Detailed information for compound 1733276

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 752.504 | Formula: C35H32Br2N10
  • H donors: 2 H acceptors: 6 LogP: 8.74 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCc1n(Cc2ccc(cc2)c2ccccc2c2nn[nH]n2)c[n+](c1Br)Cc1ccc(cc1)c1ccccc1c1nn[nH]n1.[Br-]
  • InChi: 1S/C35H32BrN10.BrH/c1-2-3-12-32-33(36)46(22-25-15-19-27(20-16-25)29-9-5-7-11-31(29)35-39-43-44-40-35)23-45(32)21-24-13-17-26(18-14-24)28-8-4-6-10-30(28)34-37-41-42-38-34;/h4-11,13-20,23H,2-3,12,21-22H2,1H3,(H,37,38,41,42)(H,39,40,43,44);1H/q+1;/p-1
  • InChiKey: XWQVNEPEOYFGER-UHFFFAOYSA-M  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens angiotensin II receptor, type 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyroglutamylated rfamide peptide receptor angiotensin II receptor, type 1 359 aa 403 aa 19.1 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni transient receptor potential channel 4 0.0107 0.1959 0.1916
Entamoeba histolytica aminopeptidase, putative 0.0026 0.0289 0.4635
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0026 0.0289 0.4045
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0045 0.0681 0.284
Onchocerca volvulus 0.0022 0.0206 0.6467
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.0289 0.3813
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0047 0.0708 0.1587
Echinococcus multilocularis aminopeptidase N 0.0026 0.0289 0.0289
Toxoplasma gondii aminopeptidase N protein 0.0026 0.0289 0.3532
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0047 0.0708 0.0708
Leishmania major cysteine peptidase A (CPA) 0.0022 0.0206 0.0653
Schistosoma mansoni transient receptor potential channel 0.0107 0.1959 0.1916
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0562 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.014 0.0088
Schistosoma mansoni cytochrome P450 0.0045 0.0681 0.0631
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.014 0.1497
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0045 0.0681 0.284
Echinococcus granulosus transient receptor potential gamma protein 0.0107 0.1959 0.1959
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0148 0.0148
Schistosoma mansoni biogenic amine (5HT) receptor 0.0127 0.237 0.2329
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0457 0.6923
Schistosoma mansoni ap endonuclease 0.0019 0.0128 0.0075
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0128 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0171 0.3286 0.3286
Loa Loa (eye worm) peptidase family M1 containing protein 0.0026 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0053
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0206 0.2616
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0047 0.0708 0.0708
Echinococcus granulosus dna polymerase eta 0.002 0.0148 0.0148
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0096 0.0043
Schistosoma mansoni regulator of G protein signaling 0.0019 0.014 0.0088
Echinococcus multilocularis dna polymerase kappa 0.002 0.0148 0.0148
Leishmania major cytochrome p450-like protein 0.0045 0.0681 0.3029
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0128 0.0128
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.014 0.0315
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.014 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0148 0.061
Echinococcus multilocularis cysteine protease 0.0022 0.0206 0.0206
Leishmania major cytochrome p450-like protein 0.0113 0.2077 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0148 0.1867
Echinococcus granulosus cytochrome P450 2K1 0.0045 0.0681 0.0681
Echinococcus multilocularis short transient receptor potential channel 6 0.0074 0.1276 0.1276
Toxoplasma gondii exonuclease III APE 0.0019 0.0128 0.0873
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0075 0.0075
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0289 0.0289
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.014 0.014
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0045 0.0681 0.284
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0171 0.3284 0.3284
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0045 0.0681 1
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0148 0.1629
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.0206 0.0461
Brugia malayi PXA domain containing protein 0.0019 0.014 0.0315
Onchocerca volvulus 0.0022 0.0206 0.6467
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0636 1
Onchocerca volvulus Cathepsin F homolog 0.0022 0.0206 0.6467
Onchocerca volvulus 0.0022 0.0206 0.6467
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.014 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0148 0.061
Brugia malayi Peptidase family M1 containing protein 0.0026 0.0289 0.0648
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0096 0.0096
Schistosoma mansoni aminopeptidase A (M01 family) 0.0026 0.0289 0.0237
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0148 0.047
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0045 0.0681 0.284
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0017 0.0096 0.0096
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0017 0.0096 0.0096
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0206 0.2616
Echinococcus granulosus biogenic amine 5HT receptor 0.0127 0.237 0.237
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0206 0.2998
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0128 0.0286
Schistosoma mansoni DNA polymerase eta 0.002 0.0148 0.0096
Loa Loa (eye worm) cysteine protease 0.0022 0.0206 0.0206
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.014 0.014
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.014 0.014
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0045 0.0681 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.014
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0045 0.0681 0.284
Trypanosoma cruzi aminopeptidase, putative 0.0026 0.0289 0.1166
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0128 0.1468
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0045 0.0681 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.014 0.014
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0075 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.014 0.1497
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0148 0.061
Loa Loa (eye worm) hypothetical protein 0.0107 0.1959 0.1959
Brugia malayi Cytochrome P450 family protein 0.0113 0.2077 0.4657
