Detailed information for compound 1730877

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 611.217 | Formula: C40H39ClN4
  • H donors: 1 H acceptors: 2 LogP: 10.17 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(cc1)c1nc(c(n1CCCCCCNc1c2CCCCc2nc2c1cccc2)c1ccccc1)c1ccccc1
  • InChi: 1S/C40H39ClN4/c41-32-25-23-31(24-26-32)40-44-37(29-15-5-3-6-16-29)39(30-17-7-4-8-18-30)45(40)28-14-2-1-13-27-42-38-33-19-9-11-21-35(33)43-36-22-12-10-20-34(36)38/h3-9,11,15-19,21,23-26H,1-2,10,12-14,20,22,27-28H2,(H,42,43)
  • InChiKey: ZBOYECSUZSRATG-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens butyrylcholinesterase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Carboxylesterase family protein butyrylcholinesterase 602 aa 546 aa 30.2 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni proteasome regulatory subunit-related 0.003 0.049 0.0391
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0039 0.0784 0.0688
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0027 0.0412 0.0438
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0125 0.354 0.3486
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0085 0.2256 0.2175
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0027 0.0408 0.0433
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0124 0.3526 0.3692
Brugia malayi 26S proteasome subunit P45 family protein 0.0018 0.0119 0.0016
Brugia malayi proteasome subunit beta type 2 0.012 0.3374 0.3305
Brugia malayi Proteasome/cyclosome repeat family protein 0.0029 0.0462 0.0363
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0129 0.3683 0.3847
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0125 0.3552 0.3707
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0078 0.2055 0.1989
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0169 0.4957 0.4904
Brugia malayi Ubiquitin interaction motif family protein 0.0019 0.0152 0.005
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0125 0.3552 0.3776
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0026 0.0368 0.0391
Echinococcus granulosus acetylcholinesterase 0.0082 0.2164 0.2099
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0129 0.3683 0.3617
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0135 0.3867 0.4045
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.003 0.0486 0.0387
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0096 0.2611 0.2711
Loa Loa (eye worm) proteasome subunit beta type 3 0.012 0.3374 0.3529
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.004
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0193 0.5712 0.5667
Echinococcus granulosus acetylcholinesterase 0.0082 0.2164 0.2099
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0135 0.3867 0.3803
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0119 0.0018
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0019 0.0154 0.0077
Toxoplasma gondii proteasome beta subunit 0.012 0.3374 0.3515
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0118 0.3326 0.3535
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0019 0.0154 0.0072
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0054 0.1264 0.3333
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0018 0.0119 0.0037
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.012 0.3374 0.3319
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0115 0.3216 0.3418
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0308 0.9408 1
Trypanosoma brucei proteasome beta 3 subunit, putative 0.012 0.3374 0.3529
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0118 0.3326 0.3478
Echinococcus granulosus Proteasome subunit alpha beta 0.0126 0.3587 0.3534
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0018 0.0119 0.0018
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0039 0.0784 0.0753
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0017 0.0082 0.0088
Echinococcus granulosus 26s protease regulatory subunit s10b 0.0018 0.0103 0.0021
Brugia malayi Proteasome A-type and B-type family protein 0.0308 0.9408 0.9402
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0027 0.0408 0.0328
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0096 0.2611 0.2775
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0118 0.3326 0.3463
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0126 0.3587 0.3534
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0027 0.0412 0.0312
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0144 0.4166 0.4428
Leishmania major proteasome alpha 2 subunit, putative 0.0129 0.3683 0.3915
Echinococcus granulosus 26S protease regulatory subunit 8 0.0018 0.0103 0.0021
Giardia lamblia Hypothetical protein 0.0033 0.0586 0.054
Onchocerca volvulus 0.0018 0.0119 0.0047
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0125 0.354 0.3693
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0144 0.4166 0.4428
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0018 0.0119 0.0018
Echinococcus granulosus carboxylesterase 5A 0.0082 0.2164 0.2099
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0125 0.354 0.3762
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.003 0.0486 0.0433
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0129 0.3683 0.3861
