Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.2087 | 0.9524 | 0.977 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0099 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0099 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0099 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0099 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0099 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0099 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0099 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.2134 | 0.9749 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0099 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0099 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0099 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0099 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0099 | 0 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.1095 | 0.477 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0099 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.2134 | 0.9749 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0099 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0099 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0099 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1095 | 0.477 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0099 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0099 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 41.75 % | Inhibition of ovine COX2 assessed as appearance of oxidized N,N,N,N'- tetramethyl-p-phenylenediamine at 100 uM | ChEMBL. | 23357629 |
Inhibition (binding) | = 54.1 % | Inhibition of ovine COX1 assessed as appearance of oxidized N,N,N,N'- tetramethyl-p-phenylenediamine at 100 uM | ChEMBL. | 23357629 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.