TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 621.648 | Formula: C32H27F4N5O2S
H donors: 1 H acceptors: 4 LogP: 4.96 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: OCc1nnc(n1Cc1ccc(cc1)c1ccc(cc1)C(F)(F)F)Cn1c(SCc2ccc(cc2)F)nc(=O)c2c1CCC2
InChi: 1S/C32H27F4N5O2S/c33-25-14-6-21(7-15-25)19-44-31-37-30(43)26-2-1-3-27(26)40(31)17-28-38-39-29(18-42)41(28)16-20-4-8-22(9-5-20)23-10-12-24(13-11-23)32(34,35)36/h4-15,42H,1-3,16-19H2
InChiKey: ILIMHPUEFGSEPF-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cyclins	0.0014	0.0073	0.0048
Echinococcus multilocularis	cyclins	0.006	0.1085	0.1063
Entamoeba histolytica	cyclin family protein	0.006	0.1085	0.3449
Trypanosoma cruzi	cdc2-related kinase 1	0.0054	0.0941	0.3086
Entamoeba histolytica	protein kinase, putative	0.0012	0.0025	0.0079
Trichomonas vaginalis	cyclin B, putative	0.006	0.1085	0.3573
Onchocerca volvulus		0.0032	0.0471	0.0662
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0029	0.0388	0.0364
Entamoeba histolytica	protein kinase, putative	0.0078	0.1483	0.4715
Trichomonas vaginalis	cyclins, putative	0.006	0.1085	0.3573
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0078	0.1491	0.147
Echinococcus granulosus	cyclin A3 4	0.0014	0.0073	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0278	0.5928	0.8412
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0146	0.2993	1
Loa Loa (eye worm)	TK protein kinase	0.0032	0.0465	0.0564
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0014	0.0073	0.0048
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0075	0.141	0.1388
Entamoeba histolytica	PH domain containing protein kinase, putative	0.014	0.2856	0.9078
Brugia malayi	Ras association domain family 1 isoform A	0.0073	0.1371	0.2172
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0198	0.4161	0.4146
Plasmodium vivax	protein kinase Crk2	0.0054	0.0941	0.3086
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.2993	0.2975
Trypanosoma cruzi	cdc2-related kinase 3	0.0054	0.0941	0.3086
Echinococcus granulosus	G1:S specific cyclin D1	0.0014	0.0073	0.0048
Loa Loa (eye worm)	hypothetical protein	0.006	0.1085	0.1454
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0036	0.0541	0.0517
Plasmodium vivax	cyclin 4, putative	0.0014	0.0073	0.0162
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.133	0.4397
Trypanosoma brucei	cdc2-related kinase 3	0.0054	0.0941	0.3086
Plasmodium falciparum	cyclin dependent kinase binding protein, putative	0.0014	0.0073	0.0162
Entamoeba histolytica	hypothetical protein	0.0014	0.0073	0.0232
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0071	0.133	0.1308
Echinococcus multilocularis	cyclin dependent kinase	0.0054	0.0941	0.0918
Echinococcus multilocularis	cyclin y	0.0014	0.0073	0.0048
Echinococcus granulosus	cpg binding protein	0.0034	0.0512	0.0488
Echinococcus multilocularis	epidermal growth factor receptor	0.0075	0.1416	0.1395
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0146	0.2993	0.4195
Brugia malayi	protein kinase C II.	0.0277	0.5909	0.9767
Entamoeba histolytica	protein kinase, putative	0.0071	0.133	0.4226
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.014	0.2872	0.2855
Toxoplasma gondii	cyclin dependent kinase binding protein	0.0014	0.0073	0.0162
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.003	0.0426	0.0403
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0146	0.2993	1
Echinococcus granulosus	cyclins	0.006	0.1085	0.1063
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0146	0.2993	0.2975
Entamoeba histolytica	hypothetical protein	0.0012	0.0025	0.0079
Toxoplasma gondii	AGC kinase	0.0146	0.2993	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0016	0.0111	0.0054
Echinococcus granulosus	myotubularin protein 13	0.008	0.1524	0.1503
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0146	0.2993	0.2975
Loa Loa (eye worm)	hypothetical protein	0.0205	0.4309	0.6085
Schistosoma mansoni	cyclin k	0.0014	0.0073	0.0048
Echinococcus granulosus	cyclin dependent kinase 1	0.0054	0.0941	0.0918
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0054	0.0941	0.0918
Echinococcus granulosus	cyclin B	0.006	0.1085	0.1063
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0036	0.0541	0.0517
