TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 479.571 | Formula: C26H33N5O4
H donors: 1 H acceptors: 4 LogP: 3.02 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OCc1cc(ccc1OC)c1ccc2c(n1)nc(nc2N1CCOC[C@@H]1C)N1C[C@H](C)O[C@@H](C1)C
InChi: 1S/C26H33N5O4/c1-16-15-34-10-9-31(16)25-21-6-7-22(19-5-8-23(33-4)20(11-19)14-32)27-24(21)28-26(29-25)30-12-17(2)35-18(3)13-30/h5-8,11,16-18,32H,9-10,12-15H2,1-4H3/t16-,17-,18+/m0/s1
InChiKey: PYBZGBUQJGDFIX-OKZBNKHCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0206	0.38	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.03	0.5734	0.5435
Loa Loa (eye worm)	SH2 domain-containing protein	0.03	0.5734	0.5435
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Entamoeba histolytica	ankyrin repeat protein	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0506	1	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Entamoeba histolytica	hypothetical protein, conserved	0.0206	0.38	0.3364
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0206	0.38	0.3364
Brugia malayi	tRNA modification GTPase TrmE family protein	0.03	0.5734	0.5435
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0206	0.38	0.3364
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0206	0.38	0.3364
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Echinococcus granulosus	suppressor of cytokine signaling 7	0.03	0.5734	0.5435
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.03	0.5734	0.5435
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0054	0.0656	0.0678
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Schistosoma mansoni	serine/threonine protein kinase	0.0206	0.38	0.3364
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0206	0.38	0.3364
Entamoeba histolytica	tyrosine kinase, putative	0.0206	0.38	0.3364
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/FER protein kinase	0.0206	0.38	0.3364
Entamoeba histolytica	tyrosine kinase, putative	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK protein kinase	0.0206	0.38	0.3364
Trichomonas vaginalis	conserved hypothetical protein	0.0206	0.38	1
Schistosoma mansoni	nck2/grb4	0.03	0.5734	0.5435
Echinococcus multilocularis	tyrosine kinase	0.0206	0.38	0.3364
Echinococcus granulosus	tyrosine kinase	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/FER protein kinase	0.0206	0.38	0.3364
Onchocerca volvulus		0.0506	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0206	0.38	0.3364
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Entamoeba histolytica	tyrosine kinase, putative	0.0206	0.38	0.3364
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0026	0.0065	0.017
Entamoeba histolytica	hypothetical protein	0.0206	0.38	0.3364
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.03	0.5734	0.5435
Entamoeba histolytica	receptor protein kinase, putative	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0506	1	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Brugia malayi	Receptor family ligand binding region containing protein	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine kinase	0.0506	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Entamoeba histolytica	tyrosine kinase, putative	0.0206	0.38	0.3364
Echinococcus multilocularis	NCK adaptor protein	0.03	0.5734	0.5435
Echinococcus multilocularis	tyrosine kinase	0.0506	1	1
Schistosoma mansoni	tyrosine kinase	0.0506	1	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0206	0.38	0.3364
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.03	0.5734	0.5435
Entamoeba histolytica	cysteine surface protein, putative	0.0206	0.38	0.3364
Schistosoma mansoni	suppressor of cytokine signaling	0.03	0.5734	0.5435
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.03	0.5734	0.5435
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK protein kinase	0.0206	0.38	0.3364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.014	0.0003
Onchocerca volvulus		0.0506	1	1
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK protein kinase	0.0206	0.38	0.3364
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0054	0.0656	0.0678
Echinococcus multilocularis	tensin	0.03	0.5734	0.5435
Entamoeba histolytica	hypothetical protein	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0206	0.38	0.3364
Echinococcus granulosus	SH2 domain containing adapter protein F	0.03	0.5734	0.5435
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0206	0.38	0.3364
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0506	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/FER protein kinase	0.0506	1	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0206	0.38	0.3364
Trypanosoma brucei	Pseudokinase, putative	0.0206	0.38	1
Entamoeba histolytica	tyrosine kinase, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.014	0.0003
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0206	0.38	0.3364
Entamoeba histolytica	tyrosine kinase, putative	0.0206	0.38	0.3364