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.012 0.3374 0.3586
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.012 0.3374 0.3515
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0124 0.3526 0.3692
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0039 0.0784 0.0688
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.012 0.3374 0.3305
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0118 0.3326 0.3535
Giardia lamblia 20S proteasome alpha subunit 6 0.0124 0.3526 0.3692
Echinococcus multilocularis proteasome subunit alpha type 6 0.0136 0.3895 0.3844
Echinococcus multilocularis carboxylesterase 5A 0.0082 0.2164 0.2099
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.3326 0.3535
Giardia lamblia 20S proteasome alpha subunit 7 0.0126 0.3587 0.3758
Trypanosoma cruzi 19S proteasome regulatory subunit 0.0018 0.0103 0.011
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0018 0.0119 0.0018
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0124 0.3526 0.3747
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0115 0.3216 0.3345
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0136 0.3895 0.4139
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0039 0.0784 0.0753
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0115 0.3216 0.3345
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0368 0.0391
Brugia malayi proteasome subunit alpha type 6 0.0136 0.3895 0.3831
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0019 0.0154 0.0055
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0125 0.3552 0.3707
Schistosoma mansoni hypothetical protein 0.0193 0.5712 0.5667
Brugia malayi proteasome subunit alpha type 3 0.0126 0.3587 0.352
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0019 0.0152 0.005
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0039 0.0784 0.0834
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0039 0.0784 0.0708
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0326 1 1
Schistosoma mansoni 26S proteasome subunit S9 0.0033 0.0586 0.0488
Toxoplasma gondii PCI domain-containing protein 0.0035 0.0665 0.0604
Giardia lamblia Proteasome subunit beta type 3 0.012 0.3374 0.3529
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0412 0.0332
Schistosoma mansoni hypothetical protein 0.0078 0.2055 0.1972
Toxoplasma gondii proteasome subunit alpha type, putative 0.0073 0.1887 0.1917
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0135 0.3867 0.411
Toxoplasma gondii PCI domain-containing protein 0.0027 0.0408 0.0327
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0154 0.0164
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0026 0.0368 0.0268
Loa Loa (eye worm) proteasome 26S subunit 0.0018 0.0103 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.004
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0124 0.3526 0.3678
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0018 0.0119 0.0127
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0118 0.3326 0.3478
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0027 0.0408 0.0328
Giardia lamblia 20S proteasome alpha subunit 4 0.0169 0.4957 0.5226
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0018 0.0103 0.0022
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0368 0.0391
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.003 0.0486 0.0433
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0136 0.3895 0.4088
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0169 0.4957 0.5216
Trichomonas vaginalis 26S proteasome subunit, putative 0.0027 0.0408 0.0433
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0096 0.2611 0.2775
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0412 0.0354
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0119 0.0127
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0017 0.0082 0.0088
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0027 0.0412 0.0333
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0018 0.0119 0.0018
Trypanosoma cruzi 26S protease regulatory subunit, putative 0.0018 0.0103 0.011
Brugia malayi Carboxylesterase family protein 0.0082 0.2164 0.2082
Echinococcus multilocularis proteasome subunit alpha type 2 0.0129 0.3683 0.3631
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0136 0.3895 0.4088
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0033 0.0586 0.0623
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0035 0.0648 0.0586
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0115 0.3216 0.336
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0033 0.0586 0.0623
Loa Loa (eye worm) hypothetical protein 0.0085 0.2256 0.233
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0027 0.0412 0.0332
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0129 0.3683 0.3847
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0135 0.3867 0.4058
Trypanosoma brucei protease regulatory ATPase subunit 4 0.0018 0.0103 0.0022
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0035 0.0665 0.0604
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0033 0.0586 0.0508
Giardia lamblia Proteasome subunit beta type 2 0.012 0.3374 0.3529
