Detailed information for compound 1730878

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 811.104 | Formula: C42H78N6O9
  • H donors: 6 H acceptors: 7 LogP: 3.42 Rotable bonds: 45
    Rule of 5 violations (Lipinski): 3
  • SMILES: COC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)OC(C)(C)C
  • InChi: 1S/C42H78N6O9/c1-42(2,3)57-41(55)48-34-22-9-15-27-39(53)46-32-20-7-13-25-37(51)44-30-18-5-11-23-35(49)43-29-17-6-12-24-36(50)45-31-19-8-14-26-38(52)47-33-21-10-16-28-40(54)56-4/h5-34H2,1-4H3,(H,43,49)(H,44,51)(H,45,50)(H,46,53)(H,47,52)(H,48,55)
  • InChiKey: AZKFIYMTJCGUHM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei protease regulatory ATPase subunit 4 0.0017 0.0103 0.0022
Echinococcus granulosus proteasome subunit beta type 7 0.0319 1 1
Toxoplasma gondii proteasome regulatory subunit 0.0027 0.0412 0.033
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0034 0.0665 0.06
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Echinococcus granulosus 26S protease regulatory subunit 8 0.0017 0.0103 0.0021
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0368 0.0388
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0122 0.3556 0.3685
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0117 0.3377 0.3509
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0094 0.2614 0.2537
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0122 0.3543 0.3741
Brugia malayi Tachykinin-like peptides receptor 99D 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0368 0.0304
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0117 0.3377 0.3566
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0132 0.387 0.4086
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0115 0.3329 0.3443
Brugia malayi Melatonin receptor type 1A 0.0025 0.0362 0.0262
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0362 0.0282
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0141 0.4169 0.4401
Brugia malayi Dopamine receptor protein 2 0.0025 0.0362 0.0262
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0119 0.0126
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0362 0.0282
Giardia lamblia 20S proteasome alpha subunit 5 0.0132 0.387 0.4034
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Schistosoma mansoni biogenic amine receptor 0.0025 0.0362 0.0262
Echinococcus granulosus orexin receptor type 2 0.0025 0.0362 0.0282
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0112 0.3219 0.3399
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0121 0.3529 0.3657
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0165 0.4959 0.4907
Giardia lamblia 20S proteasome alpha subunit 6 0.0121 0.3529 0.3671
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0412 0.033
Giardia lamblia 20S proteasome alpha subunit 2 0.0126 0.3687 0.3839
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0141 0.4169 0.4401
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0077 0.2054 0.1988
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0362 0.0282
Leishmania major proteasome alpha 3 subunit, putative 0.0122 0.3543 0.3741
Brugia malayi putative neuropeptide receptor 0.0025 0.0362 0.0262
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0038 0.0784 0.0747
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0132 0.387 0.3807
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0029 0.0489 0.0517
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0362 0.0282
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0017 0.0103 0.0109
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0117 0.3377 0.3566
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0122 0.3543 0.3672
Echinococcus multilocularis dro:myosuppressin receptor 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.004
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0094 0.2614 0.276
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0029 0.0489 0.0412
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0025 0.0362 0.0298
Loa Loa (eye worm) proteasome subunit beta type 1 0.0141 0.4169 0.4352
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0115 0.3329 0.326
Loa Loa (eye worm) PAS-3 protein 0.0108 0.3076 0.3188
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0018 0.0119 0.004
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0082 0.0087
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0122 0.3543 0.3741
Schistosoma mansoni adenoreceptor 0.0025 0.0362 0.0262
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0019 0.0154 0.0072
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0362 0.0282
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0027 0.0412 0.0312
Echinococcus granulosus subfamily T1A non peptidase ue 0.0132 0.387 0.382
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0132 0.387 0.4021
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0018 0.0119 0.0037
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0412 0.0332
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0034 0.0665 0.0702
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative 0.0016 0.0082 0.0087
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0019 0.0154 0.0054
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0038 0.0784 0.0688
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0123 0.359 0.3722
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0025 0.0362 0.0298
Leishmania major proteasome beta 5 subunit, putative 0.0302 0.9472 1
Brugia malayi Serotonin receptor 0.0025 0.0362 0.0262
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0094 0.2614 0.268
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.002 0.0189 0.0199
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0123 0.359 0.3537
Plasmodium vivax proteasome subunit beta type-3, putative 0.0117 0.3377 0.3495
Onchocerca volvulus 0.0025 0.0362 0.0743
Brugia malayi proteasome subunit beta type 2 0.0117 0.3377 0.3308
Giardia lamblia Proteasome subunit beta type 3 0.0117 0.3377 0.3509