Schistosoma mansoni	cyclin G2	0.0014	0.0073	0.0048
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0036	0.0541	0.0517
Echinococcus multilocularis	cyclin B	0.006	0.1085	0.1063
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0471	0.0666
Brugia malayi	RhoGEF domain containing protein	0.0073	0.1371	0.2172
Giardia lamblia	G2/mitotic-specific cyclin B	0.006	0.1085	0.3467
Giardia lamblia	Kinase, AGC PKA	0.0146	0.2993	1
Brugia malayi	SRC-1	0.0036	0.0541	0.0783
Echinococcus multilocularis	protein kinase c iota type	0.022	0.4641	0.4627
Echinococcus granulosus	cyclin dependent kinase 5	0.0054	0.0941	0.0918
Schistosoma mansoni	cyclin G	0.0014	0.0073	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0182	0.3797	0.5351
Entamoeba histolytica	diacylglycerol kinase, putative	0.0073	0.1371	0.4356
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0071	0.133	0.1806
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.133	0.1308
Brugia malayi	Protein kinase domain containing protein	0.0045	0.075	0.1134
Schistosoma mansoni	serine/threonine protein kinase	0.0078	0.1491	0.147
Schistosoma mansoni	tyrosine kinase	0.0073	0.1377	0.1356
Trypanosoma cruzi	cyclin 9, putative	0.0014	0.0073	0.0162
Brugia malayi	Furin-like cysteine rich region family protein	0.0139	0.2832	0.4618
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0054	0.0941	0.1247
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0073	0.0162
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0073	0.0162
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0146	0.2993	0.2975
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.133	0.4397
Trypanosoma cruzi	cyclin, putative	0.006	0.1085	0.3573
Schistosoma mansoni	serine/threonine kinase	0.0071	0.133	0.1308
Echinococcus multilocularis	cyclins	0.006	0.1085	0.1063
Brugia malayi	RhoGAP domain containing protein	0.0073	0.1371	0.2172
Echinococcus granulosus	Protein kinase C brain isozyme	0.0259	0.5505	0.5494
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0036	0.0541	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1499	0.2049
Echinococcus multilocularis	Cyclin L1	0.0014	0.0073	0.0048
Trypanosoma cruzi	cdc2-related kinase 3	0.0054	0.0941	0.3086
Echinococcus multilocularis	dnaJ subfamily B	0.0461	1	1
Toxoplasma gondii	hypothetical protein	0.0046	0.0763	0.2488
Entamoeba histolytica	protein kinase, putative	0.0012	0.0025	0.0079
Echinococcus multilocularis	cyclins	0.006	0.1085	0.1063
Entamoeba histolytica	protein kinase, putative	0.0078	0.1483	0.4715
Trypanosoma brucei	mitotic cyclin 6	0.006	0.1085	0.3573
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0146	0.2993	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0032	0.0465	0.0442
Schistosoma mansoni	hypothetical protein	0.0014	0.0073	0.0048
Loa Loa (eye worm)	TK/INSR protein kinase	0.0045	0.075	0.0973
Loa Loa (eye worm)	hypothetical protein	0.006	0.1085	0.1454
Entamoeba histolytica	protein kinase, putative	0.0012	0.0025	0.0079
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0036	0.0541	0.0517
Echinococcus granulosus	raf serine:threonine protein kinase	0.0075	0.141	0.1388
Entamoeba histolytica	cell division protein kinase 2, putative	0.0054	0.0941	0.299
Echinococcus granulosus	Cyclin L1	0.0014	0.0073	0.0048
Trichomonas vaginalis	cyclin B, putative	0.006	0.1085	0.3573
Brugia malayi	Protein kinase domain containing protein	0.0071	0.133	0.2103
Entamoeba histolytica	diacylglycerol kinase, putative	0.0073	0.1371	0.4356
Echinococcus granulosus	serine:threonine protein kinase N2	0.0133	0.2702	0.2684
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0194	0.4053	0.5718
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0054	0.0941	0.3086
Trypanosoma brucei	cdc2-related kinase 1	0.0054	0.0941	0.3086
Schistosoma mansoni	tyrosine kinase	0.0036	0.0541	0.0517
Echinococcus multilocularis	cyclin	0.0014	0.0073	0.0048
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0259	0.5505	0.5494
Trichomonas vaginalis	cyclins, putative	0.0014	0.0073	0.0162
Echinococcus granulosus	tyrosine kinase	0.0032	0.0465	0.0442
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0076	0.1448	0.1427
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.133	0.1308
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0041	0.0661	0.0638
