Detailed information for compound 1731453

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 366.457 | Formula: C21H26N4O2
  • H donors: 1 H acceptors: 3 LogP: 1.09 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C[C@@H]1C[C@H]2[C@@H](N1C(=O)[C@H](C1CCN(CC1)C(=O)Cc1ccccc1)N)C2
  • InChi: 1S/C21H26N4O2/c22-13-17-11-16-12-18(16)25(17)21(27)20(23)15-6-8-24(9-7-15)19(26)10-14-4-2-1-3-5-14/h1-5,15-18,20H,6-12,23H2/t16-,17+,18+,20+/m1/s1
  • InChiKey: ADWGIUYHFWJNSG-LXZJYRNTSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0063 0.0331
Loa Loa (eye worm) hypothetical protein 0.0058 0.0163 0.0572
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.1173 0.4282
Brugia malayi Integrin alpha pat-2 precursor 0.0101 0.0366 0.1276
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.2718 1
Echinococcus multilocularis muscleblind protein 1 0.0154 0.0614 0.0608
Echinococcus multilocularis lamin dm0 0.0028 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0025
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0053 0.014 0.0133
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0045 0.0101 0.0101
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0347 0.2032
Echinococcus granulosus lamin 0.0028 0.002 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0111 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0053 0.014 0.0493
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0116 0.0372
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0034 0.0026
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0021 0.0062
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0493
Loa Loa (eye worm) prolyl oligopeptidase 0.0209 0.0875 0.3077
Loa Loa (eye worm) acetylcholinesterase 1 0.0627 0.2843 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0053 0.014 0.0493
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.038 0.1678 0.5901
Loa Loa (eye worm) hypothetical protein 0.0051 0.0131 0.046
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0272 0.1173 0.4117
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0097 0.0344 0.3286
Schistosoma mansoni DNA topoisomerase type I 0.0191 0.079 0.079
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0059 0.0304
Echinococcus multilocularis microtubule associated protein 2 0.2145 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0063 0.0223
Brugia malayi beta-lactamase 0.0037 0.0063 0.021
Entamoeba histolytica hypothetical protein 0.0037 0.0063 0.022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0053 0.014 0.048
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0028 0.0021 0.0014
Brugia malayi hypothetical protein 0.0025 0.0007 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0111 0.0104
Onchocerca volvulus 0.0028 0.002 0.0153
Mycobacterium ulcerans cell division protein FtsZ 0.0312 0.136 1
Schistosoma mansoni gliotactin 0.0106 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0154 0.0614 0.2161
Brugia malayi Pre-SET motif family protein 0.0031 0.0034 0.0105
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0068 0.0211 0.0726
Mycobacterium ulcerans DNA gyrase subunit A 0.0031 0.0034 0.022
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0209 0.0875 0.0868
Mycobacterium tuberculosis Conserved protein 0.0037 0.0063 0.0441
Brugia malayi hypothetical protein 0.0037 0.0063 0.021
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.022 0.1269
Brugia malayi DNA topoisomerase I 0.0191 0.079 0.2769
Loa Loa (eye worm) hypothetical protein 0.0167 0.0676 0.2376
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0025
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0347 0.2054
Loa Loa (eye worm) hypothetical protein 0.0154 0.0614 0.2161
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0007 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0347 0.123
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0015 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0731 0.2649
Loa Loa (eye worm) hypothetical protein 0.0106 0.0388 0.1364
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0068 0.0211 0.0764
Onchocerca volvulus 0.0037 0.0062 0.0564
Trypanosoma cruzi hypothetical protein 0.0068 0.0211 0.1216
Onchocerca volvulus 0.0099 0.0355 0.3396
Loa Loa (eye worm) hypothetical protein 0.0037 0.0063 0.0223
Loa Loa (eye worm) hypothetical protein 0.0028 0.0021 0.0075
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0627 0.2843 0.2843
Echinococcus multilocularis integrin alpha ps 0.0045 0.0103 0.0095
Brugia malayi ThiF family protein 0.005 0.0123 0.0419
Plasmodium falciparum flap endonuclease 1 0.0027 0.0015 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.1173 0.4282
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0053 0.014 0.0493
Echinococcus granulosus neuroligin 0.0106 0.0388 0.0381
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0025
Plasmodium vivax DNA gyrase subunit B, putative 0.0083 0.0282 0.113