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0412 0.033
Echinococcus granulosus proteasome subunit beta t family 0.0117 0.3377 0.3322
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0018 0.0119 0.0126
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0123 0.359 0.3736
Echinococcus granulosus alpha 1A adrenergic receptor 0.0025 0.0362 0.0282
Toxoplasma gondii proteasome subunit beta type, putative 0.0302 0.9472 1
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0362 0.0282
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0165 0.4959 0.5236
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0027 0.0412 0.0312
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0115 0.3329 0.3443
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Entamoeba histolytica proteasome regulatory subunit, putative 0.0025 0.0368 0.0283
Echinococcus granulosus peptide allatostatin:somatostatin 0.0025 0.0362 0.0282
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0082 0.0087
Brugia malayi Dopamine receptor protein 1 0.0025 0.0362 0.0262
Plasmodium vivax proteasome subunit beta type-1, putative 0.0141 0.4169 0.434
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0025 0.0362 0.0262
Brugia malayi 26S protease regulatory subunit 6A 0.0019 0.0154 0.0052
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0154 0.0163
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0112 0.3219 0.3326
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0018 0.0119 0.004
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0152 0.0161
Onchocerca volvulus 0.0025 0.0362 0.0743
Brugia malayi larval opioid receptor 0.0025 0.0362 0.0262
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0025 0.0368 0.0283
Schistosoma mansoni amine GPCR 0.0025 0.0362 0.0262
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0362 0.0298
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0122 0.3556 0.3699
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0362 0.0282
Echinococcus granulosus g protein coupled receptor 0.0025 0.0362 0.0282
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0025 0.0362 0.0262
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0362 0.0282
Brugia malayi G protein-coupled receptor F59B2.13 0.0025 0.0362 0.0262
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0123 0.359 0.3722
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0038 0.0784 0.0688
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Echinococcus granulosus serotonin receptor 0.0025 0.0362 0.0282
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0117 0.3377 0.3566
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0038 0.0784 0.0747
Leishmania major proteasome beta-1 subunit, putative 0.0122 0.3556 0.3754
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0122 0.3556 0.3754
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0165 0.4959 0.5183
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0019 0.0154 0.0077
Brugia malayi Ubiquitin interaction motif family protein 0.0019 0.0152 0.005
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0026 0.0407 0.043
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Schistosoma mansoni neuropeptide f receptor 76f 0.0025 0.0362 0.0262
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0025 0.0362 0.0282
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0025 0.0362 0.0262
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Leishmania major hypothetical protein, conserved 0.0043 0.0954 0.1008
Echinococcus granulosus dro:myosuppressin receptor 0.0025 0.0362 0.0282
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0115 0.3329 0.3458
Giardia lamblia Hypothetical protein 0.0032 0.0586 0.0536
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0025 0.0362 0.0262
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0019 0.0152 0.005
Echinococcus multilocularis adhesion regulating molecule 1 0.0083 0.2254 0.219
Schistosoma mansoni hypothetical protein 0.0025 0.0362 0.0262
Brugia malayi Serotonin receptor 0.0025 0.0362 0.0262
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Brugia malayi proteasome subunit alpha type 2 0.0126 0.3687 0.3621
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0119 0.0126
Brugia malayi Proteasome A-type and B-type family protein 0.0302 0.9472 0.9466
Echinococcus granulosus allatostatin A receptor 0.0025 0.0362 0.0282
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0043 0.0954 0.0909
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0034 0.0665 0.0568
Entamoeba histolytica proteasome regulatory subunit, putative 0.0029 0.0486 0.0409
Loa Loa (eye worm) TYRA-2 protein 0.0025 0.0362 0.0298
Leishmania major proteasome alpha 2 subunit, putative 0.0126 0.3687 0.3892
Echinococcus multilocularis G-protein coupled receptor, putative 0.0025 0.0362 0.0282
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0025 0.0362 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0025 0.0362 0.0282
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0165 0.4959 0.5183
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0117 0.3377 0.3495
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0362 0.0298
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0141 0.4169 0.4401
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0027 0.0412 0.033
Onchocerca volvulus 0.0025 0.0362 0.0743
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0121 0.3529 0.3462
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0094 0.2614 0.276
Echinococcus granulosus g protein coupled receptor 0.0025 0.0362 0.0282
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0362 0.0282
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0126 0.3687 0.3839
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0132 0.387 0.4021
Brugia malayi follicle stimulating hormone receptor 0.0025 0.0362 0.0262
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0165 0.4959 0.5194
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0108 0.3082 0.3253
