Detailed information for compound 1730878

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 811.104 | Formula: C42H78N6O9
  • H donors: 6 H acceptors: 7 LogP: 3.42 Rotable bonds: 45
    Rule of 5 violations (Lipinski): 3
  • SMILES: COC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)OC(C)(C)C
  • InChi: 1S/C42H78N6O9/c1-42(2,3)57-41(55)48-34-22-9-15-27-39(53)46-32-20-7-13-25-37(51)44-30-18-5-11-23-35(49)43-29-17-6-12-24-36(50)45-31-19-8-14-26-38(52)47-33-21-10-16-28-40(54)56-4/h5-34H2,1-4H3,(H,43,49)(H,44,51)(H,45,50)(H,46,53)(H,47,52)(H,48,55)
  • InChiKey: AZKFIYMTJCGUHM-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi RE15519p 0.0025 0.0362 0.0262
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0034 0.0665 0.0702
Echinococcus granulosus neuropeptide s receptor 0.0025 0.0362 0.0282
Plasmodium vivax proteasome subunit beta type-3, putative 0.0117 0.3377 0.3495
Leishmania major proteasome regulatory ATPase subunit 0.0017 0.0103 0.0109
Brugia malayi proteasome subunit alpha type 2 0.0126 0.3687 0.3621
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0126 0.3687 0.3892
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0038 0.0784 0.0747
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0032 0.0586 0.0508
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0019 0.0154 0.0054
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0302 0.9472 1
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0112 0.3219 0.3399
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0117 0.3377 0.3566
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0019 0.0154 0.0163
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0029 0.0489 0.0411
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Brugia malayi proteasome subunit beta type 1 0.0141 0.4169 0.4108
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0154 0.0052
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0362 0.0282
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0025 0.0362 0.0262
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0362 0.0282
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0027 0.0412 0.0332
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Onchocerca volvulus 0.0025 0.0362 0.0743
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0362 0.0262
Plasmodium falciparum proteasome subunit beta type-5 0.0302 0.9472 1
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0141 0.4169 0.4401
Brugia malayi Serotonin receptor 0.0025 0.0362 0.0262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0094 0.2614 0.268
Echinococcus multilocularis sex peptide receptor 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0023 0.0304 0.0236
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0133 0.3898 0.405
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0029 0.0486 0.0409
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.004
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0362 0.0282
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0019 0.0154 0.0072
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0165 0.4959 0.4917
Echinococcus granulosus 26s protease regulatory subunit s10b 0.0017 0.0103 0.0021
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0029 0.0486 0.0513
Loa Loa (eye worm) proteasome Regulatory Particle 0.0029 0.0486 0.043
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0188 0.5709 0.5664
Giardia lamblia 20S proteasome alpha subunit 4 0.0165 0.4959 0.5194
Plasmodium vivax proteasome subunit beta type-4, putative 0.0115 0.3329 0.3443
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0018 0.0119 0.0126
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0126 0.3687 0.3825
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0112 0.3219 0.3326
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Schistosoma mansoni neuropeptide f receptor 76f 0.0025 0.0362 0.0262
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.002 0.0189 0.0199
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Toxoplasma gondii peptidase, T1 family protein 0.0123 0.359 0.3722
Brugia malayi Dopamine receptor protein 2 0.0025 0.0362 0.0262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0034 0.0665 0.0568
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0165 0.4959 0.5183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Leishmania major proteasome beta-1 subunit, putative 0.0122 0.3556 0.3754
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0117 0.3377 0.3509
Echinococcus granulosus G protein coupled receptor 139 0.0025 0.0362 0.0282
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0121 0.3529 0.3475
Echinococcus granulosus somatostatin receptor 0.0025 0.0362 0.0282
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0038 0.0784 0.0828
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0017 0.0103 0.0109
Toxoplasma gondii PCI domain-containing protein 0.0032 0.0586 0.0515
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0025 0.0368 0.0268
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0165 0.4959 0.5183
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0154 0.0163
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0018 0.0119 0.0126
Schistosoma mansoni amine GPCR 0.0025 0.0362 0.0262
Echinococcus granulosus proteasome subunit alpha type 2 0.0126 0.3687 0.3634
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0025 0.0362 0.0262
Brugia malayi Proteasome subunit alpha type 1 0.0107 0.3062 0.2989
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0094 0.2614 0.276
Onchocerca volvulus 0.0025 0.0362 0.0743
Brugia malayi G protein-coupled receptor F59B2.13 0.0025 0.0362 0.0262
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0362 0.0282
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0026 0.0407 0.043
Echinococcus multilocularis g-protein coupled receptor 0.0025 0.0362 0.0282
Onchocerca volvulus 0.0025 0.0362 0.0743
Loa Loa (eye worm) proteasome subunit beta type 1 0.0141 0.4169 0.4352
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0122 0.3556 0.3754
