867 0.3803
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0308 0.9408 1
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0136 0.3895 0.4075
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0308 0.9408 0.9402
Schistosoma mansoni hypothetical protein 0.0193 0.5712 0.5667
Brugia malayi Proteasome/cyclosome repeat family protein 0.0029 0.0462 0.0363
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0035 0.0665 0.0625
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0019 0.0136 0.0145
Echinococcus granulosus proteasome subunit beta t family 0.012 0.3374 0.3319
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0136 0.3895 0.4075
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0126 0.3587 0.3812
Echinococcus granulosus proteasome subunit alpha type 2 0.0129 0.3683 0.3631
Toxoplasma gondii hypothetical protein 0.0024 0.0304 0.0216
Toxoplasma gondii 26s proteasome subunit p55, putative 0.003 0.049 0.0415
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0144 0.4166 0.4366
Plasmodium vivax proteasome subunit beta type-3, putative 0.012 0.3374 0.3515
Leishmania major proteasome alpha 1 subunit, putative 0.0136 0.3895 0.4139
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.003 0.0486 0.0387
Brugia malayi proteasome subunit alpha type 2 0.0129 0.3683 0.3617
Giardia lamblia 20S proteasome alpha subunit 7 0.0126 0.3587 0.3758
Leishmania major proteasome regulatory ATPase subunit 0.0018 0.0103 0.011
Plasmodium vivax proteasome subunit beta type-2, putative 0.012 0.3374 0.3515
Brugia malayi Proteasome subunit alpha type 7-1 0.0169 0.4957 0.4904
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0018 0.0119 0.0037
Toxoplasma gondii SAC3/GANP family protein 0.0026 0.0368 0.0285
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0129 0.3683 0.3847
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0368 0.0391
Loa Loa (eye worm) RPN-3 protein 0.0035 0.0665 0.0625
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0125 0.354 0.3762
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0125 0.354 0.3762
Toxoplasma gondii proteasome subunit alpha1, putative 0.0136 0.3895 0.4075
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0019 0.0136 0.0036
Entamoeba histolytica proteasome regulatory subunit, putative 0.0026 0.0368 0.0285
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0027 0.0408 0.0433
Loa Loa (eye worm) carboxylesterase 0.0082 0.2164 0.2232
Plasmodium vivax proteasome subunit beta type-1, putative 0.0144 0.4166 0.4366
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0124 0.3526 0.3692
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0135 0.3867 0.4045
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0119 0.0127
Echinococcus granulosus subfamily T1A non peptidase ue 0.0135 0.3867 0.3816
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0412 0.0438
Echinococcus granulosus proteasome subunit beta type 7 0.0326 1 1
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0078 0.2055 0.1989
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0019 0.0154 0.0164
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.003 0.0486 0.0517
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0018 0.0119 0.0127
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0018 0.0119 0.0016
Leishmania major proteasome alpha 7 subunit, putative 0.0169 0.4957 0.5268
Loa Loa (eye worm) hypothetical protein 0.0082 0.2164 0.2232
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.3326 0.3535
Entamoeba histolytica proteasome regulatory subunit, putative 0.0027 0.0408 0.0327
Giardia lamblia 26S proteasome regulatory subunit, putative 0.002 0.0189 0.0114
Leishmania major proteasome alpha 7 subunit, putative 0.0126 0.3587 0.3812
Brugia malayi proteasome subunit beta type 3 0.012 0.3374 0.3305
Toxoplasma gondii proteasome subunit beta type, putative 0.0308 0.9408 1
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.003 0.0486 0.0412
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0018 0.0119 0.0018
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0078 0.2055 0.1989
Leishmania major proteasome beta 2 subunit, putative 0.0115 0.3216 0.3418
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0018 0.0119 0.0127
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0019 0.0154 0.0164
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0169 0.4957 0.5226
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0033 0.0586 0.0519
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0039 0.0784 0.0688
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0033 0.0586 0.0623
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0018 0.0119 0.004
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0119 0.0127
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0019 0.0154 0.0055
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0129 0.3683 0.3617
Echinococcus granulosus 26s protease regulatory subunit s10b 0.0018 0.0103 0.0021
Onchocerca volvulus 0.0018 0.0119 0.0047
Echinococcus multilocularis proteasome subunit beta type 7 0.0326 1 1
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0154 0.0052
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0019 0.0154 0.0077
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0129 0.3683 0.3915
