Detailed information for compound 1730878

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 811.104 | Formula: C42H78N6O9
  • H donors: 6 H acceptors: 7 LogP: 3.42 Rotable bonds: 45
    Rule of 5 violations (Lipinski): 3
  • SMILES: COC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)OC(C)(C)C
  • InChi: 1S/C42H78N6O9/c1-42(2,3)57-41(55)48-34-22-9-15-27-39(53)46-32-20-7-13-25-37(51)44-30-18-5-11-23-35(49)43-29-17-6-12-24-36(50)45-31-19-8-14-26-38(52)47-33-21-10-16-28-40(54)56-4/h5-34H2,1-4H3,(H,43,49)(H,44,51)(H,45,50)(H,46,53)(H,47,52)(H,48,55)
  • InChiKey: AZKFIYMTJCGUHM-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0132 0.387 0.3807
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0368 0.0388
Brugia malayi larval opioid receptor 0.0025 0.0362 0.0262
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0362 0.0298
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0034 0.0665 0.0587
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0025 0.0362 0.0262
Toxoplasma gondii proteasome subunit alpha1, putative 0.0133 0.3898 0.405
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0152 0.0071
Schistosoma mansoni opsin-like receptor 0.0025 0.0362 0.0262
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0302 0.9472 1
Onchocerca volvulus 0.0025 0.0362 0.0743
Brugia malayi PCI domain containing protein 0.0026 0.0407 0.0308
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0025 0.0368 0.0288
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0038 0.0784 0.0727
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0117 0.3377 0.3322
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0119 0.0126
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0119 0.0126
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0025 0.0362 0.0262
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0302 0.9472 1
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0038 0.0784 0.0688
Echinococcus granulosus neuropeptide receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0362 0.0282
Schistosoma mansoni hypothetical protein 0.0025 0.0362 0.0262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Echinococcus multilocularis sex peptide receptor 0.0025 0.0362 0.0282
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0115 0.3329 0.3274
Loa Loa (eye worm) hypothetical protein 0.0023 0.0304 0.0236
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0034 0.0648 0.055
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0412 0.033
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Schistosoma mansoni hypothetical protein 0.0026 0.0407 0.0308
Brugia malayi Serotonin receptor 0.0025 0.0362 0.0262
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0117 0.3377 0.3566
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0094 0.2614 0.268
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0112 0.3219 0.3326
Giardia lamblia Proteasome subunit beta type 3 0.0117 0.3377 0.3509
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.004
Onchocerca volvulus 0.0025 0.0362 0.0743
Echinococcus multilocularis somatostatin receptor 0.0025 0.0362 0.0282
Echinococcus granulosus proteasome subunit beta t family 0.0117 0.3377 0.3322
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0029 0.0489 0.0412
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0029 0.0486 0.0407
Brugia malayi proteasome subunit alpha type 4 0.0108 0.3076 0.3004
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0122 0.3556 0.3489
Toxoplasma gondii proteasome regulatory subunit 0.0027 0.0412 0.033
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Echinococcus multilocularis g-protein coupled receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Loa Loa (eye worm) RPT-2 protein 0.0018 0.0119 0.004
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Leishmania major proteasome beta 3 subunit, putative 0.0117 0.3377 0.3566
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0362 0.0282
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0133 0.3898 0.3834
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0165 0.4959 0.5194
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0038 0.0784 0.0688
Loa Loa (eye worm) PCI domain-containing protein 0.0029 0.0489 0.0434
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0165 0.4959 0.5183
Echinococcus multilocularis proteasome subunit alpha type 2 0.0126 0.3687 0.3634
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0122 0.3543 0.349
Schistosoma mansoni adenoreceptor 0.0025 0.0362 0.0262
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0132 0.387 0.4086
Entamoeba histolytica proteasome regulatory subunit, putative 0.0032 0.0586 0.0515
Echinococcus multilocularis allatostatin A receptor 0.0025 0.0362 0.0282
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0362 0.0282
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0032 0.0586 0.0619
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0083 0.2254 0.2296
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0029 0.0486 0.043
Loa Loa (eye worm) PAS-3 protein 0.0108 0.3076 0.3188
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0112 0.3219 0.3399
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0026 0.0407 0.043
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0133 0.3898 0.4064
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0123 0.359 0.3722
Echinococcus granulosus adhesion regulating molecule 1 0.0083 0.2254 0.219
Loa Loa (eye worm) hypothetical protein 0.0083 0.2254 0.2313
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0025 0.0368 0.0288
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0133 0.3898 0.405
Brugia malayi 20S proteasome alpha5 subunit 0.0132 0.387 0.3807
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0034 0.0665 0.0568
Leishmania major proteasome alpha 7 subunit, putative 0.0165 0.4959 0.5236
Echinococcus multilocularis G protein coupled receptor 139 0.0025 0.0362 0.0282
