Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 52 nM | Inhibitory activity against thrombin induced platelet aggregation | ChEMBL. | 8759623 |
Ki (binding) | = 10 nM | Inhibition of human alpha-thrombin. | ChEMBL. | 8759623 |
Ki (binding) | = 2900 nM | Inhibition of bovine trypsin | ChEMBL. | 8759623 |
Selectivity (binding) | = 290 | Inhibition of trypsin, selectivity with respect to thrombin | ChEMBL. | 8759623 |
Selectivity (binding) | = 37000 | Compound was tested for inhibition of tissue-type plasminogen activator(tissue plasminogen activator), selectivity with respect to thrombin | ChEMBL. | 8759623 |
Selectivity (binding) | = 40000 | Compound was tested for inhibition of plasmin, selectivity with respect to thrombin | ChEMBL. | 8759623 |
Selectivity (binding) | > 50000 | Compound was tested for inhibition of activated protein C .selectivity with respect to thrombin | ChEMBL. | 8759623 |
Selectivity (binding) | > 50000 | Compound was tested for inhibition of streptokinase(SK) .selectivity with respect to thrombin | ChEMBL. | 8759623 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.