Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1607 | 1 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0661 | 0.2236 | 0.2236 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1607 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0754 | 0.2994 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1607 | 1 | 1 |
Onchocerca volvulus | 0.0389 | 0 | 0.5 | |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0661 | 0.2236 | 0.2236 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0754 | 0.2994 | 1 |
Brugia malayi | CHE-14 protein | 0.0661 | 0.2236 | 0.2236 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1607 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0661 | 0.2236 | 0.2236 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0661 | 0.2236 | 0.2236 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0754 | 0.2994 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0661 | 0.2236 | 0.2236 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0389 | 0 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1607 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0389 | 0 | 0.5 |
Schistosoma mansoni | patched 1 | 0.0661 | 0.2236 | 0.2236 |
Echinococcus multilocularis | protein dispatched 1 | 0.0661 | 0.2236 | 0.2236 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1607 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1607 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1607 | 1 | 1 |
Echinococcus multilocularis | protein patched | 0.0661 | 0.2236 | 0.2236 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0389 | 0 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1607 | 1 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0661 | 0.2236 | 0.2236 |
Loa Loa (eye worm) | hypothetical protein | 0.0661 | 0.2236 | 0.2236 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0754 | 0.2994 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0661 | 0.2236 | 0.2236 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.79 | Inhibition of thymidylate synthase | ChEMBL. | 20153089 |
IC50 (binding) | = 16.26 uM | Concentration required for in vitro inhibition of thymidylate synthase | ChEMBL. | 2231606 |
IC50 (binding) | = 16.26 uM | Concentration required for in vitro inhibition of thymidylate synthase | ChEMBL. | 2231606 |
IC50 (functional) | = 40 uM | Concentration required to inhibit 50 percent growth of L1210 mouse leukemia cells | ChEMBL. | 2231606 |
IC50 (functional) | = 40 uM | Concentration required to inhibit 50 percent growth of L1210 mouse leukemia cells | ChEMBL. | 2231606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.