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0302 0.9472 1
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0362 0.0282
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0029 0.0486 0.0409
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0141 0.4169 0.4108
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0025 0.0362 0.0282
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0368 0.0304
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0034 0.0665 0.0587
Echinococcus multilocularis 26s protease regulatory subunit s10b 0.0017 0.0103 0.0021
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0025 0.0362 0.0282
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0412 0.033
Schistosoma mansoni biogenic amine receptor 0.0025 0.0362 0.0262
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0165 0.4959 0.5236
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0017 0.0103 0.0022
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0122 0.3543 0.3672
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0018 0.0119 0.0126
Brugia malayi Proteasome A-type and B-type family protein 0.0122 0.3556 0.3489
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0094 0.2614 0.276
Giardia lamblia 20S proteasome alpha subunit 4 0.0165 0.4959 0.5194
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0119 0.0126
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0032 0.0586 0.0619
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0032 0.0586 0.0508
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0025 0.0362 0.0298
Brugia malayi Proteasome A-type and B-type family protein 0.0115 0.3329 0.326
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0034 0.0665 0.0568
Echinococcus granulosus dro:myosuppressin receptor 0.0025 0.0362 0.0282
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0034 0.0665 0.0702
Leishmania major proteasome beta 2 subunit, putative 0.0112 0.3219 0.3399
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0154 0.0052
Loa Loa (eye worm) RPN-3 protein 0.0034 0.0665 0.0621
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0019 0.0154 0.0072
Plasmodium vivax proteasome subunit beta type-5, putative 0.0302 0.9472 1
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0029 0.0489 0.0411
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0019 0.0154 0.0077
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0026 0.0407 0.0328
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0027 0.0412 0.033
Brugia malayi Ubiquitin interaction motif family protein 0.0019 0.0152 0.005
Echinococcus multilocularis dro:myosuppressin receptor 0.0025 0.0362 0.0282
Giardia lamblia 20S proteasome alpha subunit 6 0.0121 0.3529 0.3671
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0034 0.0648 0.0581
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0154 0.0052
Echinococcus multilocularis adhesion regulating molecule 1 0.0083 0.2254 0.219
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0368 0.0388
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0025 0.0362 0.0262
Echinococcus granulosus sex peptide receptor 0.0025 0.0362 0.0282
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0026 0.0407 0.0346
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0165 0.4959 0.4907
Entamoeba histolytica proteasome regulatory subunit, putative 0.0034 0.0665 0.06
Onchocerca volvulus 0.0025 0.0362 0.0743
Leishmania major proteasome alpha 1 subunit, putative 0.0133 0.3898 0.4115
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0122 0.3556 0.3754
Echinococcus granulosus neuropeptide receptor A26 0.0025 0.0362 0.0282
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0122 0.3543 0.3741
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0025 0.0368 0.0283
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0123 0.359 0.379
Brugia malayi Proteasome A-type and B-type family protein 0.0302 0.9472 0.9466
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0362 0.0262
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0029 0.0489 0.0517
Entamoeba histolytica proteasome regulatory subunit, putative 0.0019 0.0152 0.0052
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0108 0.3082 0.3253
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0117 0.3377 0.3566
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0026 0.0407 0.0325
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0412 0.0435
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0126 0.3687 0.3825
Toxoplasma gondii PCI domain-containing protein 0.0032 0.0586 0.0515
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0034 0.0665 0.0568
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0412 0.0312
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0115 0.3329 0.3515
Schistosoma mansoni biogenic amine receptor 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0122 0.3556 0.3685
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0019 0.0152 0.005
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0141 0.4169 0.4401
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0083 0.2254 0.2174
Echinococcus granulosus 7TM GPCR rhodopsin 0.0025 0.0362 0.0282
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0094 0.2614 0.276
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0362 0.0282
Giardia lamblia 20S proteasome alpha subunit 7 0.0123 0.359 0.3736
Brugia malayi AKH receptor 0.0025 0.0362 0.0262
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0018 0.0119 0.0037
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0165 0.4959 0.4917
Giardia lamblia 20S proteasome alpha subunit 5 0.0132 0.387 0.4034
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0028 0.0462 0.0405
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0034 0.0648 0.0602
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0115 0.3329 0.3443
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Onchocerca volvulus Neuropeptide F receptor homolog 0.0025 0.0362 0.0743
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0019 0.0154 0.0163
