Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0853 | 0.9457 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0104 | 0.0981 | 0.1037 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.0104 | 0.0981 | 0.1037 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.0104 | 0.0981 | 0.0981 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0104 | 0.0981 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0261 | 0.0276 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0104 | 0.0981 | 0.1037 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0413 | 0.0437 |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.1309 | 0.1384 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.0104 | 0.0981 | 0.1037 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0853 | 0.9457 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0413 | 0.0437 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0853 | 0.9457 | 0.9457 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0853 | 0.9457 | 0.9457 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.1309 | 0.1384 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0104 | 0.0981 | 0.1037 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0261 | 0.0276 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0222 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0981 | 0.1037 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0104 | 0.0981 | 0.1037 |
Schistosoma mansoni | unc-13 (munc13) | 0.0104 | 0.0981 | 0.1037 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0104 | 0.0981 | 0.1037 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0104 | 0.0981 | 0.1037 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0413 | 0.0437 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.1309 | 0.1384 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0853 | 0.9457 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0853 | 0.9457 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0853 | 0.9457 | 0.5 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0104 | 0.0981 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0853 | 0.9457 | 0.5 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0104 | 0.0981 | 0.1037 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0853 | 0.9457 | 1 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0088 | 0.0809 | 0.7619 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0261 | 0.0261 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0104 | 0.0981 | 0.1037 |
Brugia malayi | isocitrate dehydrogenase | 0.0853 | 0.9457 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0413 | 0.0437 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0088 | 0.0809 | 0.7619 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.0104 | 0.0981 | 0.0981 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0853 | 0.9457 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0853 | 0.9457 | 1 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0104 | 0.0981 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0261 | 0.0276 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0853 | 0.9457 | 0.9457 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0104 | 0.0981 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0853 | 0.9457 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.0261 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0222 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0809 | 0.0856 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0853 | 0.9457 | 0.9457 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0222 | 0.0234 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0853 | 0.9457 | 0.9457 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0853 | 0.9457 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0853 | 0.9457 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0853 | 0.9457 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0853 | 0.9457 | 1 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0104 | 0.0981 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 14.2 nM | Binding affinity towards human dopamine D4 receptor was determined via standard competitive displacement assays using [3H]-YM 09151 as radioligand | ChEMBL. | 12372512 |
Ki (binding) | = 14.2 nM | Binding affinity towards human dopamine D4 receptor was determined via standard competitive displacement assays using [3H]-YM 09151 as radioligand | ChEMBL. | 12372512 |
Ki (binding) | = 2298 nM | Binding affinity towards Alpha-1 adrenergic receptor via standard competitive displacement assay using rat brain homogenate with [3H]-prazosin as radioligand | ChEMBL. | 12372512 |
Ki (binding) | = 2298 nM | Binding affinity towards Alpha-1 adrenergic receptor via standard competitive displacement assay using rat brain homogenate with [3H]-prazosin as radioligand | ChEMBL. | 12372512 |
Ki (binding) | > 10000 nM | Binding affinity towards human dopamine D2 receptor, using [3H]-YM-09151 as a radioligand | ChEMBL. | 12372512 |
Ki (binding) | > 10000 nM | Binding affinity towards human dopamine D2 receptor, using [3H]-YM-09151 as a radioligand | ChEMBL. | 12372512 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.