Detailed information for compound 173099

Basic information

Technical information
  • TDR Targets ID: 173099
  • Name: N-(4-chloro-3-nitrophenyl)-4-(6,7-dimethoxyqu inazolin-4-yl)piperazine-1-carboxamide
  • MW: 472.882 | Formula: C21H21ClN6O5
  • H donors: 1 H acceptors: 5 LogP: 3.05 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2ncnc(c2cc1OC)N1CCN(CC1)C(=O)Nc1ccc(c(c1)[N+](=O)[O-])Cl
  • InChi: 1S/C21H21ClN6O5/c1-32-18-10-14-16(11-19(18)33-2)23-12-24-20(14)26-5-7-27(8-6-26)21(29)25-13-3-4-15(22)17(9-13)28(30)31/h3-4,9-12H,5-8H2,1-2H3,(H,25,29)
  • InChiKey: JIJZJOKGJUGWGQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-chloro-3-nitro-phenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamide
  • N-(4-chloro-3-nitrophenyl)-4-(6,7-dimethoxy-4-quinazolinyl)-1-piperazinecarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens platelet-derived growth factor receptor, beta polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0029 0.085 0.085
Echinococcus granulosus g-protein coupled receptor 0.0029 0.085 0.085
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0188 1 1
Echinococcus granulosus roundabout 2 0.0018 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.085 0.085
Brugia malayi Dopamine receptor protein 2 0.0029 0.085 0.0753
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.085 0.085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.085 0.085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.085 0.085
Brugia malayi hypothetical protein 0.0089 0.429 0.423
Echinococcus multilocularis fmrfamide receptor 0.0029 0.085 0.085
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0188 1 1
Brugia malayi hypothetical protein 0.0029 0.085 0.0753
Loa Loa (eye worm) hypothetical protein 0.0089 0.429 0.4264
Schistosoma mansoni steroid hormone receptor ad4bp 0.0188 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.429 0.4264
Brugia malayi AKH receptor 0.0029 0.085 0.0753
Brugia malayi G protein-coupled receptor 0.0029 0.085 0.0753
Schistosoma mansoni thyroid hormone receptor 0.0188 1 1
Echinococcus granulosus orexin receptor type 2 0.0029 0.085 0.085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0188 1 1
Echinococcus granulosus g protein coupled receptor 0.0029 0.085 0.085
Echinococcus granulosus serotonin receptor 0.0029 0.085 0.085
Echinococcus multilocularis g protein coupled receptor 0.0029 0.085 0.085
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0089 0.429 0.429
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0188 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0188 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Echinococcus granulosus 7TM GPCR rhodopsin 0.0029 0.085 0.085
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0188 1 1
Brugia malayi nuclear receptor NHR-88 0.0188 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.085 0.0808
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.085 0.085
Brugia malayi Tachykinin-like peptides receptor 99D 0.0029 0.085 0.0753
Loa Loa (eye worm) hypothetical protein 0.01 0.4901 0.4878
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.085 0.085
Schistosoma mansoni alpha-1 adrenergic receptor 0.0029 0.085 0.085
Echinococcus granulosus neuropeptide s receptor 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0188 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0089 0.429 0.429
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0029 0.085 0.085
Echinococcus granulosus Nuclear hormone receptor HR96 0.0089 0.429 0.429
Echinococcus granulosus dro:myosuppressin receptor 0.0029 0.085 0.085
Brugia malayi nuclear hormone receptor 0.0089 0.429 0.423
Loa Loa (eye worm) hypothetical protein 0.0089 0.429 0.4264
Echinococcus granulosus neuropeptide receptor 0.0029 0.085 0.085
Echinococcus multilocularis serotonin receptor 0.0029 0.085 0.085
Brugia malayi putative neuropeptide receptor 0.0029 0.085 0.0753
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0089 0.429 0.4264
Echinococcus granulosus Nuclear hormone receptor HR96 0.0089 0.429 0.429
Schistosoma mansoni opsin-like receptor 0.0029 0.085 0.085
Brugia malayi nuclear receptor RXR 0.0089 0.429 0.423
Brugia malayi nuclear receptor RXR 0.01 0.4901 0.4848
Brugia malayi ORL1-like opioid receptor 0.0029 0.085 0.0753
Onchocerca volvulus Bile acid receptor homolog 0.0188 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0188 1 1
Schistosoma mansoni neuropeptide receptor 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0018 0.021 0.0165
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.01 0.4901 0.4901
Loa Loa (eye worm) hypothetical protein 0.0089 0.429 0.4264
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.085 0.085
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.085 0.085
Schistosoma mansoni thyroid hormone receptor 0.0188 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Loa Loa (eye worm) hypothetical protein 0.0188 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0188 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0188 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0029 0.085 0.085
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0029 0.085 0.0753
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.085 0.085
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.085 0.085
Echinococcus granulosus neuropeptide receptor A26 0.0029 0.085 0.085
Brugia malayi Steroid receptor seven-up type 2 0.0188 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0089 0.429 0.4264
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.085 0.0808
Echinococcus multilocularis sex peptide receptor 0.0029 0.085 0.085
Brugia malayi hypothetical protein 0.0029 0.085 0.0753