Onchocerca volvulus 0.0025 0.0362 0.0743
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0122 0.3543 0.3741
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Brugia malayi Proteasome subunit alpha type 7-1 0.0165 0.4959 0.4907
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0122 0.3543 0.3672
Echinococcus granulosus g protein coupled receptor 0.0025 0.0362 0.0282
Onchocerca volvulus 0.0018 0.0119 0.0047
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0019 0.0154 0.0054
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0032 0.0586 0.0619
Onchocerca volvulus 0.0025 0.0362 0.0743
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0038 0.0784 0.0828
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0094 0.2614 0.276
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0121 0.3529 0.3475
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0038 0.0784 0.0727
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0038 0.0784 0.0688
Echinococcus multilocularis serotonin receptor 0.0025 0.0362 0.0282
Brugia malayi proteasome subunit alpha type 1 0.0121 0.3529 0.3462
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0165 0.4959 0.5236
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0028 0.0462 0.0488
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0132 0.387 0.4086
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0154 0.0163
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0019 0.0152 0.0161
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0362 0.0282
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0302 0.9472 1
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0122 0.3556 0.3685
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus granulosus orexin receptor type 2 0.0025 0.0362 0.0282
Echinococcus granulosus Proteasome subunit alpha type 7 0.0165 0.4959 0.4917
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0094 0.2614 0.268
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0025 0.0362 0.0282
Echinococcus granulosus neuropeptide receptor 0.0025 0.0362 0.0282
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0027 0.0412 0.0435
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0025 0.0362 0.0743
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Schistosoma mansoni amine GPCR 0.0025 0.0362 0.0262
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0121 0.3529 0.3726
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0025 0.0362 0.0262
Mycobacterium ulcerans proteasome PrcB 0.0302 0.9472 1
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0017 0.0103 0.0109
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0121 0.3529 0.3657
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0029 0.0489 0.0434
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0362 0.0298
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0016 0.0082 0.0087
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0141 0.4169 0.4401
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0117 0.3377 0.3308
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0121 0.3529 0.3657
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0117 0.3377 0.3495
Echinococcus granulosus proteasome subunit beta type 7 0.0319 1 1
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0122 0.3543 0.3686
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0119 0.0017
Leishmania major proteasome beta 7 subunit, putative 0.0115 0.3329 0.3515
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0123 0.359 0.3537
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0117 0.3377 0.3495
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0025 0.0368 0.0388
Echinococcus granulosus allatostatin A receptor 0.0025 0.0362 0.0282
Toxoplasma gondii proteasome 26S regulatory subunit 0.0018 0.0136 0.0035
Onchocerca volvulus 0.0025 0.0362 0.0743
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0025 0.0362 0.0298
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0165 0.4959 0.5183
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0123 0.359 0.3722
Plasmodium vivax proteasome subunit beta type-4, putative 0.0115 0.3329 0.3443
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0032 0.0586 0.0515
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0132 0.387 0.4021
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0362 0.0262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0126 0.3687 0.3892
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Entamoeba histolytica proteasome regulatory subunit, putative 0.0026 0.0407 0.0325
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0115 0.3329 0.3443
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0123 0.359 0.3523
Leishmania major 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative 0.0017 0.0103 0.0109
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0117 0.3377 0.3566
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0019 0.0154 0.0054
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0019 0.0154 0.0163
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0082 0.0087
Loa Loa (eye worm) proteasome 26S subunit 0.0017 0.0103 0.0022
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0122 0.3556 0.3754
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0122 0.3543 0.3476
Brugia malayi 26S protease regulatory subunit 6A 0.0019 0.0154 0.0052
Schistosoma mansoni 26S protease regulatory subunit 0.0018 0.0119 0.0016
Schistosoma mansoni neuropeptide receptor 0.0025 0.0362 0.0262
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0362 0.0262
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0025 0.0362 0.0282
Schistosoma mansoni hypothetical protein 0.0188 0.5709 0.5664
Echinococcus multilocularis G-protein coupled receptor, putative 0.0025 0.0362 0.0282
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0123 0.359 0.379
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0133 0.3898 0.405