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.3326 0.3535
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0018 0.0119 0.0037
Brugia malayi 26S protease regulatory subunit 6A 0.0019 0.0154 0.0052
Giardia lamblia 26S protease regulatory subunit 7 0.0018 0.0103 0.0022
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0308 0.9408 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0368 0.0306
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0035 0.0648 0.0586
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.003 0.0486 0.0517
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0035 0.0665 0.0588
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0115 0.3216 0.336
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0412 0.0332
Toxoplasma gondii peptidase, T1 family protein 0.0126 0.3587 0.3744
Entamoeba histolytica hypothetical protein 0.0035 0.0648 0.0586
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0019 0.0154 0.0055
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0125 0.3552 0.3776
Loa Loa (eye worm) PAS-3 protein 0.011 0.3072 0.3206
Toxoplasma gondii proteasome regulatory subunit 0.0027 0.0412 0.0332
Echinococcus granulosus adhesion regulating molecule 1 0.0085 0.2256 0.2191
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0027 0.0412 0.0332
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0039 0.0784 0.0753
Loa Loa (eye worm) hypothetical protein 0.0024 0.0304 0.0238
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.003 0.0486 0.0517
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0035 0.0648 0.0586
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0018 0.0119 0.0018
Leishmania major proteasome beta 7 subunit, putative 0.0118 0.3326 0.3535
Echinococcus multilocularis 26S protease regulatory subunit 8 0.0018 0.0103 0.0021
Giardia lamblia 20S proteasome alpha subunit 3 0.0125 0.354 0.3707
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0118 0.3326 0.3463
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0129 0.3683 0.3847
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0119 0.0127
Trypanosoma brucei proteasome alpha 7 subunit 0.0126 0.3587 0.3758
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0039 0.0784 0.0688
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0126 0.3587 0.3812
Plasmodium falciparum proteasome subunit beta type-2, putative 0.012 0.3374 0.3515
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.003 0.0486 0.0412
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0412 0.0312
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0119 0.0127
Brugia malayi PCI domain containing protein 0.0027 0.0408 0.0308
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0026 0.0368 0.0391
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0026 0.0368 0.0285
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0136 0.3895 0.4075
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0085 0.2256 0.2175
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0035 0.0665 0.0588
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0027 0.0408 0.0433
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0135 0.3867 0.4045
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0125 0.354 0.3693
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0125 0.3552 0.3776
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0019 0.0154 0.0055
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0035 0.0648 0.057
Toxoplasma gondii proteasome subunit beta type, putative 0.0308 0.9408 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0126 0.3587 0.3812
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0026 0.0368 0.0288
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0169 0.4957 0.5216
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0119 0.0127
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0027 0.0408 0.0327
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0152 0.0071
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.012 0.3374 0.3586
Loa Loa (eye worm) acetylcholinesterase 1 0.0082 0.2164 0.2232
Leishmania major proteasome beta 2 subunit, putative 0.0115 0.3216 0.3418
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0035 0.0665 0.0568
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0126 0.3587 0.3744
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0039 0.0784 0.0732
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0027 0.0412 0.0312
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0096 0.2611 0.2695
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0125 0.3552 0.3721
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.012 0.3374 0.3586
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0412 0.0332
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0125 0.354 0.3473
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0308 0.9408 1
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.003 0.049 0.0411
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0144 0.4166 0.4117
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0029 0.0462 0.0407
Echinococcus multilocularis proteasome subunit beta type 6 0.0125 0.3552 0.3499
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0085 0.2256 0.2313
