Detailed information for compound 173391

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 489.651 | Formula: C24H31N3O4S2
  • H donors: 3 H acceptors: 5 LogP: 3.95 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC[C@H](C(=O)NC1(CCCC1)C(=O)NC(C(=O)O)Cc1ccc(nc1)c1cscc1)S
  • InChi: 1S/C24H31N3O4S2/c1-2-3-6-20(32)21(28)27-24(10-4-5-11-24)23(31)26-19(22(29)30)13-16-7-8-18(25-14-16)17-9-12-33-15-17/h7-9,12,14-15,19-20,32H,2-6,10-11,13H2,1H3,(H,26,31)(H,27,28)(H,29,30)/t19?,20-/m1/s1
  • InChiKey: FLYBPKUINQCIHV-GFOWMXPYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens endothelin converting enzyme 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 Get druggable targets OG5_127344 All targets in OG5_127344
Echinococcus granulosus endothelin converting enzyme 1 Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Brugia malayi Peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma japonicum ko:K01415 endothelin-converting enzyme [EC3.4.24.71], putative Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma mansoni family M13 unassigned peptidase (M13 family) Get druggable targets OG5_127344 All targets in OG5_127344
Neospora caninum hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma japonicum IPR000718,Peptidase M13, neprilysin,domain-containing Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium leprae probable zinc metalloprotease Get druggable targets OG5_127344 All targets in OG5_127344
Onchocerca volvulus Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium ulcerans zinc metalloprotease Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
Toxoplasma gondii peptidase family M13 protein Get druggable targets OG5_127344 All targets in OG5_127344
Echinococcus multilocularis endothelin converting enzyme 1 Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0062 0.0224 0.2803
Trichomonas vaginalis tubulin beta chain, putative 0.0475 0.2071 0.4443
Brugia malayi Tubulin alpha chain 0.015 0.0615 0.0615
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0146 0.0146
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0073 0.0073
Echinococcus granulosus G protein coupled receptor 139 0.0028 0.0073 0.0073
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0062 0.0224 0.0812
Trichomonas vaginalis set domain proteins, putative 0.0161 0.0666 0.1428
Leishmania major alpha tubulin 0.0475 0.2071 0.2071
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.0131 0.0111
Brugia malayi Melatonin receptor type 1A 0.0028 0.0073 0.0073
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.002 0.0042
Trypanosoma cruzi polo-like protein kinase, putative 0.0302 0.1297 0.1297
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0062 0.0224 0.0204
Toxoplasma gondii beta tubulin 0.0627 0.2754 1
Schistosoma mansoni hypothetical protein 0.0175 0.0729 0.0729
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0028 0.0073 0.0073
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0028 0.0073 0.0073
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0029 0.0077 0.0077
Schistosoma mansoni neuropeptide receptor 0.0028 0.0073 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0146 0.0146
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0016 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0065 0.0238 0.0238
Echinococcus granulosus GPCR family 2 0.0076 0.0288 0.0288
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0057 0.0202 0.0202
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0062 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Loa Loa (eye worm) TK/ABL protein kinase 0.0362 0.1568 0.1568
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0924 0.4085 0.4085
Echinococcus multilocularis neuropeptide receptor A26 0.0028 0.0073 0.0073
Schistosoma mansoni biogenic amine receptor 0.0028 0.0073 0.0073
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0046 0.015 0.015
Brugia malayi sulfakinin receptor protein 0.0028 0.0073 0.0073
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Onchocerca volvulus 0.0028 0.0073 0.0564
Echinococcus multilocularis Tubulin alpha 1 chain 0.0475 0.2071 0.2071
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.0073 0.0073
Echinococcus multilocularis thioredoxin glutathione reductase 0.0179 0.0747 0.0747
Plasmodium vivax ferrodoxin reductase, putative 0.0016 0.002 0.0071
Plasmodium vivax tubulin epsilon chain, putative 0.0344 0.1488 0.5403
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0073 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.002 0.002
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0057 0.0202 0.0202
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.002 0.002
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0062 0.0224 0.0224
Echinococcus granulosus tubulin alpha 3 chain 0.0475 0.2071 0.2071
Echinococcus multilocularis hypothetical protein 0.0475 0.2071 0.2071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0224 0.0224
Schistosoma mansoni patched 1 0.0924 0.4085 0.4085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0073 0.0073
Echinococcus multilocularis neuropeptide receptor 0.0028 0.0073 0.0073
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0302 0.1297 0.1297
Echinococcus granulosus neuropeptide s receptor 0.0028 0.0073 0.0073
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0114 0.0457 0.0457
Echinococcus granulosus tyrosine protein kinase ABL1 0.0362 0.1568 0.1568
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Trichomonas vaginalis glutathione reductase, putative 0.0062 0.0224 0.048
Echinococcus granulosus g protein coupled receptor 0.0028 0.0073 0.0073
Echinococcus multilocularis calmodulin 0.0012 0.000006084 0.000006084
Entamoeba histolytica tubulin gamma chain 0.0344 0.1488 0.5403
Schistosoma mansoni hypothetical protein 0.0076 0.0288 0.0288
Brugia malayi neuropeptide F receptor 0.0028 0.0073 0.0073
Echinococcus granulosus tubulin alpha chain 0.0475 0.2071 0.2071
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0016 0.002 0.002
Plasmodium falciparum tubulin gamma chain 0.0344 0.1488 0.5403
Schistosoma mansoni glutaminase 0.0358 0.1549 0.1549
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Trypanosoma brucei zeta tubulin 0.015 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0016 0.002 0.002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0076 0.0288 0.0288
Trypanosoma brucei zeta tubulin, putative 0.015 0.0615 0.0615
Mycobacterium tuberculosis Probable oxidoreductase 0.0062 0.0224 0.2803
Echinococcus multilocularis g-protein coupled receptor 0.0028 0.0073 0.0073
Plasmodium vivax thioredoxin reductase, putative 0.0179 0.0747 0.2713
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0062 0.0224 0.0224
Giardia lamblia Alpha-tubulin 0.0475 0.2071 0.4443
Schistosoma mansoni tubulin subunit beta 0.0627 0.2754 0.2754
Trichomonas vaginalis conserved hypothetical protein 0.015 0.0615 0.132
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.0073 0.0073
Echinococcus granulosus 7tm_1 domain containing protein 0.0028 0.0073 0.0073
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0016 0.002 0.0071
Echinococcus granulosus tyrosine protein kinase Lyn 0.0013 0.0003 0.0003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0241 0.1026 0.1026
