TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 313.378 | Formula: C15H15N5OS
H donors: 2 H acceptors: 4 LogP: 2.42 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC(Nc1c(nnc2c1ccc(c2)c1csnc1)C(=O)N)C
InChi: 1S/C15H15N5OS/c1-8(2)18-13-11-4-3-9(10-6-17-22-7-10)5-12(11)19-20-14(13)15(16)21/h3-8H,1-2H3,(H2,16,21)(H,18,19)
InChiKey: OIMDQFFAUBTXHL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	leucine-rich repeat kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	Get druggable targets OG5_131478	All targets in OG5_131478
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_131478	All targets in OG5_131478
Echinococcus granulosus	leucine rich repeat serine:threonine protein	Get druggable targets OG5_131478	All targets in OG5_131478
Loa Loa (eye worm)	TKL/LRRK protein kinase	Get druggable targets OG5_131478	All targets in OG5_131478

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0237	0.0369
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0237	0.0594
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0237	0.0594
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.1819	0.456
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1387	0.216
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0237	0.0369
Trichomonas vaginalis	CAMK family protein kinase	0.0107	0.3989	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0237	0.0369
Brugia malayi	hypothetical protein	0.0041	0.1386	0.2158
Brugia malayi	Isocitrate dehydrogenase	0.0018	0.049	0.0763
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.1387	0.3476
Mycobacterium ulcerans	lipase LipD	0.0041	0.1387	0.5
Onchocerca volvulus		0.0011	0.0237	0.0594
Schistosoma mansoni	coup transcription factor	0.0011	0.0237	0.0594
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0237	0.0369
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.1387	0.0943
Brugia malayi	RNA binding protein	0.0072	0.26	0.4051
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.1386	0.2158
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1387	0.216
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.1387	0.216
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0075	0.2719	0.637
Trichomonas vaginalis	CAMK family protein kinase	0.0107	0.3989	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0025	0.004
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0237	0.0369
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.1387	0.0943
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0107	0.3989	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0025	0.004
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.049	0.0763
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0237	0.0369
Echinococcus multilocularis	muscleblind protein	0.0169	0.642	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0237	0.0369
Brugia malayi	RNA recognition motif domain containing protein	0.0072	0.26	0.4051
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.049	0.0763
Echinococcus multilocularis	isocitrate dehydrogenase	0.0018	0.049	0.0763
Trichomonas vaginalis	CAMK family protein kinase	0.0107	0.3989	1
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.1387	0.2563
Brugia malayi	Protein kinase domain containing protein	0.0071	0.2555	0.398
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0237	0.0369
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0237	0.0369
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.1387	0.0943
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0075	0.2719	0.637
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.1819	0.2833
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0237	0.0594
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0237	0.0594
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0025	0.004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0237	0.0369
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.1387	0.0943
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0075	0.2719	0.637
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0237	0.0594
Echinococcus granulosus	muscleblind protein	0.0169	0.642	1
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0237	0.0594
Onchocerca volvulus		0.0041	0.1387	0.3476
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.049	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0169	0.642	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0018	0.049	0.0763
Trichomonas vaginalis	CAMK family protein kinase	0.0053	0.1871	0.1863
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.1387	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0025	0.004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0237	0.0369
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0237	0.0369
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0237	0.0369
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0237	0.0369
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.1819	0.2833
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0237	0.0369
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.1387	0.2563
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.26	0.6519
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1387	0.216
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0107	0.3989	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0107	0.3989	1
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.1386	0.3473
Trypanosoma brucei	polo-like protein kinase	0.0107	0.3989	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0025	0.004
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0237	0.0369
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0025	0.0064
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.1819	0.456
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0237	0.0369
Brugia malayi	hypothetical protein	0.0006	0.0025	0.004
Brugia malayi	hypothetical protein	0.0006	0.0025	0.004
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0237	0.0369
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.1819	0.2833
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0237	0.0369
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0075	0.2719	0.637
Giardia lamblia	Kinase, PLK	0.0107	0.3989	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.26	0.6519
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0237	0.0594
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0237	0.0369
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0025	0.0064
Brugia malayi	beta-lactamase family protein	0.0041	0.1387	0.216
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0107	0.3989	0.6214
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0025	0.004
Brugia malayi	ecdysteroid receptor	0.0011	0.0237	0.0369
Leishmania major	hypothetical protein, conserved	0.0041	0.1387	0.2563
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0107	0.3989	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0237	0.0594
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.1819	0.456
Loa Loa (eye worm)	hypothetical protein	0.0169	0.642	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0237	0.0369
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.1387	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.1387	0.2563
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.1387	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0237	0.0369
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0237	0.0369
Brugia malayi	nuclear receptor RXR	0.0006	0.0025	0.004
Trichomonas vaginalis	CAMK family protein kinase	0.0107	0.3989	1
