Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0272 | 1 | 1 |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0272 | 1 | 1 |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0087 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0272 | 1 | 1 |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0272 | 1 | 1 |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0272 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0272 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0272 | 1 | 1 |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 1 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0087 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0272 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0272 | 1 | 1 |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0272 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 250 uM | Concentration of the compound required to reduce the viability of mock-infected CEM cells by 50% | ChEMBL. | 11714616 |
EC50 (functional) | = 20 uM | Effective concentration required to inhibit HIV-1 induced cytopathicity by 50% in CEM cells | ChEMBL. | 11714616 |
EC50 (functional) | > 250 uM | Effective concentration required to inhibit HIV-2 induced cytopathicity by 50% in CEM cells | ChEMBL. | 11714616 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.