Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | D-amino-acid oxidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-amino-acid oxidase | 347 aa | 378 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0645 | 0.1243 | 0.5 | |
Schistosoma mansoni | acetylcholinesterase | 0.0645 | 0.1243 | 0.1243 |
Loa Loa (eye worm) | carboxylesterase | 0.0645 | 0.1243 | 0.1243 |
Loa Loa (eye worm) | hypothetical protein | 0.0645 | 0.1243 | 0.1243 |
Echinococcus granulosus | acetylcholinesterase | 0.3815 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0645 | 0.1243 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0645 | 0.1243 | 0.1243 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0645 | 0.1243 | 0.5 |
Onchocerca volvulus | 0.0645 | 0.1243 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0645 | 0.1243 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3815 | 1 | 1 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.1795 | 0.4421 | 0.4421 |
Onchocerca volvulus | 0.0645 | 0.1243 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.3815 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0645 | 0.1243 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0645 | 0.1243 | 0.1243 |
Schistosoma mansoni | gliotactin | 0.0645 | 0.1243 | 0.1243 |
Loa Loa (eye worm) | hypothetical protein | 0.0645 | 0.1243 | 0.1243 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3815 | 1 | 1 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0195 | 0 | 0.5 |
Onchocerca volvulus | 0.0645 | 0.1243 | 0.5 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0645 | 0.1243 | 0.1243 |
Loa Loa (eye worm) | hypothetical protein | 0.0645 | 0.1243 | 0.1243 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3815 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0645 | 0.1243 | 0.1243 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0645 | 0.1243 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0645 | 0.1243 | 0.1243 |
Loa Loa (eye worm) | carboxylesterase | 0.0645 | 0.1243 | 0.1243 |
Brugia malayi | Carboxylesterase family protein | 0.3815 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0645 | 0.1243 | 0.1243 |
Loa Loa (eye worm) | hypothetical protein | 0.0645 | 0.1243 | 0.1243 |
Loa Loa (eye worm) | carboxylesterase | 0.3815 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0645 | 0.1243 | 0.1243 |
Onchocerca volvulus | 0.0645 | 0.1243 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.3815 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0645 | 0.1243 | 0.1243 |
Echinococcus multilocularis | acetylcholinesterase | 0.3815 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.3815 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0645 | 0.1243 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.3815 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3815 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 140 nM | Inhibition of human recombinant DAAO after 30 mins by plate reader analysis | ChEMBL. | 23566269 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.