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0133 0.3898 0.4064
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0122 0.3543 0.3741
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0362 0.0262
Echinococcus granulosus fmrfamide receptor 0.0025 0.0362 0.0282
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0362 0.0282
Echinococcus granulosus proteasome subunit alpha type 6 0.0133 0.3898 0.3847
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0026 0.0407 0.0328
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0119 0.0126
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0027 0.0412 0.0332
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0362 0.0282
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0034 0.0648 0.057
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0165 0.4959 0.5236
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0032 0.0586 0.0488
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0152 0.0161
Toxoplasma gondii PCI domain-containing protein 0.0032 0.0586 0.0515
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0029 0.0486 0.0409
Onchocerca volvulus Notchless protein homolog 0.0123 0.359 1
Echinococcus granulosus Proteasome subunit alpha beta 0.0123 0.359 0.3537
Brugia malayi putative neuropeptide receptor NPR1 0.0025 0.0362 0.0262
Plasmodium falciparum proteasome subunit beta type-5 0.0302 0.9472 1
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0302 0.9472 1
Toxoplasma gondii proteasome subunit alpha type, putative 0.0071 0.1886 0.1903
Leishmania major proteasome beta 2 subunit, putative 0.0117 0.3377 0.3566
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0018 0.0119 0.004
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0029 0.0486 0.043
Trypanosoma cruzi 20S proteasome subunit 0.0117 0.3377 0.3566
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0029 0.0486 0.0513
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0025 0.0362 0.0262
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0154 0.0163
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0029 0.0489 0.0411
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0117 0.3377 0.3495
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0154 0.0052
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0412 0.0435
Brugia malayi proteasome subunit alpha type 1 0.0121 0.3529 0.3462
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0117 0.3377 0.3509
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0152 0.0071
Echinococcus granulosus G protein coupled receptor 139 0.0025 0.0362 0.0282
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0362 0.0298
Brugia malayi sulfakinin receptor protein 0.0025 0.0362 0.0262
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0165 0.4959 0.4917
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0112 0.3219 0.3341
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0132 0.387 0.4086
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0362 0.0262
Plasmodium vivax proteasome subunit beta type-4, putative 0.0115 0.3329 0.3443
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0117 0.3377 0.3566
Giardia lamblia 26S protease regulatory subunit 6A 0.0019 0.0154 0.0077
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0038 0.0784 0.0828
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0122 0.3543 0.3672
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0094 0.2614 0.268
Plasmodium falciparum proteasome subunit beta type-4 0.0115 0.3329 0.3443
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0362 0.0262
Brugia malayi Proteasome/cyclosome repeat family protein 0.0028 0.0462 0.0363
Plasmodium vivax proteasome subunit beta type-6, putative 0.0122 0.3556 0.3685
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0019 0.0152 0.0161
Echinococcus multilocularis serotonin receptor 0.0025 0.0362 0.0282
Toxoplasma gondii hypothetical protein 0.0023 0.0304 0.0215
Onchocerca volvulus 0.0025 0.0362 0.0743
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0119 0.0017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0034 0.0648 0.057
Mycobacterium ulcerans proteasome PrcB 0.0302 0.9472 1
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0132 0.387 0.4034
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0117 0.3377 0.3495
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0034 0.0648 0.055
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0126 0.3687 0.3621
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0038 0.0784 0.0688
Trypanosoma brucei proteasome beta 6 subunit 0.0141 0.4169 0.4352
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0133 0.3898 0.4115
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0027 0.0412 0.033
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0038 0.0784 0.0828
Echinococcus granulosus somatostatin receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0032 0.0586 0.0508
Brugia malayi Dopamine receptor 0.0025 0.0362 0.0262
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0362 0.0282
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0025 0.0362 0.0282
Onchocerca volvulus 0.0025 0.0362 0.0743
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0362 0.0282
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0362 0.0262
Onchocerca volvulus 0.0025 0.0362 0.0743
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0027 0.0412 0.0332
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0132 0.387 0.3807
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis proteasome subunit beta type 7 0.0319 1 1
Echinococcus multilocularis serotonin receptor 0.0025 0.0362 0.0282
Echinococcus granulosus 7tm_1 domain containing protein 0.0025 0.0362 0.0282
Onchocerca volvulus 0.0018 0.0119 0.0047
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0302 0.9472 1
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0052 0.1264 0.3328