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0029 0.085 0.085
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0029 0.085 0.085
Brugia malayi hypothetical protein 0.0029 0.085 0.0753
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0029 0.085 0.0753
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.085 0.085
Brugia malayi Dopamine receptor 0.0029 0.085 0.0753
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.085 0.085
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0046 0.0046
Echinococcus multilocularis somatostatin receptor 0.0029 0.085 0.085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0188 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0188 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0188 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0188 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0029 0.085 0.085
Brugia malayi nuclear hormone receptor family member nhr-6 0.0089 0.429 0.423
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0188 1 1
Schistosoma mansoni neuropeptide receptor 0.0029 0.085 0.085
Brugia malayi neuropeptide F receptor 0.0029 0.085 0.0753
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Brugia malayi RE15519p 0.0029 0.085 0.0753
Brugia malayi steroid hormone receptor 0.0188 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0188 1 1
Brugia malayi Melatonin receptor type 1A 0.0029 0.085 0.0753
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0029 0.085 0.085
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0029 0.085 0.085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0188 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0188 1 1
Schistosoma mansoni adenoreceptor 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0089 0.429 0.4264
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.085 0.085
Schistosoma mansoni myosin xvIII 0.0029 0.085 0.085
Loa Loa (eye worm) nuclear hormone receptor 0.0089 0.429 0.4264
Schistosoma mansoni hypothetical protein 0.0029 0.085 0.085
Echinococcus multilocularis allatostatin A receptor 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0188 1 1
Schistosoma mansoni histamine h1 receptor 0.0029 0.085 0.085
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0089 0.429 0.4264
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.085 0.085
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0188 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0029 0.085 0.085
Echinococcus granulosus sex peptide receptor 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Brugia malayi hypothetical protein 0.0029 0.085 0.0753
Echinococcus multilocularis neuropeptide FF receptor 2 0.0029 0.085 0.085
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0029 0.085 0.085
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0029 0.085 0.085
Echinococcus granulosus alpha 1A adrenergic receptor 0.0029 0.085 0.085
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.085 0.085
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0188 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.085 0.085
Schistosoma mansoni amine GPCR 0.0029 0.085 0.085
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0029 0.085 0.085
Brugia malayi larval opioid receptor 0.0029 0.085 0.0753
Echinococcus multilocularis G protein coupled receptor 139 0.0029 0.085 0.085
Echinococcus multilocularis dro:myosuppressin receptor 0.0029 0.085 0.085
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0188 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Schistosoma mansoni hypothetical protein 0.0029 0.085 0.085
Echinococcus granulosus neuropeptide receptor 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Loa Loa (eye worm) hypothetical protein 0.0089 0.429 0.4264
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0016 0.0104 0.0059
Echinococcus multilocularis neuropeptide s receptor 0.0029 0.085 0.085
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0188 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0089 0.429 0.429
Echinococcus granulosus 7tm_1 domain containing protein 0.0029 0.085 0.085
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.085 0.085
Echinococcus multilocularis G-protein coupled receptor, putative 0.0029 0.085 0.085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0188 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0089 0.429 0.429
Brugia malayi neuropeptide F receptor 0.0029 0.085 0.0753
Echinococcus multilocularis g-protein coupled receptor 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0089 0.429 0.4264
Brugia malayi sulfakinin receptor protein 0.0029 0.085 0.0753
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0029 0.085 0.0808
Echinococcus granulosus thyroid hormone receptor alpha 0.0089 0.429 0.429
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.01 0.4901 0.4878
Brugia malayi hypothetical protein 0.0029 0.085 0.0753
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0029 0.085 0.085
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.085 0.0808
Schistosoma mansoni nuclear receptor nhr-48 0.0089 0.429 0.429
Echinococcus granulosus neuropeptide FF receptor 2 0.0029 0.085 0.085
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.085 0.085
Loa Loa (eye worm) TYRA-2 protein 0.0029 0.085 0.0808
Schistosoma mansoni opsin-like receptor 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0188 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0089 0.429 0.376
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0029 0.085 0.085
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.085 0.085
Schistosoma mansoni nuclear receptor 0.0089 0.429 0.429
