Detailed information for compound 173135

Basic information

Technical information
  • TDR Targets ID: 173135
  • Name: (2,6-dimethylphenyl)-[2-methyl-1-(2-morpholin -4-ylethyl)indol-3-yl]methanone
  • MW: 376.491 | Formula: C24H28N2O2
  • H donors: 0 H acceptors: 1 LogP: 4.07 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1C(=O)c1c(C)n(c2c1cccc2)CCN1CCOCC1)C
  • InChi: 1S/C24H28N2O2/c1-17-7-6-8-18(2)22(17)24(27)23-19(3)26(21-10-5-4-9-20(21)23)12-11-25-13-15-28-16-14-25/h4-10H,11-16H2,1-3H3
  • InChiKey: ZBHSHHLFIVULKY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2,6-dimethylphenyl)-[2-methyl-1-(2-morpholinoethyl)indol-3-yl]methanone
  • (2,6-dimethylphenyl)-[2-methyl-1-(2-morpholinoethyl)-3-indolyl]methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0337 0.4349 0.5073
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0094 0.1069 0.1067
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0115 0.1363 0.1589
Toxoplasma gondii proteasome subunit 0.0115 0.1363 0.1589
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0639 0.8403 0.8705
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.1069 0.1067
Onchocerca volvulus 0.0094 0.1069 0.1215
Echinococcus multilocularis neuropeptide Y receptor 0.0094 0.1069 0.1067
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0094 0.1069 0.1067
Echinococcus multilocularis sex peptide receptor 0.0094 0.1069 0.1067
Leishmania major proteasome beta 3 subunit, putative 0.0115 0.1363 0.1589
Brugia malayi proteasome subunit alpha type 1 0.0115 0.1363 0.1583
Echinococcus granulosus geminin 0.016 0.1958 0.2026
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0639 0.8403 0.8403
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0115 0.1363 0.1589
Brugia malayi ORL1-like opioid receptor 0.0094 0.1069 0.1239
Echinococcus multilocularis serotonin receptor 0.0094 0.1069 0.1067
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0639 0.8403 0.9811
Echinococcus multilocularis proteasome (prosome, macropain) 0.0651 0.8565 0.8565
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0089 0.1013 0.1174
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0272 0.3467 0.2922
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0115 0.1363 0.1361
Brugia malayi cytochrome P450 0.0089 0.1013 0.1174
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0094 0.1069 0.1239
Brugia malayi GYF domain containing protein 0.006 0.0616 0.071
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0094 0.1069 0.1105
Echinococcus granulosus tm gpcr rhodopsin 0.0094 0.1069 0.1105
Loa Loa (eye worm) hypothetical protein 0.0337 0.4349 0.5073
Echinococcus granulosus proteasome subunit alpha type 6 0.0115 0.1363 0.141
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0115 0.1363 0.1589
Loa Loa (eye worm) melatonin receptor type 1A 0.0094 0.1069 0.1239
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Loa Loa (eye worm) hypothetical protein 0.0057 0.0573 0.066
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0434 0.565 0.6596
Brugia malayi Protein K4 0.0016 0.0017 0.001
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Schistosoma mansoni hypothetical protein 0.0015 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Giardia lamblia 20S proteasome alpha subunit 5 0.0115 0.1363 0.1591
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0639 0.8403 0.9811
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0115 0.1363 0.1589
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0094 0.1069 0.1215
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0009 0.0008
Brugia malayi nuclear receptor RXR 0.0301 0.3863 0.4504
Brugia malayi Nuclear hormone receptor-like 1 0.0337 0.4349 0.5073
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0115 0.1363 0.1361
Brugia malayi Nuclear hormone receptor E75 0.0301 0.3863 0.4504
Echinococcus granulosus subfamily T1A non peptidase ue 0.0115 0.1363 0.141
Echinococcus granulosus neuropeptide receptor 0.0094 0.1069 0.1105
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0115 0.1363 0.1589
Schistosoma mansoni biogenic amine receptor 0.0094 0.1069 0.1067
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0301 0.3863 0.3861
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0115 0.1363 0.1589
Onchocerca volvulus 0.0301 0.3863 0.4561
Brugia malayi Proteasome A-type and B-type family protein 0.0115 0.1363 0.1583
Loa Loa (eye worm) hypothetical protein 0.0081 0.0904 0.1047
Trypanosoma brucei C-8 sterol isomerase, putative 0.0632 0.8314 0.9706
Echinococcus granulosus GPCR family 2 0.0015 0.0008 0.0006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0008 0.0006
Echinococcus granulosus allatostatin A receptor 0.0094 0.1069 0.1105
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0115 0.1363 0.1589
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0118 0.1397 0.1629
Schistosoma mansoni hypothetical protein 0.0119 0.1405 0.1403
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0115 0.1363 0.1589
Schistosoma mansoni biogenic amine receptor 0.0094 0.1069 0.1067
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0089 0.1013 0.118
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0115 0.1363 0.1589
Brugia malayi larval opioid receptor 0.0094 0.1069 0.1239
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0089 0.1013 0.118
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0272 0.3467 0.4047
Brugia malayi G-protein coupled receptor 0.0094 0.1069 0.1239
Loa Loa (eye worm) hypothetical protein 0.0301 0.3863 0.4504
Loa Loa (eye worm) hypothetical protein 0.0639 0.8403 0.9811
Echinococcus multilocularis neuropeptide receptor 0.0094 0.1069 0.1067
Leishmania major C-8 sterol isomerase-like protein 0.0632 0.8314 0.9706
Loa Loa (eye worm) hypothetical protein 0.0639 0.8403 0.9811
Brugia malayi proteasome subunit alpha type 2 0.0115 0.1363 0.1583
Brugia malayi Cytochrome P450 family protein 0.0089 0.1013 0.1174
Brugia malayi Nuclear hormone receptor-like 1 0.0337 0.4349 0.5073
Echinococcus granulosus neuropeptide s receptor 0.0527 0.6904 0.7151
Plasmodium vivax cardiolipin synthetase, putative 0.0016 0.0017 0.0018
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0115 0.1363 0.1589
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0089 0.1013 0.118
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0094 0.1069 0.1067
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0115 0.1363 0.1589
Brugia malayi Tachykinin-like peptides receptor 99D 0.0094 0.1069 0.1239
Loa Loa (eye worm) neuropeptide F receptor 0.0094 0.1069 0.1239
Echinococcus granulosus proteasome subunit beta type 7 0.0115 0.1363 0.141
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0115 0.1363 0.1589
Schistosoma mansoni neuropeptide receptor 0.0094 0.1069 0.1067
Onchocerca volvulus 0.0094 0.1069 0.1215
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.1957 0.0825
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.1957 0.0825
Loa Loa (eye worm) TYRA-2 protein 0.0094 0.1069 0.1239
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.1069 0.1105
