TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 282.418 | Formula: C17H30O3
H donors: 1 H acceptors: 2 LogP: 4.74 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCCC(C/C(=C\[C@@]1(CC)OC(=O)C[C@@H]1O)/CC)C
InChi: 1S/C17H30O3/c1-5-8-9-13(4)10-14(6-2)12-17(7-3)15(18)11-16(19)20-17/h12-13,15,18H,5-11H2,1-4H3/b14-12-/t13?,15-,17+/m0/s1
InChiKey: AKYYOIDSLIDKRA-DTZVSXBBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0023	0.0058	0.0095
Echinococcus granulosus	defective proboscis extension response	0.0089	0.0804	0.1438
Echinococcus granulosus	leucine rich repeat containing protein 4	0.0023	0.0058	0.0103
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0511	0.5591	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0031	0.0149	0.0149
Onchocerca volvulus	Protein ultraspiracle homolog	0.0511	0.5591	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0051	0.0384	0.0632
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0511	0.5591	1
Brugia malayi	nuclear receptor NHR-88	0.0241	0.2533	0.4162
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0037	0.0217	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0023	0.0058	0.0095
Schistosoma mansoni	cell adhesion molecule	0.0051	0.0384	0.0687
Brugia malayi	nuclear receptor RXR	0.027	0.286	0.47
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0041	0.0266	0.5
Loa Loa (eye worm)	immunoglobulin domain-containing protein	0.0029	0.0128	0.0211
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0058	0.0103
Echinococcus multilocularis	neuroglian	0.0111	0.106	0.106
Loa Loa (eye worm)	hypothetical protein	0.0511	0.5591	0.9187
Echinococcus multilocularis	titin	0.0023	0.0058	0.0058
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0051	0.0384	0.0384
Echinococcus granulosus	insulin growth factor binding	0.0023	0.0058	0.0103
Echinococcus granulosus	roundabout 2	0.0051	0.0384	0.0687
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0511	0.5591	0.9187
Onchocerca volvulus	Tyrosine kinase homolog	0.046	0.5013	0.8955
Loa Loa (eye worm)	TK/ROR protein kinase	0.0031	0.0149	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0511	0.5591	0.9187
Schistosoma mansoni	titin	0.0023	0.0058	0.0103
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0511	0.5591	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0511	0.5591	0.9187
Brugia malayi	Animal haem peroxidase family protein	0.0023	0.0058	0.0095
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0029	0.0128	0.023
Echinococcus multilocularis	neuroglian	0.0051	0.0384	0.0384
Echinococcus multilocularis	roundabout 2	0.014	0.1387	0.1387
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0511	0.5591	0.9187
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0029	0.0128	0.0128
Brugia malayi	hypothetical protein	0.0089	0.0804	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0241	0.2533	0.4162
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0266	0.5
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0429	0.0704
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0241	0.2533	0.453
Echinococcus granulosus	FTZ F1 alpha	0.0511	0.5591	1
Onchocerca volvulus		0.0241	0.2533	0.4473
Schistosoma mansoni	titin	0.0051	0.0384	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0804	0.1321
Schistosoma mansoni	myosin-binding protein-related	0.0023	0.0058	0.0103
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0023	0.0058	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0128	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0241	0.2533	0.2533
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.0568	0.1015
Echinococcus multilocularis	titin	0.0023	0.0058	0.0058
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0241	0.2533	0.4473
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.027	0.286	0.5115
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0128	0.0211
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0804	0.1321
Schistosoma mansoni	inositol monophosphatase	0.0041	0.0266	0.0476
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0511	0.5591	1
Schistosoma mansoni	basigin related	0.0029	0.0128	0.023
Schistosoma mansoni	vesicular amine transporter	0.0089	0.0804	0.1438
Brugia malayi	Nuclear hormone receptor-like 1	0.0511	0.5591	0.9187
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0041	0.0266	0.5
Brugia malayi	hypothetical protein	0.0241	0.2533	0.4162
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0023	0.0058	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0241	0.2533	0.4162
Schistosoma mansoni	hypothetical protein	0.0029	0.0128	0.023
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0051	0.0384	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Brugia malayi	steroid hormone receptor	0.0511	0.5591	0.9187
