Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.0079 | 0.1323 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0019 | 0.0079 | 0.1323 |
Loa Loa (eye worm) | ctsf protein | 0.0019 | 0.0079 | 0.0941 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0013 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0064 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0064 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0064 | 0.0671 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0079 | 0.0599 | 1 |
Plasmodium vivax | vivapain-2 | 0.0019 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0079 | 0.0599 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.1173 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.1173 | 1 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.1173 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0013 | 0.0025 | 0.0421 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0017 | 0.0064 | 0.1063 |
Loa Loa (eye worm) | cysteine protease | 0.0019 | 0.0079 | 0.0941 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0017 | 0.0064 | 0.0671 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0017 | 0.0064 | 0.1063 |
Onchocerca volvulus | 0.0019 | 0.0079 | 0.0941 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.0079 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Onchocerca volvulus | Cathepsin L homolog | 0.0019 | 0.0079 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0064 | 0.0671 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0017 | 0.0064 | 0.1063 |
Leishmania major | oxidoreductase-like protein | 0.0079 | 0.0599 | 1 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0079 | 0.0599 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.0079 | 0.1323 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0017 | 0.0064 | 0.1063 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0017 | 0.0064 | 0.1063 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0013 | 0.0025 | 0.0421 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0079 | 0.1323 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0072 | 0.0538 | 0.8988 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0079 | 0.0599 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0019 | 0.0079 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Brugia malayi | Cathepsin L-like precursor | 0.0013 | 0.0025 | 0.0421 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0017 | 0.0064 | 0.1063 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0079 | 0.0599 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0064 | 0.0671 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0017 | 0.0064 | 0.1063 |
Brugia malayi | Cathepsin L-like precursor | 0.0013 | 0.0025 | 0.0421 |
Trypanosoma brucei | pteridine reductase 1 | 0.0079 | 0.0599 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Brugia malayi | cathepsin L-like precursor | 0.0013 | 0.0025 | 0.0421 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0017 | 0.0064 | 0.0671 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0017 | 0.0064 | 0.1063 |
Loa Loa (eye worm) | fibroinase | 0.0019 | 0.0079 | 0.0941 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.1173 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0072 | 0.0538 | 0.8834 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0538 | 0.8988 |
Leishmania major | cathepsin L-like protease | 0.0072 | 0.0538 | 0.8834 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0538 | 0.8988 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0017 | 0.0064 | 0.1063 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0538 | 0.8988 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0017 | 0.0064 | 0.1063 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0079 | 0.0599 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0019 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | oxidoreductase | 0.0079 | 0.0599 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0079 | 0.1323 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0019 | 0.0079 | 0.1323 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0079 | 0.0599 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.1173 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0017 | 0.0064 | 0.1063 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0079 | 0.0599 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0079 | 0.0599 | 1 |
Toxoplasma gondii | 3-ketoacyl-(acyl-carrier-protein) reductase | 0.0079 | 0.0599 | 0.0524 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Onchocerca volvulus | 0.0019 | 0.0079 | 0.0941 | |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0057 | 0.0405 | 0.6764 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0019 | 0.0079 | 0.1323 |
Onchocerca volvulus | 0.0019 | 0.0079 | 0.0941 | |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0017 | 0.0064 | 0.1063 |
Onchocerca volvulus | 0.0079 | 0.0599 | 1 | |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.0079 | 0.0599 | 0.0599 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0017 | 0.0064 | 0.0671 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0538 | 0.8988 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0017 | 0.0064 | 0.1063 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Schistosoma mansoni | nuclear hormone receptor | 0.0017 | 0.0064 | 0.1063 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0017 | 0.0064 | 0.1063 |
Schistosoma mansoni | dihydropteridine reductase | 0.0079 | 0.0599 | 1 |
Leishmania major | cathepsin L-like protease | 0.0072 | 0.0538 | 0.8834 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0538 | 0.8988 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0017 | 0.0064 | 0.1063 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0017 | 0.0064 | 0.1063 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0017 | 0.0064 | 0.1063 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0019 | 0.0079 | 0.0941 |
Entamoeba histolytica | cysteine protease, putative | 0.0019 | 0.0079 | 0.1323 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0017 | 0.0064 | 0.1063 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0599 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0017 | 0.0064 | 0.1063 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0072 | 0.0538 | 0.8988 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0017 | 0.0064 | 0.1063 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0064 | 0.0671 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0017 | 0.0064 | 0.1063 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0017 | 0.0064 | 0.1063 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0017 | 0.0064 | 0.1063 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0017 | 0.0064 | 0.1063 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0017 | 0.0064 | 0.0671 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0013 | 0.0025 | 0.0421 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0079 | 0.0599 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0017 | 0.0064 | 0.1063 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.1173 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0017 | 0.0064 | 0.1063 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0079 | 0.1323 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0066 | 0.0484 | 0.8086 |