Trypanosoma brucei phosphatidylglycerolphosphate synthase, mitochondrial 0.0016 0.0017 0.0018
Onchocerca volvulus 0.0301 0.3863 0.4561
Onchocerca volvulus Glucosylceramidase homolog 0.016 0.1957 0.2279
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0639 0.8403 0.8403
Trypanosoma brucei proteasome beta 6 subunit 0.0434 0.565 0.6596
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0731 0.9654 1
Brugia malayi Nuclear hormone receptor E75 0.0301 0.3863 0.4504
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0016 0.0017 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0008 0.0006
Schistosoma mansoni retinoic acid receptor RXR 0.0731 0.9654 0.9654
Schistosoma mansoni alpha-1 adrenergic receptor 0.0094 0.1069 0.1067
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0115 0.1363 0.1583
Schistosoma mansoni cytochrome P450 0.0089 0.1013 0.1011
Loa Loa (eye worm) hypothetical protein 0.0323 0.4155 0.4847
Echinococcus multilocularis neuropeptide FF receptor 2 0.0094 0.1069 0.1067
Loa Loa (eye worm) hypothetical protein 0.0639 0.8403 0.9811
Brugia malayi GnHR receptor homolog 0.0094 0.1069 0.1239
Schistosoma mansoni amine GPCR 0.0094 0.1069 0.1067
Brugia malayi Calcitonin receptor-like protein seb-1 0.0047 0.0441 0.0505
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0094 0.1069 0.1067
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0094 0.1069 0.1067
Plasmodium vivax proteasome subunit beta type-4, putative 0.0115 0.1363 0.1589
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0639 0.8403 1
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0115 0.1363 0.1589
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.1363 0.1589
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.1069 0.1067
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0115 0.1363 0.1361
Loa Loa (eye worm) hypothetical protein 0.0301 0.3863 0.4504
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0047 0.0441 0.0505
Brugia malayi hypothetical protein 0.0301 0.3863 0.4504
Loa Loa (eye worm) nuclear hormone receptor 0.0301 0.3863 0.4504
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0089 0.1013 0.118
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0115 0.1363 0.1589
Brugia malayi Dopamine receptor protein 1 0.0094 0.1069 0.1239
Plasmodium vivax proteasome subunit beta type-2, putative 0.0272 0.3467 0.4047
Echinococcus granulosus dro:myosuppressin receptor 0.0094 0.1069 0.1105
Leishmania major cytochrome p450-like protein 0.0089 0.1013 0.118
Schistosoma mansoni hypothetical protein 0.0032 0.0241 0.0238
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0089 0.1013 0.1174
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.1069 0.1067
Entamoeba histolytica phospholipase D, putative 0.0097 0.1113 0.1297
Loa Loa (eye worm) hypothetical protein 0.0301 0.3863 0.4504
Loa Loa (eye worm) G-protein coupled receptor 0.0094 0.1069 0.1239
Chlamydia trachomatis phospholipase D superfamily protein 0.0016 0.0017 0.5
Schistosoma mansoni hypothetical protein 0.0094 0.1069 0.1067
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0115 0.1363 0.141
Echinococcus granulosus proteasome subunit beta type 6 0.0115 0.1363 0.141
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0434 0.565 0.5852
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0089 0.1013 0.118
Giardia lamblia 20S proteasome alpha subunit 6 0.0115 0.1363 0.1591
Schistosoma mansoni coup transcription factor 0.0639 0.8403 0.8403
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0016 0.0017 0.5
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0301 0.3863 0.3861
Brugia malayi Proteasome subunit alpha type 1 0.0115 0.1363 0.1583
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0115 0.1363 0.1361
Brugia malayi Cytochrome P450 family protein 0.0124 0.1482 0.1722
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0115 0.1363 0.1589
Plasmodium vivax proteasome subunit beta type-5, putative 0.0651 0.8565 1
Onchocerca volvulus 0.006 0.0616 0.0672
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0115 0.1363 0.1589
Onchocerca volvulus 0.0094 0.1069 0.1215
Loa Loa (eye worm) hypothetical protein 0.0301 0.3863 0.4504
Loa Loa (eye worm) cytochrome P450 family protein 0.0089 0.1013 0.1174
Brugia malayi hypothetical protein 0.0301 0.3863 0.4504
Entamoeba histolytica hypothetical protein 0.0034 0.0265 0.0306
Brugia malayi hypothetical protein 0.0337 0.4349 0.5073
Brugia malayi nuclear hormone receptor family member nhr-6 0.0301 0.3863 0.4504
Brugia malayi hypothetical protein 0.0337 0.4349 0.5073
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0115 0.1363 0.1361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0639 0.8403 0.9811
Onchocerca volvulus 0.0094 0.1069 0.1215
Echinococcus granulosus phospholipase D1 0.0097 0.1113 0.1151
Giardia lamblia 20S proteasome alpha subunit 7 0.0115 0.1363 0.1591
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.1069 0.1067
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0009 0.0007
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0115 0.1363 0.1589
Onchocerca volvulus Neuropeptide F receptor homolog 0.0094 0.1069 0.1215
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Echinococcus granulosus proteasome subunit alpha type 2 0.0115 0.1363 0.141
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0094 0.1069 0.1239
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0118 0.1397 0.1629
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Loa Loa (eye worm) hypothetical protein 0.0639 0.8403 0.9811
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.1069 0.1105
Leishmania major proteasome alpha 1 subunit, putative 0.0115 0.1363 0.1589
Echinococcus multilocularis phospholipase D 0.0086 0.0961 0.0959
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0639 0.8403 0.9811
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0639 0.8403 0.8403
Echinococcus multilocularis neuropeptide receptor A26 0.0527 0.6904 0.6903
Brugia malayi Cytochrome P450 family protein 0.0089 0.1013 0.1174
Toxoplasma gondii proteasome subunit alpha type, putative 0.0115 0.1363 0.1589
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.1363 0.1589
Loa Loa (eye worm) hypothetical protein 0.0137 0.1659 0.1929
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0089 0.1013 0.1174
Echinococcus granulosus microtubule associated protein 2 0.065 0.8561 0.8867
Brugia malayi Dopamine receptor 0.0094 0.1069 0.1239
Schistosoma mansoni opsin-like receptor 0.0094 0.1069 0.1067
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.1363 0.1589
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0089 0.1013 0.118
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0301 0.3863 0.4
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0094 0.1069 0.1067
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.1957 0.0825
Loa Loa (eye worm) hypothetical protein 0.0301 0.3863 0.4504
Leishmania major proteasome alpha 1 subunit, putative 0.0115 0.1363 0.1589
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0639 0.8403 0.9811