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0018 0.0119 0.0127
Giardia lamblia 26S protease regulatory subunit 6A 0.0019 0.0154 0.0077
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0169 0.4957 0.5268
Plasmodium vivax proteasome subunit beta type-2, putative 0.012 0.3374 0.3515
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0412 0.0438
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0115 0.3216 0.3345
Brugia malayi proteasome subunit alpha type 4 0.011 0.3072 0.3
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0018 0.0119 0.004
Trypanosoma brucei proteasome beta 7 subunit 0.0118 0.3326 0.3478
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0124 0.3526 0.3472
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0027 0.0412 0.0354
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.012 0.3374 0.3586
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0126 0.3587 0.3744
Entamoeba histolytica proteasome regulatory subunit, putative 0.0019 0.0152 0.0053
Brugia malayi proteasome subunit beta type 3 0.012 0.3374 0.3305
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0022
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.012 0.3374 0.3305
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0412 0.0438
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0019 0.0152 0.0162
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0152 0.0071
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0308 0.9408 0.9402
Loa Loa (eye worm) hypothetical protein 0.0026 0.0368 0.0306
Leishmania major 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative 0.0018 0.0103 0.011
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0125 0.354 0.3486
Trypanosoma cruzi 20S proteasome subunit 0.012 0.3374 0.3586
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.3326 0.3535
Toxoplasma gondii heat shock protein hslv, putative 0.0096 0.2611 0.2695
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0135 0.3867 0.4045
Toxoplasma gondii proteasome subunit alpha1, putative 0.0136 0.3895 0.4075
Onchocerca volvulus Notchless protein homolog 0.0126 0.3587 1
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0124 0.3526 0.3678
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0169 0.4957 0.5268
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0119 0.0127
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0026 0.0368 0.0268
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0136 0.3895 0.4139
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.012 0.3374 0.3586
Plasmodium vivax proteasome subunit beta type-1, putative 0.0144 0.4166 0.4366
Loa Loa (eye worm) proteasome Regulatory Particle 0.003 0.0486 0.0433
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0039 0.0784 0.0834
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0154 0.0052
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0125 0.354 0.3762
Leishmania major hypothetical protein, conserved 0.0044 0.0955 0.1015
Loa Loa (eye worm) carboxylesterase 0.0082 0.2164 0.2232
Echinococcus granulosus proteasome subunit alpha type 2 0.0129 0.3683 0.3631
Toxoplasma gondii 26s proteasome subunit p55, putative 0.003 0.049 0.0415
Leishmania major proteasome alpha 1 subunit, putative 0.0124 0.3526 0.3747
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0126 0.3587 0.3812
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0169 0.4957 0.5216
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0019 0.0154 0.0164
Giardia lamblia 20S proteasome alpha subunit 1 0.0136 0.3895 0.4088
Brugia malayi proteasome subunit alpha type 2 0.0129 0.3683 0.3617
Echinococcus granulosus proteasome prosome macropain 0.0308 0.9408 0.9404
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0144 0.4166 0.4366
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0026 0.0368 0.0268
Giardia lamblia 20S proteasome alpha subunit 2 0.0129 0.3683 0.3861
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0035 0.0665 0.0625
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0033 0.0586 0.0488
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0096 0.2611 0.2695
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0135 0.3867 0.4045
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0144 0.4166 0.4428
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0035 0.0648 0.057
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.003 0.049 0.0521
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0412 0.0438
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0169 0.4957 0.4915
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0169 0.4957 0.5226
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.3326 0.3535
Loa Loa (eye worm) hypothetical protein 0.0193 0.5712 0.6036
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.002 0.0189 0.0201
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0135 0.3867 0.4058
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0124 0.3526 0.3458
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0125 0.3552 0.3721
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0026 0.0383 0.0407
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0144 0.4166 0.4366