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.1173 0.4282
Brugia malayi Kelch motif family protein 0.0032 0.0037 0.0118
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0731 0.2649
Loa Loa (eye worm) hypothetical protein 0.0037 0.0063 0.0223
Brugia malayi nuclear receptor NHR-88 0.0025 0.0007 0.0012
Loa Loa (eye worm) carboxylesterase 0.0627 0.2843 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0106 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0025
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0111 0.039
Brugia malayi hypothetical protein 0.0486 0.2178 0.7658
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0063 0.0056
Trypanosoma cruzi DNA topoisomerase II, putative 0.0135 0.0526 0.3103
Onchocerca volvulus Bile acid receptor homolog 0.0053 0.014 0.1317
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0062 0.0055
Echinococcus multilocularis acetylcholinesterase 0.0627 0.2843 0.2838
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0069
Echinococcus granulosus acetylcholinesterase 0.0627 0.2843 0.2838
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0097 0.0344 0.3286
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0015 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0053 0.014 0.048
Schistosoma mansoni intermediate filament proteins 0.0028 0.002 0.002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0246 0.0855
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.002 0.0069
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.0246 0.0239
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0111 0.0111
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0246 0.1425
Echinococcus multilocularis DNA topoisomerase 1 0.0191 0.079 0.0783
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0053 0.014 0.0133
Echinococcus multilocularis thyroid hormone receptor alpha 0.0053 0.014 0.0133
Mycobacterium ulcerans DNA gyrase subunit B 0.0083 0.0282 0.2049
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0053 0.014 0.0133
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0053 0.014 0.0133
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0033 0.0043 0.0206
Schistosoma mansoni nuclear hormone receptor 0.0053 0.014 0.014
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0493 0.2212 0.7779
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0493
Schistosoma mansoni RAR-like nuclear receptor 0.0053 0.014 0.014
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0123 0.0123
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0015 0.0041
Trypanosoma brucei DNA topoisomerase ii 0.016 0.0645 0.3815
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.0059 0.0407
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0033 0.0043 0.0206
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0025
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0053 0.014 0.0493
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0347 0.3319
Brugia malayi nuclear hormone receptor family member nhr-6 0.0025 0.0007 0.0012
Echinococcus multilocularis survival motor neuron protein 1 0.0486 0.2178 0.2172
Loa Loa (eye worm) hypothetical protein 0.0106 0.0388 0.1364
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0025 0.0007 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0347 0.123
Loa Loa (eye worm) hypothetical protein 0.0028 0.0021 0.0075
Mycobacterium ulcerans glutaminase 0.0275 0.1187 0.8726
Plasmodium falciparum DNA gyrase subunit B 0.0083 0.0282 0.113
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0131 0.0447
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0063 0.0441
Echinococcus granulosus para nitrobenzyl esterase 0.0106 0.0388 0.0381
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.016 0.0645 0.3815
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0135 0.0526 0.3103
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0031 0.0034 0.022
Loa Loa (eye worm) hypothetical protein 0.0056 0.0152 0.0535
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0053 0.014 0.0133
Trichomonas vaginalis esterase, putative 0.0037 0.0063 0.0179
Plasmodium vivax DNA gyrase subunit A, putative 0.0031 0.0034 0.0104
Schistosoma mansoni retinoic acid receptor RXR 0.0053 0.014 0.014
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0272 0.1173 0.4125
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0034 0.0034
Loa Loa (eye worm) DNA topoisomerase I 0.0191 0.079 0.2779
Loa Loa (eye worm) carboxylesterase 0.0106 0.0388 0.1364
Loa Loa (eye worm) hypothetical protein 0.0028 0.0021 0.0075
Echinococcus granulosus lamin dm0 0.0028 0.002 0.0012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.1006 0.7392
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.005 0.0123 0.0116
Brugia malayi hypothetical protein 0.0025 0.0008 0.0016
Giardia lamblia Kinase, PLK 0.0097 0.0347 0.123
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0015 0.0028
Schistosoma mansoni integrin beta subunit 0.0122 0.0465 0.0465