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1131	0.1858
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0241	0.2533	0.453
Brugia malayi	hypothetical protein	0.027	0.286	0.47
Echinococcus granulosus	basement membrane specific heparan sulfate	0.0029	0.0128	0.023
Loa Loa (eye worm)	inositol-1	0.0041	0.0266	0.0437
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0051	0.0384	0.0687
Echinococcus multilocularis	down syndrome cell adhesion	0.0023	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.027	0.286	0.47
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0037	0.0217	0.5
Echinococcus granulosus	cpg binding protein	0.0034	0.0183	0.0328
Schistosoma mansoni	nuclear hormone receptor	0.0241	0.2533	0.453
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0511	0.5591	0.9187
Brugia malayi	Wrapper/rega-1/klingon homolog protein 1	0.0023	0.0058	0.0095
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0511	0.5591	0.5591
Schistosoma mansoni	cell adhesion molecule	0.0023	0.0058	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Echinococcus multilocularis	FTZ F1 alpha	0.0511	0.5591	0.5591
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0051	0.0384	0.0632
Brugia malayi	basement membrane proteoglycan	0.0029	0.0128	0.0211
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Brugia malayi	hypothetical protein	0.027	0.286	0.47
Schistosoma mansoni	septate junction protein	0.0051	0.0384	0.0687
Brugia malayi	protein unc-22	0.0023	0.0058	0.0095
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0029	0.0128	0.023
Brugia malayi	Steroid receptor seven-up type 2	0.0511	0.5591	0.9187
Echinococcus granulosus	pro neuregulin 2 membrane bound	0.0023	0.0058	0.0103
Brugia malayi	nuclear receptor NHR-67	0.0241	0.2533	0.4162
Echinococcus granulosus	titin	0.0023	0.0058	0.0103
Echinococcus multilocularis	leucine rich repeat containing protein 4	0.0029	0.0128	0.0128
Schistosoma mansoni	netrin receptor unc5	0.0029	0.0128	0.023
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0511	0.5591	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.023	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0511	0.5591	0.9187
Brugia malayi	ecdysone receptor	0.0241	0.2533	0.4162
Loa Loa (eye worm)	hypothetical protein	0.0511	0.5591	0.9187
Echinococcus granulosus	titin	0.0023	0.0058	0.0103
Schistosoma mansoni	neuroglian	0.0051	0.0384	0.0687
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0051	0.0384	0.0384
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0241	0.2533	0.453
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.027	0.286	0.47
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0128	0.0211
Echinococcus granulosus	titin	0.0023	0.0058	0.0103
Echinococcus multilocularis	Immunoglobulin	0.0029	0.0128	0.0128
Brugia malayi	nuclear hormone receptor	0.0241	0.2533	0.4162
Echinococcus multilocularis	Immunoglobulin subtype	0.0029	0.0128	0.0128
Loa Loa (eye worm)	hypothetical protein	0.027	0.286	0.47
Loa Loa (eye worm)	hypothetical protein	0.027	0.286	0.47
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0511	0.5591	0.9187
Loa Loa (eye worm)	TK protein kinase	0.0031	0.0149	0.0244
Schistosoma mansoni	hypothetical protein	0.0029	0.0128	0.023
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0511	0.5591	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0241	0.2533	0.4473
Brugia malayi	conserved hypotetical protein	0.0241	0.2533	0.4162
Echinococcus granulosus	lachesin	0.0051	0.0384	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0804	0.1321
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.0029	0.0128	0.0128
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0429	0.0704
Schistosoma mansoni	tyrosine kinase	0.006	0.0475	0.085
Echinococcus granulosus	titin	0.0023	0.0058	0.0103
Loa Loa (eye worm)	disorganized muscle protein 1	0.0023	0.0058	0.0095
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0023	0.0058	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0241	0.2533	0.4162
Echinococcus multilocularis	Immunoglobulin	0.0089	0.0804	0.0804
Brugia malayi	Prion-like-	0.0023	0.0058	0.0095
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.0486	1
Brugia malayi	nuclear receptor NHR-88	0.0511	0.5591	0.9187
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0511	0.5591	1
Echinococcus multilocularis	Immunoglobulin	0.0089	0.0804	0.0804
Onchocerca volvulus		0.0241	0.2533	0.4473
Echinococcus granulosus	Immunoglobulin subtype	0.0029	0.0128	0.023
Echinococcus multilocularis	titin	0.0023	0.0058	0.0058
Schistosoma mansoni	RAR-like nuclear receptor	0.0511	0.5591	1
