Detailed information for compound 1735460

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 475.416 | Formula: C22H13F4N3O3S
  • H donors: 1 H acceptors: 3 LogP: 5.03 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C1=NN([C@](C1)(O)C(F)(F)F)c1scc(n1)c1cc2ccccc2oc1=O
  • InChi: 1S/C22H13F4N3O3S/c23-14-7-5-12(6-8-14)16-10-21(31,22(24,25)26)29(28-16)20-27-17(11-33-20)15-9-13-3-1-2-4-18(13)32-19(15)30/h1-9,11,31H,10H2/t21-/m1/s1
  • InChiKey: PKNTVQNOFCIXDL-OAQYLSRUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0043 0.0055 0.0727
Onchocerca volvulus 0.0029 0.0028 0.0375
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0408 0.0752 0.2824
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0408 0.0752 0.2824
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0088 0.3523
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0522
Brugia malayi Bromodomain containing protein 0.0076 0.0118 0.1571
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.0408 0.1527
Toxoplasma gondii ABC1 family protein 0.0035 0.0039 0.391
Schistosoma mansoni hypothetical protein 0.0064 0.0096 0.0095
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0055 0.0122
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0145 0.025 0.0612
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0522
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0006 0.0407
Entamoeba histolytica acyl-CoA synthetase, putative 0.0145 0.025 0.5038
Loa Loa (eye worm) hypothetical protein 0.0193 0.034 0.453
Echinococcus multilocularis ecdysone induced protein 78C 0.0408 0.0752 0.2824
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0142 1
Brugia malayi hypothetical protein 0.0228 0.0408 0.5428
Schistosoma mansoni retinoic acid receptor RXR 0.0408 0.0752 0.0751
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0408 0.0752 1
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.0057 0.4003
Onchocerca volvulus Bile acid receptor homolog 0.0408 0.0752 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0152 0.2027
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0145 0.025 0.0612
Echinococcus multilocularis thyroid hormone receptor alpha 0.0408 0.0752 0.2824
Onchocerca volvulus Peter pan protein homolog 0.0061 0.0089 0.1182
Mycobacterium tuberculosis Probable reductase 0.0112 0.0186 0.0452
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0407
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0055 0.0122
Onchocerca volvulus 0.0043 0.0055 0.0727
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0055 0.0122
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0088 0.032
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0046 0.0062 0.0826
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0088 0.9616
Onchocerca volvulus 0.0193 0.034 0.453
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0006 0.0407
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0407
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0039 0.277
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0008 0.0562
Brugia malayi Calcitonin receptor-like protein seb-1 0.0094 0.0152 0.2027
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0055 0.0727
Brugia malayi ecdysteroid receptor 0.0408 0.0752 1
Echinococcus granulosus apoptotic protease activating factor 1 0.0058 0.0083 0.0302
Loa Loa (eye worm) hypothetical protein 0.0206 0.0366 0.4864
Loa Loa (eye worm) hypothetical protein 0.0408 0.0752 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0094 0.0152 0.2027
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0045 0.3162
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0145 0.025 0.0612
Onchocerca volvulus 0.0145 0.0251 0.3337
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0012 0.0155
Echinococcus multilocularis nuclear receptor nhr 48 0.0193 0.034 0.1273
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0016 0.0016
Schistosoma mansoni thyroid hormone receptor 0.0408 0.0752 0.0751
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0005 0.0004
Schistosoma mansoni hypothetical protein 0.0058 0.0083 0.0083
Brugia malayi Pip kinase protein 2 0.0157 0.0272 0.3616
Schistosoma mansoni cpg binding protein 0.0029 0.0028 0.0028
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0408 0.0752 1
Echinococcus multilocularis GPCR, family 2 0.003 0.003 0.0101
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0043 0.0055 0.3858
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0008 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0145 0.025 0.0612
Plasmodium vivax acetyl-CoA synthetase, putative 0.0043 0.0055 0.0122
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.2111 0.3998 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0088 0.0142 0.0522
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0005 0.0004
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0006 0.0407
Brugia malayi hypothetical protein 0.0193 0.034 0.453
Loa Loa (eye worm) steroid hormone receptor 0.0408 0.0752 1
Entamoeba histolytica hypothetical protein 0.007 0.0106 0.2145
Echinococcus granulosus nuclear receptor nhr 48 0.0193 0.034 0.1273
Leishmania major 4-coumarate:coa ligase-like protein 0.0145 0.025 1
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0045 0.1791
Echinococcus granulosus neuropeptide s receptor 0.0453 0.0838 0.315
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.04 0.5318
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0193 0.034 0.453
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0003 0.0003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0016 0.0005 0.0005