Loa Loa (eye worm) integrin beta-2 0.0208 0.0867 0.3049
Onchocerca volvulus Protein ultraspiracle homolog 0.0053 0.014 0.1317
Schistosoma mansoni inositol monophosphatase 0.0076 0.0246 0.0246
Leishmania major mitochondrial DNA topoisomerase II 0.016 0.0645 0.3832
Leishmania major C-8 sterol isomerase-like protein 0.038 0.1678 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0347 0.123
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0063 0.021
Onchocerca volvulus 0.0025 0.0007 0.0034
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0347 0.2032
Giardia lamblia Fructose-bisphosphate aldolase 0.06 0.2718 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0053 0.014 0.0133
Schistosoma mansoni integrin alpha-ps 0.0045 0.0103 0.0103
Schistosoma mansoni DNA topoisomerase type I 0.0191 0.079 0.079
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0063 0.0441
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.022 0.1269
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0097 0.0344 0.3286
Entamoeba histolytica hypothetical protein 0.0037 0.0063 0.022
Echinococcus multilocularis acetylcholinesterase 0.0627 0.2843 0.2838
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.0776 0.2817
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0143 0.0563 0.1968
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.014 0.0133
Trypanosoma brucei cytochrome P450, putative 0.0036 0.0059 0.0304
Giardia lamblia DNA repair protein RAD52 0.0358 0.1578 0.5781
Leishmania major DNA topoisomerase ii 0.0135 0.0526 0.3121
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0106 0.0388 0.0381
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0068 0.0211 0.0731
Loa Loa (eye worm) hypothetical protein 0.0097 0.0345 0.1212
Brugia malayi Carboxylesterase family protein 0.0627 0.2843 1
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0062 0.0431
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0072 0.0226 0.0219
Schistosoma mansoni integrin alpha 0.0101 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0126 0.0484 0.1702
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.2824
Toxoplasma gondii DNA topoisomerase I, putative 0.0191 0.079 1
Schistosoma mansoni tsg101-related 0.006 0.017 0.017
Toxoplasma gondii ThiF family protein 0.0033 0.0043 0.044
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0034 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0347 0.123
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0063 0.0441
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0013
Echinococcus multilocularis ecdysone induced protein 78C 0.0053 0.014 0.0133
Schistosoma mansoni glutaminase 0.0275 0.1187 0.1187
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0032 0.0037 0.0131
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.0209 0.1511
Loa Loa (eye worm) hypothetical protein 0.0028 0.0021 0.0075
Toxoplasma gondii hypothetical protein 0.005 0.0123 0.1465
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0209 0.0875 0.0868
Onchocerca volvulus 0.0031 0.0034 0.0288
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0063 0.0441
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.0246 0.3042
Loa Loa (eye worm) nuclear hormone receptor 0.0025 0.0007 0.0025
Echinococcus multilocularis integrin alpha ps 0.0045 0.0103 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0053 0.014 0.048
Brugia malayi steroid hormone receptor 0.0053 0.014 0.048
Brugia malayi Nuclear hormone receptor-like 1 0.0053 0.014 0.048
Brugia malayi hypoxia-induced factor 1 0.0154 0.0615 0.2152
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0347 0.123
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0025
Giardia lamblia Telomerase catalytic subunit 0.0087 0.0299 0.1049
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0053 0.014 0.014
Plasmodium falciparum topoisomerase I 0.0191 0.079 0.3231
Onchocerca volvulus 0.0037 0.0063 0.0577
Mycobacterium tuberculosis Conserved protein 0.0037 0.0063 0.0441
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0191 0.079 0.4683
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0076 0.0246 0.1603
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0493
Brugia malayi ERG2 and Sigma1 receptor like protein 0.038 0.1678 0.5896
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.1173 0.4282
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0246 0.0855
Brugia malayi Integrin beta pat-3 precursor 0.0208 0.0867 0.304
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0059 0.0207
Onchocerca volvulus 0.0106 0.0388 0.3708
Loa Loa (eye worm) hypothetical protein 0.0035 0.0054 0.019
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0033 0.0043 0.0035
Brugia malayi photoreceptor-specific nuclear receptor 0.0053 0.014 0.048
Mycobacterium tuberculosis Carboxylesterase LipT 0.0106 0.0388 0.2832
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0836 0.3828 0.3824