Echinococcus multilocularis	roundabout 2	0.0051	0.0384	0.0384
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0089	0.0804	0.1321
Schistosoma mansoni	subfamily M23B non-peptidase homologue (M23 family)	0.0023	0.0058	0.0103
Onchocerca volvulus		0.043	0.4666	0.8328
Echinococcus granulosus	neuroglian	0.0051	0.0384	0.0687
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0089	0.0804	0.1438
Schistosoma mansoni	thyroid hormone receptor	0.0511	0.5591	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0511	0.5591	0.5591
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0511	0.5591	0.9187
Brugia malayi	basement membrane proteoglycan precursor	0.0029	0.0128	0.0211
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0029	0.0128	0.0211
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0023	0.0058	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0384	0.0632
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0051	0.0384	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0241	0.2533	0.4162
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0511	0.5591	0.9187
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0051	0.0384	0.0632
Schistosoma mansoni	coup transcription factor	0.0511	0.5591	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0051	0.0384	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0511	0.5591	0.9187
Echinococcus multilocularis	nuclear receptor nhr 48	0.0241	0.2533	0.2533
Schistosoma mansoni	nuclear receptor	0.0241	0.2533	0.453
Echinococcus granulosus	nuclear receptor nhr 48	0.0241	0.2533	0.453
Schistosoma mansoni	basigin related	0.0029	0.0128	0.023
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0128	0.0211
Schistosoma mansoni	titin	0.0023	0.0058	0.0103
Echinococcus multilocularis	cpg binding protein	0.0034	0.0183	0.0183
Schistosoma mansoni	titin	0.0023	0.0058	0.0103
Loa Loa (eye worm)	hypothetical protein	0.014	0.1387	0.2279
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0804	0.1321
Schistosoma mansoni	nuclear receptor	0.0241	0.2533	0.453
Brugia malayi	hypothetical protein	0.0241	0.2533	0.4162
Schistosoma mansoni	titin	0.0023	0.0058	0.0103
Schistosoma mansoni	nuclear hormone receptor	0.0511	0.5591	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0241	0.2533	0.2533
Schistosoma mansoni	septate junction protein	0.0029	0.0128	0.023
Loa Loa (eye worm)	CAMK protein kinase	0.0023	0.0058	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Echinococcus multilocularis		0.0023	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0511	0.5591	0.9187
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0051	0.0384	0.0632
Echinococcus multilocularis	tyrosine protein kinase otk	0.0051	0.0384	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0384	0.0632
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0128	0.0211
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0051	0.0384	0.0632
Loa Loa (eye worm)	DR-78	0.0241	0.2533	0.4162
Brugia malayi	Immunoglobulin domain containing protein	0.0029	0.0128	0.0211
Brugia malayi	Nuclear hormone receptor E75	0.0241	0.2533	0.4162
Echinococcus multilocularis	pro neuregulin 2, membrane bound	0.0029	0.0128	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0241	0.2533	0.4162
Trichomonas vaginalis	inositol monophosphatase, putative	0.0041	0.0266	0.5
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0029	0.0128	0.023
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0555	0.6086	1
Echinococcus granulosus	inositol monophosphatase 1	0.0041	0.0266	0.0476
Brugia malayi	orphan nuclear receptor NR2E1	0.0241	0.2533	0.4162
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0051	0.0384	0.0632
Echinococcus granulosus	low density lipoprotein receptor ldl	0.0029	0.0128	0.023
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0266	0.5
Brugia malayi	Prion-like-	0.0023	0.0058	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0511	0.5591	1
Schistosoma mansoni	cell adhesion molecule	0.0029	0.0128	0.023
Schistosoma mansoni	inositol monophosphatase	0.0041	0.0266	0.0476
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0029	0.0128	0.0211
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0163	0.0268
Brugia malayi	Peroxidasin	0.0051	0.0384	0.0632
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0429	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0384	0.0632
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0511	0.5591	0.5591
Schistosoma mansoni	hypothetical protein	0.0038	0.023	0.0412
Brugia malayi	nuclear receptor RXR	0.0241	0.2533	0.4162
Echinococcus granulosus	Immunoglobulin	0.0089	0.0804	0.1438
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0511	0.5591	1