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0368 0.0391
Leishmania major 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative 0.0018 0.0103 0.011
Plasmodium falciparum proteasome subunit beta type-3, putative 0.012 0.3374 0.3515
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0039 0.0784 0.0732
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0035 0.0665 0.0707
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0144 0.4166 0.4366
Leishmania major hypothetical protein, conserved 0.0044 0.0955 0.1015
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0308 0.9408 1
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0135 0.3867 0.4045
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0035 0.0648 0.057
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0412 0.0333
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0136 0.3895 0.4075
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0412 0.0438
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0044 0.0955 0.0915
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0096 0.2611 0.2534
Giardia lamblia 26S protease regulatory subunit 7 0.0018 0.0103 0.0022
Loa Loa (eye worm) RPT-2 protein 0.0018 0.0119 0.004
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0019 0.0154 0.0055
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0125 0.3552 0.3776
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0412 0.0332
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0017 0.0082 0.0088
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0039 0.0784 0.0834
Giardia lamblia 20S proteasome alpha subunit 4 0.0169 0.4957 0.5226
Loa Loa (eye worm) PCI domain-containing protein 0.003 0.049 0.0437
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0368 0.0391
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0115 0.3216 0.3418
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0054 0.1264 0.3333
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0027 0.0412 0.0312
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0033 0.0586 0.0623
Leishmania major proteasome alpha 1 subunit, putative 0.0124 0.3526 0.3747
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0096 0.2611 0.2775
Brugia malayi Proteasome A-type and B-type family protein 0.0118 0.3326 0.3256
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.012 0.34 0.3331
Leishmania major proteasome alpha 3 subunit, putative 0.0125 0.354 0.3762
Brugia malayi Carboxylesterase family protein 0.0082 0.2164 0.2082
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.012 0.3374 0.3586
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0152 0.0162
Schistosoma mansoni hypothetical protein 0.0027 0.0408 0.0308
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0019 0.0154 0.0077
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0018 0.0119 0.0037
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0154 0.0052
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.003 0.0486 0.0407
Brugia malayi proteasome subunit beta type 1 0.0144 0.4166 0.4105
Loa Loa (eye worm) proteasome regulatory particle 0.0033 0.0586 0.054
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0124 0.3526 0.3472
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0029 0.0462 0.0491
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.012 0.3374 0.3515
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.3326 0.3535
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0135 0.3867 0.411
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0115 0.3216 0.3345
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0169 0.4957 0.5216
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.3326 0.3535
Toxoplasma gondii proteasome subunit alpha type, putative 0.0125 0.354 0.3693
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0018 0.0103 0.0022
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.012 0.3374 0.3305
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0119 0.0018
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.0486 0.0412
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0119 0.0018
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0019 0.0154 0.0072
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0169 0.4957 0.5268
Loa Loa (eye worm) hypothetical protein 0.0193 0.5712 0.6036
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.003 0.0486 0.0433
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.003 0.0486 0.0517
Trypanosoma brucei proteasome beta 3 subunit, putative 0.012 0.3374 0.3529
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0119 0.0127
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.003 0.0486 0.0517
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0125 0.3552 0.3707
Echinococcus multilocularis 26s protease regulatory subunit s10b 0.0018 0.0103 0.0021
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0412 0.0332
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0035 0.0665 0.0568
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0019 0.0152 0.0162
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0035 0.0648 0.057
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0152 0.0071
Entamoeba histolytica proteasome regulatory subunit, putative 0.0033 0.0586 0.0519
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.012 0.3374 0.3586