Brugia malayi nuclear receptor NHR-67 0.0025 0.0007 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0111 0.0111
Leishmania major DNA topoisomerase IB, large subunit 0.0191 0.079 0.4697
Echinococcus granulosus sentrin specific protease 8 0.0068 0.0211 0.0204
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0106 0.0388 0.0388
Echinococcus granulosus intermediate filament protein 0.0028 0.002 0.0012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0111 0.0377
Echinococcus granulosus integrin beta 2 0.0154 0.0613 0.0606
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.022 0.0213
Brugia malayi glutaminase DH11.1 0.0275 0.1187 0.4168
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0209 0.0875 0.0875
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0209 0.0875 0.8411
Brugia malayi tailless protein 0.0025 0.0007 0.0012
Brugia malayi nuclear receptor RXR 0.0028 0.0021 0.0062
Trypanosoma brucei polo-like protein kinase 0.0097 0.0347 0.2032
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0063 0.0441
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0063 0.0056
Loa Loa (eye worm) hypothetical protein 0.0106 0.0388 0.1364
Mycobacterium ulcerans hypothetical protein 0.0037 0.0063 0.0441
Echinococcus granulosus DNA topoisomerase 1 0.0191 0.079 0.0783
Onchocerca volvulus 0.0244 0.1039 1
Loa Loa (eye worm) hypothetical protein 0.0627 0.2843 1
Brugia malayi Carboxylesterase family protein 0.0106 0.0388 0.1352
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0312 0.136 1
Echinococcus granulosus acetylcholinesterase 0.0627 0.2843 0.2838
Loa Loa (eye worm) hypothetical protein 0.0106 0.0388 0.1364
Onchocerca volvulus 0.0106 0.0388 0.3708
Brugia malayi Pre-SET motif family protein 0.0215 0.09 0.3156
Echinococcus multilocularis carboxylesterase 5A 0.0627 0.2843 0.2838
Schistosoma mansoni hypothetical protein 0.0037 0.0063 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.2718 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0106 0.0388 0.0381
Loa Loa (eye worm) ThiF family protein 0.0033 0.0043 0.015
Leishmania major cytochrome p450-like protein 0.0036 0.0059 0.033
Onchocerca volvulus 0.0025 0.0007 0.0034
Loa Loa (eye worm) hypothetical protein 0.008 0.0263 0.0927
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0053 0.014 0.0133
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0021 0.0062
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0083 0.0282 0.3496
Brugia malayi ecdysteroid receptor 0.0053 0.014 0.048
Schistosoma mansoni microtubule-associated protein tau 0.2145 1 1
Schistosoma mansoni survival motor neuron protein 0.0099 0.0355 0.0355
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.016 0.0645 0.3815
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0111 0.0104
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0143 0.0563 0.1968
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0068 0.0211 0.0211
Echinococcus multilocularis integrin alpha 3 0.0078 0.0255 0.0248
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0053 0.014 0.0133
Loa Loa (eye worm) hypothetical protein 0.0106 0.0388 0.1364
Echinococcus multilocularis sentrin specific protease 8 0.0068 0.0211 0.0204
Echinococcus granulosus ecdysone induced protein 78C 0.0053 0.014 0.0133
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0083 0.0282 0.2049
Schistosoma mansoni tsg101-related 0.006 0.017 0.017
Loa Loa (eye worm) integrin alpha pat-2 0.0156 0.0625 0.2197
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0731 0.2649
Plasmodium vivax telomerase reverse transcriptase, putative 0.0539 0.2428 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0063 0.0179
Mycobacterium ulcerans lipase LipD 0.0037 0.0063 0.0441
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0053 0.014 0.048
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.005 0.0123 0.0473
Trichomonas vaginalis set domain proteins, putative 0.0244 0.1039 0.379
Toxoplasma gondii DNA topoisomerase 2, putative 0.0143 0.0563 0.7091
Leishmania major hypothetical protein, conserved 0.0037 0.0063 0.0357
Schistosoma mansoni hypothetical protein 0.0175 0.0712 0.0712
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0029
Echinococcus multilocularis neuropeptide s receptor 0.0495 0.222 0.2214
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0063 0.0179
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0106 0.0388 0.0388
Brugia malayi hypothetical protein 0.0167 0.0676 0.2366
Loa Loa (eye worm) intermediate filament protein 0.0028 0.002 0.0069
Brugia malayi Carboxylesterase family protein 0.0106 0.0388 0.1352
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0059 0.0207
Brugia malayi Cytochrome P450 family protein 0.0036 0.0059 0.0194
Treponema pallidum fructose-bisphosphate aldolase 0.06 0.2718 1
Schistosoma mansoni single-minded 0.005 0.0123 0.0123
Loa Loa (eye worm) inositol-1 0.0076 0.0246 0.0866
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0347 0.0341