Entamoeba histolytica tubulin alpha-1 chain 0.0475 0.2071 0.7522
Brugia malayi G protein-coupled receptor 0.0028 0.0073 0.0073
Loa Loa (eye worm) BEN-1 protein 0.0627 0.2754 0.2754
Brugia malayi Tubulin beta chain 0.015 0.0615 0.0615
Echinococcus multilocularis tyrosine protein kinase Abl 0.0148 0.0607 0.0607
Plasmodium falciparum glutathione reductase 0.0179 0.0747 0.2713
Entamoeba histolytica tubulin alpha chain, putative 0.0475 0.2071 0.7522
Echinococcus multilocularis beta tubulin 0.0627 0.2754 0.2754
Trichomonas vaginalis tubulin, putative 0.0627 0.2754 0.5906
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0325 0.1402 0.3007
Brugia malayi alpha-tubulin 0.0475 0.2071 0.2071
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Brugia malayi hypothetical protein 0.0161 0.0665 0.0665
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Mycobacterium leprae cell division protein FtsZ 0.015 0.0615 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0028 0.0073 0.0073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0073 0.0073
Echinococcus granulosus tubulin alpha 3 chain 0.0475 0.2071 0.2071
Echinococcus granulosus peroxisome assembly protein 26 0.0475 0.2071 0.2071
Toxoplasma gondii thioredoxin reductase 0.0179 0.0747 0.2713
Trichomonas vaginalis tubulin beta chain, putative 0.0475 0.2071 0.4443
Leishmania major alpha tubulin 0.0475 0.2071 0.2071
Loa Loa (eye worm) hypothetical protein 0.0439 0.1911 0.1911
Echinococcus granulosus endothelin converting enzyme 1 0.0114 0.0457 0.0457
Echinococcus granulosus Tubulin beta 2C chain 0.0627 0.2754 0.2754
Trichomonas vaginalis tubulin epsilon chain, putative 0.0475 0.2071 0.4443
Brugia malayi hypothetical protein 0.0028 0.0073 0.0073
Plasmodium vivax tubulin alpha chain, putative 0.0475 0.2071 0.7522
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.0073 0.0073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0224 0.0224
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0062 0.0224 0.0224
Schistosoma mansoni aldehyde dehydrogenase 0.0041 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.2245 1 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0457 0.0457
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.003 0.0079 0.0079
Brugia malayi neuropeptide F receptor 0.0028 0.0073 0.0073
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0028 0.0073 0.0073
Plasmodium falciparum thioredoxin reductase 0.0179 0.0747 0.2713
Brugia malayi G-protein coupled receptor 0.0028 0.0073 0.0073
Echinococcus multilocularis Tubulin beta 2C chain 0.0627 0.2754 0.2754
Schistosoma mansoni hypothetical protein 0.0028 0.0073 0.0073
Treponema pallidum NADH oxidase 0.0062 0.0224 0.0636
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Brugia malayi GnHR receptor homolog 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0084 0.0323 0.0323
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0033 0.0093 0.0093
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0016 0.002 0.0071
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0028 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Schistosoma mansoni alpha tubulin 0.0475 0.2071 0.2071
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0016 0.002 0.0071
Schistosoma mansoni opsin-like receptor 0.0028 0.0073 0.0073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0073 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0146 0.0146
Loa Loa (eye worm) alpha-tubulin 0.0475 0.2071 0.2071
Leishmania major alpha tubulin 0.0475 0.2071 0.2071
Toxoplasma gondii NADPH-glutathione reductase 0.0062 0.0224 0.0812
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0057 0.0202 0.0202
Brugia malayi hypothetical protein 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0086 0.0332 0.0332
Schistosoma mansoni neuropeptide receptor 0.0028 0.0073 0.0073
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0057 0.0202 0.0202
Trichomonas vaginalis tubulin beta chain, putative 0.0475 0.2071 0.4443
Schistosoma mansoni hypothetical protein 0.0028 0.0073 0.0073
Trypanosoma cruzi polo-like protein kinase, putative 0.0302 0.1297 0.1297
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0016 0.002 0.002
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Schistosoma mansoni serine/threonine protein kinase 0.0302 0.1297 0.1297
Echinococcus granulosus Tubulin alpha 1 chain 0.0475 0.2071 0.2071
Mycobacterium ulcerans zinc metalloprotease 0.0114 0.0457 0.0438
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0302 0.1297 0.1297
Echinococcus granulosus peptide allatostatin:somatostatin 0.0028 0.0073 0.0073
Trichomonas vaginalis mercuric reductase, putative 0.0062 0.0224 0.048
Leishmania major hypothetical protein, conserved 0.0016 0.002 0.002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0057 0.0202 0.0202
Trypanosoma cruzi PAB1-binding protein , putative 0.0065 0.0238 0.0238
Schistosoma mansoni alpha-1 adrenergic receptor 0.0028 0.0073 0.0073
Echinococcus multilocularis tar DNA binding protein 0.0045 0.0146 0.0146
Brugia malayi tubulin alpha chain - mouse 0.0475 0.2071 0.2071
Brugia malayi Cell division protein ftsZ 0.015 0.0615 0.0615
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0016 0.002 0.002
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0057 0.0202 0.0202
Echinococcus granulosus Protein patched homolog 1 0.0924 0.4085 0.4085
Loa Loa (eye worm) peptidase family M13 containing protein 0.0084 0.0323 0.0323
Onchocerca volvulus 0.0028 0.0073 0.0564
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0057 0.0202 0.2504
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0146 0.0146
Trichomonas vaginalis tubulin beta chain, putative 0.0627 0.2754 0.5906
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0057 0.0202 0.0202
Schistosoma mansoni tubulin subunit beta 0.015 0.0615 0.0615
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.0073 0.0073
Leishmania major alpha tubulin 0.0475 0.2071 0.2071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0073 0.0073
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0028 0.0073 0.0073
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0028 0.0073 0.0073
Schistosoma mansoni opsin-like receptor 0.0028 0.0073 0.0073
Echinococcus granulosus g-protein coupled receptor 0.0028 0.0073 0.0073
Echinococcus multilocularis Tubulin alpha 1 chain 0.0475 0.2071 0.2071
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0016 0.002 0.0042
Schistosoma mansoni glutamate synthase 0.0016 0.002 0.002
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0016 0.002 0.0042
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0114 0.0457 0.0457
Trichomonas vaginalis CAMK family protein kinase 0.0302 0.1297 0.2781
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0041 0.0131 0.1524
Onchocerca volvulus 0.0028 0.0073 0.0564
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Plasmodium falciparum alpha tubulin 2 0.0475 0.2071 0.7522
Loa Loa (eye worm) latrophilin receptor protein 2 0.0076 0.0288 0.0288
Echinococcus multilocularis calmodulin 0.0012 0.000006084 0.000006084
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.014 0.0571 0.2075