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0061 0.0219
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0039 0.0084
Brugia malayi serine/threonine-protein kinase plk-2 0.0088 0.0142 0.1884
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0043 0.0055 0.5709
Entamoeba histolytica fatty acid elongase, putative 0.0274 0.0496 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0055 0.0122
Mycobacterium ulcerans acyl-CoA synthetase 0.0145 0.025 0.0612
Schistosoma mansoni bromodomain containing protein 0.0065 0.0097 0.0097
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0003 0.0003
Echinococcus multilocularis CREB binding protein 0.0016 0.0004 0.0002
Brugia malayi hypothetical protein 0.0216 0.0384 0.5116
Onchocerca volvulus 0.0206 0.0366 0.4864
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0039 0.277
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0043 0.0055 0.0731
Loa Loa (eye worm) hypothetical protein 0.0408 0.0752 1
Onchocerca volvulus Cell death protein 3 homolog 0.0058 0.0083 0.111
Echinococcus granulosus CREB binding protein 0.0016 0.0004 0.0002
Plasmodium falciparum acyl-CoA synthetase 0.0108 0.018 0.0437
Echinococcus granulosus Nuclear hormone receptor HR96 0.0193 0.034 0.1273
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0108 0.018 0.0437
Echinococcus granulosus CREB binding protein 0.0066 0.0099 0.0362
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0157 0.0272 0.0272
Echinococcus multilocularis peter pan 0.0061 0.0089 0.0323
Brugia malayi hypothetical protein 0.007 0.0106 0.1416
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.001 0.0128
Loa Loa (eye worm) hypothetical protein 0.0108 0.018 0.2396
Giardia lamblia Peter pan protein 0.0061 0.0089 0.6115
Brugia malayi Nuclear hormone receptor-like 1 0.0216 0.0384 0.5116
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.2111 0.3998 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.0251 0.3337
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0027 0.0054
Plasmodium vivax acyl-CoA synthetase, putative 0.0108 0.018 0.0437
Echinococcus multilocularis zinc finger protein 598 0.006 0.0088 0.032
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0043 0.0055 0.0122
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0295 0.1101
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0408 0.0752 0.2824
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0043 0.0055 0.0122
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0094 0.0152 0.2027
Mycobacterium tuberculosis Conserved protein 0.0035 0.0039 0.0084
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0039 0.277
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0142 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0145 0.025 0.0612
Brugia malayi nuclear receptor NHR-88 0.0193 0.034 0.453
Loa Loa (eye worm) hypothetical protein 0.0408 0.0752 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0045 0.0596
Loa Loa (eye worm) hypothetical protein 0.0216 0.0384 0.5116
Brugia malayi CXXC zinc finger family protein 0.0029 0.0028 0.0375
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0055 0.0727
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0216 0.0384 0.0384
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0008 0.0161
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0061 0.0139
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0408 0.0752 0.2824
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0043 0.0055 0.0194
Schistosoma mansoni nuclear hormone receptor 0.0193 0.034 0.034
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0008 0.0562
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0027 0.1937
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0043 0.0055 0.0727
Onchocerca volvulus 0.0145 0.025 0.3326
Schistosoma mansoni zinc finger protein 0.0193 0.034 0.034
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0408 0.0752 0.2824
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0408 0.0752 0.2824
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0408 0.0752 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0088 0.0142 0.0522
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.003 0.003 0.0101
Echinococcus granulosus lysosomal alpha glucosidase 0.0169 0.0295 0.1101
Entamoeba histolytica hypothetical protein 0.007 0.0106 0.2145
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0055 0.0122
Loa Loa (eye worm) hypothetical protein 0.0193 0.034 0.453
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0039 0.0084
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0039 0.0084
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.2111 0.3998 1
Brugia malayi ecdysone receptor 0.0193 0.034 0.453
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0039 0.0084
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0088 0.0206
Onchocerca volvulus 0.0043 0.0055 0.0727
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0006 0.0407
Entamoeba histolytica fatty acid elongase, putative 0.0274 0.0496 1
Echinococcus multilocularis FTZ F1 alpha 0.0408 0.0752 0.2824
Brugia malayi Nuclear hormone receptor E75 0.0193 0.034 0.453
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0045 0.3162
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.1573 0.5927
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0193 0.034 0.1273
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0408 0.0752 0.0751
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0039 0.0084
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0039 0.0522
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0254 0.0948