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0025 0.0362 0.0262
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0412 0.0435
Leishmania major proteasome beta 2 subunit, putative 0.0112 0.3219 0.3399
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0032 0.0586 0.0619
Echinococcus multilocularis proteasome subunit beta type 6 0.0122 0.3556 0.3502
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0165 0.4959 0.5236
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0025 0.0362 0.0262
Brugia malayi PCI domain containing protein 0.0029 0.0489 0.039
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0302 0.9472 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0123 0.359 0.379
Echinococcus multilocularis 26S protease regulatory subunit 8 0.0017 0.0103 0.0021
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0154 0.0052
Brugia malayi putative neuropeptide receptor NPR1 0.0025 0.0362 0.0262
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0122 0.3543 0.3741
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0017 0.0103 0.0022
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0117 0.3377 0.3566
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0117 0.3377 0.3566
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0029 0.0486 0.0407
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0132 0.387 0.3807
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0034 0.0648 0.0581
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Brugia malayi GnHR receptor homolog 0.0025 0.0362 0.0262
Echinococcus multilocularis neuropeptide receptor A26 0.0025 0.0362 0.0282
Brugia malayi 26S proteasome subunit P45 family protein 0.0018 0.0119 0.0016
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0019 0.0154 0.0077
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0115 0.3329 0.3274
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0362 0.0262
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Plasmodium vivax proteasome subunit beta type-5, putative 0.0302 0.9472 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.2254 0.2313
Echinococcus multilocularis neuropeptide FF receptor 2 0.0025 0.0362 0.0282
Trypanosoma cruzi 19S proteasome regulatory subunit 0.0017 0.0103 0.0109
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0132 0.387 0.4021
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0117 0.3377 0.3322
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0122 0.3556 0.3699
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0115 0.3329 0.3458
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0132 0.387 0.4034
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0027 0.0412 0.033
Entamoeba histolytica proteasome regulatory subunit, putative 0.0025 0.0368 0.0283
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0362 0.0282
Brugia malayi proteasome subunit alpha type 1 0.0121 0.3529 0.3462
Brugia malayi sulfakinin receptor protein 0.0025 0.0362 0.0262
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0362 0.0282
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0025 0.0362 0.0298
Echinococcus granulosus neuropeptide FF receptor 2 0.0025 0.0362 0.0282
Schistosoma mansoni hypothetical protein 0.0025 0.0362 0.0262
Echinococcus granulosus Proteasome subunit alpha beta 0.0123 0.359 0.3537
Plasmodium falciparum proteasome subunit beta type-4 0.0115 0.3329 0.3443
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0029 0.0486 0.0513
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0123 0.359 0.379
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0032 0.0586 0.0619
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0152 0.0161
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0038 0.0784 0.0727
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0412 0.0435
Onchocerca volvulus 0.0025 0.0362 0.0743
Schistosoma mansoni biogenic amine receptor 0.0025 0.0362 0.0262
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0029 0.0486 0.043
Onchocerca volvulus Notchless protein homolog 0.0123 0.359 1
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0082 0.0087
Trypanosoma cruzi 26S protease regulatory subunit, putative 0.0017 0.0103 0.0109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0122 0.3543 0.3686
Schistosoma mansoni neuropeptide receptor 0.0025 0.0362 0.0262
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0302 0.9472 1
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0032 0.0586 0.0515
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0123 0.359 0.3537
Toxoplasma gondii proteasome regulatory subunit 0.0027 0.0412 0.033
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0094 0.2614 0.2537
Brugia malayi proteasome subunit beta type 2 0.0117 0.3377 0.3308
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0027 0.0412 0.0312
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0018 0.0119 0.0017
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0133 0.3898 0.4115
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0019 0.0154 0.0072
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0077 0.2054 0.1988
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0126 0.3687 0.3839
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0019 0.0154 0.0163
Trypanosoma brucei proteasome alpha 7 subunit 0.0123 0.359 0.3736
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Toxoplasma gondii PCI domain-containing protein 0.0034 0.0665 0.06
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0141 0.4169 0.4401
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0122 0.3543 0.349
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0083 0.2254 0.2296
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0412 0.0435
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0412 0.0332
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0165 0.4959 0.4917
Brugia malayi Serotonin receptor 0.0025 0.0362 0.0262
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0018 0.0119 0.0037
