Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0267 | 0.74 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0267 | 0.74 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0267 | 0.74 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0267 | 0.74 | 0.74 |
Schistosoma mansoni | nuclear hormone receptor | 0.0267 | 0.74 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0267 | 0.74 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0267 | 0.74 | 0.74 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0267 | 0.74 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.74 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.74 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0267 | 0.74 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0267 | 0.74 | 0.74 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0267 | 0.74 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0267 | 0.74 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0267 | 0.74 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0267 | 0.74 | 0.74 |
Onchocerca volvulus | 0.0267 | 0.74 | 0.5 | |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0267 | 0.74 | 0.74 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0267 | 0.74 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0267 | 0.74 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0267 | 0.74 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.74 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0267 | 0.74 | 0.74 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0267 | 0.74 | 0.74 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0267 | 0.74 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0267 | 0.74 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0267 | 0.74 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0267 | 0.74 | 0.74 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0267 | 0.74 | 0.74 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0267 | 0.74 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0267 | 0.74 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0267 | 0.74 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0267 | 0.74 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0267 | 0.74 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0267 | 0.74 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0267 | 0.74 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0267 | 0.74 | 0.74 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0267 | 0.74 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0267 | 0.74 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0267 | 0.74 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0267 | 0.74 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.74 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0267 | 0.74 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0267 | 0.74 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0267 | 0.74 | 0.74 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.74 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0267 | 0.74 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0267 | 0.74 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0267 | 0.74 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0267 | 0.74 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0312 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0267 | 0.74 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0267 | 0.74 | 0.74 |
Schistosoma mansoni | thyroid hormone receptor | 0.0267 | 0.74 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0267 | 0.74 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0267 | 0.74 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0267 | 0.74 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0267 | 0.74 | 0.74 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0267 | 0.74 | 0.74 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0267 | 0.74 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0267 | 0.74 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0267 | 0.74 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.74 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0267 | 0.74 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0267 | 0.74 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.74 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0267 | 0.74 | 0.74 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0267 | 0.74 | 0.74 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0267 | 0.74 | 0.74 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0267 | 0.74 | 0.74 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.74 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0267 | 0.74 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 20.5 nM | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | ChEMBL. | 23445496 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23445496 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.