Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1284 | 0.5 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1284 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1284 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1284 | 0.5 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1284 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1284 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1284 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1284 | 0.5 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1284 | 0.5 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.1284 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1284 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1284 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1284 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1284 | 0.5 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1284 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1284 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1284 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1284 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1284 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1284 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 98.19 % | Antitumor activity against human MDA-MB-468 cells assessed as cell growth at 0.1 uM | ChEMBL. | 23434641 |
GI (functional) | = 99 % | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 12 to 28 days by L.J. agar MIC method | ChEMBL. | 23434641 |
MIC (functional) | = 100 ug ml-1 | Antimicrobial activity against Escherichia coli MTCC 443 assessed as growth inhibition measured after overnight incubation by broth dilution method | ChEMBL. | 23434641 |
MIC (functional) | = 250 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 12 to 28 days by L.J. agar MIC method | ChEMBL. | 23434641 |
MIC (functional) | = 500 ug ml-1 | Antimicrobial activity against Candida albicans MTCC 227 assessed as growth inhibition measured after overnight incubation by broth dilution method | ChEMBL. | 23434641 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.