Leishmania major proteasome alpha 3 subunit, putative 0.0115 0.1363 0.1589
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.1957 0.0825
Brugia malayi hypothetical protein 0.0094 0.1069 0.1239
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0639 0.8403 0.8705
Echinococcus granulosus orexin receptor type 2 0.0094 0.1069 0.1105
Loa Loa (eye worm) proteasome subunit beta type 2 0.0272 0.3467 0.4042
Brugia malayi nuclear hormone receptor 0.0301 0.3863 0.4504
Plasmodium falciparum mitochondrial cardiolipin synthase, putative 0.0016 0.0017 0.0018
Brugia malayi hypothetical protein 0.0094 0.1069 0.1239
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0651 0.8565 0.8565
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0115 0.1363 0.1583
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0115 0.1363 0.1591
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2073 0.0986
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0651 0.8565 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0009 0.0007
Echinococcus multilocularis G-protein coupled receptor, putative 0.0094 0.1069 0.1067
Trypanosoma cruzi cytochrome P450, putative 0.0124 0.1482 0.1728
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0115 0.1363 0.141
Schistosoma mansoni nuclear hormone receptor 0.0639 0.8403 0.8403
Brugia malayi nuclear receptor NHR-67 0.0301 0.3863 0.4504
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0094 0.1069 0.1239
Brugia malayi hypothetical protein 0.0094 0.1069 0.1239
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0115 0.1363 0.1589
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0054
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0337 0.4349 0.4348
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0115 0.1363 0.1589
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0089 0.1013 0.118
Loa Loa (eye worm) hypothetical protein 0.0337 0.4349 0.5073
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0094 0.1069 0.1067
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0089 0.1013 0.118
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.1957 0.0825
Echinococcus granulosus 7tm_1 domain containing protein 0.0094 0.1069 0.1105
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0009 0.0008
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0089 0.1013 0.118
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0115 0.1363 0.1589
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0243 0.3084 0.3594
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0115 0.1363 0.141
Schistosoma mansoni hypothetical protein 0.0015 0.0008 0.0006
Brugia malayi nuclear receptor NHR-88 0.0301 0.3863 0.4504
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.1069 0.1105
Loa Loa (eye worm) hypothetical protein 0.0301 0.3863 0.4504
Loa Loa (eye worm) hypothetical protein 0.0301 0.3863 0.4504
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.1069 0.1105
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0434 0.565 0.6596
Schistosoma mansoni hypothetical protein 0.0094 0.1069 0.1067
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0115 0.1363 0.1589
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.1069 0.1067
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0009 0.0007
Echinococcus granulosus dnaJ subfamily B 0.0385 0.4996 0.5174
Brugia malayi hypothetical protein 0.0034 0.0265 0.0299
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0434 0.565 0.5649
Loa Loa (eye worm) G-protein coupled receptor 0.0094 0.1069 0.1239
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0434 0.565 0.5649
Brugia malayi orphan nuclear receptor NR2E1 0.0301 0.3863 0.4504
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0115 0.1363 0.1361
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0115 0.1363 0.1589
Loa Loa (eye worm) hypothetical protein 0.0047 0.0441 0.0505
Schistosoma mansoni growth hormone secretagogue receptor 0.0094 0.1069 0.1067
Plasmodium vivax proteasome subunit beta type-1, putative 0.0434 0.565 0.6596
Brugia malayi proteasome subunit beta type 3 0.0115 0.1363 0.1583
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0632 0.8314 0.9706
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0115 0.1363 0.1361
Schistosoma mansoni cpg binding protein 0.0029 0.0193 0.0191
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0115 0.1363 0.1589
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0337 0.4349 0.4504
Echinococcus multilocularis somatostatin receptor 0.0094 0.1069 0.1067
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0651 0.8565 1
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0115 0.1363 0.1361
Echinococcus granulosus alpha 1A adrenergic receptor 0.0094 0.1069 0.1105
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0243 0.3084 0.3594
Brugia malayi Dopamine receptor protein 2 0.0094 0.1069 0.1239
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0115 0.1363 0.1361
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0115 0.1363 0.1589
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0115 0.1363 0.0463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.1069 0.1067
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0115 0.1363 0.1589
Brugia malayi proteasome subunit alpha type 6 0.0115 0.1363 0.1583
Trypanosoma brucei cardiolipin synthetase, putative 0.0034 0.0263 0.0305
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0115 0.1363 0.1589
Brugia malayi putative neuropeptide receptor NPR1 0.0094 0.1069 0.1239
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0089 0.1013 0.118
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0434 0.565 0.5952
Mycobacterium ulcerans proteasome PrcA 0.0115 0.1363 0.1589
Schistosoma mansoni steroid hormone receptor ad4bp 0.0639 0.8403 0.8403
Echinococcus multilocularis fmrfamide receptor 0.0094 0.1069 0.1067
Schistosoma mansoni histamine h1 receptor 0.0094 0.1069 0.1067
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0639 0.8403 0.9811
Brugia malayi proteasome subunit alpha type 3 0.0115 0.1363 0.1583
Brugia malayi CXXC zinc finger family protein 0.0027 0.0173 0.0192
Brugia malayi nuclear receptor NHR-88 0.0639 0.8403 0.9811
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0639 0.8403 0.8403
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0094 0.1069 0.1239
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0639 0.8403 0.9811
Entamoeba histolytica hypothetical protein 0.0034 0.0265 0.0306
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0115 0.1363 0.1361
Schistosoma mansoni thyroid hormone receptor 0.0757 1 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0301 0.3863 0.4
Brugia malayi proteasome subunit beta type 1 0.0434 0.565 0.6593
Giardia lamblia 20S proteasome alpha subunit 2 0.0115 0.1363 0.1591
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0089 0.1013 0.1174
Loa Loa (eye worm) proteasome subunit beta type 3 0.0115 0.1363 0.1583
Onchocerca volvulus 0.0094 0.1069 0.1215
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0272 0.3467 0.4047
