Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0119 | 0 | 0.5 | |
Schistosoma mansoni | dihydrofolate reductase | 0.0238 | 0.9883 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0238 | 0.9883 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0238 | 0.9883 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0238 | 0.9883 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0239 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0238 | 0.9883 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0239 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0239 | 1 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0238 | 0.9883 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0238 | 0.9883 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0238 | 0.9883 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0238 | 0.9883 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0238 | 0.9883 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0239 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0239 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 14 % | Inhibition of TERT transcriptional activity in human H1299 cells assessed SEAP activity at 100 uM incubated for 24 hrs by SEAP assay | ChEMBL. | 23279865 |
Activity (binding) | = 96 % | Inhibition of TERT transcriptional activity in human H1299 cells assessed SEAP activity at 10 uM incubated for 24 hrs by SEAP assay | ChEMBL. | 23279865 |
Activity (binding) | = 97 % | Inhibition of TERT transcriptional activity in human H1299 cells assessed SEAP activity at 1 uM incubated for 24 hrs by SEAP assay | ChEMBL. | 23279865 |
IC50 (functional) | = 21.6 uM | Growth inhibition of human PC3 cells after 48 hrs by SRB assay | ChEMBL. | 23279865 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.