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Onchocerca volvulus 0.0025 0.0362 0.0743
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0122 0.3556 0.3699
Onchocerca volvulus 0.0018 0.0119 0.0047
Brugia malayi proteasome subunit alpha type 2 0.0126 0.3687 0.3621
Leishmania major proteasome beta 2 subunit, putative 0.0117 0.3377 0.3566
Entamoeba histolytica hypothetical protein 0.0034 0.0648 0.0581
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0027 0.0412 0.0351
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0115 0.3329 0.3458
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0362 0.0282
Leishmania major proteasome alpha 7 subunit, putative 0.0123 0.359 0.379
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0122 0.3543 0.3741
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0122 0.3543 0.349
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0115 0.3329 0.3515
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0412 0.0332
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0132 0.387 0.4034
Trypanosoma cruzi 20S proteasome subunit 0.0117 0.3377 0.3566
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0123 0.359 0.3722
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0018 0.0119 0.0016
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0038 0.0784 0.0688
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0165 0.4959 0.5236
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0302 0.9472 1
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0362 0.0298
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0034 0.0665 0.0621
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0029 0.0486 0.0387
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0302 0.9472 1
Giardia lamblia 20S proteasome alpha subunit 1 0.0133 0.3898 0.4064
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0025 0.0362 0.0298
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0121 0.3529 0.3726
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0018 0.0119 0.0017
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0082 0.0087
Onchocerca volvulus 0.0025 0.0362 0.0743
Echinococcus granulosus neuropeptide s receptor 0.0025 0.0362 0.0282
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0368 0.0388
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0362 0.0282
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0122 0.3556 0.3699
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0165 0.4959 0.5183
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0034 0.0648 0.0581
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0025 0.0362 0.0282
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0117 0.3377 0.3322
Schistosoma mansoni myosin xvIII 0.0025 0.0362 0.0262
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0018 0.0119 0.0037
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0112 0.3219 0.3326
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0026 0.0407 0.043
Toxoplasma gondii SAC3/GANP family protein 0.0025 0.0368 0.0283
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0154 0.0163
Schistosoma mansoni alpha-1 adrenergic receptor 0.0025 0.0362 0.0262
Brugia malayi proteasome subunit alpha type 6 0.0133 0.3898 0.3834
Trypanosoma brucei proteasome beta 7 subunit 0.0115 0.3329 0.3458
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0119 0.0126
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Brugia malayi Serotonin receptor 0.0025 0.0362 0.0262
Echinococcus granulosus 7tm_1 domain containing protein 0.0025 0.0362 0.0282
Entamoeba histolytica proteasome regulatory subunit, putative 0.0025 0.0368 0.0283
Plasmodium falciparum proteasome subunit beta type-5 0.0302 0.9472 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0362 0.0282
Echinococcus granulosus neuropeptide FF receptor 2 0.0025 0.0362 0.0282
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0077 0.2054 0.1988
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0141 0.4169 0.434
Trypanosoma brucei proteasome beta 6 subunit 0.0141 0.4169 0.4352
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0018 0.0136 0.0144
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0029 0.0486 0.0513
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0132 0.387 0.4021
Trypanosoma cruzi 19S proteasome regulatory subunit 0.0017 0.0103 0.0109
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0029 0.0486 0.0513
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0022
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0412 0.033
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0082 0.0087
Echinococcus granulosus proteasome prosome macropain 0.0302 0.9472 0.9467
Brugia malayi neuropeptide F receptor 0.0025 0.0362 0.0262
Giardia lamblia 26S proteasome regulatory subunit, putative 0.002 0.0189 0.0114
Schistosoma mansoni amine GPCR 0.0025 0.0362 0.0262
Echinococcus granulosus 26s protease regulatory subunit s10b 0.0017 0.0103 0.0021
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0362 0.0262
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0018 0.0119 0.004
Echinococcus granulosus subfamily T1A non peptidase ue 0.0132 0.387 0.382
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0018 0.0119 0.0017
Brugia malayi Melatonin receptor type 1A 0.0025 0.0362 0.0262
Leishmania major proteasome alpha 3 subunit, putative 0.0122 0.3543 0.3741
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0018 0.0119 0.0017
Loa Loa (eye worm) proteasome subunit beta type 2 0.0117 0.3377 0.3509
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0117 0.3377 0.3495
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0027 0.0412 0.0332
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0362 0.0282
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0118 0.3403 0.3334
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0165 0.4959 0.5183
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0018 0.0119 0.0126
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0025 0.0362 0.0262