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0053
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.014 0.014
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0022 0.0206 0.2685
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.014 0.1497
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0148 0.047
Loa Loa (eye worm) hypothetical protein 0.0127 0.237 0.237
Brugia malayi Cathepsin L-like precursor 0.0022 0.0206 0.0461
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0148 0.061
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0159 0.303 0.2993
Loa Loa (eye worm) CYP4Cod1 0.0113 0.2077 0.2077
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0289 0.0289
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0171 0.3284 0.3284
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0148 0.047
Loa Loa (eye worm) hypothetical protein 0.0026 0.0289 0.0289
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0045 0.0681 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0045 0.0681 0.284
Loa Loa (eye worm) TATA binding protein associated factor 0.0026 0.0289 0.0289
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0042 0.0607 0.0607
Schistosoma mansoni regulator of G protein signaling 0.0019 0.014 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0206 0.0891
Loa Loa (eye worm) ctsf protein 0.0022 0.0206 0.0206
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0778 0.0729
Schistosoma mansoni hypothetical protein 0.0016 0.0074 0.0021
Echinococcus multilocularis dna polymerase eta 0.002 0.0148 0.0148
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0128 0.0873
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0045 0.0683 0.0683
Echinococcus granulosus axis inhibition protein axin 0.0019 0.014 0.014
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0206 0.0754
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0017 0.0096 0.0096
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0206 0.2616
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.014 0.014
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0148 0.061
Loa Loa (eye worm) cytochrome P450 family protein 0.0105 0.1912 0.1912
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0636 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0206 0.2616
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0206 0.2616
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0148 0.061
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0045 0.0681 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.014 0.0088
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0045 0.0683 0.0683
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0026 0.0289 0.0237
Onchocerca volvulus 0.0026 0.0289 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0074 0.0074
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.014 0.0315
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.0206 0.0206
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0636 0.9261
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0022 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0205 0.3998 0.3998
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0096 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0206 0.0891
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0128 0.0943
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0562 1
Brugia malayi PXA domain containing protein 0.0019 0.014 0.0315
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0206 0.0891
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0045 0.0681 0.284
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0096 0.0096
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0206 0.2616
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0045 0.0681 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0148
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0206 0.2616
Brugia malayi Cyclic-nucleotide gated cation channel 0.0017 0.0096 0.0215
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0045 0.0681 0.284
Echinococcus granulosus potassium voltage gated channel subfamily H 0.002 0.0166 0.0166
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0148 0.0104
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0045 0.0681 1
Schistosoma mansoni hypothetical protein 0.0034 0.0457 0.0407
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0636 0.0636
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.014 0.014
Trypanosoma cruzi Aminopeptidase M1, putative 0.0026 0.0289 0.1166
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0026 0.0289 0.0237
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0045 0.0681 0.284
Trypanosoma brucei Aminopeptidase M1, putative 0.0026 0.0289 0.1296
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0022 0.0206 0.2685
Echinococcus granulosus aminopeptidase N 0.0026 0.0289 0.0289
Leishmania major cathepsin L-like protease 0.0022 0.0206 0.0653
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0289 0.107
Schistosoma mansoni transient receptor potential channel 0.0074 0.1276 0.123
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0148 0.0366
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0206 0.0891
Echinococcus granulosus short transient receptor potential channel 6 0.0074 0.1271 0.1271
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0075 0.0075
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0096 0.0043
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0045 0.0681 1
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0206 0.0754
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0495 1 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0045 0.0681 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0206 0.0891
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0206 0.0891
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0148 0.061
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0074 0.0074
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0128 0.1087
Brugia malayi hypothetical protein 0.0019 0.014 0.0315
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0788 0.1766
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0045 0.0681 0.3029
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0047 0.0708 0.0708
Brugia malayi TATA binding protein associated factor 0.0026 0.0289 0.0648
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0289 0.0289
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0148 0.061