Loa Loa (eye worm)	hypothetical protein	0.0241	0.2533	0.4162
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0041	0.0266	0.5
Schistosoma mansoni	hypothetical protein	0.0023	0.0058	0.0103
Schistosoma mansoni	titin	0.0023	0.0058	0.0103
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0058	0.0103
Schistosoma mansoni	nephrin related	0.0029	0.0128	0.023
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0804	0.1321
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0241	0.2533	0.4162
Schistosoma mansoni	thyroid hormone receptor	0.0511	0.5591	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0029	0.0128	0.023
Brugia malayi	ecdysteroid receptor	0.0511	0.5591	0.9187
Echinococcus multilocularis	transfer RNA-Phe	0.0023	0.0058	0.0058
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Brugia malayi	Leucine Rich Repeat family protein	0.0023	0.0058	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0384	0.0632
Schistosoma mansoni	cell adhesion molecule	0.0023	0.0058	0.0103
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0511	0.5591	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Schistosoma mansoni	roundabout	0.0051	0.0384	0.0687
Loa Loa (eye worm)	LAD-2 short isoform	0.0029	0.0128	0.0211
Echinococcus granulosus	titin	0.0023	0.0058	0.0103
Schistosoma mansoni	cell adhesion molecule	0.0117	0.1131	0.2022
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.023	0.0378
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0031	0.0149	0.0244
Schistosoma mansoni	nephrin related	0.0023	0.0058	0.0103
Echinococcus multilocularis	lachesin	0.0051	0.0384	0.0384
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0029	0.0128	0.023
Loa Loa (eye worm)	hypothetical protein	0.0241	0.2533	0.4162
Brugia malayi	Immunoglobulin domain containing protein	0.0029	0.0128	0.0211
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0511	0.5591	0.9187
Loa Loa (eye worm)	hypothetical protein	0.0241	0.2533	0.4162
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0241	0.2533	0.453
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0511	0.5591	0.9187
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0051	0.0384	0.0632
Echinococcus granulosus	ecdysone induced protein 78C	0.0511	0.5591	1
Echinococcus granulosus	3'partial\|cell adhesion molecule:down regulated by	0.0029	0.0128	0.023
Brugia malayi	nuclear hormone receptor	0.0511	0.5591	0.9187
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0023	0.0058	0.0103
Schistosoma mansoni	cell adhesion molecule	0.0029	0.0128	0.023
Schistosoma mansoni	hypothetical protein	0.0029	0.0128	0.023
Loa Loa (eye worm)	projectin	0.0023	0.0058	0.0095
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Echinococcus multilocularis	leucine rich repeats and immunoglobulin	0.0023	0.0058	0.0058
Schistosoma mansoni	hypothetical protein	0.0023	0.0058	0.0103
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0511	0.5591	0.9187
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0555	0.6086	1
Echinococcus multilocularis	peroxidasin	0.0051	0.0384	0.0384
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0051	0.0384	0.0384
Brugia malayi	Nuclear hormone receptor-like 1	0.027	0.286	0.47
Brugia malayi	kettin	0.0023	0.0058	0.0095
Schistosoma mansoni	retinoic acid receptor RXR	0.0511	0.5591	1
Onchocerca volvulus	Bile acid receptor homolog	0.0511	0.5591	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0241	0.2533	0.2533
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0051	0.0384	0.0632
Echinococcus granulosus	contactin	0.0051	0.0384	0.0687
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0051	0.0384	0.0687
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0023	0.0058	0.0095
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0511	0.5591	0.9187
Schistosoma mansoni	peroxidasin	0.0029	0.0128	0.023
Brugia malayi	Nuclear hormone receptor-like 1	0.027	0.286	0.47
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0023	0.0058	0.0095
Brugia malayi	tailless protein	0.0241	0.2533	0.4162
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0241	0.2533	0.4162
Brugia malayi	Prion-like-	0.0051	0.0384	0.0632
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0241	0.2533	0.4162
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0241	0.2533	0.453
Echinococcus multilocularis	hemicentin 1	0.0051	0.0384	0.0384
Schistosoma mansoni	hypothetical protein	0.0029	0.0128	0.023
Schistosoma mansoni	nuclear receptor nhr-48	0.0241	0.2533	0.453
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0266	0.5
Echinococcus multilocularis	netrin receptor unc 5	0.0029	0.0128	0.0128
Echinococcus granulosus	nephrin	0.0023	0.0058	0.0103
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Loa Loa (eye worm)	hypothetical protein	0.027	0.286	0.47