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.012 0.3374 0.3305
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0085 0.2256 0.2175
Echinococcus multilocularis proteasome (prosome, macropain) 0.0308 0.9408 0.9404
Toxoplasma gondii peptidase, T1 family protein 0.0126 0.3587 0.3744
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0126 0.3587 0.3758
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.049 0.0415
Plasmodium falciparum proteasome subunit beta type-5 0.0308 0.9408 1
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0129 0.3683 0.3861
Brugia malayi Ubiquitin interaction motif family protein 0.0019 0.0152 0.005
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0039 0.0784 0.0834
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.003 0.0486 0.0412
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.012 0.3374 0.3305
Echinococcus granulosus carboxylesterase 5A 0.0082 0.2164 0.2099
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0125 0.354 0.3693
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0027 0.0412 0.0333
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0039 0.0784 0.0753
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0026 0.0368 0.0285
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0169 0.4957 0.5216
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0022
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0027 0.0412 0.0438
Trypanosoma brucei Regulatory particle triple-A ATPase subunit 6 0.0018 0.0103 0.0022
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0412 0.0438
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0125 0.354 0.3473
Brugia malayi PCI domain containing protein 0.0027 0.0408 0.0308
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0035 0.0648 0.0607
Giardia lamblia Proteasome subunit beta type 2 0.012 0.3374 0.3529
Toxoplasma gondii PCI domain-containing protein 0.0035 0.0665 0.0604
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0119 0.0127
Echinococcus granulosus 26S protease regulatory subunit 8 0.0018 0.0103 0.0021
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.003 0.049 0.0521
Echinococcus granulosus proteasome subunit alpha type 6 0.0136 0.3895 0.3844
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0125 0.354 0.3693
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0118 0.3326 0.327
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0144 0.4166 0.4105
Schistosoma mansoni 26S proteasome subunit S9 0.0033 0.0586 0.0488
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0027 0.0412 0.0332
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.003 0.049 0.0415
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0136 0.3895 0.4088
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0085 0.2256 0.2175
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0129 0.3683 0.3847
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0135 0.3867 0.4045
Schistosoma mansoni 26S protease regulatory subunit 0.0018 0.0119 0.0016
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0096 0.2611 0.2711
Loa Loa (eye worm) hypothetical protein 0.0024 0.0304 0.0238
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0115 0.3216 0.3418
Brugia malayi Proteasome subunit alpha type 1 0.011 0.3058 0.2986
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0027 0.0412 0.0332
Trypanosoma cruzi 19S proteasome regulatory subunit 0.0018 0.0103 0.011
Brugia malayi proteasome subunit alpha type 6 0.0136 0.3895 0.3831
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0169 0.4957 0.4915
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0027 0.0412 0.0333
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0026 0.0368 0.0391
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0135 0.3867 0.4045
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0169 0.4957 0.4904
Toxoplasma gondii heat shock protein hslv, putative 0.0096 0.2611 0.2695
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0027 0.0412 0.0332
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.012 0.3374 0.3319
Echinococcus multilocularis adhesion regulating molecule 1 0.0085 0.2256 0.2191
Trichomonas vaginalis proteasome regulatory subunits, putative 0.003 0.049 0.0521
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0126 0.3587 0.3744
Trypanosoma brucei proteasome beta 6 subunit 0.0144 0.4166 0.4378
Brugia malayi proteasome subunit alpha type 1 0.0124 0.3526 0.3458
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0035 0.0648 0.0551
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0026 0.0368 0.0288
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0118 0.3326 0.3463
Leishmania major proteasome beta 2 subunit, putative 0.012 0.3374 0.3586
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0035 0.0665 0.0568
Loa Loa (eye worm) hypothetical protein 0.0026 0.0368 0.0306
Echinococcus granulosus proteasome subunit beta type 6 0.0125 0.3552 0.3499
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0126 0.3587 0.3744
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0029 0.0462 0.0407
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0039 0.0784 0.0708
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0308 0.9408 1
Brugia malayi Proteasome A-type and B-type family protein 0.0308 0.9408 0.9402