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0132 0.387 0.382
Brugia malayi proteasome subunit alpha type 3 0.0123 0.359 0.3523
Echinococcus multilocularis G protein coupled receptor 139 0.0025 0.0362 0.0282
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0017 0.0103 0.0109
Echinococcus granulosus hypothetical protein 0.0025 0.0362 0.0282
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Brugia malayi PCI domain containing protein 0.0026 0.0407 0.0308
Toxoplasma gondii proteasome subunit alpha type, putative 0.0071 0.1886 0.1903
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0121 0.3529 0.3475
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0117 0.3377 0.3495
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0117 0.3377 0.3308
Echinococcus granulosus proteasome subunit beta type 6 0.0122 0.3556 0.3502
Echinococcus granulosus proteasome subunit beta type 7 0.0319 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0025 0.0362 0.0298
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0152 0.0161
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0025 0.0362 0.0282
Onchocerca volvulus 0.0025 0.0362 0.0743
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0025 0.0362 0.0262
Entamoeba histolytica proteasome regulatory subunit, putative 0.0029 0.0489 0.0412
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0122 0.3543 0.3476
Onchocerca volvulus 0.0025 0.0362 0.0743
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0108 0.3082 0.3253
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0115 0.3329 0.3515
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0362 0.0262
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0121 0.3529 0.3657
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0026 0.0407 0.0346
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0038 0.0784 0.0747
Brugia malayi ORL1-like opioid receptor 0.0025 0.0362 0.0262
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0019 0.0152 0.005
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0132 0.387 0.4021
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0025 0.0362 0.0282
Schistosoma mansoni hypothetical protein 0.0026 0.0407 0.0308
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0122 0.3556 0.3685
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0362 0.0298
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0038 0.0784 0.0688
Echinococcus multilocularis neuropeptide s receptor 0.0025 0.0362 0.0282
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0112 0.3219 0.3326
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0368 0.0388
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0029 0.0486 0.0407
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0121 0.3529 0.3657
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0165 0.4959 0.4907
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0119 0.0126
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0362 0.0262
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0126 0.3687 0.3825
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0025 0.0368 0.0268
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0154 0.0052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0027 0.0412 0.0435
Onchocerca volvulus 0.0025 0.0362 0.0743
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0122 0.3543 0.3741
Onchocerca volvulus Neuropeptide F receptor homolog 0.0025 0.0362 0.0743
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0122 0.3543 0.3672
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0112 0.3219 0.3399
Schistosoma mansoni growth hormone secretagogue receptor 0.0025 0.0362 0.0262
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0028 0.0462 0.0405
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0362 0.0282
Echinococcus granulosus neuropeptide receptor 0.0025 0.0362 0.0282
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0132 0.387 0.3807
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0132 0.387 0.4021
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Onchocerca volvulus 0.0025 0.0362 0.0743
Brugia malayi Proteasome/cyclosome repeat family protein 0.0028 0.0462 0.0363
Echinococcus granulosus alpha 1A adrenergic receptor 0.0025 0.0362 0.0282
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0119 0.0126
Loa Loa (eye worm) proteasome 26S subunit 0.0017 0.0103 0.0022
Echinococcus multilocularis orexin receptor type 2 0.0025 0.0362 0.0282
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0368 0.0388
Brugia malayi proteasome subunit alpha type 4 0.0108 0.3076 0.3004
Echinococcus granulosus fmrfamide receptor 0.0025 0.0362 0.0282
Schistosoma mansoni biogenic amine receptor 0.0025 0.0362 0.0262
Brugia malayi G protein-coupled receptor 0.0025 0.0362 0.0262
Brugia malayi putative neuropeptide receptor 0.0025 0.0362 0.0262
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0112 0.3219 0.3399
Brugia malayi Dopamine receptor protein 1 0.0025 0.0362 0.0262
Schistosoma mansoni neuropeptide receptor 0.0025 0.0362 0.0262
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0362 0.0282
Leishmania major proteasome beta 2 subunit, putative 0.0117 0.3377 0.3566
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Giardia lamblia 20S proteasome alpha subunit 3 0.0122 0.3543 0.3686
Echinococcus multilocularis proteasome subunit alpha type 6 0.0133 0.3898 0.3847
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0025 0.0362 0.0262
Brugia malayi neuropeptide F receptor 0.0025 0.0362 0.0262
Entamoeba histolytica hypothetical protein 0.0034 0.0648 0.0581
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0038 0.0784 0.0708
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0018 0.0119 0.0017
Leishmania major proteasome beta 5 subunit, putative 0.0302 0.9472 1
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0133 0.3898 0.4115
Brugia malayi larval opioid receptor 0.0025 0.0362 0.0262
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0025 0.0362 0.0282
Onchocerca volvulus 0.0025 0.0362 0.0743