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0241	0.2533	0.4162
Schistosoma mansoni	hypothetical protein	0.0023	0.0058	0.0103
Schistosoma mansoni	hypothetical protein	0.0023	0.0058	0.0103
Loa Loa (eye worm)	hypothetical protein	0.027	0.286	0.47
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0029	0.0128	0.0128
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0511	0.5591	0.9187
Schistosoma mansoni	hypothetical protein	0.0023	0.0058	0.0103
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0089	0.0804	0.0804
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0511	0.5591	0.9187
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.027	0.286	0.5115
Loa Loa (eye worm)	hypothetical protein	0.0241	0.2533	0.4162
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Echinococcus multilocularis	roundabout 2	0.0051	0.0384	0.0384
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0511	0.5591	0.9187
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0511	0.5591	1
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0041	0.0266	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Schistosoma mansoni	septate junction protein	0.0051	0.0384	0.0687
Schistosoma mansoni	cpg binding protein	0.0032	0.0163	0.0291
Loa Loa (eye worm)	animal heme peroxidase	0.0023	0.0058	0.0095
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0031	0.0149	0.0266
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0511	0.5591	0.9187
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0511	0.5591	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0511	0.5591	0.5591
Schistosoma mansoni	zinc finger protein	0.0241	0.2533	0.453
Echinococcus granulosus	pro neuregulin 2 membrane bound	0.0029	0.0128	0.023
Schistosoma mansoni	nephrin	0.0111	0.106	0.1896
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0117	0.1131	0.2022
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0051	0.0384	0.0384
Brugia malayi	hypothetical protein	0.0029	0.0128	0.0211
Loa Loa (eye worm)	one IG domain family member	0.0023	0.0058	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Echinococcus granulosus	roundabout 2	0.0051	0.0384	0.0687
Schistosoma mansoni	septate junction protein	0.0029	0.0128	0.023
Schistosoma mansoni	basigin related	0.0029	0.0128	0.023
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0384	0.0632
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0029	0.0128	0.0211
Brugia malayi	Nuclear hormone receptor E75	0.0241	0.2533	0.4162
Loa Loa (eye worm)	hypothetical protein	0.0511	0.5591	0.9187
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0511	0.5591	0.9187
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0804	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0384	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0511	0.5591	0.9187
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0511	0.5591	0.5591
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0051	0.0384	0.0384
Echinococcus granulosus	Opioid binding protein:cell adhesion molecule	0.0023	0.0058	0.0103
Schistosoma mansoni	hypothetical protein	0.0029	0.0128	0.023
Echinococcus multilocularis	hemicentin 1	0.0051	0.0384	0.0384
Schistosoma mansoni	hypothetical protein	0.0023	0.0058	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Schistosoma mansoni	cpg binding protein	0.0034	0.0183	0.0328
Loa Loa (eye worm)	steroid hormone receptor	0.0511	0.5591	0.9187
Echinococcus granulosus	leucine rich repeats and immunoglobulin	0.0023	0.0058	0.0103
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0241	0.2533	0.2533
Loa Loa (eye worm)	hypothetical protein	0.0241	0.2533	0.4162
Schistosoma mansoni	titin	0.0023	0.0058	0.0103
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0511	0.5591	0.9187
Echinococcus multilocularis	Immunoglobulin	0.0029	0.0128	0.0128
Brugia malayi	Fibronectin type III domain containing protein	0.0089	0.0804	0.1321
Echinococcus multilocularis	cell adhesion molecule:down regulated by	0.0029	0.0128	0.0128
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0511	0.5591	0.5591
Brugia malayi	Prion-like-	0.0023	0.0058	0.0095
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0511	0.5591	1
Schistosoma mansoni	titin	0.0023	0.0058	0.0103
Loa Loa (eye worm)	nuclear hormone receptor	0.0241	0.2533	0.4162
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0266	0.5
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0029	0.0128	0.023
Echinococcus granulosus	neuroglian	0.0111	0.106	0.1896
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0511	0.5591	1
Echinococcus multilocularis	titin	0.0023	0.0058	0.0058
Echinococcus granulosus	hemicentin 1	0.0051	0.0384	0.0687