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0076 0.0246 0.1787
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0025 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0054 0.0142 0.0499
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0063 0.0179
Brugia malayi follicle stimulating hormone receptor 0.0493 0.2212 0.7777
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.014 0.0133
Brugia malayi Carboxylesterase family protein 0.0627 0.2843 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0063 0.0056
Brugia malayi Probable DNA topoisomerase II 0.0143 0.0563 0.1968
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0059 0.0207
Brugia malayi beta-lactamase family protein 0.0037 0.0063 0.021
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.0209 0.1511
Brugia malayi ecdysone receptor 0.0025 0.0007 0.0012
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0015 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0731 0.2649
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0347 0.123
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.022 0.0213
Brugia malayi Inositol-1 0.0076 0.0246 0.0854
Onchocerca volvulus Huntingtin homolog 0.0126 0.0484 0.4635
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0053 0.014 0.048
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0087 0.0299 0.174
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.2718 1
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0033 0.0043 0.0035
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0053 0.014 0.014
Echinococcus granulosus SUMO activating enzyme subunit 1 0.005 0.0123 0.0116
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0493
Chlamydia trachomatis DNA gyrase subunit B 0.0083 0.0282 1
Echinococcus granulosus integrin alpha ps 0.0045 0.0103 0.0095
Brugia malayi hypothetical protein 0.0106 0.0388 0.1352
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.002 0.0056
Schistosoma mansoni hypothetical protein 0.0099 0.0355 0.0355
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0033 0.0043 0.0043
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0143 0.0563 0.0556
Brugia malayi nuclear receptor RXR 0.0025 0.0007 0.0012
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0347 0.1222
Trichomonas vaginalis glutaminase, putative 0.0275 0.1187 0.4336
Toxoplasma gondii ABC1 family protein 0.0037 0.0063 0.0706
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0053 0.014 0.048
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0293 0.1271 0.9344
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0063 0.0331
Echinococcus multilocularis musashi 0.0028 0.002 0.0012
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0059 0.0304
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0034 0.0026
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0063 0.0441
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0007 0.0007
Brugia malayi nuclear hormone receptor 0.0053 0.014 0.048
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0246 0.1425
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0063 0.0331
Entamoeba histolytica DNA topoisomerase II, putative 0.0143 0.0563 0.2059
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0053 0.014 0.048
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0731 0.2649
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0015 0.0008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0131 0.046
Plasmodium falciparum DNA topoisomerase 2 0.0143 0.0563 0.2291
Loa Loa (eye worm) hypothetical protein 0.0106 0.0388 0.1364
Brugia malayi Steroid receptor seven-up type 2 0.0053 0.014 0.048
Onchocerca volvulus 0.0037 0.0063 0.0577
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0034 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0053 0.014 0.048
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0063 0.0179
Schistosoma mansoni DNA topoisomerase type I 0.0191 0.079 0.079
Loa Loa (eye worm) hypothetical protein 0.0627 0.2843 1
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0028 0.0021 0.0077
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0053 0.014 0.014
Onchocerca volvulus Huntingtin homolog 0.0126 0.0484 0.4635
Brugia malayi hypothetical protein 0.0126 0.0484 0.1691
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0493
Trypanosoma brucei C-8 sterol isomerase, putative 0.038 0.1678 1
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0072 0.0226 0.0219
Brugia malayi prolyl oligopeptidase family protein 0.007 0.022 0.0762
Echinococcus granulosus integrin alpha 3 0.0078 0.0255 0.0248
Toxoplasma gondii RNA-directed DNA polymerase 0.0087 0.0299 0.3715
Plasmodium vivax topoisomerase I, putative 0.0191 0.079 0.3231
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.09 0.3165
Trypanosoma cruzi C-8 sterol isomerase, putative 0.038 0.1678 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0345 0.1212