Trypanosoma brucei alpha tubulin, putative 0.0195 0.0818 0.0818
Schistosoma mansoni amine GPCR 0.0028 0.0073 0.0073
Trichomonas vaginalis tubulin beta chain, putative 0.0475 0.2071 0.4443
Onchocerca volvulus 0.0033 0.0093 0.0714
Schistosoma mansoni hypothetical protein 0.003 0.0079 0.0079
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0016 0.002 0.002
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0016 0.002 0.002
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0073 0.0073
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0615 0.1318
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0028 0.0073 0.0073
Trypanosoma cruzi beta tubulin, putative 0.0627 0.2754 0.2754
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0571 0.1225
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Schistosoma mansoni growth hormone secretagogue receptor 0.0028 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0076 0.0288 0.0288
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0046 0.015 0.015
Brugia malayi follicle stimulating hormone receptor 0.0028 0.0073 0.0073
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0302 0.1297 0.1297
Brugia malayi Tachykinin-like peptides receptor 99D 0.0028 0.0073 0.0073
Entamoeba histolytica thioredoxin reductase, putative 0.0016 0.002 0.0071
Schistosoma mansoni neuropeptide receptor 0.0028 0.0073 0.0073
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.2245 1 1
Loa Loa (eye worm) BEN-1 protein 0.0627 0.2754 0.2754
Plasmodium falciparum ataxin-2 like protein, putative 0.0065 0.0238 0.0863
Schistosoma mansoni disulfide oxidoreductase 0.0016 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0325 0.1402 0.1402
Loa Loa (eye worm) tubulin beta-4 chain 0.0627 0.2754 0.2754
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Loa Loa (eye worm) thioredoxin reductase 0.0179 0.0747 0.0747
Brugia malayi hypothetical protein 0.0028 0.0073 0.0073
Trypanosoma brucei tubulin delta chain 0.015 0.0615 0.0615
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0016 0.002 0.0071
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0016 0.002 0.002
Giardia lamblia Delta tubulin 0.015 0.0615 0.132
Schistosoma mansoni sulfide quinone reductase 0.0016 0.002 0.002
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0028 0.0073 0.0073
Echinococcus granulosus 7TM GPCR rhodopsin 0.0028 0.0073 0.0073
Trypanosoma cruzi zeta tubulin, putative 0.015 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0016 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0086 0.0332 0.0332
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0325 0.1402 0.1402
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0571 0.1225
Echinococcus multilocularis tubulin alpha 3 chain 0.0475 0.2071 0.2071
Plasmodium falciparum glutathione reductase 0.0062 0.0224 0.0812
Echinococcus multilocularis tubulin alpha chain 0.0475 0.2071 0.2071
Echinococcus multilocularis sex peptide receptor 0.0028 0.0073 0.0073
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Brugia malayi putative neuropeptide receptor NPR1 0.0028 0.0073 0.0073
Trichomonas vaginalis tubulin epsilon chain, putative 0.015 0.0615 0.132
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0028 0.0073 0.0073
Brugia malayi G protein-coupled receptor F59B2.13 0.0028 0.0073 0.0073
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0028 0.0073 0.0073
Trypanosoma cruzi alpha tubulin, putative 0.0475 0.2071 0.2071
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0016 0.002 0.0042
Onchocerca volvulus 0.0028 0.0073 0.0564
Trichomonas vaginalis tubulin beta chain, putative 0.0195 0.0818 0.1755
Leishmania major hypothetical protein, conserved 0.0065 0.0238 0.0238
Echinococcus granulosus calmodulin 0.0012 0.000006084 0.000006084
Echinococcus multilocularis tubulin alpha chain 0.0475 0.2071 0.2071
Trypanosoma cruzi epsilon tubulin, putative 0.0344 0.1488 0.1488
Toxoplasma gondii beta-1 tubulin, putative 0.0627 0.2754 1
Echinococcus multilocularis allatostatin A receptor 0.0028 0.0073 0.0073
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0016 0.002 0.002
Echinococcus multilocularis tubulin alpha 0.0344 0.1488 0.1488
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0037 0.0037
Echinococcus multilocularis tubulin alpha 1C chain 0.0475 0.2071 0.2071
Echinococcus granulosus Tubulin alpha 1 chain 0.0475 0.2071 0.2071
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0028 0.0073 0.0564
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0571 0.1225
Loa Loa (eye worm) programmed cell death 8 0.0016 0.002 0.002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0062 0.0224 0.0224
Mycobacterium ulcerans glutaminase 0.0358 0.1549 0.1532
Loa Loa (eye worm) hypothetical protein 0.0924 0.4085 0.4085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0571 0.1225
Schistosoma mansoni hypothetical protein 0.0028 0.0073 0.0073
Echinococcus multilocularis Tubulin beta 2C chain 0.0627 0.2754 0.2754
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0016 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Onchocerca volvulus 0.0028 0.0073 0.0564
Echinococcus granulosus tubulin gamma 1 chain 0.0344 0.1488 0.1488
Echinococcus multilocularis peroxisome assembly protein 26 0.0475 0.2071 0.2071
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.0073 0.0073
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0062 0.0224 0.3424
Leishmania major alpha tubulin 0.0475 0.2071 0.2071
Trichomonas vaginalis tubulin, putative 0.0195 0.0818 0.1755
Mycobacterium ulcerans cell division protein FtsZ 0.015 0.0615 0.0597
Trichomonas vaginalis apoptosis inducing factor, putative 0.0016 0.002 0.0042
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0627 0.2754 0.2754
Trichomonas vaginalis glutamate synthase, putative 0.0016 0.002 0.0042
Echinococcus multilocularis serotonin receptor 0.0439 0.1911 0.1911
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.0073 0.0073
Schistosoma mansoni biogenic amine (5HT) receptor 0.0439 0.1911 0.1911
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0016 0.002 0.002
Echinococcus granulosus dro:myosuppressin receptor 0.0028 0.0073 0.0073
Onchocerca volvulus 0.0028 0.0073 0.0564
Loa Loa (eye worm) hypothetical protein 0.0161 0.0665 0.0665
Leishmania major epsilon tubulin, putative 0.0344 0.1488 0.1488
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0084 0.0323 0.0323
Echinococcus multilocularis neuropeptide FF receptor 2 0.0028 0.0073 0.0073
Loa Loa (eye worm) glutaminase 0.0358 0.1549 0.1549
Trichomonas vaginalis tubulin alpha chain, putative 0.0627 0.2754 0.5906
Loa Loa (eye worm) tubulin alpha chain 0.0475 0.2071 0.2071
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.2245 1 1
Brugia malayi hypothetical protein 0.0042 0.0134 0.0134
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0056 0.0199 0.0199
Echinococcus granulosus g protein coupled receptor 0.0028 0.0073 0.0073
Toxoplasma gondii alpha tubulin TUBA1 0.0475 0.2071 0.7522
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0016 0.002 0.0071
Toxoplasma gondii beta-tubulin, putative 0.0627 0.2754 1