Echinococcus multilocularis proteasome subunit alpha type 2 0.0126 0.3687 0.3634
Echinococcus multilocularis proteasome subunit beta type 6 0.0122 0.3556 0.3502
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0025 0.0362 0.0262
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0368 0.0388
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0038 0.0784 0.0747
Onchocerca volvulus 0.0025 0.0362 0.0743
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0025 0.0368 0.0288
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0121 0.3529 0.3726
Loa Loa (eye worm) hypothetical protein 0.0023 0.0304 0.0236
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0133 0.3898 0.4115
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0133 0.3898 0.405
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0117 0.3377 0.3308
Brugia malayi PCI domain containing protein 0.0029 0.0489 0.039
Loa Loa (eye worm) RPT-2 protein 0.0018 0.0119 0.004
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0018 0.0119 0.0126
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0029 0.0489 0.0517
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0362 0.0298
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0165 0.4959 0.5183
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0302 0.9472 1
Toxoplasma gondii proteasome subunit alpha1, putative 0.0133 0.3898 0.405
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0017 0.0103 0.0109
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0017 0.0103 0.0022
Brugia malayi proteasome subunit alpha type 3 0.0123 0.359 0.3523
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0018 0.0119 0.0017
Brugia malayi ORL1-like opioid receptor 0.0025 0.0362 0.0262
Echinococcus multilocularis somatostatin receptor 0.0025 0.0362 0.0282
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0018 0.0119 0.0017
Giardia lamblia 26S proteasome regulatory subunit, putative 0.002 0.0189 0.0114
Schistosoma mansoni biogenic amine receptor 0.0025 0.0362 0.0262
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0026 0.0407 0.0325
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0038 0.0784 0.0708
Entamoeba histolytica hypothetical protein 0.0034 0.0648 0.0581
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0115 0.3329 0.3274
Schistosoma mansoni histamine h1 receptor 0.0025 0.0362 0.0262
Leishmania major proteasome alpha 1 subunit, putative 0.0133 0.3898 0.4115
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0029 0.0486 0.0409
Toxoplasma gondii PCI domain-containing protein 0.0034 0.0665 0.06
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0152 0.0071
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0412 0.0435
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0112 0.3219 0.3341
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0126 0.3687 0.3825
Echinococcus multilocularis sex peptide receptor 0.0025 0.0362 0.0282
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0133 0.3898 0.4064
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0165 0.4959 0.4917
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0029 0.0489 0.0411
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0117 0.3377 0.3308
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0032 0.0586 0.0508
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0025 0.0362 0.0282
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0112 0.3219 0.3326
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0083 0.2254 0.2296
Brugia malayi Proteasome A-type and B-type family protein 0.0115 0.3329 0.326
Brugia malayi Probable 26S protease regulatory subunit 4 0.0018 0.0119 0.0016
Leishmania major proteasome alpha 7 subunit, putative 0.0123 0.359 0.379
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0034 0.0648 0.0581
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0362 0.0282
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0122 0.3556 0.3685
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0362 0.0282
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0141 0.4169 0.4401
Brugia malayi GnHR receptor homolog 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0188 0.5709 0.5992
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0025 0.0368 0.0388
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0026 0.0383 0.0404
Entamoeba histolytica proteasome regulatory subunit, putative 0.0026 0.0407 0.0325
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0362 0.0282
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0362 0.0282
Onchocerca volvulus 0.0025 0.0362 0.0743
Brugia malayi G-protein coupled receptor 0.0025 0.0362 0.0262
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0302 0.9472 1
Schistosoma mansoni 26S proteasome subunit S9 0.0032 0.0586 0.0488
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0122 0.3543 0.3672
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0018 0.0119 0.0037
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0112 0.3219 0.3341
Toxoplasma gondii peptidase, T1 family protein 0.0123 0.359 0.3722
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0132 0.387 0.4086
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0165 0.4959 0.4917
Giardia lamblia Proteasome subunit beta type 1 0.0141 0.4169 0.4352
Toxoplasma gondii proteasome 26S regulatory subunit 0.0018 0.0136 0.0035
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0029 0.0486 0.0387
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0117 0.3377 0.3566
Toxoplasma gondii proteasome subunit alpha type, putative 0.0122 0.3543 0.3672
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Onchocerca volvulus 0.0025 0.0362 0.0743
Trypanosoma cruzi serine peptidase, Clan SJ, family S16, putative 0.0017 0.0103 0.0109
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0362 0.0282
Brugia malayi Proteasome subunit alpha type 7-1 0.0165 0.4959 0.4907
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0025 0.0362 0.0282
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0122 0.3543 0.349