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.014 0.0088
Echinococcus multilocularis hyperpolarization activated cyclic 0.0017 0.0096 0.0096
Schistosoma mansoni ap endonuclease 0.0019 0.0128 0.0075
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.014 0.0315
Leishmania major cathepsin L-like protease 0.0022 0.0206 0.0653
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0017 0.0096 0.0096
Giardia lamblia DINP protein human, muc B family 0.002 0.0148 0.0468
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0017 0.0096 0.0096
Brugia malayi isocitrate dehydrogenase 0.0016 0.0075 0.0168
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.0289 0.1166
Echinococcus granulosus GPCR family 2 0.0016 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0033 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.0062 0.102 0.102
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0457 0.1026
Schistosoma mansoni hypothetical protein 0.0016 0.0074 0.0021
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0495 1 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0128 0.0264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0206 0.0891
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.014
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0045 0.0681 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0128 0.0512
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0128 0.0369
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.0206 0.2616
Trypanosoma brucei aminopeptidase, putative 0.0026 0.0289 0.1296
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0096 0.0096
Echinococcus multilocularis transient receptor potential gamma protein 0.0107 0.1959 0.1959
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0045 0.0681 0.284
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.014 0.0315
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0045 0.0681 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0289 0.107
Plasmodium vivax vivapain-2 0.0022 0.0206 0.2329
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0128 0.0128
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0045 0.0681 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0026 0.0289 0.4045
Loa Loa (eye worm) hypothetical protein 0.0017 0.0096 0.0096
Schistosoma mansoni transient receptor potential channel 0.0074 0.1271 0.1225
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.014 0.014
Leishmania major cathepsin L-like protease 0.0022 0.0206 0.0653
Echinococcus granulosus axis inhibition protein axin 0.0019 0.014 0.014
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0562 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0045 0.0681 0.284
Brugia malayi hypothetical protein 0.0026 0.0289 0.0648
Brugia malayi Cathepsin L-like precursor 0.0022 0.0206 0.0461
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0788 0.0788
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0045 0.0681 0.284
Onchocerca volvulus 0.0022 0.0206 0.6467
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0148 0.061
Trypanosoma cruzi cruzipain precursor, putative 0.0022 0.0206 0.0754
Schistosoma mansoni axis inhibition protein axin 0.0019 0.014 0.0088
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.014 0.1497
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0096 0.0043
Brugia malayi hypothetical protein 0.0026 0.0289 0.0648
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0075 0.0075
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0022 0.0206 0.0206
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0045 0.0681 0.284
Loa Loa (eye worm) cytochrome P450 family protein 0.0113 0.2077 0.2077
Echinococcus granulosus hyperpolarization activated cyclic 0.0017 0.0096 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.014 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0206 0.0891
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0075 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0206 0.2616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0206 0.2616
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0289 0.107
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0148 0.0104
Loa Loa (eye worm) hypothetical protein 0.0067 0.1139 0.1139
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0017 0.0096 0.0732
Echinococcus granulosus TRP transient receptor potential channel 0.0045 0.0683 0.0683
Toxoplasma gondii cathepsin CPL 0.0022 0.0206 0.2157
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0206 0.0153
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.2778 0.623
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.0206 0.0206
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0017 0.0096 0.0732
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.014 0.0088
Onchocerca volvulus Cathepsin L homolog 0.0022 0.0206 0.6467
Onchocerca volvulus 0.0022 0.0206 0.6467
Echinococcus granulosus short transient receptor potential channel 6 0.0074 0.1276 0.1276
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0026 0.0289 0.0289
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0026 0.0289 0.1166
Trypanosoma cruzi cytochrome P450, putative 0.0113 0.2077 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0289 0.0289
Brugia malayi Peptidase family M1 containing protein 0.0026 0.0289 0.0648
Plasmodium falciparum cysteine proteinase falcipain 3 0.0022 0.0206 0.2685
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.2693 0.2693
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0074 0.0074
Brugia malayi Cytochrome P450 family protein 0.0113 0.2077 0.4657
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0148 0.0148
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0026 0.0289 0.0289
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0026 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0026 0.0289 0.0289
Brugia malayi Cytochrome P450 family protein 0.0045 0.0681 0.1527
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0075 0.0022
Trypanosoma brucei cytochrome P450, putative 0.0113 0.2077 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0148 0.061
Echinococcus granulosus ankyrin repeat protein 0.0159 0.303 0.303
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0206 0.0153
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0026 0.0289 0.1296
Mycobacterium ulcerans aminopeptidase N PepN 0.0026 0.0289 0.0827
Mycobacterium leprae Conserved hypothetical protein 0.0045 0.0681 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.014 0.1497