Trypanosoma cruzi Emopamil binding protein, putative 0.0118 0.1397 0.1629
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2073 0.0986
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0115 0.1363 0.1589
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0094 0.1069 0.1239
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0639 0.8403 0.9811
Echinococcus granulosus ecdysone induced protein 78C 0.0639 0.8403 0.8705
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0639 0.8403 0.8403
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0115 0.1363 0.1589
Leishmania major cytochrome p450-like protein 0.0124 0.1482 0.1728
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0301 0.3863 0.3861
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0115 0.1363 0.1589
Brugia malayi RE15519p 0.0094 0.1069 0.1239
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0119 0.1405 0.1453
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0115 0.1363 0.1589
Onchocerca volvulus 0.0094 0.1069 0.1215
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0115 0.1363 0.1361
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0115 0.1363 0.1589
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0115 0.1363 0.1589
Echinococcus multilocularis phospholipase D1 0.0097 0.1113 0.1111
Brugia malayi sulfakinin receptor protein 0.0094 0.1069 0.1239
Onchocerca volvulus Notchless protein homolog 0.0115 0.1363 0.1567
Schistosoma mansoni hypothetical protein 0.0094 0.1069 0.1067
Entamoeba histolytica hypothetical protein 0.0034 0.0265 0.0306
Schistosoma mansoni amine GPCR 0.0094 0.1069 0.1067
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0639 0.8403 0.8403
Schistosoma mansoni CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 0.0016 0.0017 0.0015
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0009 0.0008
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0115 0.1363 0.1589
Loa Loa (eye worm) cytochrome P450 family protein 0.0124 0.1482 0.1722
Brugia malayi proteasome subunit beta type 2 0.0272 0.3467 0.4042
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Echinococcus multilocularis 0.0089 0.1013 0.1011
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0089 0.1013 0.118
Brugia malayi Proteasome A-type and B-type family protein 0.0115 0.1363 0.1583
Brugia malayi AKH receptor 0.0094 0.1069 0.1239
Brugia malayi hypothetical protein 0.0094 0.1069 0.1239
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0094 0.1069 0.1239
Schistosoma mansoni adenoreceptor 0.0094 0.1069 0.1067
Onchocerca volvulus 0.0094 0.1069 0.1215
Echinococcus granulosus neuropeptide receptor A26 0.0527 0.6904 0.7151
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Loa Loa (eye worm) hypothetical protein 0.0301 0.3863 0.4504
Schistosoma mansoni hypothetical protein 0.016 0.1958 0.1956
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0115 0.1363 0.1589
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Echinococcus granulosus neuropeptide receptor 0.0094 0.1069 0.1105
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0272 0.3467 0.359
Onchocerca volvulus 0.0094 0.1069 0.1215
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0115 0.1363 0.1589
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0394 0.5113 0.5112
Brugia malayi Phospholipase D. Active site motif family protein 0.0034 0.0263 0.0298
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0115 0.1363 0.1589
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Brugia malayi Phospholipase d protein 1 0.0097 0.1113 0.1291
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0639 0.8403 0.9811
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0115 0.1363 0.1589
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0094 0.1069 0.1067
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0115 0.1363 0.1589
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0115 0.1363 0.1589
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0639 0.8403 0.9811
Loa Loa (eye worm) phospholipase D 0.0018 0.0055 0.0054
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0639 0.8403 0.8403
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0115 0.1363 0.1589
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0115 0.1363 0.1589
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0639 0.8403 0.9811
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0639 0.8403 0.9811
Brugia malayi conserved hypotetical protein 0.0301 0.3863 0.4504
Loa Loa (eye worm) CYP4Cod1 0.0124 0.1482 0.1722
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.1069 0.1067
Loa Loa (eye worm) hypothetical protein 0.0081 0.0904 0.1047
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0115 0.1363 0.1361
Toxoplasma gondii peptidase, T1 family protein 0.0115 0.1363 0.1589
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0094 0.1069 0.1067
Echinococcus multilocularis cpg binding protein 0.0029 0.0193 0.0191
Schistosoma mansoni zinc finger protein 0.0301 0.3863 0.3861
Echinococcus granulosus cytochrome P450 2K1 0.0089 0.1013 0.1047
Plasmodium falciparum proteasome subunit beta type-4 0.0115 0.1363 0.1589
Loa Loa (eye worm) hypothetical protein 0.0337 0.4349 0.5073
Echinococcus granulosus fmrfamide receptor 0.0094 0.1069 0.1105
Echinococcus granulosus Nuclear hormone receptor HR96 0.0301 0.3863 0.4
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0115 0.1363 0.1583
Echinococcus multilocularis neuropeptides capa receptor 0.0094 0.1069 0.1067
Schistosoma mansoni neuropeptide F-like receptor 0.0094 0.1069 0.1067
Echinococcus granulosus 7TM GPCR rhodopsin 0.0094 0.1069 0.1105
Trichomonas vaginalis glucosylceramidase, putative 0.0243 0.3084 0.2389
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0094 0.1069 0.1067
Loa Loa (eye worm) PAS-3 protein 0.0115 0.1363 0.1583
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0301 0.3863 0.4561
Trypanosoma cruzi Emopamil binding protein, putative 0.0118 0.1397 0.1629
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0115 0.1363 0.1589
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0434 0.565 0.6596
Brugia malayi Steroid receptor seven-up type 2 0.0639 0.8403 0.9811
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0115 0.1363 0.1583
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0115 0.1363 0.1589
Brugia malayi nuclear receptor RXR 0.0337 0.4349 0.5073
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0337 0.4349 0.4348
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0009 0.0008
Echinococcus granulosus peptide allatostatin:somatostatin 0.0094 0.1069 0.1105
Leishmania major proteasome alpha 7 subunit, putative 0.0115 0.1363 0.1589
Echinococcus multilocularis phospholipase d3 0.0018 0.0055 0.0052
Echinococcus granulosus phospholipase D 0.0086 0.0961 0.0993
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0115 0.1363 0.1589
Brugia malayi G protein-coupled receptor 0.0094 0.1069 0.1239
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0639 0.8403 0.8705
Schistosoma mansoni hypothetical protein 0.0034 0.0265 0.0262
