Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0746 | 0.8865 | 0.8862 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0214 | 0.1753 | 0.6828 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0274 | 0.2556 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0085 | 0.0024 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0746 | 0.8865 | 0.8862 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0149 | 0.0881 | 0.3383 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0274 | 0.2556 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.0145 | 0.0827 | 0.3172 |
Echinococcus granulosus | protein kinase C gamma type | 0.0214 | 0.1753 | 0.6828 |
Entamoeba histolytica | protein kinase, putative | 0.0085 | 0.0024 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0085 | 0.0024 | 0.5 |
Toxoplasma gondii | AGC kinase | 0.0085 | 0.0024 | 0.5 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0125 | 0.0564 | 0.2131 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0125 | 0.0564 | 0.2131 |
Entamoeba histolytica | protein kinase, putative | 0.0085 | 0.0024 | 0.5 |
Brugia malayi | protein kinase C II. | 0.0149 | 0.0881 | 0.6029 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0149 | 0.0881 | 0.3383 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0274 | 0.2556 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0085 | 0.0024 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0085 | 0.0024 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0125 | 0.0564 | 0.2131 |
Schistosoma mansoni | atypical protein kinase C | 0.0145 | 0.0827 | 0.3172 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0564 | 0.0541 |
Entamoeba histolytica | protein kinase, putative | 0.0085 | 0.0024 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0085 | 0.0024 | 1 |
Brugia malayi | Protein kinase c protein 2 | 0.0191 | 0.1445 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0085 | 0.0024 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0149 | 0.0881 | 0.0858 |
Loa Loa (eye worm) | hypothetical protein | 0.0746 | 0.8865 | 0.8862 |
Trichomonas vaginalis | AGC family protein kinase | 0.0085 | 0.0024 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0085 | 0.0024 | 0.5 |
Echinococcus multilocularis | protein kinase c iota type | 0.0145 | 0.0827 | 0.3172 |
Onchocerca volvulus | 0.0746 | 0.8865 | 0.5 | |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0274 | 0.2556 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0085 | 0.0024 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0806 | 0.9667 | 0.9667 |
Trichomonas vaginalis | AGC family protein kinase | 0.0085 | 0.0024 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1367 | 0.1346 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0149 | 0.0881 | 0.3383 |
Trichomonas vaginalis | AGC family protein kinase | 0.0085 | 0.0024 | 1 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0131 | 0.0642 | 0.0619 |
Trichomonas vaginalis | AGC family protein kinase | 0.0085 | 0.0024 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0085 | 0.0024 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Time (functional) | = 532.5 s | Anticonvulsant activity against subcutaneous pentylenetetrazole-induced seizures in mouse assessed as onset time for tonic seizures at 10 mg/kg, ip measured after 0.5 hrs by pentylene tetrazole test (Rvb = 385.5 +/-10.90 secs) | ChEMBL. | 23352511 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.