Loa Loa (eye worm)	hypothetical protein	0.0206	0.38	0.3364
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Loa Loa (eye worm)	hypothetical protein	0.03	0.5734	0.5435
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0206	0.38	0.3364
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0206	0.38	0.3364
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.03	0.5734	0.5435
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Entamoeba histolytica	serine/threonine kinase, putative	0.0206	0.38	0.3364
Brugia malayi	STAT protein, DNA binding domain containing protein	0.03	0.5734	0.5435
Echinococcus granulosus	tyrosine protein kinase csk	0.0206	0.38	0.3364
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.03	0.5734	0.5435
Echinococcus multilocularis	epidermal growth factor receptor	0.0206	0.38	0.3364
Brugia malayi	hypothetical protein	0.0206	0.38	0.3364
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Loa Loa (eye worm)	hypothetical protein	0.0206	0.38	0.3364
Echinococcus multilocularis	tensin	0.03	0.5734	0.5435
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.03	0.5734	0.5435
Loa Loa (eye worm)	TK protein kinase	0.0206	0.38	0.3364
Entamoeba histolytica	receptor protein kinase, putative	0.0206	0.38	0.3364
Echinococcus granulosus	tyrosine protein kinase shark	0.0506	1	1
Entamoeba histolytica	hypothetical protein	0.0206	0.38	0.3364
Schistosoma mansoni	hypothetical protein	0.03	0.5734	0.5435
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0506	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0656	0.1413
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Trichomonas vaginalis	conserved hypothetical protein	0.0206	0.38	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine kinase	0.0506	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Schistosoma mansoni	tensin-related	0.03	0.5734	0.5435
Loa Loa (eye worm)	hypothetical protein	0.03	0.5734	0.5435
Echinococcus multilocularis	protein tyrosine kinase	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Echinococcus multilocularis	protein kinase	0.0206	0.38	0.3364
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0043	0.0427	0.1125
Echinococcus granulosus	tyrosine protein kinase Srms	0.0506	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0206	0.38	0.3364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0204	0.0179
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0426	0.0785
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0206	0.38	0.3364
Echinococcus granulosus	SH2 domain containing protein 7	0.03	0.5734	0.5435
Brugia malayi	hypothetical protein	0.0506	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.03	0.5734	0.5435
Entamoeba histolytica	tyrosine kinase, putative	0.0206	0.38	0.3364
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0206	0.38	0.3364
Echinococcus multilocularis	activated cdc42 kinase 1	0.0206	0.38	0.3364
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0206	0.38	1
Echinococcus granulosus	epidermal growth factor receptor	0.0206	0.38	0.3364
Trichomonas vaginalis	conserved hypothetical protein	0.0206	0.38	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0206	0.38	0.3364
Brugia malayi	SH2 domain containing protein	0.03	0.5734	0.5435
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0206	0.38	1
Schistosoma mansoni	tyrosine kinase	0.0506	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/RYK protein kinase	0.0206	0.38	0.3364
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0206	0.38	0.3364
Brugia malayi	Variant SH3 domain containing protein	0.03	0.5734	0.5435
Onchocerca volvulus		0.03	0.5734	0.312
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.014	0.0003
Schistosoma mansoni	protein kinase	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0506	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0206	0.38	0.3364
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0206	0.38	0.3364
Entamoeba histolytica	tyrosine kinase, putative	0.0206	0.38	0.3364
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0506	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Entamoeba histolytica	tyrosin kinase, putative	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0206	0.38	0.3364
Echinococcus granulosus	expressed conserved protein	0.03	0.5734	0.5435
Echinococcus granulosus	signal transduction protein lnk realted	0.03	0.5734	0.5435
Loa Loa (eye worm)	hypothetical protein	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Brugia malayi	SH2 domain containing protein	0.0506	1	1
Onchocerca volvulus		0.03	0.5734	0.312
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0369	0.0627
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0206	0.38	0.3364
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0206	0.38	0.3364
Schistosoma mansoni	protein kinase	0.0206	0.38	0.3364
Plasmodium falciparum	tyrosine kinase-like protein	0.0206	0.38	0.5
Schistosoma mansoni	protein kinase	0.0206	0.38	0.3364
