Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0562 | 1 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.0562 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0562 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0562 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0562 | 1 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0562 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0562 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0562 | 1 | 1 |
Echinococcus granulosus | c src tyrosine kinase | 0.0562 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0562 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0562 | 1 | 1 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0562 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0562 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0562 | 1 | 1 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0562 | 1 | 1 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0562 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0562 | 1 | 1 |
Brugia malayi | SRC-1 | 0.0562 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0562 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0562 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0562 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0562 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0562 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0562 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0562 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0562 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0562 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0562 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0562 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0562 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0562 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0562 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0562 | 1 | 1 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0562 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0562 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0562 | 1 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.0562 | 1 | 1 |
Onchocerca volvulus | 0.0562 | 1 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.0562 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0562 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0562 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.0562 | 1 | 1 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0562 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0562 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0562 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0562 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0562 | 1 | 1 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0562 | 1 | 1 |
Echinococcus multilocularis | tyrosine kinase | 0.0562 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0562 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0562 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0562 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0562 | 1 | 1 |
Onchocerca volvulus | 0.0562 | 1 | 1 | |
Loa Loa (eye worm) | TK protein kinase | 0.0562 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0562 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0562 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0562 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0562 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0562 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0562 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.0562 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0562 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0562 | 1 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0562 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0562 | 1 | 1 |
Onchocerca volvulus | 0.0562 | 1 | 1 | |
Brugia malayi | protein-tyrosine kinase | 0.0562 | 1 | 1 |
Onchocerca volvulus | 0.0562 | 1 | 1 | |
Onchocerca volvulus | 0.0562 | 1 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0562 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0562 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0562 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0562 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2 nM | Binding affinity towards human dopamine D4 receptor was determined via standard competitive displacement assays using [3H]-YM 09151 as radioligand | ChEMBL. | 12372512 |
Ki (binding) | = 2 nM | Binding affinity towards human dopamine D4 receptor was determined via standard competitive displacement assays using [3H]-YM 09151 as radioligand | ChEMBL. | 12372512 |
Ki (binding) | > 10000 nM | Binding affinity towards human dopamine D2 receptor, using [3H]-YM-09151 as a radioligand | ChEMBL. | 12372512 |
Ki (binding) | > 10000 nM | Binding affinity towards human dopamine D2 receptor, using [3H]-YM-09151 as a radioligand | ChEMBL. | 12372512 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.