Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cell polarity protein | 0.0065 | 0.0137 | 0.0137 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1352 | 1 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0092 | 0.0346 | 0.0509 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0419 | 0.0688 |
Schistosoma mansoni | acetylcholinesterase | 0.0101 | 0.0419 | 0.0419 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0419 | 0.0688 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0065 | 0.0137 | 0.0137 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0101 | 0.0419 | 0.0419 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0101 | 0.0419 | 0.0286 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0101 | 0.0419 | 0.0286 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.0346 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0101 | 0.0419 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0419 | 0.0688 |
Schistosoma mansoni | septate junction protein | 0.0065 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0419 | 0.0688 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0092 | 0.0346 | 0.0509 |
Schistosoma mansoni | notch | 0.0065 | 0.0137 | 0.0137 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0092 | 0.0346 | 0.0346 |
Onchocerca volvulus | 0.0101 | 0.0419 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.06 | 0.424 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0101 | 0.0419 | 0.0688 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0101 | 0.0419 | 0.0286 |
Loa Loa (eye worm) | carboxylesterase | 0.06 | 0.424 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0101 | 0.0419 | 0.0419 |
Echinococcus multilocularis | carboxylesterase 5A | 0.06 | 0.424 | 0.416 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0137 | 0.0137 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0092 | 0.0346 | 0.5 |
Brugia malayi | hypothetical protein | 0.0101 | 0.0419 | 0.0688 |
Schistosoma mansoni | notch | 0.0065 | 0.0137 | 0.0137 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0065 | 0.0137 | 0.0137 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0101 | 0.0419 | 0.5 |
Onchocerca volvulus | 0.0101 | 0.0419 | 1 | |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0092 | 0.0346 | 0.0212 |
Schistosoma mansoni | notch | 0.0065 | 0.0137 | 0.0137 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0092 | 0.0346 | 0.7403 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0419 | 0.0688 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0092 | 0.0346 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0137 | 0.0137 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0137 | 0.0137 |
Brugia malayi | Carboxylesterase family protein | 0.06 | 0.424 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.06 | 0.424 | 1 |
Schistosoma mansoni | slit | 0.0065 | 0.0137 | 0.0137 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0101 | 0.0419 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0101 | 0.0419 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0065 | 0.0137 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0419 | 0.0688 |
Echinococcus granulosus | acetylcholinesterase | 0.06 | 0.424 | 0.416 |
Schistosoma mansoni | notch | 0.0065 | 0.0137 | 0.0137 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.0346 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0137 | 0.0137 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0092 | 0.0346 | 0.0212 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0101 | 0.0419 | 0.0419 |
Onchocerca volvulus | 0.0101 | 0.0419 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0101 | 0.0419 | 0.0688 |
Echinococcus multilocularis | acetylcholinesterase | 0.06 | 0.424 | 0.416 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0101 | 0.0419 | 0.0286 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0101 | 0.0419 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0101 | 0.0419 | 0.0286 |
Brugia malayi | Carboxylesterase family protein | 0.0101 | 0.0419 | 0.0688 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.06 | 0.424 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0419 | 0.0688 |
Onchocerca volvulus | 0.0101 | 0.0419 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0137 | 0.0137 |
Echinococcus granulosus | neuroligin | 0.0101 | 0.0419 | 0.0286 |
Echinococcus multilocularis | neuroligin | 0.0101 | 0.0419 | 0.0286 |
Schistosoma mansoni | notch | 0.0065 | 0.0137 | 0.0137 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0101 | 0.0419 | 0.0419 |
Giardia lamblia | Kinase, PLK | 0.0092 | 0.0346 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.06 | 0.424 | 0.416 |
Echinococcus granulosus | carboxylesterase 5A | 0.06 | 0.424 | 0.416 |
Trypanosoma brucei | polo-like protein kinase | 0.0092 | 0.0346 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1352 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0101 | 0.0419 | 0.0688 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0101 | 0.0419 | 0.0419 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0137 | 0.0137 |
Schistosoma mansoni | gliotactin | 0.0101 | 0.0419 | 0.0419 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0137 | 0.0137 |
Brugia malayi | Carboxylesterase family protein | 0.06 | 0.424 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0101 | 0.0419 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0101 | 0.0419 | 0.0688 |
Loa Loa (eye worm) | carboxylesterase | 0.0101 | 0.0419 | 0.0688 |
Onchocerca volvulus | 0.0101 | 0.0419 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.06 | 0.424 | 0.416 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0101 | 0.0419 | 0.0286 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.06 | 0.424 | 0.424 |
Schistosoma mansoni | notch | 0.0065 | 0.0137 | 0.0137 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 48.61 % | Inhibition of alpha-1G calcium channel in human HEK293 cells at 10 uM by whole-cell patch-clamp method | ChEMBL. | 23395659 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.