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0026 0.0407 0.0325
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0112 0.3219 0.3341
Echinococcus granulosus subfamily T1A non peptidase ue 0.0132 0.387 0.382
Trichomonas vaginalis 26S proteasome subunit, putative 0.0026 0.0407 0.043
Leishmania major 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative 0.0017 0.0103 0.0109
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0412 0.0435
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0154 0.0163
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0019 0.0154 0.0054
Schistosoma mansoni neuropeptide receptor 0.0025 0.0362 0.0262
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0118 0.3403 0.3334
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0117 0.3377 0.3495
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0121 0.3529 0.3462
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0302 0.9472 1
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0362 0.0282
Leishmania major proteasome beta 3 subunit, putative 0.0117 0.3377 0.3566
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0302 0.9472 1
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0121 0.3529 0.3726
Schistosoma mansoni 26S protease regulatory subunit 0.0018 0.0119 0.0016
Schistosoma mansoni hypothetical protein 0.0077 0.2054 0.1971
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0018 0.0119 0.0017
Echinococcus granulosus g protein coupled receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0152 0.0071
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0141 0.4169 0.4108
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0117 0.3377 0.3495
Leishmania major hypothetical protein, conserved 0.0043 0.0954 0.1008
Brugia malayi Proteasome A-type and B-type family protein 0.0115 0.3329 0.326
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0122 0.3543 0.3672
Plasmodium vivax proteasome subunit beta type-2, putative 0.0117 0.3377 0.3495
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0362 0.0262
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0025 0.0362 0.0298
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0094 0.2614 0.268
Echinococcus granulosus g-protein coupled receptor 0.0025 0.0362 0.0282
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0362 0.0282
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0029 0.0486 0.043
Echinococcus multilocularis adhesion regulating molecule 1 0.0083 0.2254 0.219
Brugia malayi 20S proteasome alpha5 subunit 0.0132 0.387 0.3807
Schistosoma mansoni hypothetical protein 0.0025 0.0362 0.0262
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0038 0.0784 0.0828
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0117 0.3377 0.3566
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Loa Loa (eye worm) proteasome regulatory particle 0.0032 0.0586 0.0536
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0412 0.0332
Giardia lamblia Proteasome subunit beta type 1 0.0141 0.4169 0.4352
Loa Loa (eye worm) PCI domain-containing protein 0.0026 0.0407 0.0346
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0112 0.3219 0.3326
Toxoplasma gondii proteasome 26S regulatory subunit 0.0018 0.0136 0.0035
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0038 0.0784 0.0828
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0016 0.0082 0.0087
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0019 0.0153 0.0162
Echinococcus granulosus sex peptide receptor 0.0025 0.0362 0.0282
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0133 0.3898 0.4115
Echinococcus granulosus proteasome subunit beta t family 0.0117 0.3377 0.3322
Echinococcus granulosus orexin receptor type 2 0.0025 0.0362 0.0282
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0018 0.0136 0.0144
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0119 0.0126
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0132 0.387 0.4021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0018 0.0119 0.0017
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0362 0.0282
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0026 0.0383 0.0404
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0082 0.0087
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0029 0.0489 0.0517
Leishmania major proteasome alpha 2 subunit, putative 0.0126 0.3687 0.3892
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0027 0.0412 0.0351
Schistosoma mansoni amine GPCR 0.0025 0.0362 0.0262
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0027 0.0412 0.0351
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0018 0.0119 0.004
Brugia malayi Probable 26S protease regulatory subunit 4 0.0018 0.0119 0.0016
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0362 0.0282
Schistosoma mansoni 26S proteasome subunit S9 0.0032 0.0586 0.0488
Schistosoma mansoni hypothetical protein 0.0025 0.0362 0.0262
Brugia malayi G-protein coupled receptor 0.0025 0.0362 0.0262
Toxoplasma gondii SAC3/GANP family protein 0.0025 0.0368 0.0283
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis somatostatin receptor 0.0025 0.0362 0.0282
Loa Loa (eye worm) PCI domain-containing protein 0.0029 0.0489 0.0434
Giardia lamblia 26S proteasome regulatory subunit, putative 0.002 0.0189 0.0114
Entamoeba histolytica proteasome regulatory subunit, putative 0.0034 0.0665 0.06
Brugia malayi Ubiquitin interaction motif family protein 0.0019 0.0152 0.005
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0119 0.0017
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0117 0.3377 0.3566
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0165 0.4959 0.5183
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0038 0.0784 0.0688
Echinococcus granulosus 26S protease regulatory subunit 8 0.0017 0.0103 0.0021
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0025 0.0368 0.0388
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0319 1 1
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0132 0.387 0.4086