Chlamydia trachomatis oxoacyl-ACP synthase III 0.2111 0.3998 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0408 0.0752 0.2824
Brugia malayi photoreceptor-specific nuclear receptor 0.0408 0.0752 1
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.0838 0.315
Loa Loa (eye worm) pip kinase 2 0.0157 0.0272 0.3616
Toxoplasma gondii propionate-CoA ligase 0.0043 0.0055 0.5709
Loa Loa (eye worm) hypothetical protein 0.0228 0.0408 0.5428
Echinococcus granulosus histone lysine methyltransferase setb 0.0016 0.0005 0.0005
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0047 0.305
Loa Loa (eye worm) hypothetical protein 0.0193 0.034 0.453
Leishmania major hypothetical protein, conserved 0.0014 0 0.001
Schistosoma mansoni ap endonuclease 0.0018 0.0008 0.0008
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0145 0.025 1
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0006 0.0407
Brugia malayi nuclear receptor RXR 0.0193 0.034 0.453
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0012 0.0824
Loa Loa (eye worm) hypothetical protein 0.0216 0.0384 0.5116
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0145 0.025 0.0612
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0142 0.0141
Trichomonas vaginalis antibiotic synthetase, putative 0.0043 0.0055 0.3858
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0408 0.0752 0.2824
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0216 0.0384 0.1439
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0193 0.034 0.453
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0522
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0043 0.0055 0.0194
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0408 0.0752 0.0751
Onchocerca volvulus 0.0035 0.0039 0.0522
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0106 0.0106
Brugia malayi nuclear receptor NHR-88 0.0408 0.0752 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0193 0.034 0.453
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0055 0.0122
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0014 0.0191
Schistosoma mansoni hypothetical protein 0.0046 0.006 0.006
Schistosoma mansoni RAR-like nuclear receptor 0.0408 0.0752 0.0751
Echinococcus multilocularis tumor protein p63 0.1405 0.2652 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0028 0.0375
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0055 0.0122
Leishmania major 4-coumarate:coa ligase-like protein 0.0145 0.025 1
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0037 0.0043 0.0094
Loa Loa (eye worm) CBP-B 0.0074 0.0114 0.1512
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0157 0.0272 0.1013
Loa Loa (eye worm) oxidoreductase 0.0043 0.0055 0.0727
Entamoeba histolytica hypothetical protein 0.007 0.0106 0.2145
Brugia malayi Thioredoxin reductase 0.0049 0.0067 0.0888
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0033 0.0036 0.0125
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0016 0.0048
Leishmania major acetyl-CoA synthetase, putative 0.0043 0.0055 0.2185
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0027 0.1937
Schistosoma mansoni ap endonuclease 0.0018 0.0008 0.0008
Trichomonas vaginalis ssf, putative 0.0061 0.0089 0.6273
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.021 0.8104
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0043 0.0055 0.0122
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0043 0.0055 0.0122
Brugia malayi Cytochrome P450 family protein 0.0031 0.0032 0.0426
Schistosoma mansoni alpha-glucosidase 0.0145 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0193 0.034 0.453
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0408 0.0752 1
Echinococcus granulosus cpg binding protein 0.0032 0.0035 0.0118
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0043 0.0055 0.0122
Loa Loa (eye worm) hypothetical protein 0.0064 0.0096 0.1274
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0408 0.0752 0.2824
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0043 0.0055 0.1101
Mycobacterium ulcerans acetyl-CoA synthetase 0.0043 0.0055 0.0122
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0032 0.0426
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0045 0.3162
Schistosoma mansoni hypothetical protein 0.0046 0.0062 0.0062
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0008 0.0017
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.003 0.003 0.0101
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0055 0.3858
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0039 0.277
Mycobacterium ulcerans hypothetical protein 0.0145 0.025 0.0612
Entamoeba histolytica fatty acid elongase, putative 0.0274 0.0496 1
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.2111 0.3998 1
Leishmania major cytochrome p450-like protein 0.002 0.0012 0.0467
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.0057 0.4003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0408 0.0752 0.0751
Brugia malayi Steroid receptor seven-up type 2 0.0408 0.0752 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0408 0.0752 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0067 0.0153
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0061 0.6491
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.0754 0.2832
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0008 0.0562
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.021 0.0512
Loa Loa (eye worm) hypothetical protein 0.0408 0.0752 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.0295 0.3924
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0039 0.277