Brugia malayi Tyrosine-protein kinase abl-1 0.022 0.0929 0.0929
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0016 0.002 0.0071
Brugia malayi G-protein coupled receptor 0.0028 0.0073 0.0073
Brugia malayi glutathione reductase 0.0179 0.0747 0.0747
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.0073 0.0073
Plasmodium vivax glutathione reductase, putative 0.0179 0.0747 0.2713
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0073 0.0073
Onchocerca volvulus 0.0028 0.0073 0.0564
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Schistosoma mansoni amine GPCR 0.0028 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0165 0.0684 0.0684
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0028 0.007 0.007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0073 0.0073
Brugia malayi peptidase family M13 containing protein 0.0028 0.007 0.007
Brugia malayi RE15519p 0.0028 0.0073 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0571 0.1225
Giardia lamblia Beta tubulin 0.0627 0.2754 0.5906
Trichomonas vaginalis CAMK family protein kinase 0.0302 0.1297 0.2781
Echinococcus multilocularis glutamate synthase 0.0016 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.002
Giardia lamblia Gamma tubulin 0.0344 0.1488 0.3191
Trypanosoma brucei beta tubulin 0.0627 0.2754 0.2754
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Loa Loa (eye worm) hypothetical protein 0.0137 0.0561 0.0561
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.002 0.0042
Loa Loa (eye worm) tubulin gamma chain 0.0344 0.1488 0.1488
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Schistosoma mansoni neuropeptide receptor 0.0028 0.0073 0.0073
Brugia malayi glutamate synthase 0.0016 0.002 0.002
Brugia malayi Tubulin beta chain 0.0195 0.0818 0.0818
Trypanosoma brucei NADH dehydrogenase 0.0016 0.002 0.002
Trichomonas vaginalis tubulin alpha chain, putative 0.0195 0.0818 0.1755
Toxoplasma gondii aldehyde dehydrogenase 0.0041 0.0131 0.0474
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0058 0.0204 0.0204
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.015 0.0615 0.2235
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0073 0.0073
Onchocerca volvulus 0.0028 0.0073 0.0564
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0615 0.1318
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.2245 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0627 0.2754 0.2754
Schistosoma mansoni biogenic amine receptor 0.0028 0.0073 0.0073
Plasmodium vivax delta tubulin, putative 0.015 0.0615 0.2235
Echinococcus granulosus tubulin alpha chain 0.0475 0.2071 0.2071
Echinococcus granulosus Tubulin alpha 1 chain 0.0475 0.2071 0.2071
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0073 0.0073
Loa Loa (eye worm) alpha-tubulin 0.0475 0.2071 0.2071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0224 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.015 0.0615 0.132
Leishmania major alpha tubulin 0.0475 0.2071 0.2071
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.002 0.0037 0.0037
Echinococcus multilocularis tubulin alpha chain 0.0475 0.2071 0.2071
Echinococcus multilocularis neuropeptide s receptor 0.0028 0.0073 0.0073
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.015 0.0615 0.2235
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0073 0.0073
Mycobacterium leprae probable zinc metalloprotease 0.0114 0.0457 0.7334
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0016 0.002 0.002
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0016 0.002 0.002
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.0073 0.0073
Giardia lamblia Fructose-bisphosphate aldolase 0.014 0.0571 0.1225
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0062 0.0224 0.0224
Trichomonas vaginalis CAMK family protein kinase 0.0302 0.1297 0.2781
Echinococcus granulosus calmodulin 0.0012 0.000006084 0.000006084
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0073 0.0073
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0016 0.002 0.002
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0062 0.0224 0.0224
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0062 0.0224 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0627 0.2754 0.2754
Schistosoma mansoni hypothetical protein 0.0029 0.0077 0.0077
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0057 0.0202 0.0733
Schistosoma mansoni aldehyde dehydrogenase 0.0041 0.0131 0.0131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0037 0.0037
Schistosoma mansoni neprilysin-2 (M13 family) 0.0058 0.0204 0.0204
Echinococcus multilocularis endothelin converting enzyme 1 0.0114 0.0457 0.0457
Giardia lamblia Glutamate synthase 0.0016 0.002 0.0042
Echinococcus multilocularis dro:myosuppressin receptor 0.0028 0.0073 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.002 0.0037 0.0037
Echinococcus multilocularis tubulin epsilon chain 0.0344 0.1488 0.1488
Echinococcus granulosus Tubulin beta 2C chain 0.0627 0.2754 0.2754
Trypanosoma cruzi NADH dehydrogenase, putative 0.0016 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.002
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0016 0.002 0.0071
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0068 0.0251 0.0232
Brugia malayi Tubulin alpha chain 0.0475 0.2071 0.2071
Brugia malayi Isocitrate dehydrogenase 0.0057 0.0202 0.0202
Trichomonas vaginalis tubulin gamma chain, putative 0.0344 0.1488 0.3191
Onchocerca volvulus 0.0028 0.0073 0.0564
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0073 0.0073
Echinococcus multilocularis serotonin receptor 0.0439 0.1911 0.1911
Onchocerca volvulus 0.0156 0.0644 0.4967
Trichomonas vaginalis CAMK family protein kinase 0.0302 0.1297 0.2781
Echinococcus granulosus orexin receptor type 2 0.0028 0.0073 0.0073
Echinococcus granulosus biogenic amine 5HT receptor 0.0028 0.0073 0.0073
Leishmania major hypothetical protein, conserved 0.0016 0.002 0.002
Trypanosoma cruzi tubulin gamma chain 0.0344 0.1488 0.1488
Loa Loa (eye worm) RNA binding protein 0.0045 0.0146 0.0146
Echinococcus multilocularis Niemann Pick C1 protein 0.0924 0.4085 0.4085
Loa Loa (eye worm) hypothetical protein 0.0086 0.0332 0.0332
Echinococcus granulosus tubulin delta chain 0.015 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Echinococcus granulosus tubulin alpha 0.0344 0.1488 0.1488
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0016 0.002 0.002
Schistosoma mansoni tubulin subunit delta 0.015 0.0615 0.0615
Onchocerca volvulus 0.0195 0.0818 0.6312
Entamoeba histolytica serine/threonine protein kinase, putative 0.0302 0.1297 0.4708
Loa Loa (eye worm) tubulin alpha chain 0.0475 0.2071 0.2071
Trypanosoma brucei PAB1-binding protein , putative 0.0065 0.0238 0.0238
Plasmodium vivax tubulin alpha chain, putative 0.0475 0.2071 0.7522
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1053 0.4663 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0028 0.0073 0.0073
Echinococcus multilocularis fmrfamide receptor 0.0028 0.0073 0.0073
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0073 0.0073
Echinococcus multilocularis geminin 0.0175 0.0729 0.0729
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0062 0.0224 0.0204