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0094 0.2614 0.276
Echinococcus multilocularis serotonin receptor 0.0025 0.0362 0.0282
Schistosoma mansoni multiubiquitin binding protein S5a 0.0019 0.0152 0.005
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0032 0.0586 0.0515
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0133 0.3898 0.4064
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0165 0.4959 0.4917
Trypanosoma brucei proteasome beta 6 subunit 0.0141 0.4169 0.4352
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0126 0.3687 0.3825
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0029 0.0489 0.0517
Leishmania major proteasome beta 7 subunit, putative 0.0115 0.3329 0.3515
Echinococcus multilocularis proteasome (prosome, macropain) 0.0302 0.9472 0.9467
Echinococcus granulosus neuropeptide receptor 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0025 0.0362 0.0282
Schistosoma mansoni hypothetical protein 0.0025 0.0362 0.0262
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0133 0.3898 0.3834
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0368 0.0388
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0019 0.0154 0.0054
Loa Loa (eye worm) proteasome subunit beta type 2 0.0117 0.3377 0.3509
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0027 0.0412 0.033
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0115 0.3329 0.3274
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0025 0.0362 0.0262
Echinococcus granulosus neuropeptide receptor A26 0.0025 0.0362 0.0282
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0112 0.3219 0.3341
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0025 0.0368 0.0283
Mycobacterium ulcerans proteasome PrcB 0.0302 0.9472 1
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0032 0.0586 0.0536
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Schistosoma mansoni hypothetical protein 0.0188 0.5709 0.5664
Brugia malayi Dopamine receptor 0.0025 0.0362 0.0262
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0034 0.0665 0.0568
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0029 0.0486 0.0513
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0119 0.0126
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0094 0.2614 0.276
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0025 0.0362 0.0298
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0025 0.0362 0.0298
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0018 0.0119 0.0037
Echinococcus multilocularis 26s protease regulatory subunit s10b 0.0017 0.0103 0.0021
Giardia lamblia Proteasome subunit beta type 3 0.0117 0.3377 0.3509
Loa Loa (eye worm) RPN-3 protein 0.0034 0.0665 0.0621
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0025 0.0362 0.0262
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0119 0.0126
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0038 0.0784 0.0727
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0026 0.0407 0.0328
Brugia malayi Proteasome subunit alpha type 7-1 0.0165 0.4959 0.4907
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0123 0.359 0.3523
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0027 0.0412 0.0312
Toxoplasma gondii PCI domain-containing protein 0.0026 0.0407 0.0325
Toxoplasma gondii proteasome beta subunit 0.0117 0.3377 0.3495
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0112 0.3219 0.3399
Echinococcus granulosus proteasome prosome macropain 0.0302 0.9472 0.9467
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Schistosoma mansoni opsin-like receptor 0.0025 0.0362 0.0262
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0117 0.3377 0.3308
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0029 0.0489 0.0434
Entamoeba histolytica proteasome regulatory subunit, putative 0.0032 0.0586 0.0515
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0122 0.3543 0.3672
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0029 0.0489 0.0412
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0126 0.3687 0.3839
Loa Loa (eye worm) TYRA-2 protein 0.0025 0.0362 0.0298
Schistosoma mansoni amine GPCR 0.0025 0.0362 0.0262
Brugia malayi Proteasome A-type and B-type family protein 0.0122 0.3556 0.3489
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0019 0.0154 0.0054
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0117 0.3377 0.3322
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0117 0.3377 0.3566
Trypanosoma brucei proteasome beta 7 subunit 0.0115 0.3329 0.3458
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0141 0.4169 0.434
Echinococcus multilocularis proteasome subunit alpha type 2 0.0126 0.3687 0.3634
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0034 0.0665 0.06
Trypanosoma brucei Regulatory particle triple-A ATPase subunit 6 0.0017 0.0103 0.0022
Schistosoma mansoni opsin-like receptor 0.0025 0.0362 0.0262
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0362 0.0282
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0119 0.0126
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0412 0.033
Schistosoma mansoni neuropeptide receptor 0.0025 0.0362 0.0262
Giardia lamblia Hypothetical protein 0.0032 0.0586 0.0536
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0362 0.0298
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0122 0.3556 0.3489
Onchocerca volvulus 0.0025 0.0362 0.0743
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0412 0.033
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0362 0.0298
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0029 0.0486 0.0387
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Echinococcus granulosus peptide allatostatin:somatostatin 0.0025 0.0362 0.0282
Brugia malayi follicle stimulating hormone receptor 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0029 0.0489 0.0412
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0025 0.0362 0.0282
Brugia malayi AKH receptor 0.0025 0.0362 0.0262
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0117 0.3377 0.3495