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0032 0.0586 0.0619
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0018 0.0119 0.0016
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0034 0.0648 0.0581
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0302 0.9472 1
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0302 0.9472 1
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0117 0.3377 0.3495
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0368 0.0388
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0025 0.0362 0.0282
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0132 0.387 0.382
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0025 0.0362 0.0262
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0362 0.0262
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0302 0.9472 1
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0123 0.359 0.3523
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0133 0.3898 0.405
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0077 0.2054 0.1988
Leishmania major proteasome alpha 1 subunit, putative 0.0121 0.3529 0.3726
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0032 0.0586 0.0619
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0083 0.2254 0.2174
Brugia malayi proteasome subunit alpha type 4 0.0108 0.3076 0.3004
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0362 0.0282
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0025 0.0368 0.0283
Echinococcus multilocularis allatostatin A receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0121 0.3529 0.3475
Brugia malayi Proteasome subunit alpha type 1 0.0107 0.3062 0.2989
Schistosoma mansoni multiubiquitin binding protein S5a 0.0019 0.0152 0.005
Schistosoma mansoni neuropeptide receptor 0.0025 0.0362 0.0262
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0025 0.0362 0.0262
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0094 0.2614 0.268
Schistosoma mansoni growth hormone secretagogue receptor 0.0025 0.0362 0.0262
Echinococcus granulosus g protein coupled receptor 0.0025 0.0362 0.0282
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0302 0.9472 0.9466
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0025 0.0362 0.0298
Loa Loa (eye worm) proteasome subunit beta type 3 0.0117 0.3377 0.3509
Schistosoma mansoni hypothetical protein 0.0025 0.0362 0.0262
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Trypanosoma cruzi 26S protease regulatory subunit, putative 0.0017 0.0103 0.0109
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0019 0.0153 0.0162
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0133 0.3898 0.3834
Schistosoma mansoni amine GPCR 0.0025 0.0362 0.0262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0122 0.3556 0.3754
Schistosoma mansoni amine GPCR 0.0025 0.0362 0.0262
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0094 0.2614 0.276
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0026 0.0407 0.043
Trypanosoma cruzi 19S proteasome regulatory subunit 0.0017 0.0103 0.0109
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0122 0.3543 0.3672
Schistosoma mansoni hypothetical protein 0.0026 0.0407 0.0308
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0032 0.0586 0.0619
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis proteasome (prosome, macropain) 0.0302 0.9472 0.9467
Giardia lamblia 20S proteasome alpha subunit 7 0.0123 0.359 0.3736
Echinococcus granulosus neuropeptide FF receptor 2 0.0025 0.0362 0.0282
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0025 0.0368 0.0268
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0117 0.3377 0.3322
Schistosoma mansoni opsin-like receptor 0.0025 0.0362 0.0262
Toxoplasma gondii heat shock protein hslv, putative 0.0094 0.2614 0.268
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0117 0.3377 0.3308
Giardia lamblia 20S proteasome alpha subunit 3 0.0122 0.3543 0.3686
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0121 0.3529 0.3657
Loa Loa (eye worm) PCI domain-containing protein 0.0029 0.0489 0.0434
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0123 0.359 0.3722
Loa Loa (eye worm) RPN-3 protein 0.0034 0.0665 0.0621
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0132 0.387 0.4021
Leishmania major proteasome beta 7 subunit, putative 0.0115 0.3329 0.3515
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0029 0.0486 0.0407
Giardia lamblia 20S proteasome alpha subunit 4 0.0165 0.4959 0.5194
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0019 0.0154 0.0054
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0119 0.0126
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0025 0.0362 0.0262
Brugia malayi G protein-coupled receptor 0.0025 0.0362 0.0262
Echinococcus granulosus proteasome subunit alpha type 2 0.0126 0.3687 0.3634
Entamoeba histolytica proteasome regulatory subunit, putative 0.0019 0.0152 0.0052
Echinococcus multilocularis g-protein coupled receptor 0.0025 0.0362 0.0282
Onchocerca volvulus 0.0025 0.0362 0.0743
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Echinococcus granulosus proteasome subunit beta type 6 0.0122 0.3556 0.3502
Entamoeba histolytica proteasome regulatory subunit, putative 0.0034 0.0665 0.06
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0018 0.0119 0.0017
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Echinococcus granulosus tachykinin peptides receptor 99D 0.0025 0.0362 0.0282
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0029 0.0486 0.0409
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0122 0.3543 0.3686
Brugia malayi 20S proteasome alpha5 subunit 0.0132 0.387 0.3807
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0029 0.0486 0.0387
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0412 0.0351
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0126 0.3687 0.3839
Loa Loa (eye worm) proteasome regulatory particle 0.0032 0.0586 0.0536
