Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | No references | |
Mus musculus | prostaglandin-endoperoxide synthase 1 | Starlite/ChEMBL | References |
Mus musculus | prostaglandin-endoperoxide synthase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0111 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0111 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0111 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0111 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 430 nM | In Vitro Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 0.023 uM | Inhibition of Escherichia coli lipopolysaccharide-induced COX2 activity in mouse J774 cells assessed as decrease in PGE2 levels after 24 hrs by RIA | ChEMBL. | 23534442 |
IC50 (binding) | = 0.43 uM | Inhibition of COX2 in Escherichia coli LPS-stimulated mouse J774 cells using arachidonic acid as substrate assessed as decrease in PGE2 production preincubated for 15 mins followed by substrate addition measured after 30 mins by radioimmunoassay | PATENT. | No reference |
IC50 (binding) | = 2.9 uM | Inhibition of arachidonic acid-induced COX1 activity in mouse J774 cells assessed as decrease in PGE2 levels incubated for 15 mins prior to arachidonic acid-challenge measured after 30 mins by RIA | ChEMBL. | 23534442 |
Inhibition (binding) | < 20 % | Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as decrease in PGE2 production at 10 uM preincubated for 15 mins followed by substrate addition measured after 30 mins by radioimmunoassay relative to control | PATENT. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.