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.085 0.085
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0188 1 1
Schistosoma mansoni amine GPCR 0.0029 0.085 0.085
Echinococcus granulosus G protein coupled receptor 139 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Brugia malayi ecdysone receptor 0.0089 0.429 0.423
Brugia malayi nuclear hormone receptor 0.0188 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.085 0.085
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0029 0.085 0.085
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.085 0.0808
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0188 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.085 0.085
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0029 0.085 0.0808
Brugia malayi hypothetical protein 0.01 0.4901 0.4848
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Echinococcus multilocularis neuropeptide receptor 0.0029 0.085 0.085
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0188 1 1
Loa Loa (eye worm) hypothetical protein 0.01 0.4901 0.4878
Onchocerca volvulus 0.0188 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Echinococcus granulosus FTZ F1 alpha 0.0188 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0188 1 1
Schistosoma mansoni biogenic amine receptor 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0188 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0188 1 1
Brugia malayi G-protein coupled receptor 0.0029 0.085 0.0753
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0029 0.085 0.0808
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.085 0.085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0188 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Loa Loa (eye worm) hypothetical protein 0.0089 0.429 0.4264
Onchocerca volvulus 0.0089 0.429 0.376
Echinococcus granulosus fmrfamide receptor 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Echinococcus granulosus g protein coupled receptor 0.0029 0.085 0.085
Schistosoma mansoni amine GPCR 0.0029 0.085 0.085
Brugia malayi G protein-coupled receptor F59B2.13 0.0029 0.085 0.0753
Loa Loa (eye worm) DR-78 0.0089 0.429 0.4264
Echinococcus multilocularis g protein coupled receptor 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Loa Loa (eye worm) hypothetical protein 0.0018 0.021 0.0165
Brugia malayi hypothetical protein 0.01 0.4901 0.4848
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0188 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Echinococcus granulosus somatostatin receptor 0.0029 0.085 0.085
Brugia malayi hypothetical protein 0.0029 0.085 0.0753
Echinococcus multilocularis roundabout 2 0.0018 0.021 0.021
Schistosoma mansoni hypothetical protein 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0089 0.429 0.4264
Brugia malayi hypothetical protein 0.0029 0.085 0.0753
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0188 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0188 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0029 0.085 0.085
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0089 0.429 0.376
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.085 0.085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.085 0.085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Loa Loa (eye worm) hypothetical protein 0.01 0.4901 0.4878
Onchocerca volvulus 0.0089 0.429 0.376
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Schistosoma mansoni biogenic amine receptor 0.0029 0.085 0.085
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0089 0.429 0.429
Echinococcus multilocularis FTZ F1 alpha 0.0188 1 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0188 1 1
Schistosoma mansoni opsin-like receptor 0.0029 0.085 0.085
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.01 0.4901 0.4878
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.085 0.085
Echinococcus granulosus ecdysone induced protein 78C 0.0188 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Brugia malayi hypothetical protein 0.0029 0.085 0.0753
Schistosoma mansoni nuclear hormone receptor 0.0089 0.429 0.429
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.085 0.085
Schistosoma mansoni neuropeptide receptor 0.0029 0.085 0.085
Brugia malayi hypothetical protein 0.0029 0.085 0.0753
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.085 0.085
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0188 1 1
Schistosoma mansoni amine GPCR 0.0029 0.085 0.085
Echinococcus granulosus peptide allatostatin:somatostatin 0.0029 0.085 0.085
Schistosoma mansoni retinoic acid receptor RXR 0.0188 1 1
Brugia malayi Nuclear hormone receptor E75 0.0089 0.429 0.423
Schistosoma mansoni amine GPCR 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Loa Loa (eye worm) hypothetical protein 0.01 0.4901 0.4878
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0029 0.085 0.085
Brugia malayi follicle stimulating hormone receptor 0.0029 0.085 0.0753
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0188 1 1
Brugia malayi tailless protein 0.0089 0.429 0.423
Schistosoma mansoni nuclear hormone receptor 0.0188 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0029 0.085 0.085
Schistosoma mansoni zinc finger protein 0.0089 0.429 0.429
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0188 1 1
Brugia malayi Dopamine receptor protein 1 0.0029 0.085 0.0753
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.085 0.085
Brugia malayi conserved hypotetical protein 0.0089 0.429 0.423
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0089 0.429 0.429
Brugia malayi hypothetical protein 0.0029 0.085 0.0753
Schistosoma mansoni nuclear hormone receptor 0.0089 0.429 0.429