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0019 0.0154 0.0072
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0362 0.0262
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0034 0.0648 0.0581
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0117 0.3377 0.3322
Brugia malayi Proteasome/cyclosome repeat family protein 0.0028 0.0462 0.0363
Echinococcus multilocularis 26S protease regulatory subunit 8 0.0017 0.0103 0.0021
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0027 0.0412 0.033
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0362 0.0282
Onchocerca volvulus 0.0025 0.0362 0.0743
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0132 0.387 0.4086
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0362 0.0262
Brugia malayi proteasome subunit alpha type 6 0.0133 0.3898 0.3834
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0165 0.4959 0.5194
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0121 0.3529 0.3475
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0026 0.0407 0.0328
Plasmodium vivax proteasome subunit beta type-5, putative 0.0302 0.9472 1
Onchocerca volvulus 0.0025 0.0362 0.0743
Echinococcus multilocularis proteasome subunit alpha type 6 0.0133 0.3898 0.3847
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0121 0.3529 0.3671
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0026 0.0407 0.0325
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0141 0.4169 0.4108
Echinococcus multilocularis neuropeptide receptor A26 0.0025 0.0362 0.0282
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0027 0.0412 0.0351
Loa Loa (eye worm) hypothetical protein 0.0025 0.0368 0.0304
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0121 0.3529 0.3671
Plasmodium vivax proteasome subunit beta type-7, putative 0.0112 0.3219 0.3326
Echinococcus granulosus proteasome prosome macropain 0.0302 0.9472 0.9467
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0115 0.3329 0.3458
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0028 0.0462 0.0488
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0034 0.0665 0.0568
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0123 0.359 0.379
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0027 0.0412 0.0351
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0025 0.0362 0.0262
Onchocerca volvulus 0.0025 0.0362 0.0743
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0121 0.3529 0.3726
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0412 0.0435
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0362 0.0282
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0133 0.3898 0.4115
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0094 0.2614 0.5
Echinococcus granulosus adhesion regulating molecule 1 0.0083 0.2254 0.219
Giardia lamblia Proteasome subunit beta type 2 0.0117 0.3377 0.3509
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0132 0.387 0.4021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0122 0.3556 0.3699
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0034 0.0665 0.0587
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0123 0.359 0.379
Trypanosoma brucei proteasome beta 7 subunit 0.0115 0.3329 0.3458
Entamoeba histolytica proteasome regulatory subunit, putative 0.0032 0.0586 0.0515
Schistosoma mansoni opsin-like receptor 0.0025 0.0362 0.0262
Onchocerca volvulus 0.0025 0.0362 0.0743
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Brugia malayi neuropeptide F receptor 0.0025 0.0362 0.0262
Echinococcus multilocularis 26s protease regulatory subunit s10b 0.0017 0.0103 0.0021
Schistosoma mansoni amine GPCR 0.0025 0.0362 0.0262
Toxoplasma gondii PCI domain-containing protein 0.0026 0.0407 0.0325
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0112 0.3219 0.3399
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0133 0.3898 0.405
Brugia malayi RE15519p 0.0025 0.0362 0.0262
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0412 0.033
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus granulosus sex peptide receptor 0.0025 0.0362 0.0282
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0018 0.0119 0.0017
Schistosoma mansoni neuropeptide receptor 0.0025 0.0362 0.0262
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0025 0.0362 0.0262
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0029 0.0489 0.0412
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0083 0.2254 0.2174
Schistosoma mansoni hypothetical protein 0.0025 0.0362 0.0262
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0115 0.3329 0.3515
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0141 0.4169 0.412
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0025 0.0362 0.0262
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0029 0.0486 0.0513
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0154 0.0052
Loa Loa (eye worm) proteasome 26S subunit 0.0017 0.0103 0.0022
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0122 0.3543 0.349
Onchocerca volvulus 0.0025 0.0362 0.0743
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0412 0.0332
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Trichomonas vaginalis 26S proteasome subunit, putative 0.0026 0.0407 0.043
Schistosoma mansoni alpha-1 adrenergic receptor 0.0025 0.0362 0.0262
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0117 0.3377 0.3495
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0025 0.0362 0.0298
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0126 0.3687 0.3825
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0117 0.3377 0.3322
Loa Loa (eye worm) hypothetical protein 0.0083 0.2254 0.2313
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0122 0.3543 0.3476
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0038 0.0784 0.0727
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0025 0.0362 0.0743
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0016 0.0082 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Echinococcus granulosus Proteasome subunit alpha type 7 0.0165 0.4959 0.4917