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0053 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0058 0.0163 0.0572
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.014 0.0133
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0293 0.1271 0.9344
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0025
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.022 0.1269
Schistosoma mansoni lamin 0.0028 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0021 0.0075
Schistosoma mansoni nuclear receptor 0.0025 0.0007 0.0007
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.007 0.022 0.2711
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0007 0.0034
Loa Loa (eye worm) nuclear receptor NHR-67 0.0025 0.0007 0.0025
Leishmania major ubiquitin-activating enzyme-like protein 0.0033 0.0043 0.0233
Echinococcus multilocularis integrin beta 2 0.0154 0.0613 0.0606
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.0246 0.0855
Loa Loa (eye worm) glutaminase 2 0.0275 0.1187 0.4175
Schistosoma mansoni steroid hormone receptor ad4bp 0.0053 0.014 0.014
Brugia malayi hypothetical protein 0.0028 0.0021 0.0062
Plasmodium vivax ubiquitin activating enzyme, putative 0.005 0.0123 0.0473
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0347 0.0341
Echinococcus multilocularis conserved hypothetical protein 0.0711 0.3241 0.3236
Entamoeba histolytica hypothetical protein 0.0102 0.0369 0.1346
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0013
Echinococcus granulosus survival motor neuron protein 1 0.0486 0.2178 0.2172
Echinococcus multilocularis neuroligin 0.0106 0.0388 0.0381
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0034 0.0324
Leishmania major hypothetical protein, conserved 0.0025 0.0008 0.0027
Plasmodium falciparum telomerase reverse transcriptase 0.0539 0.2428 1
Brugia malayi Carboxylesterase family protein 0.0106 0.0388 0.1352
Mycobacterium ulcerans carboxylesterase, LipT 0.0106 0.0388 0.2832
Onchocerca volvulus 0.0106 0.0388 0.3708
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0063 0.0179
Brugia malayi hypothetical protein 0.0072 0.0226 0.0784
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0053 0.014 0.048
Echinococcus granulosus FTZ F1 alpha 0.0053 0.014 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0347 0.123
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0021 0.0021
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0015 0.0053
Mycobacterium leprae cell division protein FtsZ 0.0312 0.136 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.0484 0.1702
Onchocerca volvulus Glucosylceramidase homolog 0.0179 0.0731 0.7022
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0053 0.014 0.1317
Brugia malayi intermediate filament protein 0.0028 0.002 0.0056
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.06 0.2718 1
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0102 0.0369 0.1346
Mycobacterium ulcerans beta-lactamase 0.0037 0.0063 0.0441
Leishmania major telomerase reverse transcriptase, putative 0.0087 0.0299 0.1762
Brugia malayi Cell division protein ftsZ 0.0154 0.0615 0.2152
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0062 0.0206
Echinococcus granulosus geminin 0.0175 0.0712 0.0705
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0358 0.1578 0.5799
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0087 0.0299 0.2848
Schistosoma mansoni nuclear receptor 0.0025 0.0007 0.0007
Brugia malayi hypothetical protein 0.0028 0.0021 0.0062
Loa Loa (eye worm) hypothetical protein 0.0072 0.0226 0.0796
Brugia malayi conserved hypotetical protein 0.0025 0.0007 0.0012
Schistosoma mansoni zinc finger protein 0.0025 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0493
Onchocerca volvulus 0.0106 0.0388 0.3708
Brugia malayi nuclear hormone receptor family member odr-7 0.0025 0.0007 0.0012
Loa Loa (eye worm) TOPoisomerase family member 0.0143 0.0563 0.1979
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0063 0.0223
Plasmodium vivax DNA topoisomerase II, putative 0.0143 0.0563 0.2291
Schistosoma mansoni nuclear receptor nhr-48 0.0025 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0025
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0493
Brugia malayi nuclear receptor NHR-88 0.0053 0.014 0.048
Trypanosoma brucei telomerase reverse transcriptase 0.0087 0.0299 0.174
Brugia malayi PAS domain containing protein 0.005 0.0123 0.0421
Schistosoma mansoni coup transcription factor 0.0053 0.014 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.0776 0.2817
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0087 0.0299 0.174
Trichomonas vaginalis Sentrin-specific protease, putative 0.0068 0.0211 0.0726
Echinococcus multilocularis FTZ F1 alpha 0.0053 0.014 0.0133
Echinococcus granulosus carboxylesterase 5A 0.0627 0.2843 0.2838
Loa Loa (eye worm) glutaminase 0.0275 0.1187 0.4175
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0063 0.0441