Echinococcus granulosus adhesion regulating molecule 1 0.0083 0.2254 0.219
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0115 0.3329 0.3443
Entamoeba histolytica proteasome regulatory subunit, putative 0.0019 0.0152 0.0052
Onchocerca volvulus 0.0025 0.0362 0.0743
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0123 0.359 0.3722
Giardia lamblia 26S protease regulatory subunit 7 0.0017 0.0103 0.0022
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0094 0.2614 0.268
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0115 0.3329 0.3515
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0122 0.3543 0.349
Loa Loa (eye worm) proteasome subunit beta type 3 0.0117 0.3377 0.3509
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0034 0.0665 0.0587
Brugia malayi Tachykinin-like peptides receptor 99D 0.0025 0.0362 0.0262
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0362 0.0282
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0094 0.2614 0.2697
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0038 0.0784 0.0708
Echinococcus granulosus 7TM GPCR rhodopsin 0.0025 0.0362 0.0282
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0025 0.0362 0.0282
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0026 0.0407 0.043
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0412 0.0351
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0018 0.0119 0.004
Onchocerca volvulus 0.0025 0.0362 0.0743
Brugia malayi Proteasome/cyclosome repeat family protein 0.0028 0.0462 0.0363
Schistosoma mansoni opsin-like receptor 0.0025 0.0362 0.0262
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0019 0.0152 0.0161
Giardia lamblia 20S proteasome alpha subunit 5 0.0132 0.387 0.4034
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0032 0.0586 0.0619
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0122 0.3556 0.3699
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0019 0.0154 0.0077
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0018 0.0119 0.0037
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0034 0.0648 0.057
Loa Loa (eye worm) PAS-3 protein 0.0108 0.3076 0.3188
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0126 0.3687 0.3621
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0025 0.0362 0.0262
Onchocerca volvulus 0.0018 0.0119 0.0047
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0302 0.9472 1
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0141 0.4169 0.412
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0412 0.0312
Echinococcus multilocularis allatostatin A receptor 0.0025 0.0362 0.0282
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Giardia lamblia 20S proteasome alpha subunit 2 0.0126 0.3687 0.3839
Onchocerca volvulus 0.0025 0.0362 0.0743
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0029 0.0486 0.0409
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0165 0.4959 0.5236
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0018 0.0119 0.0126
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0302 0.9472 1
Echinococcus multilocularis serotonin receptor 0.0025 0.0362 0.0282
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0018 0.0119 0.0017
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0025 0.0368 0.0304
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0029 0.0489 0.0411
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0122 0.3543 0.3741
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0026 0.0407 0.0328
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0094 0.2614 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0362 0.0262
Giardia lamblia 20S proteasome alpha subunit 6 0.0121 0.3529 0.3671
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0362 0.0282
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0034 0.0648 0.057
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0018 0.0119 0.004
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0165 0.4959 0.5183
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0152 0.0071
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0025 0.0362 0.0262
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0025 0.0368 0.0288
Echinococcus granulosus dro:myosuppressin receptor 0.0025 0.0362 0.0282
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0123 0.359 0.3736
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0029 0.0486 0.0387
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0018 0.0119 0.0016
Trypanosoma cruzi serine peptidase, Clan SJ, family S16, putative 0.0017 0.0103 0.0109
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0025 0.0362 0.0282
Echinococcus granulosus g protein coupled receptor 0.0025 0.0362 0.0282
Leishmania major proteasome alpha 1 subunit, putative 0.0121 0.3529 0.3726
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0165 0.4959 0.5236
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0032 0.0586 0.0508
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0115 0.3329 0.326
Onchocerca volvulus 0.0025 0.0362 0.0743
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0412 0.033
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0362 0.0282
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0362 0.0262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0032 0.0586 0.0488
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0027 0.0412 0.0312
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0302 0.9472 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0362 0.0282
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0122 0.3543 0.3672
Schistosoma mansoni amine GPCR 0.0025 0.0362 0.0262
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0026 0.0407 0.043
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0038 0.0784 0.0688
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0141 0.4169 0.4401
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0126 0.3687 0.3825
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0362 0.0282
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0119 0.0017
