Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | oxidoreductase-like protein | 0.0067 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0015 | 0.0139 |
Leishmania major | pteridine reductase 1 | 0.0067 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0067 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0083 | 0.0176 | 0.0176 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0067 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.099 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0152 | 0.0918 | 1 |
Brugia malayi | Hemopexin family protein | 0.0097 | 0.0325 | 0.3045 |
Onchocerca volvulus | 0.0068 | 0.0015 | 0.0161 | |
Mycobacterium ulcerans | hydrolase | 0.0083 | 0.0176 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0015 | 0.0139 |
Onchocerca volvulus | 0.0097 | 0.0325 | 0.3537 | |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0325 | 0.9094 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0068 | 0.0015 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0176 | 0.1655 |
Brugia malayi | Matrixin family protein | 0.0068 | 0.0015 | 0.0139 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0083 | 0.0176 | 0.0176 |
Loa Loa (eye worm) | matrixin family protein | 0.0152 | 0.0918 | 0.8609 |
Brugia malayi | Matrixin family protein | 0.0068 | 0.0015 | 0.0139 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0068 | 0.0015 | 0.0415 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0067 | 0 | 0.5 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0067 | 0 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.099 | 1 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0249 | 0.1969 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0067 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.099 | 1 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.099 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.099 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.099 | 1 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0067 | 0 | 0.5 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0067 | 0 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0083 | 0.0176 | 0.1655 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.099 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0068 | 0.0015 | 0.0139 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0067 | 0 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0165 | 0.1066 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0067 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0067 | 0 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0015 | 0.0139 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0249 | 0.1969 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0152 | 0.0918 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0068 | 0.0015 | 0.0161 |
Brugia malayi | Matrixin family protein | 0.0165 | 0.1066 | 1 |
Brugia malayi | Matrixin family protein | 0.0068 | 0.0015 | 0.0139 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.01 | 0.0357 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.09 nM | Inhibition of human recombinant MMP2 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 mins | ChEMBL. | 23375794 |
IC50 (binding) | = 4.32 nM | Inhibition of human recombinant MMP9 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 mins | ChEMBL. | 23375794 |
IC50 (binding) | = 5293.55 nM | Inhibition of human recombinant MMP1 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 mins | ChEMBL. | 23375794 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.