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0057 0.0202 0.0733
Schistosoma mansoni tubulin subunit alpha 0.0475 0.2071 0.2071
Echinococcus granulosus glutamate synthase 0.0016 0.002 0.002
Echinococcus multilocularis survival motor neuron protein 1 0.0161 0.0665 0.0665
Echinococcus granulosus alpha 1A adrenergic receptor 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Trichomonas vaginalis tubulin gamma chain, putative 0.0627 0.2754 0.5906
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0058 0.0204 0.0204
Schistosoma mansoni histamine h1 receptor 0.0028 0.0073 0.0073
Treponema pallidum cell division protein FtsZ 0.015 0.0615 0.1858
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0028 0.0073 0.0073
Trypanosoma brucei alpha tubulin 0.0475 0.2071 0.2071
Loa Loa (eye worm) tubulin alpha-3 chain 0.028 0.1199 0.1199
Treponema pallidum ATP-binding protein (ylxH-1) 0.0732 0.3226 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0323 0.0323
Toxoplasma gondii isocitrate dehydrogenase 0.0057 0.0202 0.0733
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0057 0.0202 0.0202
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0195 0.0818 0.1755
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0016 0.002 0.0071
Trichomonas vaginalis tubulin alpha chain, putative 0.0344 0.1488 0.3191
Trichomonas vaginalis tubulin beta chain, putative 0.0475 0.2071 0.4443
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0058 0.0204 0.0204
Trichomonas vaginalis tubulin epsilon chain, putative 0.0627 0.2754 0.5906
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Schistosoma mansoni myosin xvIII 0.0028 0.0073 0.0073
Schistosoma mansoni alpha tubulin 0.0475 0.2071 0.2071
Brugia malayi AKH receptor 0.0028 0.0073 0.0073
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0062 0.0224 0.0224
Brugia malayi Tubulin alpha-2 chain 0.0475 0.2071 0.2071
Loa Loa (eye worm) zinc metallopeptidase 4 0.0028 0.007 0.007
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0114 0.0457 0.6005
Trypanosoma brucei beta tubulin 0.0627 0.2754 0.2754
Loa Loa (eye worm) hypothetical protein 0.0084 0.0323 0.0323
Schistosoma mansoni hypothetical protein 0.0028 0.0073 0.0073
Echinococcus multilocularis tubulin alpha chain 0.0475 0.2071 0.2071
Brugia malayi latrophilin 2 splice variant baaae 0.0165 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Echinococcus multilocularis tubulin alpha 3 chain 0.0475 0.2071 0.2071
Echinococcus multilocularis G protein coupled receptor 139 0.0028 0.0073 0.0073
Echinococcus granulosus neuropeptide receptor A26 0.0028 0.0073 0.0073
Echinococcus granulosus tubulin alpha chain 0.0475 0.2071 0.2071
Giardia lamblia NADH oxidase lateral transfer candidate 0.0062 0.0224 0.048
Toxoplasma gondii isocitrate dehydrogenase 0.0057 0.0202 0.0733
Onchocerca volvulus 0.002 0.0037 0.0283
Echinococcus multilocularis Tubulin beta 2C chain 0.0627 0.2754 0.2754
Trypanosoma cruzi NADH dehydrogenase, putative 0.0016 0.002 0.002
Echinococcus multilocularis tubulin delta chain 0.015 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.002 0.0033 0.0033
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0016 0.002 0.002
Brugia malayi serine/threonine-protein kinase plk-2 0.0302 0.1297 0.1297
Schistosoma mansoni tubulin subunit alpha 0.0475 0.2071 0.2071
Trichomonas vaginalis CAMK family protein kinase 0.0302 0.1297 0.2781
Brugia malayi ORL1-like opioid receptor 0.0028 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0175 0.0729 0.0729
Leishmania major alpha tubulin 0.0475 0.2071 0.2071
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.0073 0.0073
Trichomonas vaginalis tubulin beta-1 chain, putative 0.015 0.0615 0.132
Trypanosoma cruzi trypanothione reductase, putative 0.0179 0.0747 0.0747
Brugia malayi Serotonin receptor 0.0028 0.0073 0.0073
Echinococcus multilocularis neuropeptide receptor 0.0028 0.0073 0.0073
Trypanosoma brucei polo-like protein kinase 0.0302 0.1297 0.1297
Plasmodium falciparum tubulin delta chain, putative 0.015 0.0615 0.2235
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0028 0.0073 0.0073
Schistosoma mansoni tyrosine kinase 0.0357 0.1544 0.1544
Echinococcus granulosus tubulin alpha chain 0.0475 0.2071 0.2071
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.2245 1 1
Trichomonas vaginalis tubulin, putative 0.015 0.0615 0.132
Trichomonas vaginalis CAMK family protein kinase 0.0302 0.1297 0.2781
Onchocerca volvulus 0.0028 0.0073 0.0564
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0076 0.0288 0.0288
Echinococcus multilocularis Tubulin beta 2C chain 0.0627 0.2754 0.2754
Schistosoma mansoni amine GPCR 0.0028 0.0073 0.0073
Trypanosoma brucei alpha tubulin 0.0475 0.2071 0.2071
Schistosoma mansoni biogenic amine (5HT) receptor 0.0028 0.0073 0.0073
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0062 0.0224 0.0812
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.1053 0.4663 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.002 0.0037 0.0133
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0016 0.002 0.0071
Brugia malayi RNA recognition motif domain containing protein 0.0045 0.0146 0.0146
Plasmodium falciparum alpha tubulin 1 0.0475 0.2071 0.7522
Echinococcus granulosus sterol regulatory element binding protein 0.0924 0.4085 0.4085
Brugia malayi isocitrate dehydrogenase 0.0057 0.0202 0.0202
Echinococcus granulosus neuropeptide receptor 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0362 0.1568 0.1568
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.2245 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0627 0.2754 0.2754
Echinococcus granulosus fmrfamide receptor 0.0028 0.0073 0.0073
Entamoeba histolytica tubulin family protein 0.0627 0.2754 1
Brugia malayi Serotonin receptor 0.0028 0.0073 0.0073
Brugia malayi CHE-14 protein 0.0924 0.4085 0.4085
Loa Loa (eye worm) hypothetical protein 0.0439 0.1911 0.1911
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0224 0.0224
Brugia malayi hypothetical protein 0.0028 0.0073 0.0073
Echinococcus granulosus neuropeptide FF receptor 2 0.0028 0.0073 0.0073
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0028 0.0073 0.0073
Echinococcus multilocularis G-protein coupled receptor, putative 0.0028 0.0073 0.0073
Brugia malayi hypothetical protein 0.0028 0.0073 0.0073
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0062 0.0224 0.0812
Leishmania major alpha tubulin 0.0475 0.2071 0.2071
Echinococcus multilocularis fmrfamide receptor 0.0028 0.0073 0.0073
Schistosoma mansoni sulfide quinone reductase 0.0016 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Onchocerca volvulus 0.0028 0.0073 0.0564
Plasmodium falciparum ataxin-2 like protein, putative 0.0065 0.0238 0.0863
Plasmodium vivax tubulin gamma chain, putative 0.0344 0.1488 0.5403
Trichomonas vaginalis glutamate synthase, putative 0.0016 0.002 0.0042
Onchocerca volvulus 0.0016 0.002 0.0152
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0475 0.2071 0.2071
Leishmania major NADH dehydrogenase, putative 0.0016 0.002 0.002
Echinococcus granulosus beta tubulin 0.0627 0.2754 0.2754
Trichomonas vaginalis tubulin alpha chain, putative 0.0195 0.0818 0.1755
