TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 257.26 | Formula: C15H12FNO2
H donors: 2 H acceptors: 2 LogP: 2.93 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccccc1F)/C=C/c1cccc(c1)O
InChi: 1S/C15H12FNO2/c16-13-6-1-2-7-14(13)17-15(19)9-8-11-4-3-5-12(18)10-11/h1-10,18H,(H,17,19)/b9-8+
InChiKey: QCDWMGBNZNDWIQ-CMDGGOBGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	Starlite/ChEMBL	References
Homo sapiens	matrix metallopeptidase 1 (interstitial collagenase)	Starlite/ChEMBL	References
Homo sapiens	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Matrixin family protein	matrix metallopeptidase 1 (interstitial collagenase)	403 aa	401 aa	27.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.8239	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0129	0.1939	0.2353
Plasmodium falciparum	protein kinase, putative	0.0129	0.1939	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0223	0.8239	0.7816
Toxoplasma gondii	protein kinase domain-containing protein	0.0129	0.1939	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0223	0.8239	0.7816
Leishmania major	hypothetical protein, conserved	0.0129	0.1939	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.8239	1
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.1939	0.5
Onchocerca volvulus		0.0223	0.8239	1
Trypanosoma brucei	Pseudokinase, putative	0.0129	0.1939	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0129	0.1939	0.2353
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Schistosoma mansoni	protein kinase	0.0129	0.1939	0.2353
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Brugia malayi	Protein kinase domain containing protein	0.0223	0.8239	1
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0152	0.3479	0.2444
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TK family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0223	0.8239	0.7816
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.8239	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.8239	1
Echinococcus multilocularis	c src tyrosine kinase	0.0223	0.8239	0.7816
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0129	0.1939	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0223	0.8239	1
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.8239	1
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Schistosoma mansoni	serine/threonine RGC	0.0129	0.1939	0.2353
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0223	0.8239	0.7816
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0223	0.8239	0.7816
Loa Loa (eye worm)	matrixin family protein	0.0152	0.3479	0.2444
Onchocerca volvulus	Matrilysin homolog	0.0152	0.3479	0.2444
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Brugia malayi	hypothetical protein	0.0223	0.8239	1
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0223	0.8239	0.7816
Toxoplasma gondii	protein kinase	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Toxoplasma gondii	STE kinase	0.0129	0.1939	0.5
Echinococcus granulosus	tyrosine kinase	0.0223	0.8239	0.7816
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.8239	1
Schistosoma mansoni	serine/threonine protein kinase	0.0129	0.1939	0.2353
Schistosoma mansoni	protein kinase	0.0129	0.1939	0.2353
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trypanosoma cruzi	protein kinase, putative	0.0129	0.1939	0.5
Brugia malayi	Protein kinase domain containing protein	0.0223	0.8239	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0223	0.8239	0.7816
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0129	0.1939	0.2353
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0223	0.8239	0.7816
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0223	0.8239	0.7816
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.1939	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0223	0.8239	0.7816
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Brugia malayi	SH2 domain containing protein	0.0223	0.8239	1
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0223	0.8239	1
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0129	0.1939	0.2353
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.8239	1
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine protein kinase	0.0129	0.1939	0.2353
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0223	0.8239	1
Plasmodium vivax	protein kinase, putative	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0223	0.8239	0.7816
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0129	0.1939	0.2353
Loa Loa (eye worm)	hypothetical protein	0.0223	0.8239	1
Schistosoma mansoni	protein kinase	0.0129	0.1939	0.2353
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0249	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trypanosoma cruzi	protein kinase, putative	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0223	0.8239	1
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0223	0.8239	0.7816
Schistosoma mansoni	protein kinase	0.0129	0.1939	0.2353
Plasmodium falciparum	protein kinase, putative	0.0129	0.1939	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0223	0.8239	0.7816
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0129	0.1939	0.2353
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Schistosoma mansoni	protein kinase	0.0129	0.1939	0.2353
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0129	0.1939	0.2353
Schistosoma mansoni	serine/threonine protein kinase	0.0129	0.1939	0.2353
Plasmodium falciparum	protein kinase, putative	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0129	0.1939	0.5
Onchocerca volvulus		0.0223	0.8239	1
Onchocerca volvulus		0.0223	0.8239	1
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0223	0.8239	0.7816
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	STE family protein kinase	0.0129	0.1939	0.5
Schistosoma mansoni	hypothetical protein	0.0129	0.1939	0.2353