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0071	0.133	0.1308
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0012	0.0025	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1371	0.1864
Echinococcus multilocularis	cyclin dependent kinase 1	0.0054	0.0941	0.0918
Trichomonas vaginalis	cyclins, putative	0.006	0.1085	0.3573
Schistosoma mansoni	atypical protein kinase C	0.0226	0.4765	0.4752
Leishmania major	cyclin	0.006	0.1085	0.3573
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.2993	0.2975
Echinococcus multilocularis	epidermal growth factor receptor	0.0139	0.2832	0.2814
Schistosoma mansoni	tyrosine kinase	0.0073	0.1377	0.1356
Loa Loa (eye worm)	hypothetical protein	0.0109	0.2178	0.3024
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0941	0.1452
Echinococcus granulosus	epidermal growth factor receptor	0.0075	0.1416	0.1395
Plasmodium falciparum	cyclin 1	0.0014	0.0073	0.0162
Trypanosoma cruzi	cyclin 6, putative	0.006	0.1085	0.3573
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0014	0.0073	0.0162
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0146	0.2993	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0073	0.0162
Brugia malayi	Hr1 repeat family protein	0.0071	0.133	0.2103
Schistosoma mansoni	protein kinase C	0.0079	0.1499	0.1478
Echinococcus granulosus	NDR protein kinase	0.0071	0.133	0.1308
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0941	0.0918
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.006	0.1085	0.3573
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0079	0.1499	0.1478
Toxoplasma gondii	hypothetical protein	0.0014	0.0073	0.0162
Trypanosoma cruzi	cyclin, putative	0.006	0.1085	0.3573
Echinococcus multilocularis	cyclins	0.006	0.1085	0.1063
Echinococcus granulosus	insulin receptor	0.0045	0.075	0.0727
Schistosoma mansoni	diacylglycerol kinase theta	0.0073	0.1371	0.1349
Trichomonas vaginalis	cyclin D, putative	0.006	0.1085	0.3573
Trypanosoma brucei	mitotic cyclin	0.0014	0.0073	0.0162
Entamoeba histolytica	p21-activated kinase	0.0012	0.0025	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.1483	0.4915
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0146	0.2993	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0012	0.0025	0.0079
Schistosoma mansoni	cyclin l	0.0014	0.0073	0.0048
Onchocerca volvulus		0.0278	0.5928	0.9744
Echinococcus granulosus	Rac GTPase activating protein 1	0.0073	0.1371	0.1349
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0071	0.133	0.1806
Brugia malayi	C1-like domain containing protein	0.0283	0.6048	1
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0014	0.0073	0.0048
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0036	0.0541	0.0517
Leishmania major	protein kinase A catalytic subunit	0.0146	0.2993	1
Entamoeba histolytica	protein kinase, putative	0.0012	0.0025	0.0079
Schistosoma mansoni	serine/threonine protein kinase	0.0259	0.5505	0.5494
Echinococcus granulosus	tyrosine protein kinase Blk	0.0032	0.0465	0.0442
Trypanosoma cruzi	mitotic cyclin, putative	0.0014	0.0073	0.0162
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0146	0.2993	0.4886
Loa Loa (eye worm)	hypothetical protein	0.0205	0.4309	0.6085
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1371	0.1864
Echinococcus granulosus	tyrosine protein kinase Src42A	0.003	0.0426	0.0403
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0146	0.2993	0.2975
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0071	0.133	0.1806
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0036	0.0541	0.0517
Trichomonas vaginalis	cyclin B3, putative	0.0014	0.0073	0.0162
Brugia malayi	Cyclin, N-terminal domain containing protein	0.006	0.1085	0.1694
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0146	0.2993	1
Echinococcus multilocularis	cyclin dependent kinase 1	0.0054	0.0941	0.0918
Echinococcus granulosus	unc 13 munc13	0.0079	0.1499	0.1478
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0073	0.0162
Toxoplasma gondii	diacylglycerol kinase, putative	0.0073	0.1371	0.4535
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0054	0.0941	0.3086
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0153	0.3146	1
Entamoeba histolytica	cyclin C, putative	0.0014	0.0073	0.0232