Brugia malayi Tubulin beta-1 chain 0.0627 0.2754 0.2754
Schistosoma mansoni tubulin subunit beta 0.0627 0.2754 0.2754
Schistosoma mansoni neprilysin 0.003 0.0079 0.0079
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0179 0.0747 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0475 0.2071 0.4443
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0076 0.0288 0.0288
Leishmania major alpha tubulin 0.0475 0.2071 0.2071
Echinococcus multilocularis isocitrate dehydrogenase 0.0057 0.0202 0.0202
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0057 0.0202 0.0202
Echinococcus granulosus serotonin receptor 0.0028 0.0073 0.0073
Echinococcus granulosus tubulin alpha chain 0.0475 0.2071 0.2071
Loa Loa (eye worm) hypothetical protein 0.2245 1 1
Loa Loa (eye worm) tubulin beta chain 0.015 0.0615 0.0615
Onchocerca volvulus 0.0056 0.0199 0.1535
Brugia malayi Latrophilin receptor protein 2 0.0076 0.0288 0.0288
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0073 0.0073
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0241 0.1026 0.1026
Schistosoma mansoni tubulin subunit beta 0.0627 0.2754 0.2754
Schistosoma mansoni glutamate synthase 0.0016 0.002 0.002
Loa Loa (eye worm) tubulin beta chain 0.0627 0.2754 0.2754
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0114 0.0457 0.0457
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Echinococcus granulosus Tubulin beta 2C chain 0.0627 0.2754 0.2754
Echinococcus granulosus allatostatin A receptor 0.0028 0.0073 0.0073
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.028 0.1199 0.2572
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0016 0.002 0.002
Echinococcus multilocularis CalModulin family member (cmd 1) 0.0012 0.000006084 0.000006084
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0028 0.0073 0.0073
Trypanosoma brucei beta tubulin 0.0344 0.1488 0.1488
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0073 0.0073
Echinococcus granulosus Tubulin beta 2C chain 0.0627 0.2754 0.2754
Schistosoma mansoni tubulin subunit alpha 0.015 0.0615 0.0615
Loa Loa (eye worm) tubulin alpha 2 0.0325 0.1402 0.1402
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0062 0.0224 0.0224
Brugia malayi hypothetical protein 0.0065 0.0238 0.0238
Schistosoma mansoni hypothetical protein 0.0076 0.0288 0.0288
Trypanosoma cruzi zeta tubulin, putative 0.015 0.0615 0.0615
Loa Loa (eye worm) tubulin alpha 2 0.013 0.053 0.053
Trypanosoma cruzi tubulin delta chain 0.015 0.0615 0.0615
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0073 0.0073
Brugia malayi tubulin alpha-2 chain 0.0475 0.2071 0.2071
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0041 0.0131 0.0131
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.028 0.1199 0.1199
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0062 0.0224 0.0224
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0028 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0086 0.0332 0.0332
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0016 0.002 0.0071
Echinococcus granulosus beta tubulin 0.0627 0.2754 0.2754
Giardia lamblia Beta tubulin 0.0627 0.2754 0.5906
Trypanosoma cruzi tubulin delta chain 0.015 0.0615 0.0615
Echinococcus granulosus tar DNA binding protein 0.0045 0.0146 0.0146
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0016 0.002 0.0071
Trypanosoma brucei trypanothione reductase 0.0179 0.0747 0.0747
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0045 0.0146 0.0146
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Loa Loa (eye worm) hypothetical protein 0.0165 0.0684 0.0684
Toxoplasma gondii LsmAD domain-containing protein 0.0065 0.0238 0.0863
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0073 0.0073
Schistosoma mansoni tubulin subunit gamma 0.0344 0.1488 0.1488
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0146 0.0146
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.0073 0.0073
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0016 0.002 0.002
Loa Loa (eye worm) glutaminase 2 0.0358 0.1549 0.1549
Toxoplasma gondii alpha-tubulin I, putative 0.0475 0.2071 0.7522
Loa Loa (eye worm) beta-tubulin 0.0627 0.2754 0.2754
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.2245 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0062 0.0224 0.0224
Trichomonas vaginalis tubulin alpha chain, putative 0.0195 0.0818 0.1755
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0073 0.0073
Echinococcus granulosus sex peptide receptor 0.0028 0.0073 0.0073
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.0073 0.0073
Echinococcus granulosus tubulin alpha 1C chain 0.0475 0.2071 0.2071
Entamoeba histolytica tubulin family protein 0.0627 0.2754 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0179 0.0747 0.0747
Leishmania major alpha tubulin 0.0475 0.2071 0.2071
Onchocerca volvulus Neuropeptide F receptor homolog 0.0028 0.0073 0.0564
Trypanosoma brucei epsilon tubulin 0.0344 0.1488 0.1488
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Echinococcus granulosus Niemann Pick C1 protein 0.0924 0.4085 0.4085
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0062 0.0224 0.3424
Schistosoma mansoni alpha tubulin 0.0475 0.2071 0.2071
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0028 0.0073 0.0073
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.0073 0.0073
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0057 0.0202 0.0202
Brugia malayi Peptidase family M13 containing protein 0.0114 0.0457 0.0457
Trichomonas vaginalis tubulin, putative 0.0195 0.0818 0.1755
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0062 0.0224 0.2803
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Plasmodium vivax ataxin-2 like protein, putative 0.0065 0.0238 0.0863
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0016 0.002 0.002
Trypanosoma brucei epsilon tubulin 0.0344 0.1488 0.1488
Trichomonas vaginalis conserved hypothetical protein 0.0924 0.4085 0.8761
Schistosoma mansoni neuropeptide f receptor 76f 0.0028 0.0073 0.0073
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0016 0.002 0.0071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0073 0.0073
Brugia malayi Pre-SET motif family protein 0.002 0.0037 0.0037
Leishmania major zeta tubulin, putative 0.015 0.0615 0.0615
Schistosoma mansoni amine GPCR 0.0028 0.0073 0.0073
Echinococcus granulosus tachykinin peptides receptor 99D 0.0028 0.0073 0.0073
Plasmodium vivax tubulin beta chain, putative 0.0627 0.2754 1
Giardia lamblia Alpha-tubulin 0.0475 0.2071 0.4443
Brugia malayi Calcitonin receptor-like protein seb-1 0.0241 0.1026 0.1026
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0062 0.0224 0.0204
Echinococcus multilocularis tubulin gamma 1 chain 0.0344 0.1488 0.1488
Trichomonas vaginalis tubulin gamma chain, putative 0.0344 0.1488 0.3191
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.0073 0.0073
Echinococcus granulosus tubulin alpha 1C chain 0.0475 0.2071 0.2071
Entamoeba histolytica disulphide oxidoreductase, putative 0.0016 0.002 0.0071
Onchocerca volvulus 0.0028 0.0073 0.0564
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Echinococcus granulosus tubulin subunit beta 0.0627 0.2754 0.2754