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0018 0.0119 0.0017
Giardia lamblia 20S proteasome alpha subunit 2 0.0126 0.3687 0.3839
Onchocerca volvulus 0.0025 0.0362 0.0743
Leishmania major proteasome beta-1 subunit, putative 0.0122 0.3556 0.3754
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0025 0.0368 0.0304
Onchocerca volvulus 0.0025 0.0362 0.0743
Echinococcus multilocularis proteasome subunit beta type 7 0.0319 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0094 0.2614 0.2697
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0302 0.9472 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0025 0.0362 0.0262
Trypanosoma brucei Regulatory particle triple-A ATPase subunit 6 0.0017 0.0103 0.0022
Toxoplasma gondii proteasome subunit 0.0122 0.3556 0.3685
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0034 0.0648 0.0581
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0019 0.0154 0.0072
Onchocerca volvulus Notchless protein homolog 0.0123 0.359 1
Brugia malayi Proteasome subunit alpha type 1 0.0107 0.3062 0.2989
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0165 0.4959 0.5194
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0362 0.0262
Trypanosoma brucei protease regulatory ATPase subunit 4 0.0017 0.0103 0.0022
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0121 0.3529 0.3657
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0362 0.0282
Loa Loa (eye worm) proteasome subunit beta type 1 0.0141 0.4169 0.4352
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0165 0.4959 0.4917
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0132 0.387 0.382
Leishmania major proteasome regulatory ATPase subunit 0.0017 0.0103 0.0109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0122 0.3543 0.3672
Echinococcus granulosus proteasome subunit alpha type 2 0.0126 0.3687 0.3634
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0152 0.0161
Plasmodium vivax proteasome subunit beta type-1, putative 0.0141 0.4169 0.434
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0412 0.0435
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0123 0.359 0.379
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0025 0.0368 0.0283
Giardia lamblia 26S protease regulatory subunit 8 0.0017 0.0103 0.0022
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0094 0.2614 0.268
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0121 0.3529 0.3462
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0038 0.0784 0.0828
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0034 0.0648 0.057
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0029 0.0486 0.043
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0123 0.359 0.3736
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0132 0.387 0.4086
Schistosoma mansoni multiubiquitin binding protein S5a 0.0019 0.0152 0.005
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0083 0.2254 0.2174
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0029 0.0486 0.0409
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0026 0.0383 0.0404
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0123 0.359 0.3722
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0141 0.4169 0.412
Brugia malayi proteasome subunit alpha type 3 0.0123 0.359 0.3523
Toxoplasma gondii proteasome subunit alpha type, putative 0.0122 0.3543 0.3672
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0029 0.0489 0.0517
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0132 0.387 0.4021
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0115 0.3329 0.3458
Schistosoma mansoni biogenic amine receptor 0.0025 0.0362 0.0262
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0025 0.0362 0.0262
Echinococcus granulosus 26S protease regulatory subunit 8 0.0017 0.0103 0.0021
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0117 0.3377 0.3322
Loa Loa (eye worm) hypothetical protein 0.0188 0.5709 0.5992
Toxoplasma gondii proteasome beta subunit 0.0117 0.3377 0.3495
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0027 0.0412 0.0312
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0025 0.0362 0.0282
Brugia malayi Proteasome/cyclosome repeat family protein 0.0028 0.0462 0.0363
Echinococcus granulosus alpha 1A adrenergic receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0362 0.0282
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0133 0.3898 0.4115
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0133 0.3898 0.405
Brugia malayi G protein-coupled receptor F59B2.13 0.0025 0.0362 0.0262
Loa Loa (eye worm) proteasome subunit beta type 3 0.0117 0.3377 0.3509
Echinococcus multilocularis proteasome subunit alpha type 6 0.0133 0.3898 0.3847
Schistosoma mansoni amine GPCR 0.0025 0.0362 0.0262
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0412 0.0435
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0362 0.0262
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0362 0.0282
Giardia lamblia Proteasome subunit beta type 2 0.0117 0.3377 0.3509
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0302 0.9472 1
Echinococcus multilocularis proteasome (prosome, macropain) 0.0302 0.9472 0.9467
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0029 0.0486 0.0407
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0018 0.0119 0.0126
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0018 0.0119 0.004
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0026 0.0407 0.0328
Toxoplasma gondii peptidase, T1 family protein 0.0123 0.359 0.3722
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0412 0.0351
Brugia malayi follicle stimulating hormone receptor 0.0025 0.0362 0.0262
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0117 0.3377 0.3509
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0368 0.0304
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0362 0.0282
Onchocerca volvulus 0.0025 0.0362 0.0743
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0025 0.0362 0.0298
