Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 10 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04440 c-Jun N-terminal kinase, putative | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Echinococcus granulosus | c-Jun N-terminal kinases | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Brugia malayi | Stress-activated protein kinase jnk-1 | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma japonicum | IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.2257 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1821 | 0.7771 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1821 | 0.7771 | 0.7771 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1821 | 0.7771 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1821 | 0.7771 | 0.5 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.2257 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1821 | 0.7771 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1821 | 0.7771 | 0.7771 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.2257 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.2257 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1821 | 0.7771 | 0.7771 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.2257 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1821 | 0.7771 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.1821 | 0.7771 | 0.7771 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.2257 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1821 | 0.7771 | 1 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.2257 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1821 | 0.7771 | 0.7771 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1821 | 0.7771 | 0.7771 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.2257 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1821 | 0.7771 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.2257 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.2257 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.2257 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 4.97 | Binding affinity to JNK3 (unknown origin) by surface plasmon resonance analysis in presence of ATP | ChEMBL. | 23416008 |
Kd (binding) | = 10.7 uM | Binding affinity to JNK3 (unknown origin) by surface plasmon resonance analysis in presence of ATP | ChEMBL. | 23416008 |
Kd (binding) | = 10.7 uM | Binding affinity to N-terminal His6X-tagged human recombinant JNK3 catalytic domain expressed in Escherichia coli BL21 (DE3) by surface plasmon resonance analysis | ChEMBL. | 23498914 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.