Echinococcus multilocularis nuclear receptor nhr 48 0.0301 0.3863 0.3861
Plasmodium falciparum phosphatidylglycerophosphate synthase 0.0016 0.0017 0.0018
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0115 0.1363 0.1583
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0115 0.1363 0.1589
Echinococcus granulosus g protein coupled receptor 0.0094 0.1069 0.1105
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0301 0.3863 0.4504
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0094 0.1069 0.1067
Onchocerca volvulus 0.0094 0.1069 0.1215
Schistosoma mansoni myosin xvIII 0.0094 0.1069 0.1067
Schistosoma mansoni nuclear receptor nhr-48 0.0301 0.3863 0.3861
Trichomonas vaginalis glucosylceramidase, putative 0.0243 0.3084 0.2389
Leishmania major proteasome beta-1 subunit, putative 0.0115 0.1363 0.1589
Loa Loa (eye worm) hypothetical protein 0.0639 0.8403 0.9811
Schistosoma mansoni hypothetical protein 0.0015 0.0008 0.0006
Trypanosoma cruzi cytochrome P450, putative 0.0124 0.1482 0.1728
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0089 0.1013 0.118
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0008 0.0006
Schistosoma mansoni nuclear receptor 0.0301 0.3863 0.3861
Echinococcus multilocularis g protein coupled receptor 0.0094 0.1069 0.1067
Schistosoma mansoni amine GPCR 0.0094 0.1069 0.1067
Echinococcus granulosus nuclear receptor nhr 48 0.0301 0.3863 0.4
Brugia malayi Proteasome subunit alpha type 7-1 0.0115 0.1363 0.1583
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0089 0.1013 0.1174
Brugia malayi Melatonin receptor type 1A 0.0094 0.1069 0.1239
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0089 0.1013 0.1174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0639 0.8403 0.9811
Giardia lamblia Proteasome subunit beta type 2 0.0272 0.3467 0.4048
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0089 0.1013 0.118
Schistosoma mansoni phospholipase D 0.0097 0.1113 0.1111
Echinococcus multilocularis neuropeptide s receptor 0.0527 0.6904 0.6903
Loa Loa (eye worm) hypothetical protein 0.0301 0.3863 0.4504
Trypanosoma brucei cytochrome P450, putative 0.0124 0.1482 0.1728
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0639 0.8403 0.8403
Echinococcus multilocularis g-protein coupled receptor 0.0094 0.1069 0.1067
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0639 0.8403 0.9811
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0301 0.3863 0.4561
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0639 0.8403 0.8705
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.1069 0.1105
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0115 0.1363 0.1589
Onchocerca volvulus 0.0118 0.1397 0.1608
Plasmodium vivax proteasome subunit beta type-7, putative 0.0115 0.1363 0.1589
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0094 0.1069 0.1067
Echinococcus granulosus neuropeptides capa receptor 0.0094 0.1069 0.1105
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0115 0.1363 0.1589
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0094 0.1069 0.1105
Brugia malayi Proteasome A-type and B-type family protein 0.0115 0.1363 0.1583
Trypanosoma brucei proteasome alpha 7 subunit 0.0115 0.1363 0.1589
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0094 0.1069 0.1239
Trypanosoma cruzi cardiolipin synthetase, putative 0.0034 0.0263 0.0305
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0089 0.1013 0.1174
Brugia malayi nuclear hormone receptor family member odr-7 0.0301 0.3863 0.4504
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0115 0.1363 0.1589
Brugia malayi Nuclear hormone receptor-like 1 0.0639 0.8403 0.9811
Plasmodium vivax proteasome subunit beta type-3, putative 0.0115 0.1363 0.1589
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0639 0.8403 0.9811
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0115 0.1363 0.1583
Giardia lamblia 20S proteasome alpha subunit 3 0.0115 0.1363 0.1591
Brugia malayi neuropeptide F receptor 0.0094 0.1069 0.1239
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0089 0.1013 0.118
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0089 0.1013 0.118
Loa Loa (eye worm) hypothetical protein 0.0337 0.4349 0.5073
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0094 0.1069 0.1067
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0115 0.1363 0.1589
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0008 0.0006
Entamoeba histolytica phospholipase D active site domain-containing protein 0.0081 0.0904 0.1053
Echinococcus granulosus proteasome prosome macropain 0.0651 0.8565 0.8872
Echinococcus granulosus sex peptide receptor 0.0094 0.1069 0.1105
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0115 0.1363 0.1361
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0034 0.0265 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0639 0.8403 0.9811
Trypanosoma brucei Emopamil binding protein, putative 0.0118 0.1397 0.1629
Loa Loa (eye worm) hypothetical protein 0.0639 0.8403 0.9811
Schistosoma mansoni RAR-like nuclear receptor 0.0639 0.8403 0.8403
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0124 0.1482 0.1728
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0094 0.1069 0.1067
Schistosoma mansoni biogenic amine receptor 0.0094 0.1069 0.1067
Onchocerca volvulus Protein ultraspiracle homolog 0.0639 0.8403 1
Echinococcus multilocularis serotonin receptor 0.0094 0.1069 0.1067
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Toxoplasma gondii proteasome beta subunit 0.0115 0.1363 0.1589
Onchocerca volvulus 0.0094 0.1069 0.1215
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0115 0.1363 0.1589
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.1069 0.1067
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0115 0.1363 0.1361
Echinococcus multilocularis proteasome subunit alpha type 6 0.0115 0.1363 0.1361
Giardia lamblia Proteasome subunit beta type 3 0.0115 0.1363 0.1591
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Echinococcus granulosus Nuclear hormone receptor HR96 0.0301 0.3863 0.4
Loa Loa (eye worm) hypothetical protein 0.0639 0.8403 0.9811
Loa Loa (eye worm) hypothetical protein 0.0063 0.0658 0.0759
Brugia malayi 20S proteasome alpha5 subunit 0.0115 0.1363 0.1583
Leishmania major cytochrome p450-like protein 0.0089 0.1013 0.118
Trypanosoma cruzi cardiolipin synthetase, putative 0.0034 0.0263 0.0305
Echinococcus multilocularis geminin 0.016 0.1958 0.1956
Loa Loa (eye worm) proteasome subunit beta type 1 0.0434 0.565 0.6593
Schistosoma mansoni cpg binding protein 0.0029 0.0193 0.0191
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Echinococcus granulosus neuropeptide FF receptor 2 0.0094 0.1069 0.1105
Echinococcus granulosus neuropeptides capa receptor 0.0094 0.1069 0.1105
Schistosoma mansoni nuclear hormone receptor 0.0301 0.3863 0.3861
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0272 0.3467 0.2922
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0115 0.1363 0.1589
Loa Loa (eye worm) hypothetical protein 0.0301 0.3863 0.4504