Trypanosoma cruzi 26S protease regulatory subunit, putative 0.0017 0.0103 0.0109
Echinococcus granulosus tachykinin peptides receptor 99D 0.0025 0.0362 0.0282
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0019 0.0154 0.0054
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0119 0.0126
Plasmodium vivax proteasome subunit beta type-6, putative 0.0122 0.3556 0.3685
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0121 0.3529 0.3475
Echinococcus granulosus G protein coupled receptor 139 0.0025 0.0362 0.0282
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0141 0.4169 0.434
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Onchocerca volvulus 0.0025 0.0362 0.0743
Toxoplasma gondii PCI domain-containing protein 0.0034 0.0665 0.06
Brugia malayi proteasome subunit beta type 2 0.0117 0.3377 0.3308
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0132 0.387 0.4021
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0362 0.0282
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0126 0.3687 0.3839
Entamoeba histolytica proteasome regulatory subunit, putative 0.0029 0.0489 0.0412
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0117 0.3377 0.3495
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0132 0.387 0.3807
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0119 0.0017
Echinococcus multilocularis neuropeptide receptor A26 0.0025 0.0362 0.0282
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0132 0.387 0.4021
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0362 0.0282
Brugia malayi G-protein coupled receptor 0.0025 0.0362 0.0262
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0029 0.0489 0.0412
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0133 0.3898 0.4115
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0032 0.0586 0.0515
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Loa Loa (eye worm) PCI domain-containing protein 0.0026 0.0407 0.0346
Brugia malayi sulfakinin receptor protein 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Giardia lamblia 26S protease regulatory subunit 6A 0.0019 0.0154 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0025 0.0362 0.0298
Echinococcus granulosus fmrfamide receptor 0.0025 0.0362 0.0282
Giardia lamblia 26S protease regulatory subunit 7 0.0017 0.0103 0.0022
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0094 0.2614 0.2537
Schistosoma mansoni neuropeptide receptor 0.0025 0.0362 0.0262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Schistosoma mansoni 26S proteasome subunit S9 0.0032 0.0586 0.0488
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0126 0.3687 0.3825
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0115 0.3329 0.3274
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0362 0.0298
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0019 0.0154 0.0077
Echinococcus granulosus hypothetical protein 0.0025 0.0362 0.0282
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Schistosoma mansoni growth hormone secretagogue receptor 0.0025 0.0362 0.0262
Toxoplasma gondii PCI domain-containing protein 0.0026 0.0407 0.0325
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0017 0.0103 0.0109
Brugia malayi PCI domain containing protein 0.0029 0.0489 0.039
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0362 0.0282
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0362 0.0282
Brugia malayi Dopamine receptor protein 2 0.0025 0.0362 0.0262
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0117 0.3377 0.3308
Brugia malayi RE15519p 0.0025 0.0362 0.0262
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0121 0.3529 0.3671
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0025 0.0362 0.0262
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0112 0.3219 0.3341
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0029 0.0489 0.0412
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0362 0.0282
Giardia lamblia Hypothetical protein 0.0032 0.0586 0.0536
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0077 0.2054 0.1988
Schistosoma mansoni neuropeptide receptor 0.0025 0.0362 0.0262
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Echinococcus multilocularis orexin receptor type 2 0.0025 0.0362 0.0282
Onchocerca volvulus 0.0025 0.0362 0.0743
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0412 0.0332
Toxoplasma gondii hypothetical protein 0.0023 0.0304 0.0215
Brugia malayi GnHR receptor homolog 0.0025 0.0362 0.0262
Brugia malayi Dopamine receptor protein 1 0.0025 0.0362 0.0262
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0026 0.0407 0.0325
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0141 0.4169 0.4401
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0032 0.0586 0.0488
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0112 0.3219 0.3399
Echinococcus granulosus Proteasome subunit alpha beta 0.0123 0.359 0.3537
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Brugia malayi G protein-coupled receptor 0.0025 0.0362 0.0262
Brugia malayi 26S proteasome subunit P45 family protein 0.0018 0.0119 0.0016
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0119 0.0126
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0122 0.3543 0.3672
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0029 0.0486 0.0409
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0038 0.0784 0.0747
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0117 0.3377 0.3566
Echinococcus granulosus g protein coupled receptor 0.0025 0.0362 0.0282
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Leishmania major proteasome alpha 1 subunit, putative 0.0121 0.3529 0.3726
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0115 0.3329 0.326
Brugia malayi Proteasome/cyclosome repeat family protein 0.0028 0.0462 0.0363
Echinococcus multilocularis neuropeptide s receptor 0.0025 0.0362 0.0282
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0133 0.3898 0.4115
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0025 0.0362 0.0262
