Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | SRC-1 | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0026 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0026 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0026 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0026 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0026 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0026 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0026 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0026 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0026 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine kinase | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0026 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0026 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.5 | 0.5 | |
Brugia malayi | SRC-1 | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0026 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of recombinant human MAO-A expressed in baculovirus infected BT1-TN-5B1-4 cells assessed as inhibition of production of hydrogen peroxide from p-tyramine at 100 uM after 15 mins by Amplex Red assay | ChEMBL. | 23207410 | |
Inhibition (binding) | = 40 % | Inhibition of recombinant human MAO-B expressed in baculovirus infected BT1-TN-5B1-4 cells assessed as inhibition of production of hydrogen peroxide from p-tyramine at 100 uM after 15 mins by Amplex Red assay | ChEMBL. | 23207410 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.