Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Aminopeptidase N | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus multilocularis | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus granulosus | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Onchocerca volvulus | Get druggable targets OG5_127217 | All targets in OG5_127217 | |
Schistosoma japonicum | ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Aminopeptidase N | 963 aa | 893 aa | 32.0 % | |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 28.8 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 988 aa | 28.5 % |
Echinococcus granulosus | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 975 aa | 29.1 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 29.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0145 | 0.2481 | 0.2481 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0145 | 0.2481 | 0.3757 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0145 | 0.2481 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0145 | 0.2481 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1275 | 0.1275 |
Echinococcus granulosus | carbonic anhydrase II | 0.0145 | 0.2481 | 0.3757 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.6604 | 0.6604 |
Echinococcus granulosus | acetylcholinesterase | 0.0297 | 0.6604 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0145 | 0.2481 | 0.2481 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0145 | 0.2481 | 0.3757 |
Echinococcus granulosus | aminopeptidase N | 0.0143 | 0.2418 | 0.3662 |
Echinococcus granulosus | acetylcholinesterase | 0.0297 | 0.6604 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0145 | 0.2481 | 0.2481 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.6604 | 0.6604 |
Loa Loa (eye worm) | carboxylesterase | 0.0297 | 0.6604 | 0.6604 |
Brugia malayi | Carboxylesterase family protein | 0.0297 | 0.6604 | 0.6604 |
Leishmania major | carbonic anhydrase-like protein | 0.0145 | 0.2481 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0297 | 0.6604 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0116 | 0.1677 | 0.1677 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0145 | 0.2481 | 0.2481 |
Brugia malayi | Carboxylesterase family protein | 0.0297 | 0.6604 | 0.6604 |
Plasmodium falciparum | carbonic anhydrase | 0.0054 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0297 | 0.6604 | 0.6604 |
Onchocerca volvulus | 0.0143 | 0.2418 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0297 | 0.6604 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0143 | 0.2418 | 0.3662 |
Toxoplasma gondii | hypothetical protein | 0.0054 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0297 | 0.6604 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0143 | 0.2418 | 0.2418 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0145 | 0.2481 | 0.3757 |
Echinococcus granulosus | carboxylesterase 5A | 0.0297 | 0.6604 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0145 | 0.2481 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.2017 | 0.2017 |
Echinococcus multilocularis | acetylcholinesterase | 0.0297 | 0.6604 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.66 uM | Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by spectrophotometric analysis | ChEMBL. | 23453219 |
IC50 (binding) | > 100 uM | Inhibition of HDAC1/HDAC3/HDAC5/HDAC8 in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate incubated for 5 mins prior to substrate measured after 30 mins by spectrophotometric analysis | ChEMBL. | 23453219 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.