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0206	0.38	0.3364
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0206	0.38	0.3364
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.03	0.5734	0.5435
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0262	0.0337
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0506	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0206	0.38	0.3364
Entamoeba histolytica	tyrosine kinase, putative	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Echinococcus multilocularis	protein kinase	0.0206	0.38	0.3364
Onchocerca volvulus		0.03	0.5734	0.312
Brugia malayi	integrin-linked kinase	0.0206	0.38	0.3364
Echinococcus granulosus	insulin receptor	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.03	0.5734	0.312
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0206	0.38	0.5
Echinococcus multilocularis	FL cytokine receptor	0.0206	0.38	0.3364
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.03	0.5734	0.5435
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0506	1	1
Loa Loa (eye worm)	hypothetical protein	0.03	0.5734	0.5435
Schistosoma mansoni	protein kinase	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Onchocerca volvulus		0.03	0.5734	0.312
Brugia malayi	Sex muscle abnormal protein 5	0.03	0.5734	0.5435
Schistosoma mansoni	SH2A	0.03	0.5734	0.5435
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0656	0.1413
Echinococcus multilocularis	SH2 motif	0.03	0.5734	0.5435
Echinococcus granulosus	SH2 motif	0.03	0.5734	0.5435
Loa Loa (eye worm)	TK/ABL protein kinase	0.0506	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/DDR protein kinase	0.0206	0.38	0.3364
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0206	0.38	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0206	0.38	0.3364
Trichomonas vaginalis	conserved hypothetical protein	0.0206	0.38	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.03	0.5734	0.5435
Loa Loa (eye worm)	TK/FER protein kinase	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.03	0.5734	0.5435
Echinococcus granulosus	SHC transforming protein 3	0.03	0.5734	0.5435
Loa Loa (eye worm)	SRC-1	0.0506	1	1
Brugia malayi	SH2 domain containing protein	0.0506	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.03	0.5734	0.5435
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0206	0.38	0.3364
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0206	0.38	0.3364
Loa Loa (eye worm)	hypothetical protein	0.03	0.5734	0.5435
Echinococcus granulosus	hypothetical protein	0.03	0.5734	0.5435
Trichomonas vaginalis	conserved hypothetical protein	0.0206	0.38	1
Brugia malayi	SH2 domain containing protein	0.03	0.5734	0.5435
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Echinococcus multilocularis	activin receptor type	0.0206	0.38	0.3364
Giardia lamblia	Kinase, NEK	0.0206	0.38	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0206	0.38	0.3364
Entamoeba histolytica	serine/threonine kinase, putative	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0506	1	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.03	0.5734	0.5435
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Trypanosoma cruzi	protein kinase, putative	0.0206	0.38	1
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0206	0.38	0.3364
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0206	0.38	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0369	0.0627
Schistosoma mansoni	tensin	0.03	0.5734	0.5435
Loa Loa (eye worm)	TK/INSR protein kinase	0.0206	0.38	0.3364
Echinococcus granulosus	kinase suppressor of Ras 1	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/FER protein kinase	0.0506	1	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0206	0.38	0.3364
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0506	1	1
Echinococcus multilocularis	N chimaerin	0.03	0.5734	0.5435
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Echinococcus multilocularis	SH2 motif	0.03	0.5734	0.5435
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Plasmodium falciparum	protein kinase, putative	0.0206	0.38	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0369	0.0627
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0369	0.0627
Brugia malayi	SH2 domain containing protein	0.03	0.5734	0.5435
Schistosoma mansoni	ephrin receptor	0.0206	0.38	0.3364
Toxoplasma gondii	protein kinase domain-containing protein	0.0206	0.38	1
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.03	0.5734	0.312
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.03	0.5734	0.5435
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0206	0.38	0.3364
Echinococcus granulosus	activated cdc42 kinase 1	0.0206	0.38	0.3364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0369	0.0627
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0506	1	1
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/FER protein kinase	0.0506	1	1
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Giardia lamblia	Protein 21.1	0.0206	0.38	1
