Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | NIMA related kinase 4 | 0.1722 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1722 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1722 | 1 | 1 |
Plasmodium vivax | serine/threonine-protein kinase NEK4, putative | 0.1722 | 1 | 1 |
Leishmania major | protein kinase, putative,serine/threonine-protein kinase Nek1, putative | 0.1722 | 1 | 1 |
Toxoplasma gondii | NEK kinase | 0.1722 | 1 | 1 |
Trypanosoma cruzi | NIMA-related kinase, putative | 0.1722 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0972 | 0.5309 | 0.9051 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0813 | 0.4313 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1722 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0813 | 0.4313 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0813 | 0.4313 | 0.5 |
Trypanosoma brucei | Serine/threonine-protein kinase NEK16, putative | 0.1722 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0813 | 0.4313 | 0.4313 |
Trichomonas vaginalis | STE family protein kinase | 0.1722 | 1 | 1 |
Trypanosoma brucei | Serine/threonine-protein kinase NEK11, putative | 0.1722 | 1 | 1 |
Trypanosoma brucei | NIMA-related protein kinase | 0.1722 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1722 | 1 | 1 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.1095 | 0.6081 | 0.6252 |
Plasmodium vivax | serine/threonine-protein kinase Nek1, putative | 0.1722 | 1 | 1 |
Leishmania major | protein kinase, putative | 0.1722 | 1 | 1 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.1095 | 0.6081 | 0.6252 |
Echinococcus granulosus | serine:threonine protein kinase Nek1 | 0.1678 | 0.9726 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0813 | 0.4313 | 0.5 |
Leishmania major | serine/threonine-protein kinase, putative | 0.1722 | 1 | 1 |
Plasmodium falciparum | NIMA related kinase 2 | 0.1722 | 1 | 1 |
Toxoplasma gondii | NEK kinase | 0.1722 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1722 | 1 | 1 |
Giardia lamblia | Kinase, NEK | 0.1722 | 1 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0813 | 0.4313 | 0.5 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK11, putative | 0.1722 | 1 | 1 |
Trypanosoma cruzi | protein kinase, putative | 0.1678 | 0.9726 | 0.9726 |
Toxoplasma gondii | NEK kinase | 0.1722 | 1 | 1 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.1095 | 0.6081 | 1 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK16, putative | 0.1722 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase Nek1 | 0.1678 | 0.9726 | 1 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK11, putative | 0.1722 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1061 | 0.5866 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = -24 % | Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes. | ChEMBL. | 7636873 |
Inhibition (binding) | = -24 % | Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes. | ChEMBL. | 7636873 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.