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0115 0.3216 0.336
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.003 0.0486 0.0387
Plasmodium falciparum proteasome subunit beta type-4 0.0118 0.3326 0.3463
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0039 0.0784 0.0753
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0033 0.0586 0.0508
Giardia lamblia 26S protease regulatory subunit 8 0.0018 0.0103 0.0022
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0119 0.0127
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0136 0.3895 0.4088
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.003 0.0486 0.0407
Leishmania major proteasome alpha 2 subunit, putative 0.0129 0.3683 0.3915
Entamoeba histolytica proteasome regulatory subunit, putative 0.0019 0.0152 0.0053
Giardia lamblia 26S protease regulatory subunit 6A 0.0019 0.0154 0.0077
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0082 0.2164 0.2082
Giardia lamblia 20S proteasome alpha subunit 6 0.0124 0.3526 0.3692
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0035 0.0665 0.0568
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.3326 0.3535
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0026 0.0368 0.0268
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0085 0.2256 0.2313
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0027 0.0408 0.0328
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0124 0.3526 0.3747
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0136 0.3895 0.4139
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0018 0.0119 0.0018
Brugia malayi Probable 26S protease regulatory subunit 4 0.0018 0.0119 0.0016
Loa Loa (eye worm) hypothetical protein 0.0082 0.2164 0.2232
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0169 0.4957 0.5216
Toxoplasma gondii proteasome 26S regulatory subunit 0.0019 0.0136 0.0036
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0124 0.3526 0.3678
Brugia malayi Proteasome/cyclosome repeat family protein 0.0029 0.0462 0.0363
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0019 0.0154 0.0055
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0027 0.0408 0.0327
Giardia lamblia Proteasome subunit beta type 1 0.0144 0.4166 0.4378
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0129 0.3683 0.3847
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0124 0.3526 0.3472
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0018 0.0119 0.004
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0136 0.3895 0.3831
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0308 0.9408 1
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0019 0.0154 0.0072
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0169 0.4957 0.5216
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0035 0.0665 0.0604
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0027 0.0412 0.0354
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0129 0.3683 0.3847
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.003 0.0486 0.0433
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0039 0.0784 0.0708
Loa Loa (eye worm) proteasome subunit beta type 2 0.012 0.3374 0.3529
Trypanosoma cruzi 20S proteasome subunit 0.012 0.3374 0.3586
Echinococcus multilocularis proteasome subunit beta type 6 0.0125 0.3552 0.3499
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.003 0.049 0.0415
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0125 0.354 0.3486
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0135 0.3867 0.4058
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0125 0.354 0.3693
Echinococcus multilocularis carboxylesterase 5A 0.0082 0.2164 0.2099
Brugia malayi PCI domain containing protein 0.003 0.049 0.0391
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0135 0.3867 0.3816
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.003 0.049 0.0521
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0019 0.0153 0.0163
Echinococcus multilocularis 26S protease regulatory subunit 8 0.0018 0.0103 0.0021
Toxoplasma gondii proteasome regulatory subunit 0.0027 0.0412 0.0332
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0125 0.3552 0.3776
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0018 0.0103 0.011
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0118 0.3326 0.3478
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0412 0.0333
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0026 0.0368 0.0391
Toxoplasma gondii proteasome subunit alpha type, putative 0.0073 0.1887 0.1917
Plasmodium vivax proteasome subunit beta type-4, putative 0.0118 0.3326 0.3463
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0019 0.0154 0.0055
Entamoeba histolytica hypothetical protein 0.0035 0.0648 0.0586
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0125 0.354 0.3707
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0126 0.3587 0.3534
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0124 0.3526 0.3678
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0125 0.3552 0.3721
Giardia lamblia 20S proteasome alpha subunit 5 0.0135 0.3867 0.4058
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0126 0.3587 0.3744
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0039 0.0784 0.0688
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0033 0.0586 0.054