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0506	1	1
Entamoeba histolytica	hypothetical protein	0.0206	0.38	0.3364
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0506	1	1
Echinococcus granulosus	protein kinase	0.0206	0.38	0.3364
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0506	1	1
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Entamoeba histolytica	tyrosin kinase, putative	0.0206	0.38	0.3364
Loa Loa (eye worm)	hypothetical protein	0.0206	0.38	0.3364
Entamoeba histolytica	tyrosine kinase, putative	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK protein kinase	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0506	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0198	0.0161
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0206	0.38	0.3364
Trichomonas vaginalis	AGC family protein kinase	0.0206	0.38	1
Brugia malayi	hypothetical protein	0.03	0.5734	0.5435
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Brugia malayi	SH2 domain containing protein	0.03	0.5734	0.5435
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0656	0.1413
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0204	0.0179
Schistosoma mansoni	growth factor receptor-bound protein	0.03	0.5734	0.5435
Entamoeba histolytica	serine/threonine kinase, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0206	0.38	0.3364
Brugia malayi	Tensin	0.03	0.5734	0.5435
Loa Loa (eye worm)	hypothetical protein	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Leishmania major	protein kinase, putative	0.0206	0.38	1
Echinococcus granulosus	tyrosine kinase	0.0506	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0206	0.38	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.0206	0.38	0.3364
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0206	0.38	0.3364
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0506	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0206	0.38	1
Brugia malayi	Protein kinase domain containing protein	0.0506	1	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0206	0.38	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0206	0.38	0.3364
Loa Loa (eye worm)	hypothetical protein	0.0206	0.38	0.3364
Echinococcus multilocularis	tyrosine protein kinase csk	0.0206	0.38	0.3364
Schistosoma mansoni	protein kinase	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/FER protein kinase	0.0206	0.38	0.3364
Echinococcus granulosus	NCK adaptor protein	0.03	0.5734	0.5435
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Toxoplasma gondii	protein kinase	0.0206	0.38	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0206	0.38	0.3364
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0206	0.38	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/FER protein kinase	0.0506	1	1
Brugia malayi	SH2 domain containing protein	0.03	0.5734	0.5435
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0506	1	1
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0426	0.0785
Giardia lamblia	Kinase, NEK	0.0206	0.38	1
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Trichomonas vaginalis	TK family protein kinase	0.0206	0.38	1
Schistosoma mansoni	protein tyrosine kinase	0.0206	0.38	0.3364
Brugia malayi	Variant SH3 domain containing protein	0.03	0.5734	0.5435
Entamoeba histolytica	protein kinase, putative	0.03	0.5734	0.5435
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Brugia malayi	C-terminal src kinase protein 1	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK protein kinase	0.0206	0.38	0.3364
Echinococcus multilocularis	tyrosine protein kinase csk	0.0206	0.38	0.3364
Brugia malayi	Tyrosine-protein kinase PR2	0.0206	0.38	0.3364
Schistosoma mansoni	GTPase activating protein	0.03	0.5734	0.5435
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0506	1	1
Brugia malayi	Guanylyl cyclase protein 23	0.0206	0.38	0.3364
Loa Loa (eye worm)	hypothetical protein	0.0206	0.38	0.3364
Brugia malayi	protein-tyrosine kinase	0.0506	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Brugia malayi	Variant SH3 domain containing protein	0.03	0.5734	0.5435
Echinococcus granulosus	tyrosine protein kinase HCK	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Loa Loa (eye worm)	hypothetical protein	0.03	0.5734	0.5435
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0426	0.0785
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0206	0.38	0.3364
Echinococcus multilocularis	SH2 domain containing protein 7	0.03	0.5734	0.5435
Loa Loa (eye worm)	hypothetical protein	0.0506	1	1
Entamoeba histolytica	hypothetical protein	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/FER protein kinase	0.0506	1	1
Entamoeba histolytica	hypothetical protein	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Brugia malayi	RhoGAP domain containing protein	0.03	0.5734	0.5435
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0206	0.38	0.3364
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0206	0.38	0.3364
