Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0213 | 0.0573 | 0.0556 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0016 | 0.0237 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.0142 | 0.207 |
Onchocerca volvulus | 0.004 | 0.0017 | 0.0224 | |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0213 | 0.0573 | 0.0556 |
Echinococcus multilocularis | tumor protein p63 | 0.0791 | 0.243 | 0.4058 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0213 | 0.0573 | 0.0556 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0213 | 0.0573 | 0.0556 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0058 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0075 | 0.1122 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0213 | 0.0573 | 0.0556 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0044 | 0.0029 | 0.0435 |
Toxoplasma gondii | exonuclease III APE | 0.0044 | 0.0029 | 0.0029 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0213 | 0.0573 | 0.8539 |
Leishmania major | hypothetical protein, conserved | 0.0058 | 0.0073 | 0.1007 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.0142 | 0.2475 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1899 | 0.5988 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.3148 | 1 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.3148 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.3148 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0044 | 0.0029 | 0.5 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.0213 | 0.0573 | 0.0573 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0016 | 0.0278 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0213 | 0.0573 | 0.0556 |
Mycobacterium tuberculosis | Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) | 0.0213 | 0.0573 | 0.0556 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0017 | 0.026 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0058 | 0.0073 | 0.0044 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0213 | 0.0573 | 0.0556 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0058 | 0.0073 | 0.1007 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0213 | 0.0573 | 0.0556 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0017 | 0.026 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0044 | 0.0029 | 0.0012 |
Mycobacterium leprae | POSSIBLE OXIDOREDUCTASE | 0.0213 | 0.0573 | 0.0556 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.006 | 0.01 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0213 | 0.0573 | 0.0556 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0213 | 0.0573 | 0.0556 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0054 | 0.006 | 0.0891 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.006 | 0.1044 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0044 | 0.0029 | 0.0049 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0258 | 0.0716 | 0.07 |
Onchocerca volvulus | 0.0277 | 0.0779 | 1 | |
Brugia malayi | Pre-SET motif family protein | 0.0244 | 0.0671 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0017 | 0.026 |
Mycobacterium tuberculosis | Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) | 0.0213 | 0.0573 | 0.0556 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0044 | 0.0029 | 0.0012 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0213 | 0.0573 | 0.0556 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0213 | 0.0573 | 0.2357 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0213 | 0.0573 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0213 | 0.0573 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0213 | 0.0573 | 0.0556 |
Onchocerca volvulus | 0.004 | 0.0017 | 0.0224 | |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.3148 | 1 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0791 | 0.243 | 1 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0213 | 0.0573 | 1 |
Onchocerca volvulus | 0.0213 | 0.0573 | 0.7353 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.006 | 0.0246 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.3148 | 1 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0213 | 0.0573 | 1 |
Brugia malayi | beta-lactamase | 0.004 | 0.0017 | 0.026 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0213 | 0.0573 | 1 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0213 | 0.0573 | 0.8539 |
Trichomonas vaginalis | set domain proteins, putative | 0.0277 | 0.0779 | 0.0763 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0017 | 0.0072 |
Brugia malayi | hypothetical protein | 0.0079 | 0.0142 | 0.2113 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0017 | 0.0304 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0213 | 0.0573 | 0.0556 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0017 | 0.026 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0017 | 0.026 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0044 | 0.0029 | 0.0029 |
Mycobacterium ulcerans | oxidoreductase | 0.0213 | 0.0573 | 0.0556 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0213 | 0.0573 | 0.8539 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0213 | 0.0573 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0213 | 0.0573 | 1 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0213 | 0.0573 | 0.0556 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0213 | 0.0573 | 0.0556 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.006 | 0.1044 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0213 | 0.0573 | 0.0556 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0213 | 0.0573 | 0.8539 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0213 | 0.0573 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0213 | 0.0573 | 0.0556 |
Toxoplasma gondii | short chain dehydrogenase family protein, putative | 0.0213 | 0.0573 | 0.0573 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0213 | 0.0573 | 0.0556 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0017 | 0.0017 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0213 | 0.0573 | 0.0556 |