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0231
Onchocerca volvulus 0.0035 0.0039 0.0522
Schistosoma mansoni peter pan-related 0.0061 0.0089 0.0089
Echinococcus multilocularis apoptotic protease activating factor 1 0.0058 0.0083 0.0302
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0055 0.2185
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0027 0.0054
Schistosoma mansoni cellular tumor antigen P53 0.0206 0.0366 0.0365
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0039 0.0084
Brugia malayi glutathione reductase 0.0049 0.0067 0.0888
Schistosoma mansoni survival motor neuron protein 0.0046 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0408 0.0752 1
Trypanosoma brucei brix domain containing protein, putative 0.0061 0.0089 0.6273
Onchocerca volvulus 0.0035 0.0039 0.0522
Loa Loa (eye worm) hypothetical protein 0.0058 0.0083 0.111
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0408 0.0752 0.0751
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0408 0.0752 0.0751
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0522
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0091 0.0332
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0045 0.0156
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0067 0.0239
Entamoeba histolytica acyl-coA synthetase, putative 0.0145 0.025 0.5038
Loa Loa (eye worm) hypothetical protein 0.0193 0.034 0.453
Brugia malayi hypothetical protein 0.0216 0.0384 0.5116
Brugia malayi beta-lactamase family protein 0.0035 0.0039 0.0522
Loa Loa (eye worm) hypothetical protein 0.0145 0.025 0.3326
Loa Loa (eye worm) CYP4Cod1 0.002 0.0012 0.0155
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0408 0.0752 0.2824
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.003 0.003 0.04
Loa Loa (eye worm) hypothetical protein 0.0043 0.0055 0.073
Loa Loa (eye worm) hypothetical protein 0.0108 0.018 0.2396
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0045 0.3162
Loa Loa (eye worm) glutathione reductase 0.0049 0.0067 0.0888
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0043 0.0055 0.5709
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.0838 0.315
Schistosoma mansoni hypothetical protein 0.0409 0.0754 0.0753
Brugia malayi PHD-finger family protein 0.003 0.003 0.0402
Brugia malayi AMP-binding enzyme family protein 0.0145 0.025 0.3326
Brugia malayi Bromodomain containing protein 0.004 0.0051 0.0673
Loa Loa (eye worm) hypothetical protein 0.0193 0.034 0.453
Trypanosoma brucei ISWI complex protein 0.0014 0 0.0018
Trypanosoma cruzi ISWI complex protein 0.0014 0 0.0018
Loa Loa (eye worm) hypothetical protein 0.0193 0.034 0.453
Echinococcus granulosus dnaJ subfamily B 0.0409 0.0754 0.2832
Brugia malayi Cytochrome P450 family protein 0.002 0.0012 0.0155
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0043 0.0055 0.3858
Loa Loa (eye worm) hypothetical protein 0.0408 0.0752 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0006 0.0407
Loa Loa (eye worm) hypothetical protein 0.0108 0.018 0.2396
Schistosoma mansoni nuclear receptor nhr-48 0.0193 0.034 0.034
Echinococcus granulosus FTZ F1 alpha 0.0408 0.0752 0.2824
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.0542
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0043 0.0055 0.0122
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0008 0.0017
Brugia malayi nuclear receptor RXR 0.0216 0.0384 0.5116
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0088 0.0206
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.0186 0.0452
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.006
Onchocerca volvulus 0.0408 0.0752 1
Schistosoma mansoni CREB-binding protein 2 0.0103 0.0171 0.017
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0043 0.0055 0.0122
Toxoplasma gondii thioredoxin reductase 0.0049 0.0067 0.7125
Schistosoma mansoni peter pan-related 0.0061 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0365
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0142 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0102 0.0169 0.0408
Trypanosoma brucei trypanothione reductase 0.0049 0.0067 0.4713
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0016 0.0048
Schistosoma mansoni cpg binding protein 0.0032 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0193 0.034 0.453
Leishmania major hypothetical protein, conserved 0.0035 0.0039 0.1569
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.0318 0.4229
Schistosoma mansoni nuclear hormone receptor 0.0193 0.034 0.034
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0045 0.3162
Trypanosoma brucei glucosidase, putative 0.0037 0.0045 0.3162
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0039 0.0084
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0055 0.0122
Loa Loa (eye worm) nuclear hormone receptor 0.0193 0.034 0.453
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0102 0.0169 0.0408
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0408 0.0752 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0408 0.0752 1
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0103 0.0171 0.017
Schistosoma mansoni nuclear receptor 0.0193 0.034 0.034
Onchocerca volvulus 0.0046 0.0062 0.0826
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0102 0.0169 0.0408
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0043 0.0055 0.0731
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0039 0.277
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0043 0.0055 0.3858
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0216 0.0384 0.5116