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0016 0.002 0.002
Mycobacterium tuberculosis Cell division protein FtsZ 0.015 0.0615 0.8188
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Trypanosoma brucei alpha tubulin 0.0475 0.2071 0.2071
Schistosoma mansoni hypothetical protein 0.003 0.0079 0.0079
Trypanosoma brucei beta tubulin 0.0627 0.2754 0.2754
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0028 0.0073 0.0073
Loa Loa (eye worm) peptidase family M13 containing protein 0.0084 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0037
Schistosoma mansoni tubulin subunit epsilon 0.0344 0.1488 0.1488
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.0131 0.0111
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.015 0.0615 1
Trypanosoma brucei beta tubulin 0.0627 0.2754 0.2754
Schistosoma mansoni tubulin subunit beta 0.0627 0.2754 0.2754
Schistosoma mansoni hypothetical protein 0.0033 0.0093 0.0093
Echinococcus granulosus survival motor neuron protein 1 0.0161 0.0665 0.0665
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0058 0.0204 0.0204
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.014 0.0571 0.2075
Brugia malayi putative neuropeptide receptor 0.0028 0.0073 0.0073
Trichomonas vaginalis glutaminase, putative 0.0358 0.1549 0.3321
Brugia malayi hypothetical protein 0.0028 0.0073 0.0073
Echinococcus multilocularis tubulin subunit TubB 0.0475 0.2071 0.2071
Trichomonas vaginalis tubulin beta chain, putative 0.0475 0.2071 0.4443
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0041 0.0131 0.0131
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.002 0.0042
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0028 0.0073 0.0073
Trypanosoma cruzi epsilon tubulin, putative 0.0344 0.1488 0.1488
Echinococcus multilocularis calmodulin 0.0012 0.000006084 0.000006084
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Giardia lamblia Beta tubulin 0.0627 0.2754 0.5906
Toxoplasma gondii peptidase family M13 protein 0.0114 0.0457 0.1658
Giardia lamblia Kinase, PLK 0.0302 0.1297 0.2781
Echinococcus granulosus hypothetical protein 0.0028 0.0073 0.0073
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0062 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Plasmodium falciparum tubulin epsilon chain, putative 0.0344 0.1488 0.5403
Giardia lamblia Thioredoxin reductase 0.0016 0.002 0.0042
Echinococcus multilocularis tubulin beta 1 chain 0.0627 0.2754 0.2754
Loa Loa (eye worm) tubulin alpha-2 chain 0.0475 0.2071 0.2071
Plasmodium falciparum ferrodoxin reductase-like protein 0.0016 0.002 0.0071
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.0073 0.0073
Loa Loa (eye worm) isocitrate dehydrogenase 0.0057 0.0202 0.0202
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0073 0.0073
Brugia malayi RNA binding protein 0.0045 0.0146 0.0146
Echinococcus multilocularis somatostatin receptor 0.0028 0.0073 0.0073
Leishmania major delta tubulin, putative 0.015 0.0615 0.0615
Giardia lamblia Epsilon tubulin 0.015 0.0615 0.132
Loa Loa (eye worm) hypothetical protein 0.0086 0.0332 0.0332
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0073 0.0073
Onchocerca volvulus 0.0028 0.0073 0.0564
Brugia malayi hypothetical protein 0.0028 0.0073 0.0073
Schistosoma mansoni glutamate synthase 0.0016 0.002 0.002
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0475 0.2071 0.4443
Brugia malayi TAR-binding protein 0.0045 0.0146 0.0146
Treponema pallidum fructose-bisphosphate aldolase 0.014 0.0571 0.1721
Brugia malayi Pre-SET motif family protein 0.0141 0.0579 0.0579
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Schistosoma mansoni kinase 0.0153 0.0632 0.0632
Trichomonas vaginalis tubulin gamma chain, putative 0.015 0.0615 0.132
Loa Loa (eye worm) tubulin alpha 2 0.0325 0.1402 0.1402
Schistosoma mansoni adenoreceptor 0.0028 0.0073 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0037 0.0037
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0016 0.002 0.002
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0016 0.002 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0073 0.0073
Onchocerca volvulus Serine\/threonine kinase homolog 0.0302 0.1297 1
Echinococcus multilocularis tubulin subunit beta 0.0627 0.2754 0.2754
Echinococcus multilocularis GPCR, family 2 0.0076 0.0288 0.0288
Loa Loa (eye worm) melatonin receptor type 1A 0.0028 0.0073 0.0073
Brugia malayi Dopamine receptor protein 2 0.0028 0.0073 0.0073
Schistosoma mansoni opsin-like receptor 0.0028 0.0073 0.0073
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0141 0.0579 0.0579
Brugia malayi Dopamine receptor 0.0028 0.0073 0.0073
Brugia malayi hypothetical protein 0.0156 0.0644 0.0644
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0241 0.1026 0.1026
Trichomonas vaginalis CAMK family protein kinase 0.0302 0.1297 0.2781
Brugia malayi hypothetical protein 0.0028 0.0073 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0571 0.1225
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.003 0.0079 0.0079
Brugia malayi Tyrosine-protein kinase abl-1 0.0148 0.0607 0.0607
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0016 0.002 0.002
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0062 0.0224 0.0812
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1053 0.4663 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0924 0.4085 0.4085
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Echinococcus granulosus tubulin epsilon chain 0.0344 0.1488 0.1488
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0062 0.0224 0.2803
Echinococcus multilocularis tubulin alpha 1C chain 0.0475 0.2071 0.2071
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0073 0.0073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0073 0.0073
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0028 0.0073 0.0073
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.0073 0.0073
Leishmania major alpha tubulin 0.0475 0.2071 0.2071
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0924 0.4085 0.4085
Loa Loa (eye worm) TYRA-2 protein 0.0028 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0076 0.0288 0.0288
Echinococcus granulosus calmodulin 0.0012 0.000006084 0.000006084
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Echinococcus multilocularis orexin receptor type 2 0.0028 0.0073 0.0073
Echinococcus multilocularis calmodulin 0.0012 0.000006084 0.000006084
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0302 0.1297 0.1297
Leishmania major alpha tubulin 0.0475 0.2071 0.2071
Echinococcus granulosus tubulin beta 1 chain 0.0627 0.2754 0.2754
Schistosoma mansoni endothelin-converting enzyme-related 0.0028 0.007 0.007
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.002 0.0042
Loa Loa (eye worm) TAR-binding protein 0.0045 0.0146 0.0146
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0073 0.0073
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0062 0.0224 0.0224
Toxoplasma gondii selenide, water dikinase 0.0016 0.002 0.0071
Echinococcus granulosus tubulin subunit TubB 0.0475 0.2071 0.2071
Loa Loa (eye worm) hypothetical protein 0.0086 0.0332 0.0332
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0073 0.0073