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.01 0.4901 0.4901
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.085 0.085
Loa Loa (eye worm) steroid hormone receptor 0.0188 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.01 0.4901 0.4848
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0029 0.085 0.0753
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.085 0.085
Echinococcus multilocularis orexin receptor type 2 0.0029 0.085 0.085
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0188 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0188 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0089 0.429 0.423
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0029 0.085 0.085
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0089 0.429 0.429
Brugia malayi Nuclear hormone receptor-like 1 0.01 0.4901 0.4848
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.085 0.085
Echinococcus multilocularis neuropeptide receptor A26 0.0029 0.085 0.085
Brugia malayi Nuclear hormone receptor-like 1 0.0188 1 1
Loa Loa (eye worm) hypothetical protein 0.0188 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0188 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Brugia malayi nuclear receptor NHR-88 0.0089 0.429 0.423
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0029 0.085 0.0808
Loa Loa (eye worm) hypothetical protein 0.0188 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.01 0.4901 0.4901
Echinococcus multilocularis fmrfamide receptor 0.0029 0.085 0.085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0188 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0188 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.085 0.085
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0029 0.085 0.085
Echinococcus multilocularis g protein coupled receptor 0.0029 0.085 0.085
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0029 0.085 0.0753
Schistosoma mansoni nuclear receptor 0.0089 0.429 0.429
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0089 0.429 0.429
Loa Loa (eye worm) hypothetical protein 0.0089 0.429 0.4264
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.085 0.085
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Echinococcus multilocularis neuropeptide receptor 0.0029 0.085 0.085
Brugia malayi putative neuropeptide receptor NPR1 0.0029 0.085 0.0753
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0188 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Loa Loa (eye worm) hypothetical protein 0.0089 0.429 0.4264
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0089 0.429 0.423
Brugia malayi nuclear receptor NHR-67 0.0089 0.429 0.423
Echinococcus multilocularis ecdysone induced protein 78C 0.0188 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.085 0.085
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0029 0.085 0.0753
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.085 0.085
Schistosoma mansoni hypothetical protein 0.0029 0.085 0.085
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0089 0.429 0.429
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.085 0.085
Brugia malayi Serotonin receptor 0.0029 0.085 0.0753
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0029 0.085 0.0808
Echinococcus granulosus g protein coupled receptor 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0089 0.429 0.4264
Brugia malayi G-protein coupled receptor 0.0029 0.085 0.0753
Brugia malayi nuclear hormone receptor family member odr-7 0.0089 0.429 0.423
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0188 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.085 0.085
Echinococcus granulosus allatostatin A receptor 0.0029 0.085 0.085
Schistosoma mansoni RAR-like nuclear receptor 0.0188 1 1
Brugia malayi hypothetical protein 0.0089 0.429 0.423
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.085 0.085
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.085 0.085
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0029 0.085 0.085
Echinococcus granulosus hypothetical protein 0.0029 0.085 0.085
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0029 0.085 0.085
Echinococcus multilocularis serotonin receptor 0.0029 0.085 0.085
Schistosoma mansoni cell adhesion molecule 0.0015 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.085 0.085
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0188 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0029 0.085 0.0808
Schistosoma mansoni neuropeptide receptor 0.0029 0.085 0.085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0029 0.085 0.0808
Schistosoma mansoni coup transcription factor 0.0188 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0089 0.429 0.429
Brugia malayi GnHR receptor homolog 0.0029 0.085 0.0753
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.085 0.085
Echinococcus granulosus nuclear receptor nhr 48 0.0089 0.429 0.429
Schistosoma mansoni biogenic amine receptor 0.0029 0.085 0.085
Echinococcus granulosus tachykinin peptides receptor 99D 0.0029 0.085 0.085
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0188 1 1
Brugia malayi Serotonin receptor 0.0029 0.085 0.0753
Schistosoma mansoni retinoid-x-receptor (RXR) 0.01 0.4901 0.4901
Brugia malayi Nuclear hormone receptor E75 0.0089 0.429 0.423

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.47 uM l-1 Inhibition of Platelet-derived growth factor receptor beta phosphorylation ChEMBL. 12086491
IC50 (binding) = 1.47 uM l-1 Inhibition of Platelet-derived growth factor receptor beta phosphorylation ChEMBL. 12086491

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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