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0009 0.0008
Schistosoma mansoni cpg binding protein 0.0027 0.0173 0.017
Echinococcus multilocularis allatostatin A receptor 0.0094 0.1069 0.1067
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0089 0.1013 0.118
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0094 0.1069 0.1239
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0115 0.1363 0.1589
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0089 0.1013 0.118
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0115 0.1363 0.1583
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.1069 0.1067
Loa Loa (eye worm) nuclear receptor NHR-67 0.0301 0.3863 0.4504
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Trichomonas vaginalis glucosylceramidase, putative 0.0243 0.3084 0.2389
Chlamydia trachomatis phospholipase D superfamily protein 0.0016 0.0017 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0094 0.1069 0.1067
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0115 0.1363 0.1589
Brugia malayi hypothetical protein 0.0094 0.1069 0.1239
Echinococcus granulosus cpg binding protein 0.0029 0.0193 0.0198
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0047 0.0441 0.0505
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0639 0.8403 0.8705
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0089 0.1013 0.118
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.0241 0.0271
Echinococcus multilocularis neuropeptide receptor 0.0094 0.1069 0.1067
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0089 0.1013 0.1174
Echinococcus multilocularis neuropeptide Y receptor 0.0094 0.1069 0.1067
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0094 0.1069 0.1067
Brugia malayi hypothetical protein 0.0094 0.1069 0.1239
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0115 0.1363 0.1589
Brugia malayi hypothetical protein 0.0016 0.0017 0.001
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0118 0.1397 0.1629
Schistosoma mansoni hypothetical protein 0.016 0.1958 0.1956
Onchocerca volvulus 0.0027 0.0173 0.0142
Schistosoma mansoni amine GPCR 0.0094 0.1069 0.1067
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0094 0.1069 0.1105
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0089 0.1013 0.1174
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0009 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.1069 0.1105
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0089 0.1013 0.1174
Giardia lamblia Proteasome subunit beta type 1 0.0434 0.565 0.6597
Schistosoma mansoni neuropeptide f receptor 76f 0.0094 0.1069 0.1067
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0115 0.1363 0.1589
Brugia malayi hypothetical protein 0.0094 0.1069 0.1239
Loa Loa (eye worm) hypothetical protein 0.0337 0.4349 0.5073
Echinococcus granulosus G protein coupled receptor 139 0.0094 0.1069 0.1105
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.1069 0.1067
Echinococcus granulosus g-protein coupled receptor 0.0094 0.1069 0.1105
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0115 0.1363 0.1589
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0115 0.1363 0.1589
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Brugia malayi proteasome subunit alpha type 4 0.0115 0.1363 0.1583
Onchocerca volvulus 0.0094 0.1069 0.1215
Brugia malayi Serotonin receptor 0.0094 0.1069 0.1239
Leishmania major phosphatidylglycerophosphate synthase, putative 0.0018 0.0055 0.0061
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0089 0.1013 0.1174
Leishmania major cardiolipin synthetase, putative 0.0016 0.0017 0.0018
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0115 0.1363 0.1591
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0115 0.1363 0.1361
Loa Loa (eye worm) DR-78 0.0301 0.3863 0.4504
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Schistosoma mansoni thyroid hormone receptor 0.0757 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.1069 0.1067
Loa Loa (eye worm) hypothetical protein 0.0035 0.0277 0.0314
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0115 0.1363 1
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0115 0.1363 0.1361
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Brugia malayi ecdysone receptor 0.0301 0.3863 0.4504
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0115 0.1363 0.1361
Brugia malayi G protein-coupled receptor F59B2.13 0.0094 0.1069 0.1239
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.1069 0.1067
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0119 0.1405 0.1403
Loa Loa (eye worm) steroid hormone receptor 0.0639 0.8403 0.9811
Trichomonas vaginalis glucosylceramidase, putative 0.0243 0.3084 0.2389
Echinococcus granulosus Proteasome subunit alpha type 7 0.0115 0.1363 0.141
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0115 0.1363 0.1589
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.1363 0.1589
Brugia malayi Cytochrome P450 family protein 0.0124 0.1482 0.1722
Loa Loa (eye worm) hypothetical protein 0.006 0.0616 0.071
Loa Loa (eye worm) neuropeptide F receptor 0.0094 0.1069 0.1239
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0115 0.1363 0.1589
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.1957 0.0825
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0009 0.0008
Echinococcus granulosus Proteasome subunit alpha beta 0.0115 0.1363 0.141
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0094 0.1069 0.1239
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.1069 0.1067
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0089 0.1013 0.1174
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0639 0.8403 0.8403
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0272 0.3467 0.4047
Echinococcus granulosus tachykinin peptides receptor 99D 0.0094 0.1069 0.1105
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0115 0.1363 0.1361
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0016 0.0017 0.5
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0115 0.1363 0.1589
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.1957 0.0825
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0639 0.8403 0.9811
Loa Loa (eye worm) hypothetical protein 0.0301 0.3863 0.4504
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0089 0.1013 0.118
Echinococcus multilocularis FTZ F1 alpha 0.0639 0.8403 0.8403
Schistosoma mansoni neuropeptide receptor 0.0094 0.1069 0.1067
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0094 0.1069 0.1067
Loa Loa (eye worm) hypothetical protein 0.0032 0.0241 0.0271
Brugia malayi neuropeptide F receptor 0.0094 0.1069 0.1239
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0639 0.8403 0.8403
Toxoplasma gondii proteasome subunit beta type, putative 0.0651 0.8565 1
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0115 0.1363 0.1589
Echinococcus granulosus g protein coupled receptor 0.0094 0.1069 0.1105
Echinococcus granulosus tm gpcr rhodopsin 0.0094 0.1069 0.1105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0639 0.8403 0.9811