Schistosoma mansoni | ap endonuclease | 0.0044 | 0.0029 | 0.051 |
Onchocerca volvulus | 0.0116 | 0.026 | 0.3336 | |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0075 | 0.1122 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0213 | 0.0573 | 0.0556 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0058 | 0.0073 | 0.1007 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0044 | 0.0029 | 0.012 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0017 | 0.026 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0213 | 0.0573 | 0.0556 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0213 | 0.0573 | 0.0556 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0213 | 0.0573 | 0.0956 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.0142 | 0.207 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0017 | 0.026 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.0573 | 0.8539 |
Leishmania major | pteridine reductase 1 | 0.0213 | 0.0573 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.006 | 0.0246 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.3148 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0008 | 0.0112 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0044 | 0.0029 | 0.0435 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0017 | 0.0029 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0075 | 0.1122 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0016 | 0.0237 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0079 | 0.0142 | 0.0583 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.026 | 0.3874 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0058 | 0.0073 | 0.1007 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.0142 | 0.207 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.006 | 0.1044 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0075 | 0.1122 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0079 | 0.0142 | 0.2475 |
Toxoplasma gondii | 3-ketoacyl-(acyl-carrier-protein) reductase | 0.0213 | 0.0573 | 0.0573 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0017 | 0.0017 |
Leishmania major | oxidoreductase-like protein | 0.0213 | 0.0573 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0213 | 0.0573 | 0.0556 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0213 | 0.0573 | 0.0556 |
Onchocerca volvulus | 0.004 | 0.0017 | 0.0224 | |
Loa Loa (eye worm) | oxidoreductase | 0.0213 | 0.0573 | 0.8539 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.0213 | 0.0573 | 0.0556 |
Schistosoma mansoni | ap endonuclease | 0.0044 | 0.0029 | 0.051 |
Trichomonas vaginalis | hypothetical protein | 0.3148 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0044 | 0.0029 | 0.0212 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0213 | 0.0573 | 0.0556 |
Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.0213 | 0.0573 | 0.0545 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0213 | 0.0573 | 0.0556 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0044 | 0.0029 | 0.0012 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.0213 | 0.0573 | 0.0556 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0213 | 0.0573 | 0.0556 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0213 | 0.0573 | 0.0556 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0058 | 0.0073 | 0.0073 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0213 | 0.0573 | 0.0556 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0073 | 0.1093 |
Brugia malayi | hypothetical protein | 0.0058 | 0.0073 | 0.1093 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0213 | 0.0573 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0213 | 0.0573 | 0.0556 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0044 | 0.0029 | 0.0212 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0058 | 0.0073 | 0.0044 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0213 | 0.0573 | 0.0556 |
Schistosoma mansoni | dihydropteridine reductase | 0.0213 | 0.0573 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.3148 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0079 | 0.0142 | 0.0237 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0017 | 0.026 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0213 | 0.0573 | 0.0556 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0017 | 0.026 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0213 | 0.0573 | 0.0556 |
Mycobacterium ulcerans | 20-beta-hydroxysteroid dehydrogenase FabG3 | 0.0213 | 0.0573 | 0.0556 |
Mycobacterium leprae | 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI | 0.0213 | 0.0573 | 0.0556 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0017 | 0.0304 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0044 | 0.0029 | 0.0212 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0017 | 0.026 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.0142 | 0.207 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0213 | 0.0573 | 0.0573 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0054 | 0.006 | 0.0891 |
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | 0.0213 | 0.0573 | 0.0545 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0213 | 0.0573 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0213 | 0.0573 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0044 | 0.0029 | 0.5 |
Onchocerca volvulus | 0.0213 | 0.0573 | 0.7353 | |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0044 | 0.0029 | 0.0212 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0116 | 0.026 | 0.4537 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0017 | 0.026 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0044 | 0.0029 | 0.0012 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.006 | 0.01 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0244 | 0.0671 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.