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0096 0.2611 0.2695
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0144 0.4166 0.4428
Toxoplasma gondii proteasome subunit beta type 2, putative 0.012 0.3374 0.3515
Giardia lamblia 20S proteasome alpha subunit 2 0.0129 0.3683 0.3861
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0154 0.0052
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0115 0.3216 0.3418
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0033 0.0586 0.0488
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0169 0.4957 0.5268
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0118 0.3326 0.3256
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0096 0.2611 0.2775
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0412 0.0332
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0035 0.0648 0.0586
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0027 0.0408 0.0349
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0125 0.354 0.3762
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.012 0.3374 0.3586
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0125 0.3552 0.3485
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0126 0.3587 0.3744
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0027 0.0412 0.0312
Trypanosoma brucei proteasome subunit beta type-2, putative 0.012 0.3374 0.3529
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0018 0.0119 0.0018
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.3326 0.3535
Brugia malayi 26S proteasome subunit P45 family protein 0.0018 0.0119 0.0016
Echinococcus granulosus proteasome prosome macropain 0.0308 0.9408 0.9404
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0026 0.0383 0.0407
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0308 0.9408 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.004
Trypanosoma brucei proteasome alpha 7 subunit 0.0126 0.3587 0.3758
Trichomonas vaginalis 26S proteasome subunit, putative 0.0027 0.0408 0.0433
Echinococcus granulosus Proteasome subunit alpha type 7 0.0169 0.4957 0.4915
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0027 0.0412 0.0312
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.012 0.3374 0.3305
Plasmodium vivax proteasome subunit beta type-5, putative 0.0308 0.9408 1
Loa Loa (eye worm) proteasome 26S subunit 0.0018 0.0103 0.0022
Mycobacterium ulcerans proteasome PrcB 0.0308 0.9408 1
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0096 0.2611 0.2695
Trypanosoma cruzi 26S protease regulatory subunit, putative 0.0018 0.0103 0.011
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0126 0.3587 0.352
Echinococcus granulosus acetylcholinesterase 0.0082 0.2164 0.2099
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative 0.0017 0.0082 0.0088
Brugia malayi proteasome subunit alpha type 3 0.0126 0.3587 0.352
Echinococcus granulosus proteasome prosome macropain subunit beta 0.012 0.3374 0.3319
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0136 0.3895 0.4139
Giardia lamblia 26S protease regulatory subunit 6B 0.0018 0.0119 0.004
Brugia malayi proteasome subunit beta type 2 0.012 0.3374 0.3305
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.012 0.3374 0.3586
Schistosoma mansoni proteasome regulatory subunit-related 0.003 0.049 0.0391
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0096 0.2611 0.2695
Trypanosoma brucei proteasome beta 7 subunit 0.0118 0.3326 0.3478
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.011 0.3078 0.3272
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0124 0.3526 0.3458
Trypanosoma cruzi serine peptidase, Clan SJ, family S16, putative 0.0018 0.0103 0.011
Leishmania major proteasome beta-1 subunit, putative 0.0125 0.3552 0.3776
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0154 0.0164
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0026 0.0368 0.0285
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0027 0.0408 0.0328
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0135 0.3867 0.411
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0035 0.0648 0.0586
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.003 0.049 0.0411
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0135 0.3867 0.411
Echinococcus multilocularis acetylcholinesterase 0.0082 0.2164 0.2099
Echinococcus multilocularis acetylcholinesterase 0.0082 0.2164 0.2099
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0136 0.3895 0.4139
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0135 0.3867 0.4045
Toxoplasma gondii PCI domain-containing protein 0.0033 0.0586 0.0519
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0124 0.3526 0.3678
Echinococcus granulosus Proteasome subunit alpha beta 0.0126 0.3587 0.3534
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0125 0.3552 0.3776
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.002 0.0189 0.0201
Leishmania major proteasome beta 5 subunit, putative 0.0308 0.9408 1
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0118 0.3326 0.3463
Loa Loa (eye worm) hypothetical protein 0.0085 0.2256 0.233
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0144 0.4166 0.4366
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0154 0.0164
Loa Loa (eye worm) PAS-3 protein 0.011 0.3072 0.3206
Brugia malayi proteasome subunit alpha type 4 0.011 0.3072 0.3