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0027 0.0412 0.0435
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0188 0.5709 0.5664
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0029 0.0486 0.0513
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0034 0.0665 0.0587
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0025 0.0362 0.0282
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0082 0.0087
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0122 0.3556 0.3489
Onchocerca volvulus 0.0025 0.0362 0.0743
Brugia malayi PCI domain containing protein 0.0026 0.0407 0.0308
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0362 0.0282
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0032 0.0586 0.0515
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0019 0.0154 0.0054
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0115 0.3329 0.3515
Schistosoma mansoni neuropeptide receptor 0.0025 0.0362 0.0262
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0025 0.0368 0.0268
Loa Loa (eye worm) proteasome Regulatory Particle 0.0029 0.0486 0.043
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0141 0.4169 0.412
Loa Loa (eye worm) proteasome subunit beta type 2 0.0117 0.3377 0.3509
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0412 0.033
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0018 0.0136 0.0144
Onchocerca volvulus Neuropeptide F receptor homolog 0.0025 0.0362 0.0743
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Loa Loa (eye worm) melatonin receptor type 1A 0.0025 0.0362 0.0298
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0018 0.0119 0.0017
Brugia malayi Proteasome A-type and B-type family protein 0.0122 0.3556 0.3489
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0362 0.0282
Toxoplasma gondii SAC3/GANP family protein 0.0025 0.0368 0.0283
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0018 0.0119 0.0017
Toxoplasma gondii proteasome beta subunit 0.0117 0.3377 0.3495
Brugia malayi neuropeptide F receptor 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Giardia lamblia 26S protease regulatory subunit 7 0.0017 0.0103 0.0022
Echinococcus multilocularis G protein coupled receptor 139 0.0025 0.0362 0.0282
Echinococcus granulosus 7TM GPCR rhodopsin 0.0025 0.0362 0.0282
Trypanosoma brucei Regulatory particle triple-A ATPase subunit 6 0.0017 0.0103 0.0022
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0119 0.0126
Echinococcus multilocularis neuropeptide FF receptor 2 0.0025 0.0362 0.0282
Giardia lamblia 26S protease regulatory subunit 8 0.0017 0.0103 0.0022
Loa Loa (eye worm) PCI domain-containing protein 0.0026 0.0407 0.0346
Echinococcus granulosus g-protein coupled receptor 0.0025 0.0362 0.0282
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0026 0.0407 0.043
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0038 0.0784 0.0708
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0112 0.3219 0.3326
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0029 0.0486 0.043
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0121 0.3529 0.3657
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0154 0.0052
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0018 0.0119 0.0037
Entamoeba histolytica proteasome regulatory subunit, putative 0.0029 0.0489 0.0412
Schistosoma mansoni amine GPCR 0.0025 0.0362 0.0262
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0165 0.4959 0.5183
Echinococcus granulosus neuropeptide receptor A26 0.0025 0.0362 0.0282
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0019 0.0154 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0025 0.0362 0.0282
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0034 0.0648 0.0602
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0025 0.0362 0.0262
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0094 0.2614 0.2697
Echinococcus granulosus 26s protease regulatory subunit s10b 0.0017 0.0103 0.0021
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0362 0.0282
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0362 0.0282
Schistosoma mansoni 26S protease regulatory subunit 0.0018 0.0119 0.0016
Brugia malayi 26S proteasome subunit P45 family protein 0.0018 0.0119 0.0016
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0019 0.0154 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0029 0.0489 0.0412
Leishmania major proteasome beta 2 subunit, putative 0.0112 0.3219 0.3399
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0038 0.0784 0.0727
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0019 0.0154 0.0054
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0319 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0362 0.0282
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0034 0.0665 0.0702
Schistosoma mansoni proteasome regulatory subunit-related 0.0029 0.0489 0.039
Leishmania major proteasome alpha 7 subunit, putative 0.0165 0.4959 0.5236
Onchocerca volvulus 0.0025 0.0362 0.0743
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0126 0.3687 0.3825
Brugia malayi G-protein coupled receptor 0.0025 0.0362 0.0262
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0029 0.0486 0.0407
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0362 0.0262
Echinococcus granulosus neuropeptide receptor 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0028 0.0462 0.0405
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0362 0.0282
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0038 0.0784 0.0828
Trypanosoma brucei proteasome alpha 7 subunit 0.0123 0.359 0.3736
Leishmania major proteasome beta 3 subunit, putative 0.0117 0.3377 0.3566
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Leishmania major 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative 0.0017 0.0103 0.0109
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0115 0.3329 0.3274