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0237	0.0369
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.1387	0.216
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0237	0.0594
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0237	0.0594
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0237	0.0594
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0237	0.0369
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0237	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0237	0.0369
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0107	0.3989	0.6214
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.1387	0.216
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.1387	0.5
Brugia malayi	steroid hormone receptor	0.0011	0.0237	0.0369
Brugia malayi	Muscleblind-like protein	0.0169	0.642	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0107	0.3989	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0237	0.0369
Loa Loa (eye worm)	beta-lactamase	0.0041	0.1387	0.216
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0075	0.2719	0.5121
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0237	0.0594
Brugia malayi	beta-lactamase family protein	0.0041	0.1387	0.216
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0237	0.0369
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0072	0.26	0.4051
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.1819	0.2833
Echinococcus granulosus	transcription factor Dp 1	0.0043	0.1485	0.2313
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0237	0.0369
Echinococcus multilocularis	tar DNA binding protein	0.0072	0.26	0.4051
Brugia malayi	serine/threonine-protein kinase plk-2	0.0107	0.3989	0.6214
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0237	0.0369
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0237	0.0594
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.1387	0.0943
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0237	0.0369
Brugia malayi	nuclear hormone receptor	0.0011	0.0237	0.0369
Echinococcus granulosus	tar DNA binding protein	0.0072	0.26	0.4051
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0025	0.004
Brugia malayi	beta-lactamase	0.0041	0.1387	0.216
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0237	0.0369
Echinococcus granulosus	leucine rich repeat serine:threonine protein	0.0071	0.2574	0.4009
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0075	0.2719	0.4235
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0018	0.049	0.1228
Toxoplasma gondii	ABC1 family protein	0.0041	0.1387	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0237	0.0594
Echinococcus multilocularis	transcription factor Dp 1	0.0043	0.1485	0.2313
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.1387	0.0943
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1387	0.216
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0237	0.0369
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0018	0.049	0.5
Loa Loa (eye worm)	TAR-binding protein	0.0072	0.26	0.4051
Loa Loa (eye worm)	RNA binding protein	0.0072	0.26	0.4051
Mycobacterium tuberculosis	Conserved protein	0.0041	0.1387	0.0943
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.1819	0.2833
Schistosoma mansoni	kinase	0.0055	0.1927	0.483
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0237	0.0369
Mycobacterium tuberculosis	Conserved protein	0.0041	0.1387	0.0943
Schistosoma mansoni	serine/threonine protein kinase	0.0107	0.3989	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0237	0.0369
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.1387	0.3476
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0025	0.004
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0237	0.0594
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0237	0.0369
Schistosoma mansoni	hypothetical protein	0.0041	0.1386	0.3473
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.0071	0.2555	0.398
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0107	0.3989	0.6214
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0237	0.0369
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0025	0.004
Echinococcus multilocularis	muscleblind protein 1	0.0169	0.642	1
Onchocerca volvulus		0.0041	0.1387	0.3476
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0237	0.0369
Mycobacterium ulcerans	hypothetical protein	0.0041	0.1387	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0237	0.0369
Mycobacterium ulcerans	beta-lactamase	0.0041	0.1387	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.26	0.6519
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.1387	0.0943
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0237	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0025	0.004
Onchocerca volvulus		0.0041	0.1387	0.3476
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.26	0.6519
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0237	0.0369
Brugia malayi	isocitrate dehydrogenase	0.0018	0.049	0.0763
Brugia malayi	TAR-binding protein	0.0072	0.26	0.4051
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0237	0.0369
Trichomonas vaginalis	CAMK family protein kinase	0.0053	0.1871	0.1863
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0237	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1387	0.216
Mycobacterium tuberculosis	Conserved protein	0.0041	0.1387	0.0943
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0237	0.0369
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0237	0.0369
Trichomonas vaginalis	CAMK family protein kinase	0.0107	0.3989	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.1386	0.2158
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0237	0.0369
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0075	0.2719	0.4235
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0237	0.0369
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0018	0.049	0.0763
Trichomonas vaginalis	CAMK family protein kinase	0.0107	0.3989	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0237	0.0369
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.0071	0.2555	0.398
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0237	0.0369
Trichomonas vaginalis	CAMK family protein kinase	0.0107	0.3989	1
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.26	0.6519
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1387	0.216
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0237	0.0369
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0018	0.049	0.0763
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.1387	0.216
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0075	0.2719	0.6816
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0075	0.2719	0.4235
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.1819	0.2833
Mycobacterium leprae	Probable lipase LipE	0.0041	0.1387	0.5
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0075	0.2719	0.4235

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 0.29 uM	Inhibition of LRRK2 G2019S mutant (unknown origin) transfected in HEK293 cells assessed as inhibition of S935 phosphorylation	ChEMBL.	23219325
IC50 (binding)	= 0.014 uM	Inhibition of wild type GST-tagged LRRK2 (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphorylation by HTRF assay in presence of ATP	ChEMBL.	23219325
IC50 (binding)	= 0.02 uM	Inhibition of GST-tagged LRRK2 G2019S mutant (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphorylation by HTRF assay in presence of ATP	ChEMBL.	23219325

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2333121

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1732188