Onchocerca volvulus Bile acid receptor homolog 0.0639 0.8403 1
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0651 0.8565 1
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0115 0.1363 0.1589
Echinococcus granulosus somatostatin receptor 0.0094 0.1069 0.1105
Loa Loa (eye worm) hypothetical protein 0.0301 0.3863 0.4504
Echinococcus granulosus neuropeptide Y receptor 0.0094 0.1069 0.1105
Echinococcus multilocularis fmrfamide receptor 0.0094 0.1069 0.1067
Echinococcus granulosus hypothetical protein 0.0094 0.1069 0.1105
Echinococcus multilocularis dnaJ subfamily B 0.0385 0.4996 0.4995
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0089 0.1013 0.118
Echinococcus multilocularis g protein coupled receptor 0.0094 0.1069 0.1067
Schistosoma mansoni opsin-like receptor 0.0094 0.1069 0.1067
Toxoplasma gondii histone lysine methyltransferase SET1 0.0051 0.0498 0.0579
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0434 0.565 0.6596
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Onchocerca volvulus 0.0094 0.1069 0.1215
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.1069 0.1067
Giardia lamblia 20S proteasome alpha subunit 4 0.0115 0.1363 0.1591
Echinococcus multilocularis orexin receptor type 2 0.0094 0.1069 0.1067
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0632 0.8314 0.9706
Schistosoma mansoni neuropeptide receptor 0.0094 0.1069 0.1067
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0115 0.1363 0.1589
Leishmania major proteasome alpha 7 subunit, putative 0.0115 0.1363 0.1589
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0115 0.1363 0.1589
Toxoplasma gondii phospholipase D active site domain-containing protein 0.0034 0.0263 0.0305
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0009 0.0007
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0094 0.1069 0.1067
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0115 0.1363 0.1589
Schistosoma mansoni biogenic amine (5HT) receptor 0.0094 0.1069 0.1067
Schistosoma mansoni transcription factor LCR-F1 0.0034 0.0265 0.0262
Trichomonas vaginalis glucosylceramidase, putative 0.0243 0.3084 0.2389
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0009 0.0007
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0115 0.1363 0.1583
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0651 0.8565 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0094 0.1069 0.1239
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0272 0.3467 0.4047
Schistosoma mansoni neuropeptide receptor 0.0094 0.1069 0.1067
Loa Loa (eye worm) hypothetical protein 0.0632 0.8314 0.9706
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0089 0.1013 0.118
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0115 0.1363 0.1589
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0089 0.1013 0.1174
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Plasmodium falciparum proteasome subunit beta type-5 0.0651 0.8565 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0089 0.1013 0.1174
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0272 0.3467 0.4047
Brugia malayi Phospholipase D. Active site motif family protein 0.0018 0.0055 0.0054
Trypanosoma cruzi 20S proteasome subunit 0.0272 0.3467 0.4047
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0115 0.1363 0.1361
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0009 0.0008
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0009 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0089 0.1013 0.1174
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.1069 0.1067
Loa Loa (eye worm) hypothetical protein 0.0063 0.0658 0.0759
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Onchocerca volvulus 0.0639 0.8403 1
Schistosoma mansoni microtubule-associated protein tau 0.065 0.8561 0.856
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0115 0.1363 0.1361
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0115 0.1363 0.1589
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0639 0.8403 0.8705
Giardia lamblia 20S proteasome alpha subunit 1 0.0115 0.1363 0.1591
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0115 0.1363 0.1361
Brugia malayi putative neuropeptide receptor 0.0094 0.1069 0.1239
Loa Loa (eye worm) cytochrome P450 family protein 0.0124 0.1482 0.1722
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0301 0.3863 0.3861
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0057 0.0581 0.0579
Brugia malayi hypothetical protein 0.0094 0.1069 0.1239
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0639 0.8403 0.8403
Trichomonas vaginalis glucosylceramidase, putative 0.0243 0.3084 0.2389
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0434 0.565 0.6596
Schistosoma mansoni nuclear receptor 0.0301 0.3863 0.3861
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0089 0.1013 0.118
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0651 0.8565 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0337 0.4349 0.4348
Loa Loa (eye worm) hypothetical protein 0.0301 0.3863 0.4504
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0115 0.1363 0.1361
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0094 0.1069 0.1105
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Toxoplasma gondii proteasome subunit alpha1, putative 0.0115 0.1363 0.1589
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0301 0.3863 0.4504
Trypanosoma brucei proteasome beta 7 subunit 0.0115 0.1363 0.1589
Onchocerca volvulus 0.0094 0.1069 0.1215
Leishmania major proteasome alpha 2 subunit, putative 0.0115 0.1363 0.1589
Brugia malayi follicle stimulating hormone receptor 0.0094 0.1069 0.1239
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0089 0.1013 0.1174
Schistosoma mansoni hypothetical protein 0.0094 0.1069 0.1067
Mycobacterium ulcerans proteasome PrcB 0.0651 0.8565 1
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0115 0.1363 0.1591
Entamoeba histolytica phospholipase D, putative 0.0097 0.1113 0.1297
Echinococcus multilocularis GPCR, family 2 0.0015 0.0008 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.1069 0.1105
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Onchocerca volvulus 0.0094 0.1069 0.1215
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0094 0.1069 0.1067
Echinococcus multilocularis g protein coupled receptor 0.0094 0.1069 0.1067
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0639 0.8403 0.9811
Echinococcus multilocularis proteasome subunit alpha type 2 0.0115 0.1363 0.1361
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0115 0.1363 0.1361
Echinococcus granulosus g protein coupled receptor 0.0094 0.1069 0.1105
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.1363 0.1589
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0094 0.1069 0.1067
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0115 0.1363 0.1589
Schistosoma mansoni neuropeptide F-like receptor 0.0094 0.1069 0.1067
Schistosoma mansoni nuclear hormone receptor 0.0301 0.3863 0.3861
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0094 0.1069 0.1067