Schistosoma mansoni	cyclins	0.006	0.1085	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0821	0.1074
Schistosoma mansoni	hypothetical protein	0.0014	0.0073	0.0048
Brugia malayi	cell division control protein 2 homolog	0.0054	0.0941	0.1452
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0146	0.2993	0.2975
Echinococcus granulosus	tyrosine protein kinase HCK	0.0029	0.0388	0.0364
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0071	0.133	0.1806
Echinococcus granulosus	cyclins	0.006	0.1085	0.1063
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0054	0.0941	0.1247
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0941	0.0918
Echinococcus multilocularis	G1:S specific cyclin D1	0.0014	0.0073	0.0048
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0036	0.0541	0.0517
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0139	0.2832	0.3964
Schistosoma mansoni	rac gtpase activating protein	0.0073	0.1371	0.1349
Trichomonas vaginalis	cyclins, putative	0.006	0.1085	0.3573
Onchocerca volvulus		0.0205	0.4309	0.7049
Echinococcus multilocularis	protein kinase c epsilon type	0.0277	0.5909	0.5899
Schistosoma mansoni	cyclin B3	0.006	0.1085	0.1063
Echinococcus granulosus	cyclin	0.0014	0.0073	0.0048
Echinococcus granulosus	RNA directed DNA polymerase	0.0109	0.2178	0.2158
Schistosoma mansoni	protein kinase C mu	0.0283	0.6048	0.6039
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.1085	0.3573
Echinococcus granulosus	cyclin G2	0.0014	0.0073	0.0048
Echinococcus granulosus	protein kinase c iota type	0.022	0.4641	0.4627
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0036	0.0541	0.0517
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0146	0.2993	0.2975
Schistosoma mansoni	unc-13 (munc13)	0.0079	0.1499	0.1478
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0032	0.0465	0.0442
Trichomonas vaginalis	cyclins, putative	0.006	0.1085	0.3573
Echinococcus granulosus	cyclins	0.006	0.1085	0.1063
Loa Loa (eye worm)	raf kinase	0.0073	0.1371	0.1864
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.006	0.1085	0.1063
Onchocerca volvulus		0.0285	0.6082	1
Echinococcus multilocularis	protein kinase c eta type	0.0073	0.1371	0.1349
Schistosoma mansoni	cpg binding protein	0.0032	0.0471	0.0447
Echinococcus multilocularis	cyclins	0.006	0.1085	0.1063
Echinococcus multilocularis	cyclin G2	0.0014	0.0073	0.0048
Echinococcus multilocularis	cyclin b3	0.006	0.1085	0.1063
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0941	0.3086
Echinococcus granulosus	cyclins	0.006	0.1085	0.1063
Giardia lamblia	Kinase, CMGC CDK	0.0054	0.0941	0.2972
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.016	0.3306	0.4645
Toxoplasma gondii	cyclin, N-terminal domain-containing protein	0.0014	0.0073	0.0162
Schistosoma mansoni	tyrosine kinase	0.0075	0.1416	0.1395
Schistosoma mansoni	vav2	0.0083	0.1601	0.1581
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0066	0.121	0.3992
Schistosoma mansoni	serine/threonine protein kinase	0.0078	0.1491	0.147
Echinococcus multilocularis	insulin receptor	0.0045	0.075	0.0727
Brugia malayi	Protein kinase c protein 2	0.0193	0.4046	0.665
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0069	0.1277	0.1256
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.1483	0.4915
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1371	0.1864
Loa Loa (eye worm)	hypothetical protein	0.0285	0.6082	0.8633
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.133	0.1308
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0941	0.3086
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0012	0.0025	0.0079
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0153	0.3146	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.006	0.1085	0.1694
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0045	0.075	0.0727
Schistosoma mansoni	tyrosine kinase	0.0139	0.2832	0.2814
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0036	0.0541	0.0517
Schistosoma mansoni	tyrosine kinase	0.0036	0.0541	0.0517
Onchocerca volvulus		0.006	0.1085	0.1684
Brugia malayi	protein-tyrosine kinase	0.0032	0.0465	0.0657
Schistosoma mansoni	cyclin d	0.0014	0.0073	0.0048
Trichomonas vaginalis	cyclins, putative	0.006	0.1085	0.3573