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0018 0.0119 0.0017
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0027 0.0412 0.0312
Schistosoma mansoni amine GPCR 0.0025 0.0362 0.0262
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0018 0.0119 0.004
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0034 0.0648 0.057
Giardia lamblia Proteasome subunit beta type 1 0.0141 0.4169 0.4352
Echinococcus granulosus somatostatin receptor 0.0025 0.0362 0.0282
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0117 0.3377 0.3566
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0025 0.0362 0.0282
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Brugia malayi Probable 26S protease regulatory subunit 4 0.0018 0.0119 0.0016
Loa Loa (eye worm) proteasome Regulatory Particle 0.0029 0.0486 0.043
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Leishmania major proteasome alpha 2 subunit, putative 0.0126 0.3687 0.3892
Giardia lamblia 26S protease regulatory subunit 6B 0.0018 0.0119 0.004
Giardia lamblia 20S proteasome alpha subunit 3 0.0122 0.3543 0.3686
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0043 0.0954 0.0909
Echinococcus multilocularis serotonin receptor 0.0025 0.0362 0.0282
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0038 0.0784 0.0828
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0027 0.0412 0.0332
Trypanosoma brucei proteasome alpha 7 subunit 0.0123 0.359 0.3736
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0126 0.3687 0.3825
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0029 0.0489 0.0411
Echinococcus multilocularis neuropeptide FF receptor 2 0.0025 0.0362 0.0282
Leishmania major proteasome beta 5 subunit, putative 0.0302 0.9472 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0038 0.0784 0.0708
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0025 0.0362 0.0262
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0019 0.0153 0.0162
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0141 0.4169 0.434
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0027 0.0412 0.0312
Echinococcus multilocularis proteasome subunit beta type 6 0.0122 0.3556 0.3502
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0026 0.0407 0.043
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0141 0.4169 0.4401
Plasmodium vivax proteasome subunit beta type-7, putative 0.0112 0.3219 0.3326
Schistosoma mansoni proteasome regulatory subunit-related 0.0029 0.0489 0.039
Echinococcus granulosus proteasome subunit alpha type 6 0.0133 0.3898 0.3847
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0018 0.0119 0.0037
Toxoplasma gondii proteasome subunit beta type, putative 0.0302 0.9472 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0038 0.0784 0.0708
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.002 0.0189 0.0199
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0152 0.0071
Entamoeba histolytica proteasome regulatory subunit, putative 0.0029 0.0486 0.0409
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Loa Loa (eye worm) proteasome regulatory particle 0.0032 0.0586 0.0536
Brugia malayi neuropeptide F receptor 0.0025 0.0362 0.0262
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0319 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0112 0.3219 0.3341
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0025 0.0368 0.0388
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative 0.0016 0.0082 0.0087
Brugia malayi Tachykinin-like peptides receptor 99D 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus granulosus serotonin receptor 0.0025 0.0362 0.0282
Toxoplasma gondii heat shock protein hslv, putative 0.0094 0.2614 0.268
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0025 0.0362 0.0282
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0121 0.3529 0.3671
Brugia malayi Dopamine receptor 0.0025 0.0362 0.0262
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0165 0.4959 0.4917
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0126 0.3687 0.3621
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0412 0.0435
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0302 0.9472 0.9466
Schistosoma mansoni hypothetical protein 0.0025 0.0362 0.0262
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0132 0.387 0.4086
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0025 0.0368 0.0268
Onchocerca volvulus 0.0025 0.0362 0.0743
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0112 0.3219 0.3341
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0362 0.0262
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Schistosoma mansoni hypothetical protein 0.0077 0.2054 0.1971
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0027 0.0412 0.033
Schistosoma mansoni hypothetical protein 0.0025 0.0362 0.0262
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0126 0.3687 0.3825
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0117 0.3377 0.3308
Trypanosoma cruzi serine peptidase, Clan SJ, family S16, putative 0.0017 0.0103 0.0109
Brugia malayi putative neuropeptide receptor NPR1 0.0025 0.0362 0.0262
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0188 0.5709 0.5664
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0025 0.0368 0.0268
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0154 0.0052
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0141 0.4169 0.412
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0018 0.0136 0.0035
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Schistosoma mansoni amine GPCR 0.0025 0.0362 0.0262
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0112 0.3219 0.3326
Brugia malayi proteasome subunit beta type 3 0.0117 0.3377 0.3308
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0117 0.3377 0.3495
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0029 0.0486 0.0387
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0027 0.0412 0.033
Onchocerca volvulus 0.0025 0.0362 0.0743