Echinococcus multilocularis neuropeptides capa receptor 0.0094 0.1069 0.1067
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0115 0.1363 0.1361
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0094 0.1069 0.1105
Brugia malayi ecdysteroid receptor 0.0639 0.8403 0.9811
Echinococcus multilocularis proteasome subunit beta type 7 0.0115 0.1363 0.1361
Brugia malayi tailless protein 0.0301 0.3863 0.4504
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0651 0.8565 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.001
Brugia malayi Serotonin receptor 0.0094 0.1069 0.1239
Echinococcus granulosus biogenic amine 5HT receptor 0.0094 0.1069 0.1105
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0115 0.1363 0.1589
Brugia malayi hypothetical protein 0.0094 0.1069 0.1239
Leishmania major proteasome beta 5 subunit, putative 0.0651 0.8565 1
Echinococcus multilocularis G protein coupled receptor 139 0.0094 0.1069 0.1067
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0651 0.8565 1
Brugia malayi nuclear hormone receptor 0.0639 0.8403 0.9811
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0016 0.0017 0.5
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0115 0.1363 0.1583
Leishmania major proteasome beta 7 subunit, putative 0.0115 0.1363 0.1589
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Echinococcus granulosus neuropeptide Y receptor 0.0094 0.1069 0.1105
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0639 0.8403 0.8403
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0089 0.1013 0.118
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0115 0.1363 0.1589
Onchocerca volvulus 0.0094 0.1069 0.1215
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0089 0.1013 0.1174
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0094 0.1069 0.1067
Onchocerca volvulus 0.0094 0.1069 0.1215
Echinococcus granulosus phospholipase d3 0.0018 0.0055 0.0054
Toxoplasma gondii cytochrome p450 superfamily protein 0.0089 0.1013 0.118
Echinococcus multilocularis dro:myosuppressin receptor 0.0094 0.1069 0.1067
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0089 0.1013 0.118
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0651 0.8565 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0173 0.0192
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Brugia malayi G-protein coupled receptor 0.0094 0.1069 0.1239
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0094 0.1069 0.1105
Entamoeba histolytica hypothetical protein 0.0034 0.0265 0.0306
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0301 0.3863 0.3861
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0434 0.565 0.6596
Brugia malayi Proteasome A-type and B-type family protein 0.0651 0.8565 1
Toxoplasma gondii heat shock protein hslv, putative 0.0115 0.1363 0.1589
Schistosoma mansoni opsin-like receptor 0.0094 0.1069 0.1067
Echinococcus granulosus tm gpcr rhodopsin 0.0094 0.1069 0.1105
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.1069 0.1067
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0115 0.1363 0.1589
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.1069 0.1067
Echinococcus multilocularis proteasome subunit beta type 6 0.0115 0.1363 0.1361
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0094 0.1069 0.1067
Trypanosoma brucei cardiolipin synthetase 0.0034 0.0263 0.0305
Loa Loa (eye worm) hypothetical protein 0.0094 0.1069 0.1239
Echinococcus multilocularis ecdysone induced protein 78C 0.0639 0.8403 0.8403
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0115 0.1363 0.1583
Brugia malayi steroid hormone receptor 0.0639 0.8403 0.9811
Brugia malayi hypothetical protein 0.0094 0.1069 0.1239
Echinococcus granulosus proteasome subunit beta t family 0.0115 0.1363 0.141
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0089 0.1013 0.1174
Schistosoma mansoni hypothetical protein 0.0089 0.1013 0.1011
Echinococcus multilocularis microtubule associated protein 2 0.065 0.8561 0.856
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0639 0.8403 0.9811
Echinococcus granulosus thyroid hormone receptor alpha 0.0301 0.3863 0.4
Leishmania major hypothetical protein, conserved 0.0118 0.1397 0.1629
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0115 0.1363 0.1589
Brugia malayi photoreceptor-specific nuclear receptor 0.0639 0.8403 0.9811
Leishmania major proteasome beta 2 subunit, putative 0.0115 0.1363 0.1589
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0094 0.1069 0.1067
Schistosoma mansoni biogenic amine (5HT) receptor 0.0094 0.1069 0.1067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0639 0.8403 0.9811
Echinococcus granulosus FTZ F1 alpha 0.0639 0.8403 0.8705
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0115 0.1363 0.1589
Schistosoma mansoni hypothetical protein 0.0015 0.0008 0.0006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0034 0.0265 0.0262
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0089 0.1013 0.1174
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0089 0.1013 0.1174
Schistosoma mansoni amine GPCR 0.0094 0.1069 0.1067
Onchocerca volvulus 0.0094 0.1069 0.1215
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0094 0.1069 0.1067
Leishmania major proteasome beta 2 subunit, putative 0.0272 0.3467 0.4047
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0301 0.3863 0.3861
Plasmodium vivax phosphatidylglycerophosphate synthase, putative 0.0016 0.0017 0.0018
Schistosoma mansoni hypothetical protein 0.0385 0.4996 0.4995
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0094 0.1069 0.1067
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0089 0.1013 0.118
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0272 0.3467 0.3466
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0272 0.3467 0.3466
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0115 0.1363 0.1589
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0272 0.3467 0.3466
Echinococcus granulosus serotonin receptor 0.0094 0.1069 0.1105
Echinococcus granulosus biogenic amine 5HT receptor 0.0094 0.1069 0.1105
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0651 0.8565 1
Plasmodium vivax proteasome subunit beta type-6, putative 0.0115 0.1363 0.1589
Loa Loa (eye worm) cytochrome P450 0.0089 0.1013 0.1174
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0094 0.1069 0.1067

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1573 nM Concentration required to inhibit electrically induced contractions in isolated mouse vas deferens preparation in vitro ChEMBL. 7636873
IC50 (functional) = 1573 nM Concentration required to inhibit electrically induced contractions in isolated mouse vas deferens preparation in vitro ChEMBL. 7636873
Inhibition (binding) = -5 % Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes. ChEMBL. 7636873
Inhibition (binding) = -5 % Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes. ChEMBL. 7636873

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 7636873

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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