Entamoeba histolytica	cyclin, putative	0.006	0.1085	0.3449
Brugia malayi	p70 ribosomal S6 kinase beta	0.0071	0.133	0.2103
Trichomonas vaginalis	cyclin B3, putative	0.0014	0.0073	0.0162
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0073	0.1371	0.1349
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0045	0.075	0.0727
Echinococcus multilocularis	cyclin k	0.0014	0.0073	0.0048
Echinococcus multilocularis	cyclin B3 1	0.006	0.1085	0.1063
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0071	0.133	0.1308
Giardia lamblia	Kinase, CMGC CDK	0.0054	0.0941	0.2972
Echinococcus multilocularis	cyclin y	0.0014	0.0073	0.0048
Echinococcus granulosus	Diacylglycerol kinase theta	0.0073	0.1371	0.1349
Toxoplasma gondii	cyclin domain protein, cyclin H family protein	0.0014	0.0073	0.0162
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0211	0.4429	0.6258
Brugia malayi	Pleckstrin Homology Domain	0.008	0.1524	0.2429
Trichomonas vaginalis	cyclin B, putative	0.006	0.1085	0.3573
Trichomonas vaginalis	cyclin D, putative	0.0014	0.0073	0.0162
Trypanosoma brucei	cyclin dependent kinase-binding protein, putative	0.0014	0.0073	0.0162
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0036	0.0541	0.0517
Echinococcus granulosus	cyclin k	0.0014	0.0073	0.0048
Schistosoma mansoni	tyrosine kinase	0.0045	0.075	0.0727
Echinococcus granulosus	protein kinase c eta type	0.0073	0.1371	0.1349
Echinococcus multilocularis	cyclin dependent kinase 5	0.0054	0.0941	0.0918
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.2993	0.2975
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1371	0.1864
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.1483	0.4915
Loa Loa (eye worm)	TK protein kinase	0.0029	0.0388	0.0453
Entamoeba histolytica	cyclin, domain containing protein	0.0014	0.0073	0.0232
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.1483	0.4915
Echinococcus multilocularis	cyclin t1	0.0014	0.0073	0.0048
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.133	0.4397
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0076	0.1448	0.1975
Schistosoma mansoni	hypothetical protein	0.0073	0.1371	0.1349
Brugia malayi	Protein kinase domain containing protein	0.0078	0.1491	0.2373
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0032	0.0465	0.0442
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0277	0.5909	0.8385
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0071	0.133	0.1806
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0146	0.2993	1
Trichomonas vaginalis	cyclin B, putative	0.006	0.1085	0.3573
Trichomonas vaginalis	cyclin A, putative	0.0014	0.0073	0.0162
Trypanosoma cruzi	CYC2-like cyclin, putative	0.006	0.1085	0.3573
Echinococcus granulosus	cyclin B3 1	0.006	0.1085	0.1063
Echinococcus granulosus	cyclin b3	0.006	0.1085	0.1063
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.0014	0.0073	0.0048
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0014	0.0073	0.0048
Loa Loa (eye worm)	SRC-1	0.0036	0.0541	0.0672
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0283	0.6048	1
Leishmania major	cyclin 9, putative	0.0014	0.0073	0.0162
Brugia malayi	Cyclin, N-terminal domain containing protein	0.006	0.1085	0.1694
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0071	0.133	0.1308
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.1114	0.3671
Schistosoma mansoni	diacylglycerol kinase theta	0.0073	0.1371	0.1349
Schistosoma mansoni	Cyclin fold protein	0.0014	0.0073	0.0048
Onchocerca volvulus		0.0255	0.5414	0.8888
Leishmania major	mitotic cyclin, putative	0.0014	0.0073	0.0162
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0071	0.133	0.1308
Loa Loa (eye worm)	cyclin domain-containing protein	0.0281	0.5988	0.8498
Schistosoma mansoni	g1/s-specific cyclin C	0.0014	0.0073	0.0048
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0941	0.3086
Schistosoma mansoni	serine/threonine protein kinase	0.0259	0.5505	0.5494
Toxoplasma gondii	AGC kinase	0.0071	0.133	0.4397
Schistosoma mansoni	hypothetical protein	0.0461	1	1
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0109	0.2178	0.2158
Brugia malayi	Protein kinase domain containing protein	0.0078	0.1483	0.236
Entamoeba histolytica	protein kinase, putative	0.0029	0.0388	0.1234