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0121 0.3529 0.3657
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0018 0.0119 0.0037
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0122 0.3556 0.3754
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0034 0.0665 0.0702
Schistosoma mansoni opsin-like receptor 0.0025 0.0362 0.0262
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0029 0.0486 0.0513
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0025 0.0362 0.0262
Echinococcus granulosus proteasome subunit beta type 6 0.0122 0.3556 0.3502
Echinococcus granulosus g protein coupled receptor 0.0025 0.0362 0.0282
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0117 0.3377 0.3566
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0032 0.0586 0.0508
Plasmodium vivax proteasome subunit beta type-3, putative 0.0117 0.3377 0.3495
Schistosoma mansoni neuropeptide receptor 0.0025 0.0362 0.0262
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0362 0.0262
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0133 0.3898 0.4064
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0094 0.2614 0.5
Schistosoma mansoni histamine h1 receptor 0.0025 0.0362 0.0262
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0052 0.1264 0.3328
Echinococcus granulosus peptide allatostatin:somatostatin 0.0025 0.0362 0.0282
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0412 0.033
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0362 0.0282
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0038 0.0784 0.0747
Brugia malayi proteasome subunit beta type 1 0.0141 0.4169 0.4108
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0018 0.0119 0.0017
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0112 0.3219 0.3399
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0025 0.0368 0.0268
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0019 0.0154 0.0054
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Brugia malayi putative neuropeptide receptor 0.0025 0.0362 0.0262
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0112 0.3219 0.3399
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0362 0.0282
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0025 0.0362 0.0262
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0122 0.3556 0.3699
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0117 0.3377 0.3308
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0039
Plasmodium falciparum proteasome subunit beta type-4 0.0115 0.3329 0.3443
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Toxoplasma gondii proteasome subunit alpha type, putative 0.0071 0.1886 0.1903
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0152 0.0161
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0302 0.9472 1
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0038 0.0784 0.0747
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0117 0.3377 0.3509
Brugia malayi ORL1-like opioid receptor 0.0025 0.0362 0.0262
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0027 0.0412 0.0351
Loa Loa (eye worm) TYRA-2 protein 0.0025 0.0362 0.0298
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0132 0.387 0.4034
Onchocerca volvulus 0.0025 0.0362 0.0743
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0025 0.0362 0.0282
Leishmania major hypothetical protein, conserved 0.0043 0.0954 0.1008
Schistosoma mansoni hypothetical protein 0.0025 0.0362 0.0262
Brugia malayi G-protein coupled receptor 0.0025 0.0362 0.0262
Trichomonas vaginalis 26S proteasome subunit, putative 0.0026 0.0407 0.043
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0126 0.3687 0.3839
Plasmodium vivax proteasome subunit beta type-2, putative 0.0117 0.3377 0.3495
Loa Loa (eye worm) melatonin receptor type 1A 0.0025 0.0362 0.0298
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0362 0.0282
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0029 0.0489 0.0517
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0032 0.0586 0.0536
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0034 0.0665 0.06
Echinococcus granulosus g-protein coupled receptor 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Onchocerca volvulus 0.0025 0.0362 0.0743
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0362 0.0282
Schistosoma mansoni neuropeptide f receptor 76f 0.0025 0.0362 0.0262
Schistosoma mansoni opsin-like receptor 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis 26S protease regulatory subunit 8 0.0017 0.0103 0.0021

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Inhibition of trypsin-like activity of human constitutive 20s proteasome beta-2 subunit using Boc-LRR-AMC as substrate assessed as remaining activity incubated for 15 mins prior to substrate addition measured after 45 mins by fluorescence assay ChEMBL. 23540790
IC50 (binding) Inhibition of postacid activity of human constitutive 20s proteasome beta-1 subunit using Z-LLE-betaNA as substrate assessed as remaining activity incubated for 15 mins prior to substrate addition measured after 45 mins by fluorescence assay ChEMBL. 23540790
IC50 (binding) Inhibition of chymotrypsin-like activity of human constitutive 20s proteasome beta-5 subunit using Suc-LLVY-AMC as substrate assessed as remaining activity incubated for 15 mins prior to substrate addition measured after 45 mins by fluorescence assay ChEMBL. 23540790
Inhibition (binding) Inhibition of human calpain 1 using Suc-LLVY-AMC as substrate assessed as remaining enzyme activity at 20 uM incubated for 5 mins prior to substrate addition measured for 30 mins by fluorescence assay ChEMBL. 23540790
Inhibition (binding) Inhibition of human cathepsin B using Suc-LLVY-AMC as substrate assessed as remaining enzyme activity at 20 uM incubated for 15 mins prior to substrate addition measured for 30 mins by fluorescence assay ChEMBL. 23540790

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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