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0165 0.4959 0.5236
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0018 0.0119 0.0037
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0032 0.0586 0.0515
Echinococcus multilocularis orexin receptor type 2 0.0025 0.0362 0.0282
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0122 0.3556 0.3699
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0025 0.0368 0.0268
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0025 0.0362 0.0282
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0026 0.0407 0.0346
Echinococcus granulosus hypothetical protein 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0132 0.387 0.4034
Brugia malayi proteasome subunit beta type 1 0.0141 0.4169 0.4108
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0019 0.0154 0.0163
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0141 0.4169 0.434
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0126 0.3687 0.3825
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0126 0.3687 0.3892
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0119 0.0017
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0117 0.3377 0.3308
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0119 0.0126
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0123 0.359 0.3722
Schistosoma mansoni myosin xvIII 0.0025 0.0362 0.0262
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0025 0.0368 0.0388
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0132 0.387 0.4021
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0302 0.9472 1
Schistosoma mansoni neuropeptide receptor 0.0025 0.0362 0.0262
Schistosoma mansoni hypothetical protein 0.0188 0.5709 0.5664
Giardia lamblia 20S proteasome alpha subunit 1 0.0133 0.3898 0.4064
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0025 0.0362 0.0282
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0029 0.0489 0.0434
Echinococcus granulosus neuropeptide receptor 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0039
Brugia malayi proteasome subunit beta type 3 0.0117 0.3377 0.3308
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0412 0.0312
Schistosoma mansoni opsin-like receptor 0.0025 0.0362 0.0262
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0032 0.0586 0.0536
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0302 0.9472 1
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0412 0.0435
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0123 0.359 0.379
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0112 0.3219 0.3399
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0018 0.0136 0.0035
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0122 0.3556 0.3754
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Plasmodium vivax proteasome subunit beta type-2, putative 0.0117 0.3377 0.3495
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0029 0.0489 0.0517
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Brugia malayi AKH receptor 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0118 0.3403 0.3334
Schistosoma mansoni hypothetical protein 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0022
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0117 0.3377 0.3566
Giardia lamblia 26S protease regulatory subunit 6B 0.0018 0.0119 0.004
Echinococcus multilocularis neuropeptide s receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0025 0.0368 0.0288
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0121 0.3529 0.3657
Schistosoma mansoni biogenic amine receptor 0.0025 0.0362 0.0262
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0038 0.0784 0.0688
Onchocerca volvulus 0.0018 0.0119 0.0047
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0034 0.0665 0.0568
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0034 0.0665 0.0621
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0027 0.0412 0.0312
Echinococcus granulosus neuropeptide s receptor 0.0025 0.0362 0.0282
Schistosoma mansoni hypothetical protein 0.0077 0.2054 0.1971
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0141 0.4169 0.434
Leishmania major proteasome regulatory ATPase subunit 0.0017 0.0103 0.0109
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0018 0.0119 0.0126
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0112 0.3219 0.3399
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0141 0.4169 0.434
Toxoplasma gondii proteasome subunit 0.0122 0.3556 0.3685
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0025 0.0368 0.0304
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Inhibition of trypsin-like activity of human constitutive 20s proteasome beta-2 subunit using Boc-LRR-AMC as substrate assessed as remaining activity incubated for 15 mins prior to substrate addition measured after 45 mins by fluorescence assay ChEMBL. 23540790
IC50 (binding) Inhibition of postacid activity of human constitutive 20s proteasome beta-1 subunit using Z-LLE-betaNA as substrate assessed as remaining activity incubated for 15 mins prior to substrate addition measured after 45 mins by fluorescence assay ChEMBL. 23540790
IC50 (binding) Inhibition of chymotrypsin-like activity of human constitutive 20s proteasome beta-5 subunit using Suc-LLVY-AMC as substrate assessed as remaining activity incubated for 15 mins prior to substrate addition measured after 45 mins by fluorescence assay ChEMBL. 23540790
Inhibition (binding) Inhibition of human calpain 1 using Suc-LLVY-AMC as substrate assessed as remaining enzyme activity at 20 uM incubated for 5 mins prior to substrate addition measured for 30 mins by fluorescence assay ChEMBL. 23540790
Inhibition (binding) Inhibition of human cathepsin B using Suc-LLVY-AMC as substrate assessed as remaining enzyme activity at 20 uM incubated for 15 mins prior to substrate addition measured for 30 mins by fluorescence assay ChEMBL. 23540790

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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