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0018 0.0119 0.0018
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0035 0.0648 0.0551
Echinococcus granulosus proteasome subunit beta t family 0.012 0.3374 0.3319
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0129 0.3683 0.3861
Plasmodium vivax proteasome subunit beta type-5, putative 0.0308 0.9408 1
Brugia malayi PCI domain containing protein 0.003 0.049 0.0391
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0026 0.0368 0.0306
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0029 0.0462 0.0491
Loa Loa (eye worm) RPN-3 protein 0.0035 0.0665 0.0625
Entamoeba histolytica proteasome regulatory subunit, putative 0.0033 0.0586 0.0519
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0035 0.0665 0.0568
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0118 0.3326 0.327
Brugia malayi Proteasome A-type and B-type family protein 0.0125 0.3552 0.3485
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0308 0.9408 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.3326 0.3535
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0308 0.9408 1
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0019 0.0154 0.0055
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0018 0.0119 0.004
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0019 0.0154 0.0077
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0154 0.0052
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0154 0.0052
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0033 0.0586 0.0519
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0096 0.2611 0.2695
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0096 0.2611 0.5
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.003 0.049 0.0411
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0017 0.0082 0.0088
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0018 0.0119 0.0037
Echinococcus granulosus subfamily T1A non peptidase ue 0.0135 0.3867 0.3816
Loa Loa (eye worm) proteasome subunit beta type 2 0.012 0.3374 0.3529
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0019 0.0154 0.0164
Loa Loa (eye worm) RPT-2 protein 0.0018 0.0119 0.004
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.003 0.0486 0.0412
Trypanosoma brucei Regulatory particle triple-A ATPase subunit 6 0.0018 0.0103 0.0022
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0169 0.4957 0.4915
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0018 0.0119 0.004
Leishmania major proteasome beta 3 subunit, putative 0.012 0.3374 0.3586
Echinococcus multilocularis acetylcholinesterase 0.0082 0.2164 0.2099
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0118 0.3326 0.3256
Echinococcus multilocularis proteasome subunit beta type 7 0.0326 1 1
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0124 0.3526 0.3678
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0125 0.354 0.3693
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.003 0.049 0.0521
Brugia malayi Proteasome subunit alpha type 7-1 0.0169 0.4957 0.4904
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0019 0.0136 0.0036
Leishmania major proteasome alpha 3 subunit, putative 0.0125 0.354 0.3762
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0118 0.3326 0.327
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0152 0.0162
Echinococcus multilocularis proteasome (prosome, macropain) 0.0308 0.9408 0.9404
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.3326 0.3535
Brugia malayi proteasome subunit beta type 1 0.0144 0.4166 0.4105
Leishmania major proteasome regulatory ATPase subunit 0.0018 0.0103 0.011
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0308 0.9408 1
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.003 0.0486 0.0407
Mycobacterium ulcerans proteasome PrcB 0.0308 0.9408 1
Toxoplasma gondii proteasome 26S regulatory subunit 0.0019 0.0136 0.0036
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0144 0.4166 0.4428
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0126 0.3587 0.3744
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0308 0.9408 1
Plasmodium vivax proteasome subunit beta type-6, putative 0.0125 0.3552 0.3707
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.003 0.049 0.0415
Brugia malayi Carboxylesterase family protein 0.0082 0.2164 0.2082
Echinococcus granulosus Proteasome subunit alpha type 7 0.0169 0.4957 0.4915
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0129 0.3683 0.3847
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0033 0.0586 0.0623
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0135 0.3867 0.3816
Entamoeba histolytica proteasome regulatory subunit, putative 0.0027 0.0408 0.0327
Leishmania major proteasome alpha 7 subunit, putative 0.0169 0.4957 0.5268
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0027 0.0408 0.0433
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0096 0.2611 0.2775
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0027 0.0412 0.0354
Giardia lamblia Proteasome subunit beta type 1 0.0144 0.4166 0.4378
Giardia lamblia 26S protease regulatory subunit 6B 0.0018 0.0119 0.004
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0078 0.2055 0.1989