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0129	0.1939	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0223	0.8239	0.7816
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Schistosoma mansoni	protein kinase	0.0129	0.1939	0.2353
Plasmodium falciparum	tyrosine kinase-like protein	0.0129	0.1939	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0223	0.8239	0.7816
Giardia lamblia	Kinase, NEK	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0223	0.8239	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0129	0.1939	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0223	0.8239	1
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0223	0.8239	0.7816
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Onchocerca volvulus		0.0223	0.8239	1
Schistosoma mansoni	tyrosine kinase	0.0223	0.8239	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0129	0.1939	0.5
Echinococcus multilocularis	tyrosine kinase	0.0223	0.8239	0.7816
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0223	0.8239	0.7816
Brugia malayi	protein-tyrosine kinase	0.0223	0.8239	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0223	0.8239	0.7816
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0223	0.8239	0.7816
Schistosoma mansoni	serine/threonine protein kinase	0.0129	0.1939	0.2353
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Giardia lamblia	Protein 21.1	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0223	0.8239	0.7816
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Brugia malayi	SH2 domain containing protein	0.0223	0.8239	1
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Trichomonas vaginalis	AGC family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.8239	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0129	0.1939	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0129	0.1939	0.5
Schistosoma mansoni	ephrin receptor	0.0129	0.1939	0.2353
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0223	0.8239	0.7816
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0223	0.8239	0.7816
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Loa Loa (eye worm)	matrixin family protein	0.0165	0.4398	0.3904
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.1939	0.5
Schistosoma mansoni	protein kinase	0.0129	0.1939	0.2353
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.8239	1
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Onchocerca volvulus		0.0223	0.8239	1
Schistosoma mansoni	tyrosine kinase	0.0223	0.8239	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0223	0.8239	0.7816
Schistosoma mansoni	protein kinase	0.0129	0.1939	0.2353
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0223	0.8239	0.7816
Schistosoma mansoni	protein kinase	0.0129	0.1939	0.2353
Giardia lamblia	Kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Brugia malayi	Protein kinase domain containing protein	0.0223	0.8239	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0223	0.8239	0.7816
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0223	0.8239	0.7816
Giardia lamblia	Kinase, NEK	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Brugia malayi	Matrixin family protein	0.0165	0.4398	0.3904
Echinococcus granulosus	tyrosine kinase	0.0223	0.8239	0.7816
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Brugia malayi	Protein kinase domain containing protein	0.0223	0.8239	1
Trypanosoma brucei	protein kinase, putative	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0223	0.8239	0.7816
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Schistosoma mansoni	protein kinase	0.0129	0.1939	0.2353
Loa Loa (eye worm)	SRC-1	0.0223	0.8239	1
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Schistosoma mansoni	ephrin receptor	0.0129	0.1939	0.2353
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0129	0.1939	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Leishmania major	protein kinase, putative	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0223	0.8239	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0223	0.8239	0.7816
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Schistosoma mansoni	protein tyrosine kinase	0.0129	0.1939	0.2353
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0223	0.8239	0.7816
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0223	0.8239	1
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0129	0.1939	0.5
Leishmania major	protein kinase, putative	0.0129	0.1939	0.5
Brugia malayi	SRC-1	0.0223	0.8239	1
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0223	0.8239	0.7816
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Onchocerca volvulus		0.0223	0.8239	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0223	0.8239	0.7816
Schistosoma mansoni	protein kinase	0.0129	0.1939	0.2353
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Brugia malayi	Protein kinase domain containing protein	0.0223	0.8239	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0129	0.1939	0.5
Schistosoma mansoni	tyrosine kinase	0.0129	0.1939	0.2353
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0129	0.1939	0.5
Loa Loa (eye worm)	TK protein kinase	0.0223	0.8239	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.8239	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0223	0.8239	0.7816

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 8.02 nM	Inhibition of human recombinant MMP9 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 mins	ChEMBL.	23375794
IC50 (binding)	= 9.09 nM	Inhibition of human recombinant MMP2 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 mins	ChEMBL.	23375794
IC50 (binding)	= 4117.53 nM	Inhibition of human recombinant MMP1 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 mins	ChEMBL.	23375794

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2336786

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1734464