Loa Loa (eye worm) fibroinase 0.0022 0.0206 0.0206
Echinococcus granulosus cathepsin l1 0.0022 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0206 0.2616
Echinococcus multilocularis transient receptor potential ion channel A 0.0095 0.1708 0.1708
Trypanosoma cruzi aminopeptidase, putative 0.0026 0.0289 0.1166
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0075 0.0075
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0045 0.0681 0.3104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0206 0.0891
Schistosoma mansoni hypothetical protein 0.0045 0.0681 0.0631
Echinococcus multilocularis cysteine protease 0.0022 0.0206 0.0206
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.014 0.0315
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.014
Brugia malayi cytochrome P450 0.0045 0.0681 0.1527
Brugia malayi Cathepsin L-like precursor 0.0022 0.0206 0.0461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0206 0.2616
Entamoeba histolytica hypothetical protein 0.0019 0.014 0.1716
Trypanosoma brucei Aminopeptidase M1, putative 0.0026 0.0289 0.1296
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.014 0.1497
Schistosoma mansoni regulator of G protein signaling 0.0019 0.014 0.0088
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0016 0.0074 0.0021
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.2778 0.274
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0778 0.0729
Echinococcus granulosus transient receptor potential ion channel A 0.0095 0.1708 0.1708
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0026 0.0289 0.4395
Echinococcus multilocularis 0.0045 0.0681 0.0681
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0026 0.0289 0.4395
Echinococcus multilocularis serotonin receptor 0.0127 0.237 0.237
Echinococcus granulosus cathepsin l1 0.0015 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0206 0.2616
Trypanosoma cruzi cytochrome P450, putative 0.0113 0.2077 1
Leishmania major cytochrome p450-like protein 0.0045 0.0681 0.3029
Echinococcus granulosus cathepsin L cysteine proteinase 0.0022 0.0206 0.0206
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0045 0.0681 1
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0065 0.0012
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0166 0.0113
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.014 0.014
Echinococcus granulosus voltage gated potassium channel 0.002 0.0166 0.0166
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0289 0.0289
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.014 0.0315
Loa Loa (eye worm) cytochrome P450 0.0045 0.0681 0.0681
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0074
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0128 0.0369
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.014 0.014
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0026 0.0289 0.4045
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0206 0.0754
Echinococcus multilocularis voltage gated potassium channel 0.002 0.0166 0.0166
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0075 0.0108
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0075 0.0254
Leishmania major cathepsin L-like protease 0.0022 0.0206 0.0653
Loa Loa (eye worm) aminopeptidase N 0.0026 0.0289 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0206 0.2616
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0026 0.0289 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.0206 0.2616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0206 0.2616
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0148 0.047
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.014 0.014
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0045 0.0681 0.3104
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0045 0.0681 0.284
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0148 0.0096
Trypanosoma brucei unspecified product 0.002 0.0148 0.061
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0075 0.0168
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.014 0.014
Echinococcus granulosus expressed protein 0.0373 0.746 0.746
Brugia malayi Cathepsin L-like precursor 0.0022 0.0206 0.0461
Onchocerca volvulus 0.0022 0.0206 0.6467
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.014 0.0088
Toxoplasma gondii aminopeptidase N, putative 0.0026 0.0289 0.3532
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0206 0.2616
Schistosoma mansoni hypothetical protein 0.0016 0.0074 0.0021
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0457
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0074 0.0167
Brugia malayi Transient-receptor-potential like protein 0.0045 0.0683 0.1531
Onchocerca volvulus 0.0022 0.0206 0.6467
Leishmania major DNA polymerase eta, putative 0.002 0.0148 0.0366
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0045 0.0681 1
Leishmania major cathepsin L-like protease 0.0022 0.0206 0.0653
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0636 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0289 0.107
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0045 0.0681 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.014 0.1497
Toxoplasma gondii cytochrome p450 superfamily protein 0.0045 0.0681 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0045 0.0681 0.284
Brugia malayi Cathepsin L-like cysteine proteinase 0.0015 0.0053 0.0119
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.0206 0.0206
Mycobacterium ulcerans aminopeptidase N PepN 0.0026 0.0289 0.0827
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.2778 0.2778
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0148 0.0096
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0045 0.0681 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0205 0.3998 0.8965
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0128 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0206 0.2616
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0206 0.2616
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0026 0.0289 0.0289
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0045 0.0681 0.3104
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0457 0.6923
Leishmania major DNA polymerase kappa, putative 0.002 0.0148 0.0366
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.014
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0166 0.0113
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0053