Brugia malayi	Tyrosine-protein kinase abl-1	0.0506	1	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0506	1	1
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/ROR protein kinase	0.0206	0.38	0.3364
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Entamoeba histolytica	tyrosin kinase, putative	0.0206	0.38	0.3364
Schistosoma mansoni	serine/threonine protein kinase	0.0206	0.38	0.3364
Schistosoma mansoni	vav2	0.03	0.5734	0.5435
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Entamoeba histolytica	tyrosin kinase, putative	0.0206	0.38	0.3364
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/FER protein kinase	0.0206	0.38	0.3364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0287	0.0403
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Echinococcus multilocularis		0.03	0.5734	0.5435
Loa Loa (eye worm)	TK/FER protein kinase	0.0506	1	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0054	0.0656	0.0678
Schistosoma mansoni	protein kinase	0.0206	0.38	0.3364
Echinococcus multilocularis	transfer RNA-Thr	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Echinococcus multilocularis	SHC transforming protein 3	0.03	0.5734	0.5435
Echinococcus granulosus	SH2 motif	0.03	0.5734	0.5435
Brugia malayi	hypothetical protein	0.0206	0.38	0.3364
Schistosoma mansoni	tensin-related	0.03	0.5734	0.5435
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0198	0.0161
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0206	0.38	0.3364
Echinococcus granulosus	tensin	0.03	0.5734	0.5435
Trichomonas vaginalis	CAMK family protein kinase	0.0206	0.38	1
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Schistosoma mansoni	adapter molecule crk	0.03	0.5734	0.5435
Entamoeba histolytica	tyrosine kinase, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Entamoeba histolytica	tyrosine kinase, putative	0.0206	0.38	0.3364
Loa Loa (eye worm)	hypothetical protein	0.03	0.5734	0.5435
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.03	0.5734	0.5435
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0206	0.38	0.3364
Schistosoma mansoni	protein kinase	0.0206	0.38	0.3364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0426	0.0785
Plasmodium falciparum	protein kinase, putative	0.0206	0.38	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0206	0.38	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0506	1	1
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/EPH protein kinase	0.0206	0.38	0.3364
Echinococcus granulosus	c src tyrosine kinase	0.0506	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0206	0.38	0.3364
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/FER protein kinase	0.0506	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.03	0.5734	0.5435
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0204	0.0179
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0506	1	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Schistosoma mansoni	protein kinase	0.0206	0.38	0.3364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0369	0.0627
Entamoeba histolytica	serine/threonine kinase, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0206	0.38	1
Schistosoma mansoni	serine/threonine protein kinase	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Schistosoma mansoni	protein kinase	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/CSK protein kinase	0.0206	0.38	0.3364
Entamoeba histolytica	hypothetical protein	0.0206	0.38	0.3364
Schistosoma mansoni	growth factor receptor-bound protein	0.03	0.5734	0.5435
Loa Loa (eye worm)	hypothetical protein	0.0206	0.38	0.3364
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0054	0.0656	0.1727
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0206	0.38	0.3364
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0506	1	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0054	0.0656	0.0678
Entamoeba histolytica	tyrosine kinase, putative	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK protein kinase	0.0206	0.38	0.3364
Onchocerca volvulus		0.0506	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0506	1	1
Trypanosoma brucei	protein kinase, putative	0.0206	0.38	1
Loa Loa (eye worm)	hypothetical protein	0.03	0.5734	0.5435
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0506	1	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0206	0.38	0.3364
Echinococcus granulosus	tyrosine protein kinase csk	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Echinococcus granulosus	tyrosine protein kinase csk	0.0206	0.38	0.3364
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0206	0.38	0.3364
Loa Loa (eye worm)	hypothetical protein	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.03	0.5734	0.5435
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0506	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0206	0.38	0.3364
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0206	0.38	0.3364
