Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0067 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = -44 % | Antidiabetic activity in C57Bl/6J mouse assessed as change in blood glucose level at 50 mg/kg, po after 4 hrs relative to vehicle-treated control | ChEMBL. | 24900686 |
Activity (binding) | = 0.31 uM | Activation of glucokinase (unknown origin) using glucose as substrate assessed as stimulation concentration required to achieve 150% activity relative to control | ChEMBL. | 24900686 |
Inhibition (ADMET) | = 5.6 % | Time-dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate at 10 uM incubated for 3 to 24 mins prior to substrate addition measured after 10 mins by LC-MS/MS analysis in presence of NADPH | ChEMBL. | 24900686 |
Inhibition (binding) | = 19 % | Inhibition of human ERG channel at 10 uM by patch clamp method | ChEMBL. | 24900686 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.