Loa Loa (eye worm) melatonin receptor type 1A 0.0025 0.0362 0.0298
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0034 0.0665 0.0587
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Brugia malayi 26S protease regulatory subunit 6A 0.0019 0.0154 0.0052
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0083 0.2254 0.2174
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0018 0.0119 0.0017
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0122 0.3556 0.3699
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0034 0.0665 0.0702
Echinococcus granulosus serotonin receptor 0.0025 0.0362 0.0282
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative 0.0016 0.0082 0.0087
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0043 0.0954 0.0909
Trypanosoma cruzi 20S proteasome subunit 0.0117 0.3377 0.3566
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0121 0.3529 0.3657
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0115 0.3329 0.3458
Giardia lamblia 26S protease regulatory subunit 6B 0.0018 0.0119 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0362 0.0262
Brugia malayi neuropeptide F receptor 0.0025 0.0362 0.0262
Onchocerca volvulus 0.0018 0.0119 0.0047
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Toxoplasma gondii proteasome subunit alpha type, putative 0.0122 0.3543 0.3672
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Loa Loa (eye worm) RPT-2 protein 0.0018 0.0119 0.004
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0112 0.3219 0.3341
Schistosoma mansoni adenoreceptor 0.0025 0.0362 0.0262
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0123 0.359 0.379
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0025 0.0362 0.0743
Loa Loa (eye worm) hypothetical protein 0.0188 0.5709 0.5992
Plasmodium vivax proteasome subunit beta type-7, putative 0.0112 0.3219 0.3326
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0132 0.387 0.4086
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0117 0.3377 0.3322
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0133 0.3898 0.4064
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0052 0.1264 0.3328
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0025 0.0368 0.0288
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0025 0.0368 0.0268
Giardia lamblia 26S protease regulatory subunit 6A 0.0019 0.0154 0.0077
Brugia malayi Melatonin receptor type 1A 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0362 0.0282
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis proteasome subunit beta type 7 0.0319 1 1
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0034 0.0665 0.0568
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0025 0.0368 0.0388
Leishmania major proteasome alpha 3 subunit, putative 0.0122 0.3543 0.3741
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0034 0.0648 0.0602
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0121 0.3529 0.3726
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0133 0.3898 0.405
Echinococcus granulosus allatostatin A receptor 0.0025 0.0362 0.0282
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0018 0.0119 0.0037
Brugia malayi proteasome subunit beta type 3 0.0117 0.3377 0.3308
Schistosoma mansoni biogenic amine receptor 0.0025 0.0362 0.0262
Leishmania major proteasome alpha 1 subunit, putative 0.0133 0.3898 0.4115
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0117 0.3377 0.3308
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0165 0.4959 0.5194
Schistosoma mansoni histamine h1 receptor 0.0025 0.0362 0.0262
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0121 0.3529 0.3657
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0018 0.0136 0.0035
Brugia malayi G-protein coupled receptor 0.0025 0.0362 0.0262
Giardia lamblia Proteasome subunit beta type 2 0.0117 0.3377 0.3509
Toxoplasma gondii heat shock protein hslv, putative 0.0094 0.2614 0.268
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0302 0.9472 0.9466
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0117 0.3377 0.3495
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0117 0.3377 0.3308
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0028 0.0462 0.0488
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0362 0.0298
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0034 0.0665 0.0621
Onchocerca volvulus 0.0025 0.0362 0.0743
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0022
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0362 0.0282
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0034 0.0648 0.055
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0133 0.3898 0.405
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0083 0.2254 0.2174
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0026 0.0407 0.0325
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Echinococcus granulosus 7tm_1 domain containing protein 0.0025 0.0362 0.0282
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0029 0.0486 0.0409
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0132 0.387 0.4086
Leishmania major proteasome alpha 7 subunit, putative 0.0165 0.4959 0.5236
Echinococcus granulosus tachykinin peptides receptor 99D 0.0025 0.0362 0.0282
Brugia malayi hypothetical protein 0.0025 0.0362 0.0262
Echinococcus granulosus g protein coupled receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis G-protein coupled receptor, putative 0.0025 0.0362 0.0282
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0362 0.0282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0368 0.0304
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Entamoeba histolytica proteasome regulatory subunit, putative 0.0026 0.0407 0.0325
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0115 0.3329 0.3443
Leishmania major proteasome alpha 7 subunit, putative 0.0123 0.359 0.379
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0362 0.0282
Toxoplasma gondii proteasome subunit 0.0122 0.3556 0.3685
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0123 0.359 0.3722