Brugia malayi 26S protease regulatory subunit 6A 0.0019 0.0154 0.0052
Brugia malayi Proteasome A-type and B-type family protein 0.0125 0.3552 0.3485
Loa Loa (eye worm) proteasome subunit beta type 3 0.012 0.3374 0.3529
Giardia lamblia Hypothetical protein 0.0033 0.0586 0.054
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0096 0.2611 0.2775
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.003 0.049 0.0437
Entamoeba histolytica proteasome subunit beta type 3, putative 0.012 0.3374 0.3515
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0308 0.9408 1
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0018 0.0119 0.0018
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0124 0.3526 0.3692
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0169 0.4957 0.5268
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0124 0.3526 0.3747
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.004
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0018 0.0119 0.0018
Plasmodium vivax proteasome subunit beta type-7, putative 0.0115 0.3216 0.3345
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0308 0.9408 1
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0412 0.0354
Brugia malayi 20S proteasome alpha5 subunit 0.0135 0.3867 0.3803
Echinococcus multilocularis proteasome subunit alpha type 2 0.0129 0.3683 0.3631
Echinococcus granulosus acetylcholinesterase 0.0082 0.2164 0.2099
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0144 0.4166 0.4428
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0118 0.3326 0.3535
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0169 0.4957 0.4915
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0118 0.3326 0.3535
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0125 0.3552 0.3707
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0018 0.0119 0.0037
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0412 0.0332
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0018 0.0119 0.0127
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0019 0.0152 0.005
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0135 0.3867 0.3803
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0118 0.3326 0.3478
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0039 0.0784 0.0834
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0035 0.0648 0.0586
Loa Loa (eye worm) hypothetical protein 0.0026 0.0368 0.0306
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.3326 0.3535
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0018 0.0119 0.004
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0027 0.0408 0.0327
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0169 0.4957 0.5226
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0135 0.3867 0.411
Loa Loa (eye worm) proteasome subunit beta type 1 0.0144 0.4166 0.4378
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0135 0.3867 0.4058
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.012 0.3374 0.3586
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0125 0.354 0.3693
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0144 0.4166 0.4117
Loa Loa (eye worm) proteasome Regulatory Particle 0.003 0.0486 0.0433
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0017 0.0082 0.0088
Plasmodium falciparum proteasome subunit beta type-2, putative 0.012 0.3374 0.3515
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0026 0.0368 0.0268
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0125 0.354 0.3486
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0152 0.0162
Giardia lamblia 20S proteasome alpha subunit 3 0.0125 0.354 0.3707
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0115 0.3216 0.336
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0126 0.3587 0.3812
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0308 0.9408 1
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0035 0.0665 0.0707
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0144 0.4166 0.4117
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0027 0.0408 0.0433
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0017 0.0082 0.0088
Schistosoma mansoni multiubiquitin binding protein S5a 0.0019 0.0152 0.005
Loa Loa (eye worm) PCI domain-containing protein 0.0027 0.0408 0.0349
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0039 0.0784 0.0688
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0326 1 1
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0193 0.5712 0.5667
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.012 0.3374 0.3319
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0412 0.0312
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0027 0.0412 0.0354
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0096 0.2611 0.5
Plasmodium vivax proteasome subunit beta type-6, putative 0.0125 0.3552 0.3707

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Inhibition of AChE in Wistar rat brain cortex using acetylthiocholine iodide as substrate by Ellman's colorimetric method ChEMBL. 23422935
IC50 (binding) = 29.28 nM Inhibition of BuChE in human plasma using butyrylthiocholine iodide as substrate by Ellman's colorimetric method ChEMBL. 23422935

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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