Entamoeba histolytica	protein kinase, putative	0.0012	0.0025	0.0079
Echinococcus multilocularis	unc 13 (munc13)	0.0079	0.1499	0.1478
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0075	0.1416	0.1395
Trichomonas vaginalis	cyclin D, putative	0.006	0.1085	0.3573
Trichomonas vaginalis	cyclin B, putative	0.006	0.1085	0.3573
Trichomonas vaginalis	cyclin A, putative	0.006	0.1085	0.3573
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1371	0.1864
Trypanosoma brucei	cyclin 3	0.0014	0.0073	0.0162
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0073	0.1371	0.1864
Schistosoma mansoni	unc-13 (munc13)	0.0079	0.1499	0.1478
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0078	0.1491	0.147
Loa Loa (eye worm)	hypothetical protein	0.0328	0.7033	1
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0071	0.133	0.1308
Loa Loa (eye worm)	hypothetical protein	0.008	0.1524	0.2085
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0076	0.1448	0.1427
Trypanosoma brucei	cyclin 9	0.0014	0.0073	0.0162
Brugia malayi	Variant SH3 domain containing protein	0.0076	0.1448	0.2301
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0146	0.2993	0.2975
Schistosoma mansoni	cpg binding protein	0.0034	0.0512	0.0488
Echinococcus multilocularis	RNA directed DNA polymerase	0.0109	0.2178	0.2158
Plasmodium vivax	cyclin dependent kinase binding protein, putative	0.0014	0.0073	0.0162
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0283	0.6048	0.8585
Echinococcus granulosus	protein kinase c epsilon type	0.0277	0.5909	0.5899
Plasmodium vivax	hypothetical protein, conserved	0.0014	0.0073	0.0162
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0036	0.0541	0.0517
Echinococcus multilocularis	cyclins	0.006	0.1085	0.1063
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.1483	0.4915
Schistosoma mansoni	cpg binding protein	0.0034	0.0512	0.0488
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0146	0.2993	1
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0054	0.0941	0.1247
Trypanosoma cruzi	mitotic cyclin, putative	0.0014	0.0073	0.0162
Echinococcus granulosus	N chimaerin	0.0076	0.1448	0.1427
Onchocerca volvulus		0.0079	0.1499	0.2374
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0073	0.0162
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0036	0.0541	0.0517
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0078	0.1483	0.2026
Echinococcus granulosus	epidermal growth factor receptor	0.0139	0.2832	0.2814
Echinococcus granulosus	protein kinase C gamma type	0.0186	0.3885	0.387
Toxoplasma gondii	AGC kinase	0.0146	0.2993	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0036	0.0541	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2993	0.4195
Loa Loa (eye worm)	hypothetical protein	0.0255	0.5414	0.7673
Brugia malayi	Variant SH3 domain containing protein	0.0016	0.0111	0.0063
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0071	0.133	0.1308
Schistosoma mansoni	tyrosine kinase	0.0075	0.1416	0.1395
Plasmodium vivax	cyclin homologue, putative	0.0014	0.0073	0.0162
Plasmodium falciparum	protein kinase 5	0.0054	0.0941	0.3086
Echinococcus granulosus	cyclin dependent kinase	0.0054	0.0941	0.0918
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.0014	0.0073	0.0048
Trypanosoma cruzi	cdc2-related kinase 1	0.0054	0.0941	0.3086
Entamoeba histolytica	cyclin, putative	0.006	0.1085	0.3449
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0471	0.0571
Toxoplasma gondii	cyclin 4, putative	0.0014	0.0073	0.0162
Echinococcus granulosus	cyclin G2	0.0014	0.0073	0.0048
Schistosoma mansoni	cyclin B	0.006	0.1085	0.1063
Trichomonas vaginalis	cyclins, putative	0.0014	0.0073	0.0162
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0071	0.133	0.1308
Plasmodium falciparum	cyclin	0.006	0.1085	0.3573
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0073	0.1371	0.1349
Echinococcus granulosus	serine:threonine protein kinase N2	0.0071	0.133	0.1308
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0146	0.2993	1
Schistosoma mansoni	tyrosine kinase	0.0073	0.1377	0.1356
Echinococcus granulosus	cyclin y	0.0014	0.0073	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0326	0.6992	0.9941
Entamoeba histolytica	cell division protein kinase 2, putative	0.0054	0.0941	0.299