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0111 0.0111
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0033 0.0043 0.0142
Loa Loa (eye worm) hypothetical protein 0.0077 0.025 0.0879
Schistosoma mansoni thyroid hormone receptor 0.0053 0.014 0.014
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0025 0.0007 0.0007
Treponema pallidum cell division protein FtsZ 0.0312 0.136 0.494
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0025
Schistosoma mansoni thyroid hormone receptor 0.0053 0.014 0.014
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.022 0.022
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0053 0.014 0.0133
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0028 0.0021 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0034 0.0034
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0106 0.0388 0.2832
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0028 0.0021 0.0021
Plasmodium falciparum DNA gyrase subunit A 0.0031 0.0034 0.0104
Brugia malayi nuclear hormone receptor 0.0025 0.0007 0.0012
Schistosoma mansoni tsg101-related 0.0049 0.0118 0.0118
Trichomonas vaginalis spcc417.12 protein, putative 0.0106 0.0388 0.1379
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0106 0.0388 0.0388
Brugia malayi orphan nuclear receptor NR2E1 0.0025 0.0007 0.0012
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0025 0.0007 0.0025
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0135 0.0526 0.3103
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0083 0.0282 0.0924
Loa Loa (eye worm) steroid hormone receptor 0.0053 0.014 0.0493
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0053 0.014 0.048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.2718 1
Brugia malayi Cytochrome P450 family protein 0.0036 0.0059 0.0194
Schistosoma mansoni sumo-1-activating enzyme E1a 0.005 0.0123 0.0123
Schistosoma mansoni lamin 0.0028 0.002 0.002
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0054 0.0177
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0015 0.0068
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0293 0.1271 0.9344
Plasmodium vivax SET domain protein, putative 0.0031 0.0034 0.0105
Loa Loa (eye worm) beta-lactamase 0.0037 0.0063 0.0223
Brugia malayi beta-lactamase family protein 0.0037 0.0063 0.021
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.0246 0.0239
Trichomonas vaginalis hypothetical protein 0.0035 0.0053 0.0141
Mycobacterium tuberculosis Conserved protein 0.0037 0.0063 0.0441
Schistosoma mansoni hypothetical protein 0.0053 0.0138 0.0138
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0731 0.2649
Brugia malayi hypothetical protein 0.0032 0.0037 0.0118
Echinococcus granulosus neuropeptide s receptor 0.0495 0.222 0.2214
Loa Loa (eye worm) hypothetical protein 0.0486 0.2178 0.7661
Schistosoma mansoni DNA topoisomerase II 0.0143 0.0563 0.0563
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0077 0.025 0.0867
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0053 0.014 0.0493
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0063 0.0063
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0063 0.0056
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0106 0.0388 0.1379
Echinococcus granulosus single minded 2 0.0037 0.0062 0.0055
Echinococcus multilocularis BC026374 protein (S09 family) 0.0106 0.0388 0.0381
Loa Loa (eye worm) hypothetical protein 0.005 0.0123 0.0432
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0076 0.0246 0.0893
Giardia lamblia DNA topoisomerase II 0.0136 0.0527 0.1896
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0033 0.0043 0.0142
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0106 0.0388 0.2832
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0028 0.0021
Loa Loa (eye worm) Ulp1 protease 0.0068 0.0211 0.0743
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0063 0.0228
Mycobacterium tuberculosis Cell division protein FtsZ 0.0312 0.136 1
Schistosoma mansoni kinase 0.0049 0.0122 0.0122
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.2718 1
Echinococcus granulosus hypothetical protein 0.0732 0.3337 0.3333
Onchocerca volvulus 0.0028 0.002 0.0153
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0131 0.0447
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0034 0.0034
Loa Loa (eye worm) DR-78 0.0025 0.0007 0.0025
Schistosoma mansoni BC026374 protein (S09 family) 0.0106 0.0388 0.0388
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.1173 0.4282
Onchocerca volvulus 0.0053 0.014 0.1317
Echinococcus multilocularis muscleblind protein 0.0154 0.0614 0.0608
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0063 0.0063
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0063 0.0441
Onchocerca volvulus 0.0106 0.0388 0.3708
Echinococcus granulosus BC026374 protein S09 family 0.0106 0.0388 0.0381
Loa Loa (eye worm) hypothetical protein 0.0106 0.0388 0.1364
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0053 0.014 0.014
