Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | No references | |
Mus musculus | prostaglandin-endoperoxide synthase 1 | Starlite/ChEMBL | References |
Mus musculus | prostaglandin-endoperoxide synthase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.1388 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0234 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0234 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0234 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0234 | 0 | 0.5 |
Onchocerca volvulus | 0.0234 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1388 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1388 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1388 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1388 | 1 | 1 |
Onchocerca volvulus | 0.0234 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1388 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1388 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0234 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1388 | 1 | 1 |
Onchocerca volvulus | 0.0234 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.1388 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0234 | 0 | 0.5 |
Onchocerca volvulus | 0.0234 | 0 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.1388 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1388 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1388 | 1 | 1 |
Onchocerca volvulus | 0.0234 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 46 nM | In Vitro Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 0.046 uM | Inhibition of Escherichia coli lipopolysaccharide-induced COX2 activity in mouse J774 cells assessed as decrease in PGE2 levels after 24 hrs by RIA | ChEMBL. | 23534442 |
IC50 (binding) | = 0.046 uM | Inhibition of COX2 in Escherichia coli LPS-stimulated mouse J774 cells using arachidonic acid as substrate assessed as decrease in PGE2 production preincubated for 15 mins followed by substrate addition measured after 30 mins by radioimmunoassay | PATENT. | No reference |
IC50 (binding) | > 10 uM | Inhibition of arachidonic acid-induced COX1 activity in mouse J774 cells assessed as decrease in PGE2 levels incubated for 15 mins prior to arachidonic acid-challenge measured after 30 mins by RIA | ChEMBL. | 23534442 |
Inhibition (binding) | < 20 % | Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as decrease in PGE2 production at 10 uM preincubated for 15 mins followed by substrate addition measured after 30 mins by radioimmunoassay relative to control | PATENT. | No reference |
MED (functional) | = 20 mg kg-1 | Antinociceptive activity in po dosed Swiss albino mouse assessed as reduction in number of acetic acid-induced writhing counted 5 mins after acetic acid challenge counted for 10 mins | ChEMBL. | 23534442 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.