Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0042 | 0.4063 | 0.4063 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4063 | 0.4063 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0042 | 0.4063 | 0.4063 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0042 | 0.4063 | 0.4063 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0042 | 0.4063 | 0.4063 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0042 | 0.4063 | 0.4063 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0042 | 0.4063 | 0.4063 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0042 | 0.4063 | 0.4063 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0042 | 0.4063 | 0.4063 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0042 | 0.4063 | 0.4063 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0042 | 0.4063 | 0.4063 |
Schistosoma mansoni | coup transcription factor | 0.0042 | 0.4063 | 0.4063 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0042 | 0.4063 | 0.4063 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0042 | 0.4063 | 0.4063 |
Onchocerca volvulus | 0.0042 | 0.4063 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0042 | 0.4063 | 0.4063 |
Brugia malayi | nuclear receptor NHR-88 | 0.0042 | 0.4063 | 0.4063 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0042 | 0.4063 | 0.4063 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4063 | 0.4063 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0042 | 0.4063 | 0.4063 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0042 | 0.4063 | 0.4063 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0042 | 0.4063 | 0.4063 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4063 | 0.4063 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0042 | 0.4063 | 0.4063 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0042 | 0.4063 | 0.4063 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0042 | 0.4063 | 0.4063 |
Brugia malayi | nuclear hormone receptor | 0.0042 | 0.4063 | 0.4063 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0042 | 0.4063 | 0.4063 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0042 | 0.4063 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0042 | 0.4063 | 0.4063 |
Brugia malayi | TAR-binding protein | 0.0071 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0042 | 0.4063 | 0.4063 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4063 | 0.4063 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4063 | 0.4063 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0042 | 0.4063 | 0.4063 |
Brugia malayi | ecdysteroid receptor | 0.0042 | 0.4063 | 0.4063 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0042 | 0.4063 | 0.4063 |
Brugia malayi | hypothetical protein | 0.0028 | 0.1239 | 0.1239 |
Brugia malayi | steroid hormone receptor | 0.0042 | 0.4063 | 0.4063 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.1239 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0042 | 0.4063 | 0.4063 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0042 | 0.4063 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0042 | 0.4063 | 0.4063 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0042 | 0.4063 | 0.4063 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0042 | 0.4063 | 0.4063 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0042 | 0.4063 | 0.4063 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0042 | 0.4063 | 0.4063 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.1239 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1239 | 0.1239 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0042 | 0.4063 | 0.4063 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.1239 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0042 | 0.4063 | 0.4063 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0042 | 0.4063 | 0.4063 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4063 | 0.4063 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0042 | 0.4063 | 0.4063 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0042 | 0.4063 | 0.4063 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.1239 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0042 | 0.4063 | 0.4063 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.1239 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.1239 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0042 | 0.4063 | 0.4063 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0042 | 0.4063 | 0.4063 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0042 | 0.4063 | 0.4063 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4063 | 0.4063 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.1239 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0042 | 0.4063 | 0.4063 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.1239 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0042 | 0.4063 | 0.4063 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0042 | 0.4063 | 0.4063 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0042 | 0.4063 | 0.4063 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0042 | 0.4063 | 0.4063 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0042 | 0.4063 | 0.4063 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0042 | 0.4063 | 0.4063 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0042 | 0.4063 | 0.4063 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0042 | 0.4063 | 0.4063 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0042 | 0.4063 | 0.4063 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0042 | 0.4063 | 0.4063 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0042 | 0.4063 | 0.4063 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0042 | 0.4063 | 0.4063 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0042 | 0.4063 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0042 | 0.4063 | 0.4063 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4063 | 0.4063 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Cytotoxicity against yeast at 50 uM | ChEMBL. | 23410798 | |
Inhibition (binding) | = 15.2 % | Inhibition of Sir 2 protein mediated transcriptional silencing at the telomeric locus in yeast at 50 uM after 24 to 48 hrs by URA3 reporter gene assay | ChEMBL. | 23410798 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.