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0206	0.38	1
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Echinococcus multilocularis	heat shock protein 70	0.0206	0.38	0.3364
Loa Loa (eye worm)	hypothetical protein	0.03	0.5734	0.5435
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0206	0.38	0.3364
Onchocerca volvulus		0.03	0.5734	0.312
Echinococcus multilocularis	insulin receptor	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0206	0.38	0.3364
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0206	0.38	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0206	0.38	0.3364
Entamoeba histolytica	serine/threonine kinase, putative	0.0206	0.38	0.3364
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0206	0.38	0.3364
Plasmodium falciparum	protein kinase, putative	0.0206	0.38	0.5
Schistosoma mansoni	tyrosine protein kinase	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine kinase	0.0506	1	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0206	0.38	0.3364
Echinococcus granulosus	growth factor receptor bound protein 2	0.03	0.5734	0.5435
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.03	0.5734	0.5435
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0506	1	1
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK protein kinase	0.0206	0.38	0.3364
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.03	0.5734	0.5435
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0054	0.0656	0.1727
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Echinococcus granulosus	suppressor of cytokine signaling 6	0.03	0.5734	0.5435
Entamoeba histolytica	SH2 domain containing protein	0.03	0.5734	0.5435
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0206	0.38	0.3364
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0506	1	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.03	0.5734	0.5435
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0492	0.0964
Entamoeba histolytica	hypothetical protein	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Schistosoma mansoni	tyrosine kinase	0.0506	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0206	0.38	0.3364
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0206	0.38	1
Leishmania major	protein kinase, putative	0.0206	0.38	1
Onchocerca volvulus		0.03	0.5734	0.312
Trichomonas vaginalis	conserved hypothetical protein	0.0206	0.38	1
Giardia lamblia	Kinase	0.0206	0.38	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0506	1	1
Brugia malayi	Variant SH3 domain containing protein	0.03	0.5734	0.5435
Echinococcus multilocularis	tyrosine protein kinase	0.0206	0.38	0.3364
Brugia malayi	ephrin receptor 1 precursor	0.0206	0.38	0.3364
Brugia malayi	SH2 domain containing protein	0.03	0.5734	0.5435
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Trypanosoma cruzi	protein kinase, putative	0.0206	0.38	1
Schistosoma mansoni	suppressor of cytokine signaling	0.03	0.5734	0.5435
Schistosoma mansoni	protein kinase	0.0206	0.38	0.3364
Entamoeba histolytica	tyrosine kinase, putative	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.03	0.5734	0.5435
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0206	0.38	0.3364
Schistosoma mansoni	signal transduction protein lnk-related	0.03	0.5734	0.5435
Trichomonas vaginalis	STE family protein kinase	0.0206	0.38	1
Loa Loa (eye worm)	hypothetical protein	0.03	0.5734	0.5435
Onchocerca volvulus		0.0506	1	1
Loa Loa (eye worm)	hypothetical protein	0.03	0.5734	0.5435
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Echinococcus granulosus	protein tyrosine kinase	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0206	0.38	0.3364
Echinococcus granulosus	ephrin type A receptor 4 A	0.0206	0.38	0.3364
Echinococcus multilocularis	growth factor receptor bound protein 2	0.03	0.5734	0.5435
Echinococcus granulosus	tyrosine protein kinase	0.0206	0.38	0.3364
Echinococcus granulosus	integrin linked protein kinase	0.0206	0.38	0.3364
Loa Loa (eye worm)	hypothetical protein	0.03	0.5734	0.5435
Onchocerca volvulus		0.0506	1	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.03	0.5734	0.5435
Onchocerca volvulus		0.0506	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0506	1	1
Schistosoma mansoni	tensin	0.03	0.5734	0.5435
Echinococcus granulosus	tyrosine protein kinase Blk	0.0506	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.014	0.0003
Loa Loa (eye worm)	TK/FER protein kinase	0.0506	1	1
Echinococcus granulosus	activin receptor type	0.0206	0.38	0.3364
Echinococcus granulosus	tyrosine kinase	0.0506	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.03	0.5734	0.5435
Leishmania major	hypothetical protein, conserved	0.0206	0.38	1
Brugia malayi	SRC-1	0.0506	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.03	0.5734	0.5435
Toxoplasma gondii	STE kinase	0.0206	0.38	1
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.03	0.5734	0.5435
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.03	0.5734	0.5435
