Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.014 | 0.203 | 1 | |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0123 | 0.1654 | 0.1339 |
Schistosoma mansoni | hypothetical protein | 0.0497 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0497 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1667 | 0.0332 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0497 | 1 | 1 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0188 | 0.3114 | 0.2854 |
Entamoeba histolytica | hypothetical protein | 0.0497 | 1 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0497 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.203 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0497 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0497 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0497 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 uM | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay | ChEMBL. | 23347685 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.