Echinococcus multilocularis	N chimaerin	0.0076	0.1448	0.1427
Echinococcus multilocularis	cyclin A3 4	0.0014	0.0073	0.0048
Entamoeba histolytica	hypothetical protein	0.0012	0.0025	0.0079
Trichomonas vaginalis	cyclins, putative	0.0014	0.0073	0.0162
Schistosoma mansoni	tyrosine kinase	0.0045	0.075	0.0727
Brugia malayi	Protein kinase domain containing protein	0.0194	0.4053	0.666
Echinococcus multilocularis		0.0043	0.0698	0.0675
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0146	0.2993	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0032	0.0465	0.0442
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0036	0.0541	0.0517
Schistosoma mansoni	protein kinase C mu	0.0073	0.1371	0.1349
Entamoeba histolytica	cyclin, domain containing protein	0.0014	0.0073	0.0232
Schistosoma mansoni	serine/threonine protein kinase	0.0194	0.4053	0.4038
Brugia malayi	Protein kinase domain containing protein	0.0071	0.133	0.2103
Entamoeba histolytica	hypothetical protein	0.0073	0.1371	0.4356
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0281	0.5988	0.9899
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0076	0.1448	0.1427
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.133	0.1308
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0054	0.0941	0.3086
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0146	0.2993	1
Brugia malayi	diacylglycerol kinase	0.0073	0.1371	0.2172
Echinococcus granulosus	cyclin t1	0.0014	0.0073	0.0048
Trichomonas vaginalis	AGC family protein kinase	0.0146	0.2993	1
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.014	0.2872	0.2855
Schistosoma mansoni	serine/threonine protein kinase	0.0075	0.141	0.1388
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0079	0.1499	0.1478
Schistosoma mansoni	serine/threonine protein kinase	0.0277	0.5909	0.5899
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0073	0.1371	0.1864
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0073	0.1371	0.1864
Echinococcus multilocularis	cyclin G2	0.0014	0.0073	0.0048
Entamoeba histolytica	cyclin family protein	0.006	0.1085	0.3449
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0078	0.1483	0.4915
Entamoeba histolytica	protein kinase, putative	0.0071	0.133	0.4226
Trichomonas vaginalis	cyclin B, putative	0.0014	0.0073	0.0162
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0146	0.2993	0.4195
Echinococcus multilocularis	serine threonine protein kinase	0.0186	0.3885	0.387
Brugia malayi	RhoGAP domain containing protein	0.0076	0.1448	0.2301
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0146	0.2993	1
Brugia malayi	diacylglycerol kinase	0.0073	0.1371	0.2172
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.1483	0.4915
Loa Loa (eye worm)	hypothetical protein	0.0255	0.5414	0.7673
Echinococcus multilocularis	cyclins	0.006	0.1085	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0255	0.5414	0.7673
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.006	0.1085	0.1063
Trichomonas vaginalis	cyclin B3, putative	0.006	0.1085	0.3573
Trichomonas vaginalis	cyclin B, putative	0.0014	0.0073	0.0162
Echinococcus multilocularis	cpg binding protein	0.0034	0.0512	0.0488
Giardia lamblia	Hypothetical protein	0.006	0.1085	0.3467
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.012	0.2427	0.3382
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0036	0.0541	0.0517
Echinococcus granulosus	cyclin y	0.0014	0.0073	0.0048
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.1483	0.4915
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0076	0.1448	0.1427
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.1483	0.4915
Echinococcus granulosus	cyclins	0.006	0.1085	0.1063
Giardia lamblia	Cyclin A	0.006	0.1085	0.3467
Echinococcus multilocularis	myotubularin protein 13	0.008	0.1524	0.1503
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1371	0.1864
Loa Loa (eye worm)	cyclin domain-containing protein	0.006	0.1085	0.1454
Brugia malayi	protein kinase C3,putative	0.0154	0.3182	0.5203
Leishmania major	mitotic cyclin, putative	0.0014	0.0073	0.0162
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0071	0.133	0.1806

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2332374

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1732963