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0135 0.3867 0.411
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0126 0.3587 0.3758
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0019 0.0153 0.0163
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0308 0.9408 1
Echinococcus granulosus proteasome subunit beta type 6 0.0125 0.3552 0.3499
Entamoeba histolytica proteasome regulatory subunit, putative 0.0035 0.0665 0.0604
Leishmania major proteasome beta-1 subunit, putative 0.0125 0.3552 0.3776
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.003 0.0486 0.0387
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.012 0.3374 0.3319
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0033 0.0586 0.0519
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0119 0.0127
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0018 0.0119 0.0037
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0018 0.0119 0.0127
Plasmodium falciparum proteasome subunit beta type-3, putative 0.012 0.3374 0.3515
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0026 0.0368 0.0288
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0126 0.3587 0.3744
Onchocerca volvulus 0.0018 0.0119 0.0047
Toxoplasma gondii SAC3/GANP family protein 0.0026 0.0368 0.0285
Loa Loa (eye worm) proteasome regulatory particle 0.0033 0.0586 0.054
Trypanosoma cruzi serine peptidase, Clan SJ, family S16, putative 0.0018 0.0103 0.011
Toxoplasma gondii proteasome subunit alpha type, putative 0.0125 0.354 0.3693
Toxoplasma gondii PCI domain-containing protein 0.0033 0.0586 0.0519
Toxoplasma gondii proteasome subunit beta type 2, putative 0.012 0.3374 0.3515
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0039 0.0784 0.0834
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0033 0.0586 0.054
Brugia malayi Proteasome subunit alpha type 1 0.011 0.3058 0.2986
Echinococcus multilocularis acetylcholinesterase 0.0082 0.2164 0.2099
Trypanosoma brucei proteasome beta 6 subunit 0.0144 0.4166 0.4378
Plasmodium falciparum proteasome subunit beta type-5 0.0308 0.9408 1
Entamoeba histolytica proteasome subunit beta type 3, putative 0.012 0.3374 0.3515
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0368 0.0391
Brugia malayi proteasome subunit alpha type 1 0.0124 0.3526 0.3458
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0039 0.0784 0.0688
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0136 0.3895 0.3831
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.003 0.049 0.0437
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0125 0.354 0.3762
Toxoplasma gondii proteasome subunit 0.0125 0.3552 0.3707
Entamoeba histolytica proteasome regulatory subunit, putative 0.0026 0.0368 0.0285
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0044 0.0955 0.0915
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0027 0.0408 0.0349
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0144 0.4166 0.4117
Plasmodium vivax proteasome subunit beta type-7, putative 0.0115 0.3216 0.3345
Brugia malayi 20S proteasome alpha5 subunit 0.0135 0.3867 0.3803
Schistosoma mansoni hypothetical protein 0.0027 0.0408 0.0308
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0135 0.3867 0.411
Schistosoma mansoni multiubiquitin binding protein S5a 0.0019 0.0152 0.005
Echinococcus granulosus proteasome prosome macropain subunit beta 0.012 0.3374 0.3319
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0136 0.3895 0.4075
Giardia lamblia 26S proteasome regulatory subunit, putative 0.002 0.0189 0.0114
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0026 0.0368 0.0285
Leishmania major proteasome alpha 7 subunit, putative 0.0126 0.3587 0.3812
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0169 0.4957 0.5226
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0027 0.0412 0.0333
Leishmania major proteasome beta 2 subunit, putative 0.012 0.3374 0.3586
Brugia malayi Proteasome/cyclosome repeat family protein 0.0029 0.0462 0.0363
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0125 0.354 0.3693
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0412 0.0438
Giardia lamblia 20S proteasome alpha subunit 5 0.0135 0.3867 0.4058
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0124 0.3526 0.3747
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0027 0.0412 0.0312
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.012 0.3374 0.3586
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0018 0.0103 0.011
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.011 0.3078 0.3272
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0169 0.4957 0.5268
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.049 0.0415
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0035 0.0648 0.0607
Loa Loa (eye worm) PCI domain-containing protein 0.0027 0.0408 0.0349
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0082 0.2164 0.2082
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0135 0.3867 0.3803
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0017 0.0082 0.0088
Echinococcus granulosus proteasome subunit beta type 7 0.0326 1 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.2164 0.2232
