Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1657 | 0.9813 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0228 | 0.1165 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.1688 | 1 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1657 | 0.9813 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0228 | 0.1165 | 0.1187 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.1657 | 0.9813 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.1657 | 0.9813 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0228 | 0.1165 | 0.1187 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1657 | 0.9813 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1657 | 0.9813 | 1 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0228 | 0.1165 | 0.5 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.1657 | 0.9813 | 1 |
Schistosoma mansoni | fk506 binding protein | 0.0228 | 0.1165 | 0.1165 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0228 | 0.1165 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1657 | 0.9813 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0228 | 0.1165 | 0.1187 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.1657 | 0.9813 | 0.9813 |
Loa Loa (eye worm) | hypothetical protein | 0.1434 | 0.8462 | 0.8623 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.1657 | 0.9813 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.1657 | 0.9813 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.1657 | 0.9813 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.1657 | 0.9813 | 1 |
Leishmania major | FKBP-type peptidyl-prolyl cis-trans isomerase, putative | 0.0228 | 0.1165 | 0.1187 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.0228 | 0.1165 | 0.1187 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0228 | 0.1165 | 0.1187 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0228 | 0.1165 | 0.1165 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative | 0.0228 | 0.1165 | 0.1187 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0228 | 0.1165 | 0.1187 |
Echinococcus multilocularis | fk506 binding protein | 0.1657 | 0.9813 | 0.9813 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.1662 | 0.9842 | 1 |
Schistosoma mansoni | immunophilin | 0.1688 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.1688 | 1 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0228 | 0.1165 | 0.5 |
Onchocerca volvulus | 0.0228 | 0.1165 | 0.9762 | |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0259 | 0.1352 | 0.1352 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0228 | 0.1165 | 0.1187 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.146 | 0.862 | 0.862 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.1657 | 0.9813 | 0.9813 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.1165 | 0.1187 |
Echinococcus multilocularis | 0.0228 | 0.1165 | 0.1165 | |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1688 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1657 | 0.9813 | 1 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0228 | 0.1165 | 0.5 |
Leishmania major | fk506-binding protein 1-like protein | 0.1657 | 0.9813 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.1657 | 0.9813 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0228 | 0.1165 | 0.5 |
Trypanosoma brucei | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0228 | 0.1165 | 0.1187 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0228 | 0.1165 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0228 | 0.1165 | 0.1187 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.146 | 0.862 | 0.862 |
Onchocerca volvulus | 0.0233 | 0.1193 | 1 | |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.1657 | 0.9813 | 1 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0228 | 0.1165 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0228 | 0.1165 | 0.1187 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0228 | 0.1165 | 0.1187 |
Schistosoma mansoni | hypothetical protein | 0.0228 | 0.1165 | 0.1165 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1657 | 0.9813 | 1 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0228 | 0.1165 | 0.5 |
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | 0.0228 | 0.1165 | 0.1187 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.1657 | 0.9813 | 1 |
Trichomonas vaginalis | fk506 binding protein, putative | 0.0228 | 0.1165 | 0.1187 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.1657 | 0.9813 | 0.9967 |
Schistosoma mansoni | immunophilin | 0.1688 | 1 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.1657 | 0.9813 | 1 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0228 | 0.1165 | 0.1165 |
Schistosoma mansoni | immunophilin | 0.146 | 0.862 | 0.862 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.1657 | 0.9813 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 1.16 uM | Growth inhibition of human MDA-MB-468 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 23200248 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.