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Loa Loa (eye worm)	hypothetical protein	0.0206	0.38	0.3364
Loa Loa (eye worm)	hypothetical protein	0.03	0.5734	0.5435
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0206	0.38	1
Entamoeba histolytica	hypothetical protein	0.0206	0.38	0.3364
Plasmodium vivax	protein kinase, putative	0.0206	0.38	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0506	1	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Schistosoma mansoni	hypothetical protein	0.03	0.5734	0.5435
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0369	0.0627
Entamoeba histolytica	hypothetical protein	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Schistosoma mansoni	hypothetical protein	0.0206	0.38	0.3364
Brugia malayi	Protein kinase domain containing protein	0.0206	0.38	0.3364
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0206	0.38	0.3364
Schistosoma mansoni	serine/threonine RGC	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Schistosoma mansoni	shc transforming protein	0.03	0.5734	0.5435
Entamoeba histolytica	ankyrin repeat protein	0.0206	0.38	0.3364
Echinococcus multilocularis	integrin linked protein kinase	0.0206	0.38	0.3364
Loa Loa (eye worm)	hypothetical protein	0.0206	0.38	0.3364
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0206	0.38	0.3364
Schistosoma mansoni	tensin	0.03	0.5734	0.5435
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Schistosoma mansoni	protein kinase	0.0206	0.38	0.3364
Echinococcus granulosus	epidermal growth factor receptor	0.0206	0.38	0.3364
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0506	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0506	1	1
Loa Loa (eye worm)	TK protein kinase	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.03	0.5734	0.5435
Loa Loa (eye worm)	hypothetical protein	0.03	0.5734	0.5435
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0506	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0206	0.38	0.3364
Entamoeba histolytica	protein kinase domain containing protein	0.0206	0.38	0.3364
Echinococcus multilocularis	SH2 motif	0.03	0.5734	0.5435
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Entamoeba histolytica	hypothetical protein	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Brugia malayi	cytokine inducible SH2-containing protein 5	0.03	0.5734	0.5435
Entamoeba histolytica	serine/threonine kinase, putative	0.0206	0.38	0.3364
Loa Loa (eye worm)	TK/Met protein kinase	0.0206	0.38	0.3364
Loa Loa (eye worm)	hypothetical protein	0.03	0.5734	0.5435
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0206	0.38	0.3364
Brugia malayi	Raf kinase	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Loa Loa (eye worm)	hypothetical protein	0.03	0.5734	0.5435
Loa Loa (eye worm)	TK protein kinase	0.0506	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0426	0.0785
Echinococcus multilocularis	c src tyrosine kinase	0.0506	1	1
Loa Loa (eye worm)	hypothetical protein	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Schistosoma mansoni	ephrin receptor	0.0206	0.38	0.3364
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Loa Loa (eye worm)	SH2 domain-containing protein	0.03	0.5734	0.5435
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1
Echinococcus granulosus	N chimaerin	0.03	0.5734	0.5435
Echinococcus granulosus	receptor type guanylyl cyclase	0.0206	0.38	0.3364
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0206	0.38	0.3364
Loa Loa (eye worm)	STAT protein	0.03	0.5734	0.5435
Brugia malayi	Protein kinase domain containing protein	0.0506	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0206	0.38	0.3364
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0206	0.38	0.3364
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0206	0.38	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0206	0.38	0.3364
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.03	0.5734	0.5435
Brugia malayi	SH2 domain containing protein	0.03	0.5734	0.5435
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0506	1	1
Entamoeba histolytica	protein kinase, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	conserved hypothetical protein	0.0206	0.38	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0506	1	1
Schistosoma mansoni	tyrosine kinase	0.0206	0.38	0.3364
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0206	0.38	0.3364
Entamoeba histolytica	tyrosine kinase, putative	0.0206	0.38	0.3364
Trichomonas vaginalis	TKL family protein kinase	0.0206	0.38	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.85 nM	BindingDB_Patents: Biological Assay. For mTOR enzyme activity assays, mTOR protein was isolated from HeLa cell cytoplasmic extract by immunoprecipitation, and activity determined essentially as described previously using recombinant PHAS-1as a substrate (ref 21).	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2335862

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1734288