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.003 0.0486 0.0412
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0124 0.3526 0.3678
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0136 0.3895 0.4139
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0035 0.0665 0.0707
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0035 0.0665 0.0707
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0136 0.3895 0.4075
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0027 0.0412 0.0332
Plasmodium vivax proteasome subunit beta type-4, putative 0.0118 0.3326 0.3463
Echinococcus multilocularis adhesion regulating molecule 1 0.0085 0.2256 0.2191
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0135 0.3867 0.411
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0115 0.3216 0.336
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0152 0.0162
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.003 0.049 0.0415
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative 0.0017 0.0082 0.0088
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.0486 0.0412
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0103 0.011
Plasmodium vivax proteasome subunit beta type-3, putative 0.012 0.3374 0.3515
Giardia lamblia 26S protease regulatory subunit 8 0.0018 0.0103 0.0022
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0019 0.0136 0.0145
Trypanosoma brucei proteasome subunit beta type-2, putative 0.012 0.3374 0.3529
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0096 0.2611 0.2534
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0039 0.0784 0.0708
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0125 0.3552 0.3721
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0018 0.0119 0.0016
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0033 0.0586 0.0508
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0119 0.0018
Plasmodium falciparum proteasome subunit beta type-4 0.0118 0.3326 0.3463
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.012 0.34 0.3331
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0115 0.3216 0.3418
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.012 0.3374 0.3305
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.003 0.0486 0.0407
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0115 0.3216 0.3418
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0039 0.0784 0.0732
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0169 0.4957 0.4915
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0115 0.3216 0.3418
Leishmania major proteasome beta 5 subunit, putative 0.0308 0.9408 1
Leishmania major proteasome alpha 1 subunit, putative 0.0136 0.3895 0.4139
Trichomonas vaginalis proteasome regulatory subunits, putative 0.003 0.049 0.0521
Loa Loa (eye worm) PCI domain-containing protein 0.003 0.049 0.0437
Schistosoma mansoni 26S protease regulatory subunit 0.0018 0.0119 0.0016
Loa Loa (eye worm) proteasome subunit beta type 1 0.0144 0.4166 0.4378
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0135 0.3867 0.4045
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0035 0.0665 0.0568
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0125 0.3552 0.3485
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0412 0.0332
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0129 0.3683 0.3915
Brugia malayi Probable 26S protease regulatory subunit 4 0.0018 0.0119 0.0016
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0412 0.0333
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0144 0.4166 0.4366
Echinococcus granulosus proteasome subunit alpha type 6 0.0136 0.3895 0.3844
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0154 0.0164
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.012 0.3374 0.3305
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0027 0.0408 0.0327
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0308 0.9408 1
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0169 0.4957 0.5216
Echinococcus multilocularis 26s protease regulatory subunit s10b 0.0018 0.0103 0.0021
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0124 0.3526 0.3472
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0125 0.354 0.3707
Loa Loa (eye worm) hypothetical protein 0.0082 0.2164 0.2232
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.003 0.0486 0.0517
Toxoplasma gondii hypothetical protein 0.0024 0.0304 0.0216
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0126 0.3587 0.352
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0144 0.4166 0.4105
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0019 0.0154 0.0072
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0412 0.0333
Brugia malayi Proteasome A-type and B-type family protein 0.0118 0.3326 0.3256

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Inhibition of AChE in Wistar rat brain cortex using acetylthiocholine iodide as substrate by Ellman's colorimetric method ChEMBL. 23422935
IC50 (binding) = 29.28 nM Inhibition of BuChE in human plasma using butyrylthiocholine iodide as substrate by Ellman's colorimetric method ChEMBL. 23422935

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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