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0289 0.0289
Toxoplasma gondii aminopeptidase n, putative 0.0026 0.0289 0.3532
Loa Loa (eye worm) RGS-3 protein 0.0019 0.014 0.014
Echinococcus multilocularis ankyrin repeat protein 0.0159 0.303 0.303
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.002 0.0166 0.0372
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0495 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0128 0.1281
Onchocerca volvulus Cathepsin L homolog 0.0022 0.0206 0.6467
Loa Loa (eye worm) cytochrome P450 family protein 0.0113 0.2077 0.2077
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0128 0.1281
Loa Loa (eye worm) hypothetical protein 0.002 0.0166 0.0166
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0148 0.1629
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0206 0.2998
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0045 0.0681 0.284
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0148 0.061
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.014 0.014
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0148 0.1208
Echinococcus multilocularis expressed protein 0.0373 0.746 0.746
Echinococcus granulosus dna polymerase kappa 0.002 0.0148 0.0148
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0148 0.1208
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0148 0.0332
Schistosoma mansoni axis inhibition protein axin 0.0019 0.014 0.0088
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0148 0.0332
Echinococcus granulosus transient receptor potential cation channel 0.0171 0.3281 0.3281
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0096 0.0096
Echinococcus multilocularis short transient receptor potential channel 6 0.0074 0.1271 0.1271
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.0289 0.1166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0206 0.2616
Brugia malayi Cathepsin L-like precursor 0.0015 0.0053 0.0119
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0045 0.0681 0.3206
Leishmania major cathepsin L-like protease 0.0022 0.0206 0.0653
Mycobacterium leprae putative cytochrome p450 0.0045 0.0681 0.5
Entamoeba histolytica cysteine protease, putative 0.0022 0.0206 0.2998
Plasmodium vivax vivapain-2 0.0022 0.0206 0.2329
Echinococcus granulosus hyperpolarization activated cyclic 0.0017 0.0096 0.0096
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0128 0.5
Loa Loa (eye worm) hypothetical protein 0.0127 0.237 0.237
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0075 0.0075
Schistosoma mansoni 60S ribosomal protein L21 0.0015 0.0065 0.0012
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0045 0.0681 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0148 0.047
Entamoeba histolytica hypothetical protein 0.0019 0.014 0.1716
Brugia malayi hypothetical protein 0.0019 0.014 0.0315
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0026 0.0289 0.0237
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0045 0.0681 0.284
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0026 0.0289 0.1166
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.014 0.014
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0289 0.0289
Entamoeba histolytica hypothetical protein 0.0019 0.014 0.1716
Brugia malayi Peptidase family M1 containing protein 0.0026 0.0289 0.0648
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0206 0.0891
Loa Loa (eye worm) acetyltransferase 0.0147 0.2778 0.2778
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0096 0.0043
Leishmania major cathepsin L-like protease 0.0022 0.0206 0.0653
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0206 0.2616
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0206 0.2616
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0045 0.0681 0.284
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0045 0.0681 0.284
Brugia malayi hypothetical protein 0.0228 0.4459 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0045 0.0681 1
Brugia malayi Cathepsin L-like precursor 0.0022 0.0206 0.0461
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0026 0.0289 0.1166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0206 0.0891
Echinococcus granulosus cathepsin l cysteine peptidase 0.0022 0.0206 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0148 0.061
Onchocerca volvulus 0.0026 0.0289 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0206 0.2616
Brugia malayi Cathepsin L-like precursor 0.0015 0.0053 0.0119
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0096 0.0043
Echinococcus multilocularis serotonin receptor 0.0127 0.237 0.237
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0074 0.0167
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0074 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0148 0.061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0206 0.2616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0206 0.2616
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0075 0.0254
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0075 0.0075
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0026 0.0289 0.0289
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.002 0.0166 0.0166
Brugia malayi Cytochrome P450 family protein 0.0105 0.1912 0.4287
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.014 0.0088
Brugia malayi cathepsin L-like precursor 0.0015 0.0053 0.0119
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0206 0.0754
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0113 0.2077 1
Onchocerca volvulus 0.0026 0.0289 1
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.014 0.014
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.014 0.014
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0045 0.0681 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0045 0.0681 1
Leishmania major cathepsin L-like protease 0.0022 0.0206 0.0653
Brugia malayi Cathepsin L-like precursor 0.0022 0.0206 0.0461
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0045 0.0681 0.284
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0148 0.061
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0636 0.9261
Echinococcus multilocularis hyperpolarization activated cyclic 0.0017 0.0096 0.0096
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.0289 0.3813

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.15 Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis ChEMBL. 23376252

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.