Echinococcus granulosus neuropeptide receptor 0.0028 0.0073 0.0073
Echinococcus granulosus CalModulin family member cmd 1 0.0012 0.000006084 0.000006084
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0016 0.002 0.002
Onchocerca volvulus 0.0028 0.0073 0.0564
Brugia malayi MH2 domain containing protein 0.0123 0.0497 0.0497
Plasmodium falciparum tubulin beta chain 0.0627 0.2754 1
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1053 0.4663 1
Onchocerca volvulus 0.0028 0.0073 0.0564
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0068 0.0251 0.3891
Echinococcus granulosus somatostatin receptor 0.0028 0.0073 0.0073
Trypanosoma brucei tubulin gamma chain 0.0344 0.1488 0.1488
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0062 0.0224 0.0812
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0016 0.002 0.002
Leishmania major trypanothione reductase 0.0179 0.0747 0.0747
Echinococcus granulosus biogenic amine 5HT receptor 0.0439 0.1911 0.1911
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0073 0.0073
Plasmodium falciparum thioredoxin reductase 0.0062 0.0224 0.0812
Schistosoma mansoni amine GPCR 0.0028 0.0073 0.0073
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0028 0.0073 0.0073
Echinococcus multilocularis calmodulin 0.0012 0.000006084 0.000006084
Echinococcus granulosus geminin 0.0175 0.0729 0.0729
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.0073 0.0073
Trypanosoma brucei epsilon tubulin 0.0344 0.1488 0.1488
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0016 0.002 0.0071
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0028 0.0073 0.0073
Schistosoma mansoni tubulin subunit alpha 0.0475 0.2071 0.2071
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.0073 0.0073
Echinococcus multilocularis Tubulin alpha 1 chain 0.0475 0.2071 0.2071
Leishmania major gamma-tubulin 0.0344 0.1488 0.1488
Brugia malayi Thioredoxin reductase 0.0179 0.0747 0.0747
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0062 0.0224 0.0224
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0073 0.0073
Brugia malayi hypothetical protein 0.0028 0.0073 0.0073
Schistosoma mansoni tubulin subunit beta 0.0627 0.2754 0.2754
Brugia malayi hypothetical protein 0.0028 0.0073 0.0073
Echinococcus multilocularis tubulin alpha chain 0.0475 0.2071 0.2071
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0016 0.002 0.0071
Echinococcus granulosus g protein coupled receptor 0.0028 0.0073 0.0073
Brugia malayi Tubulin alpha-2 chain 0.0475 0.2071 0.2071
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0041 0.0131 0.0131
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0062 0.0224 0.3424
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.0131 0.0111
Loa Loa (eye worm) glutathione reductase 0.0179 0.0747 0.0747
Echinococcus multilocularis beta tubulin 0.0627 0.2754 0.2754
Brugia malayi beta-tubulin, identical 0.0627 0.2754 0.2754
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0028 0.007 0.007
Trypanosoma brucei alpha tubulin 0.0475 0.2071 0.2071
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0028 0.0073 0.0073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0224 0.0224
Trypanosoma cruzi trypanothione reductase, putative 0.0062 0.0224 0.0224
Schistosoma mansoni hypothetical protein 0.003 0.0079 0.0079
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0497 0.0497
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0224 0.0224
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0076 0.0288 0.0288
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0073 0.0073
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0029 0.0077 0.0077
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0057 0.0202 0.0202
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0344 0.1488 0.5403
Schistosoma mansoni tubulin subunit beta 0.0627 0.2754 0.2754
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.2245 1 1
Schistosoma mansoni biogenic amine receptor 0.0028 0.0073 0.0073
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0073 0.0073
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0114 0.0457 0.0457
Trichomonas vaginalis tubulin epsilon chain, putative 0.0627 0.2754 0.5906
Leishmania major beta tubulin 0.0627 0.2754 0.2754
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0016 0.002 0.0042
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.002 0.0042
Loa Loa (eye worm) tubulin beta-1 chain 0.0627 0.2754 0.2754
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0571 0.1225
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.0073 0.0073
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.002 0.0042
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0497 0.0497
Echinococcus multilocularis protein dispatched 1 0.0924 0.4085 0.4085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0571 0.1225
Leishmania major hypothetical protein, conserved 0.0016 0.002 0.002
Brugia malayi larval opioid receptor 0.0028 0.0073 0.0073
Schistosoma mansoni survival motor neuron protein 0.0033 0.0093 0.0093
Onchocerca volvulus 0.0028 0.0073 0.0564
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0076 0.0288 0.0288
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0016 0.002 0.002
Brugia malayi Dopamine receptor protein 1 0.0028 0.0073 0.0073
Onchocerca volvulus 0.0028 0.0073 0.0564
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0073 0.0073
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0028 0.0073 0.0073
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0016 0.002 0.0042
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0156 0.0644 0.0644
Brugia malayi Tubulin gamma chain 0.0344 0.1488 0.1488
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0037 0.0037
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0068 0.0251 0.3186
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0076 0.0288 0.0288
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0028 0.0073 0.0073
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0028 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.003 0.0079 0.0079
Plasmodium vivax SET domain protein, putative 0.002 0.0037 0.0133
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Brugia malayi glutaminase DH11.1 0.0358 0.1549 0.1549
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0073 0.0073
Echinococcus granulosus alpha tubulin 0.0475 0.2071 0.2071
Echinococcus multilocularis protein patched 0.0924 0.4085 0.4085
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0028 0.007 0.007
Schistosoma mansoni hypothetical protein 0.003 0.0079 0.0079
Trypanosoma cruzi PAB1-binding protein , putative 0.0065 0.0238 0.0238
Onchocerca volvulus 0.0161 0.0666 0.5137
Echinococcus granulosus tubulin beta 4A class IVa 0.0627 0.2754 0.2754

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.252 Inhibition of Homo sapiens (human) endothelin converting enzyme-1 ChEMBL. No reference
IC50 (binding) = 56 nM In vitro inhibition of Endothelin-converting enzyme 1. ChEMBL. 12372501
IC50 (binding) = 56 nM In vitro inhibition of Endothelin-converting enzyme 1. ChEMBL. 12372501

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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