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0123 0.359 0.3722
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0132 0.387 0.4034
Giardia lamblia 20S proteasome alpha subunit 1 0.0133 0.3898 0.4064
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0038 0.0784 0.0747
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0132 0.387 0.4086
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0025 0.0362 0.0262
Giardia lamblia 20S proteasome alpha subunit 7 0.0123 0.359 0.3736
Toxoplasma gondii proteasome subunit alpha1, putative 0.0133 0.3898 0.405
Echinococcus multilocularis dro:myosuppressin receptor 0.0025 0.0362 0.0282
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0362 0.0282
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0029 0.0489 0.0517
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0141 0.4169 0.412
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0122 0.3556 0.3754
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0362 0.0282
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0122 0.3556 0.3754
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0123 0.359 0.3722
Brugia malayi Proteasome A-type and B-type family protein 0.0302 0.9472 0.9466
Brugia malayi proteasome subunit alpha type 6 0.0133 0.3898 0.3834
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0141 0.4169 0.4401
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0122 0.3556 0.3685
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.3329 0.3515
Schistosoma mansoni amine GPCR 0.0025 0.0362 0.0262
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0362 0.0282
Giardia lamblia 26S protease regulatory subunit 8 0.0017 0.0103 0.0022
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0412 0.033
Echinococcus granulosus proteasome subunit alpha type 6 0.0133 0.3898 0.3847
Echinococcus granulosus Proteasome subunit alpha type 7 0.0165 0.4959 0.4917
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0132 0.387 0.4021
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0025 0.0362 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Toxoplasma gondii hypothetical protein 0.0023 0.0304 0.0215
Schistosoma mansoni proteasome regulatory subunit-related 0.0029 0.0489 0.039
Entamoeba histolytica proteasome regulatory subunit, putative 0.0029 0.0486 0.0409
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0025 0.0368 0.0283
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0141 0.4169 0.434
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0362 0.0262
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0029 0.0489 0.0412
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0121 0.3529 0.3671
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0121 0.3529 0.3671
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0027 0.0412 0.0332
Schistosoma mansoni alpha-1 adrenergic receptor 0.0025 0.0362 0.0262
Schistosoma mansoni myosin xvIII 0.0025 0.0362 0.0262
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0034 0.0648 0.0581
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0141 0.4169 0.434
Loa Loa (eye worm) hypothetical protein 0.0025 0.0368 0.0304
Plasmodium vivax proteasome subunit beta type-1, putative 0.0141 0.4169 0.434
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0302 0.9472 1
Toxoplasma gondii proteasome subunit beta type, putative 0.0302 0.9472 1
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0027 0.0412 0.033
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0025 0.0362 0.0262
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0038 0.0784 0.0688
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0362 0.0262
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0025 0.0362 0.0282
Plasmodium vivax proteasome subunit beta type-6, putative 0.0122 0.3556 0.3685
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0362 0.0282
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0077 0.2054 0.1988
Trypanosoma brucei protease regulatory ATPase subunit 4 0.0017 0.0103 0.0022
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0165 0.4959 0.5194
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0039
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0362 0.0282
Onchocerca volvulus 0.0025 0.0362 0.0743
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0082 0.0087
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0298
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0034 0.0648 0.0581
Onchocerca volvulus 0.0025 0.0362 0.0743
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0117 0.3377 0.3509

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Inhibition of trypsin-like activity of human constitutive 20s proteasome beta-2 subunit using Boc-LRR-AMC as substrate assessed as remaining activity incubated for 15 mins prior to substrate addition measured after 45 mins by fluorescence assay ChEMBL. 23540790
IC50 (binding) Inhibition of postacid activity of human constitutive 20s proteasome beta-1 subunit using Z-LLE-betaNA as substrate assessed as remaining activity incubated for 15 mins prior to substrate addition measured after 45 mins by fluorescence assay ChEMBL. 23540790
IC50 (binding) Inhibition of chymotrypsin-like activity of human constitutive 20s proteasome beta-5 subunit using Suc-LLVY-AMC as substrate assessed as remaining activity incubated for 15 mins prior to substrate addition measured after 45 mins by fluorescence assay ChEMBL. 23540790
Inhibition (binding) Inhibition of human calpain 1 using Suc-LLVY-AMC as substrate assessed as remaining enzyme activity at 20 uM incubated for 5 mins prior to substrate addition measured for 30 mins by fluorescence assay ChEMBL. 23540790
Inhibition (binding) Inhibition of human cathepsin B using Suc-LLVY-AMC as substrate assessed as remaining enzyme activity at 20 uM incubated for 15 mins prior to substrate addition measured for 30 mins by fluorescence assay ChEMBL. 23540790

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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