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0511	0.5591	0.5591
Echinococcus granulosus	Immunoglobulin	0.0029	0.0128	0.023
Loa Loa (eye worm)	hypothetical protein	0.0241	0.2533	0.4162
Schistosoma mansoni	nephrin	0.0051	0.0384	0.0687
Schistosoma mansoni	slit	0.0023	0.0058	0.0103
Loa Loa (eye worm)	hypothetical protein	0.014	0.1387	0.2279
Schistosoma mansoni	cell adhesion molecule	0.0023	0.0058	0.0103
Echinococcus granulosus	netrin receptor unc 5	0.0029	0.0128	0.023
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.027	0.286	0.286
Brugia malayi	Inositol-1	0.0041	0.0266	0.0437
Echinococcus granulosus	down syndrome cell adhesion	0.0023	0.0058	0.0103
Onchocerca volvulus		0.0511	0.5591	1
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0051	0.0384	0.0591
Echinococcus multilocularis	inositol monophosphatase 1	0.0041	0.0266	0.0266
Echinococcus multilocularis	Opioid binding protein:cell adhesion molecule	0.0023	0.0058	0.0058
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0089	0.0804	0.1438
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0163	0.0268
Schistosoma mansoni	cpg binding protein	0.0034	0.0183	0.0328
Echinococcus granulosus	peroxidasin	0.0051	0.0384	0.0687
Echinococcus multilocularis	twitchin	0.0023	0.0058	0.0058
Echinococcus granulosus	tyrosine protein kinase otk	0.0051	0.0384	0.0687
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0511	0.5591	0.5591
Brugia malayi	Heparan sulfate	0.0029	0.0128	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0384	0.0632
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0511	0.5591	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0429	0.0704
Echinococcus granulosus	twitchin	0.0111	0.106	0.1896
Brugia malayi	Immunoglobulin domain containing protein	0.0029	0.0128	0.0211
Onchocerca volvulus		0.0032	0.0163	0.019
Schistosoma mansoni	cell adhesion molecule	0.0051	0.0384	0.0687
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0511	0.5591	0.9187
Loa Loa (eye worm)	hypothetical protein	0.0241	0.2533	0.4162
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0058	0.0095
Echinococcus granulosus	Immunoglobulin	0.0029	0.0128	0.023
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0241	0.2533	0.4162
Echinococcus granulosus	thyroid hormone receptor alpha	0.0241	0.2533	0.453
Schistosoma mansoni	hypothetical protein	0.0029	0.0128	0.023
Schistosoma mansoni	hypothetical protein	0.0023	0.0058	0.0103
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0051	0.0384	0.0632
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0511	0.5591	0.9187
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0023	0.0058	0.0095
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.027	0.286	0.5115
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0029	0.0128	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0511	0.5591	0.9187
Schistosoma mansoni	cell adhesion molecule	0.0051	0.0384	0.0687
Schistosoma mansoni	nuclear hormone receptor	0.0241	0.2533	0.453
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0029	0.0128	0.0211
Schistosoma mansoni	netrin receptor unc5	0.0029	0.0128	0.023
Echinococcus multilocularis	insulin growth factor binding	0.0023	0.0058	0.0058
Brugia malayi	Disorganized muscle protein 1	0.0023	0.0058	0.0095
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0029	0.0128	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0384	0.0632
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0058	0.0095
Schistosoma mansoni	hemicentin	0.0023	0.0058	0.0103
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0051	0.0384	0.0632
Echinococcus granulosus	roundabout 2	0.014	0.1387	0.248
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0241	0.2533	0.453
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0241	0.2533	0.2533
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0041	0.0266	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0023	0.0058	0.0095
Echinococcus multilocularis	pro neuregulin 2, membrane bound	0.0023	0.0058	0.0058
Brugia malayi	nuclear hormone receptor family member odr-7	0.0241	0.2533	0.4162
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0051	0.0384	0.0687
Brugia malayi	photoreceptor-specific nuclear receptor	0.0511	0.5591	0.9187

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 2.2 uM	Cytotoxicity against human K562 cells after 72 hrs by MTT assay	ChEMBL.	23806071
IC50 (functional)	> 100 uM	Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay	ChEMBL.	23806071

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	23806071

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2333070

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1730950