Brugia malayi hypothetical protein 0.0054 0.0142 0.0487
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.2718 1
Brugia malayi Muscleblind-like protein 0.0154 0.0614 0.2151
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0007 0.0034
Loa Loa (eye worm) hypoxia-induced factor 1 0.0154 0.0615 0.2162
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.022 0.1293
Brugia malayi prolyl oligopeptidase family protein 0.0209 0.0875 0.3068
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0493
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.022 0.1269
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0053 0.014 0.048
Echinococcus granulosus neuropeptide receptor A26 0.0495 0.222 0.2214
Echinococcus granulosus muscleblind protein 0.0154 0.0614 0.0608
Echinococcus multilocularis neuropeptide receptor A26 0.0495 0.222 0.2214
Echinococcus multilocularis geminin 0.0175 0.0712 0.0705
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0083 0.0282 0.1871
Trypanosoma cruzi DNA topoisomerase II, putative 0.0135 0.0526 0.3103
Schistosoma mansoni inositol monophosphatase 0.0076 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0025
Entamoeba histolytica hypothetical protein 0.0037 0.0063 0.022
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0063 0.0441
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0068 0.0211 0.0726
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0191 0.079 0.4683
Schistosoma mansoni hypothetical protein 0.0175 0.0712 0.0712
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0053 0.014 0.048
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0347 0.1266
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0143 0.0563 0.0556
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.0355 0.1239
Brugia malayi hypothetical protein 0.0025 0.0007 0.0012
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0053 0.014 0.048
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0116 0.0372
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.014 0.0133
Loa Loa (eye worm) carboxylesterase 0.0106 0.0388 0.1364
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.06 0.2718 1
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0007 0.0007
Schistosoma mansoni flap endonuclease-1 0.0024 0.0003 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0037 0.0063 0.0223
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0111 0.0104
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.2718 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0246 0.1448
Brugia malayi Flap endonuclease-1 0.0027 0.0015 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0053 0.014 0.0493
Schistosoma mansoni hypothetical protein 0.0035 0.0054 0.0054
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0063 0.0063
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0731 0.2649
Trichomonas vaginalis DNA topoisomerase II, putative 0.0143 0.0563 0.2026
Entamoeba histolytica hypothetical protein 0.0037 0.0063 0.022
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0068 0.0211 0.0726
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0347 0.1211
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0063 0.0223
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0049 0.0118 0.0422
Onchocerca volvulus 0.0037 0.0063 0.0577
Mycobacterium leprae Probable lipase LipE 0.0037 0.0063 0.0441
Schistosoma mansoni acetylcholinesterase 0.0106 0.0388 0.0388
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.2718 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0028 0.0021 0.0075
Brugia malayi ThiF family protein 0.0033 0.0043 0.0137
Echinococcus granulosus flap endonuclease 1 0.0027 0.0015 0.0008
Brugia malayi Cell division protein ftsZ 0.015 0.0594 0.208
Chlamydia trachomatis DNA gyrase subunit B 0.0066 0.0199 0.6674
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.1173 0.4282
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0031 0.0034 0.0323
Echinococcus multilocularis lamin 0.0028 0.002 0.0012
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0063 0.0441
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0118
Echinococcus multilocularis para nitrobenzyl esterase 0.0106 0.0388 0.0381
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0053 0.014 0.0493
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0246 0.1425
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0037 0.0064 0.0442
Loa Loa (eye worm) hypothetical protein 0.0037 0.0063 0.0223
Brugia malayi Carboxylesterase family protein 0.0106 0.0388 0.1352
Loa Loa (eye worm) hypothetical protein 0.0032 0.0037 0.0131
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0053 0.014 0.014

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 18 nM Inhibition of human DPP4 using gly-pro-para-nitroanilide as substrate ChEMBL. 23416006

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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