Schistosoma mansoni | thyroid hormone receptor | 0.0017 | 0.0064 | 0.1063 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0079 | 0.0599 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0079 | 0.1323 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0017 | 0.0064 | 0.1063 |
Onchocerca volvulus | 0.0019 | 0.0079 | 0.0941 | |
Brugia malayi | steroid hormone receptor | 0.0017 | 0.0064 | 0.1063 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0017 | 0.0064 | 0.1063 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.0079 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0013 | 0.0025 | 0.0025 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0538 | 0.8988 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0017 | 0.0064 | 0.0671 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0538 | 0.8988 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0079 | 0.0599 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0079 | 0.0599 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0017 | 0.0064 | 0.1063 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Echinococcus granulosus | FTZ F1 alpha | 0.0017 | 0.0064 | 0.1063 |
Trichomonas vaginalis | hypothetical protein | 0.1173 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0019 | 0.0079 | 0.0941 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.0079 | 0.1323 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0017 | 0.0064 | 0.0671 |
Brugia malayi | nuclear receptor NHR-88 | 0.0017 | 0.0064 | 0.1063 |
Onchocerca volvulus | 0.0079 | 0.0599 | 1 | |
Onchocerca volvulus | 0.0017 | 0.0064 | 0.0671 | |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0017 | 0.0064 | 0.1063 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0538 | 0.8988 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0017 | 0.0064 | 0.1063 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.0079 | 0.1323 |
Brugia malayi | ecdysteroid receptor | 0.0017 | 0.0064 | 0.1063 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.0079 | 0.1323 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0017 | 0.0064 | 0.1063 |
Onchocerca volvulus | 0.0019 | 0.0079 | 0.0941 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0019 | 0.0079 | 0.0941 |
Plasmodium vivax | vivapain-2 | 0.0019 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0079 | 0.0941 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0079 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0064 | 0.0671 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.0079 | 0.1323 |
Schistosoma mansoni | coup transcription factor | 0.0017 | 0.0064 | 0.1063 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0064 | 0.0671 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0017 | 0.0064 | 0.1063 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0538 | 0.8988 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.0079 | 0.1323 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0017 | 0.0064 | 0.1063 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.1173 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0017 | 0.0064 | 0.0671 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0017 | 0.0064 | 0.1063 |
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | 0.0079 | 0.0599 | 0.0599 |
Onchocerca volvulus | Cathepsin F homolog | 0.0019 | 0.0079 | 0.0941 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0017 | 0.0064 | 0.0671 |
Onchocerca volvulus | 0.0019 | 0.0079 | 0.0941 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.0079 | 0.1323 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0538 | 0.8988 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0072 | 0.0538 | 0.8988 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0072 | 0.0538 | 0.8988 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0079 | 0.0599 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0019 | 0.0079 | 0.1323 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0079 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0013 | 0.0025 | 0.0421 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0079 | 0.0599 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0017 | 0.0064 | 0.0671 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0079 | 0.0599 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0017 | 0.0064 | 0.1063 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0079 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0017 | 0.0064 | 0.1063 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0017 | 0.0064 | 0.1063 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0019 | 0.0079 | 0.0079 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0017 | 0.0064 | 0.1063 |
Onchocerca volvulus | 0.0019 | 0.0079 | 0.0941 | |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0017 | 0.0064 | 0.1063 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0538 | 0.8988 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0017 | 0.0064 | 0.1063 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0017 | 0.0064 | 0.1063 |
Toxoplasma gondii | short chain dehydrogenase family protein, putative | 0.0079 | 0.0599 | 0.0524 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0017 | 0.0064 | 0.0671 |
Brugia malayi | nuclear hormone receptor | 0.0017 | 0.0064 | 0.1063 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0079 | 0.0599 | 0.0524 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0017 | 0.0064 | 0.1063 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0019 | 0.0079 | 0.0079 |
Leishmania major | pteridine reductase 1 | 0.0079 | 0.0599 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0017 | 0.0064 | 0.0671 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antagonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular calcium release at 1 mM measured for 90 secs by fluorescence assay | ChEMBL. | 23301527 | |
Activity (functional) | Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular calcium release at 1 mM measured for 90 secs by fluorescence assay | ChEMBL. | 23301527 | |
Activity (functional) | Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release at 1 mM measured for 90 secs by fluorescence assay | ChEMBL. | 23301527 | |
Activity (functional) | Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release at 1 mM measured for 90 secs by fluorescence assay | ChEMBL. | 23301527 | |
EC50 (functional) | > 3 | Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay | ChEMBL. | 23301527 |
EC50 (functional) | > 3 | Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay | ChEMBL. | 23301527 |
EC50 (functional) | > 1000 uM | Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay | ChEMBL. | 23301527 |
EC50 (functional) | > 1000 uM | Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay | ChEMBL. | 23301527 |
Ki (binding) | > 3.5 | Displacement of [3H]mesulergine from human 5HT2C receptor expressed in tsA201 cell membranes after 1 hr by scintillation counting analysis | ChEMBL. | 23301527 |
Ki (binding) | > 3.5 | Displacement of [3H]ketanserin from human 5HT2A receptor expressed in tsA201 cell membranes after 1 hr by scintillation counting analysis | ChEMBL. | 23301527 |
Ki (binding) | > 300 uM | Displacement of [3H]mesulergine from human 5HT2C receptor expressed in tsA201 cell membranes after 1 hr by scintillation counting analysis | ChEMBL. | 23301527 |
Ki (binding) | > 300 uM | Displacement of [3H]ketanserin from human 5HT2A receptor expressed in tsA201 cell membranes after 1 hr by scintillation counting analysis | ChEMBL. | 23301527 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.