Echinococcus granulosus zinc finger protein 598 0.006 0.0088 0.032
Brugia malayi beta-lactamase family protein 0.0035 0.0039 0.0522
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0008 0.016
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.2111 0.3998 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0055 0.0122
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.003 0.003 0.0101
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0006 0.0009
Entamoeba histolytica hypothetical protein 0.007 0.0106 0.2145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0408 0.0752 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0045 0.3162
Schistosoma mansoni steroid hormone receptor ad4bp 0.0408 0.0752 0.0751
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0055 0.3858
Echinococcus multilocularis cpg binding protein 0.0032 0.0035 0.0118
Echinococcus granulosus CREB binding protein 0.0016 0.0004 0.0002
Leishmania major trypanothione reductase 0.0049 0.0067 0.267
Entamoeba histolytica serine/threonine protein kinase, putative 0.0088 0.0142 0.2854
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0193 0.034 0.1273
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0033 0.0036 0.0125
Schistosoma mansoni cpg binding protein 0.0032 0.0035 0.0034
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0008 0.0005
Brugia malayi Cell death protein 3 precursor 0.0058 0.0083 0.111
Brugia malayi nuclear hormone receptor 0.0408 0.0752 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0008 0.0106
Plasmodium falciparum thioredoxin reductase 0.0049 0.0067 0.0153
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0043 0.0055 0.0122
Mycobacterium ulcerans beta-lactamase 0.0035 0.0039 0.0084
Loa Loa (eye worm) hypothetical protein 0.0108 0.018 0.2396
Echinococcus granulosus tumor protein p63 0.1405 0.2652 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0408 0.0752 0.2824
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0043 0.0055 0.0122
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0039 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0408 0.0752 1
Onchocerca volvulus 0.0043 0.0055 0.0727
Loa Loa (eye worm) latrophilin receptor protein 2 0.003 0.003 0.04
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0039 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0039 0.277
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0039 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0408 0.0752 1
Schistosoma mansoni zinc finger protein 0.0025 0.0021 0.0021
Echinococcus granulosus caspase 2 0.0058 0.0083 0.0302
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.0295 0.3924
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0006 0.0407
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0006 0.0231
Onchocerca volvulus 0.0193 0.034 0.453
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0108 0.018 0.0437
Schistosoma mansoni kinase 0.0045 0.0059 0.0059
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0039 0.277
Schistosoma mansoni hypothetical protein 0.003 0.003 0.003
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0012 0.0824
Brugia malayi nuclear receptor NHR-67 0.0193 0.034 0.453
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0043 0.0055 0.0122
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0045 0.0596
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0008 0.0106
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0055 0.0122
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0047 0.0104
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0043 0.0055 0.0122
Loa Loa (eye worm) acetyltransferase 0.0147 0.0254 0.3386
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0408 0.0752 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0407
Mycobacterium ulcerans hypothetical protein 0.0035 0.0039 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.04
Loa Loa (eye worm) nuclear receptor NHR-67 0.0193 0.034 0.453
Echinococcus multilocularis zinc finger protein 0.0025 0.0021 0.0066
Echinococcus multilocularis CREB binding protein 0.0073 0.0112 0.041
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0145 0.025 0.0612
Mycobacterium tuberculosis Conserved protein 0.0035 0.0039 0.0084
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0045 0.3162
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0216 0.0384 0.5116
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0045 0.4558
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0193 0.034 0.034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0408 0.0752 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0407
Echinococcus granulosus CREB binding protein 0.0103 0.0171 0.0631
Echinococcus granulosus zinc finger protein 0.0025 0.0021 0.0066
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0061 0.6491
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0045 0.3162
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0157 0.0272 0.1013
Brugia malayi beta-lactamase 0.0035 0.0039 0.0522
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.009 0.0089
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0047 0.0951
Entamoeba histolytica brix domain containing protein 0.0061 0.0089 0.179
Schistosoma mansoni nuclear receptor 0.0193 0.034 0.034
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0039 0.0522
Schistosoma mansoni acetyl-CoA synthetase 0.0043 0.0055 0.0054
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0102 0.0169 0.0408
Schistosoma mansoni coup transcription factor 0.0408 0.0752 0.0751
Loa Loa (eye worm) hypothetical protein 0.0065 0.0097 0.1297
Brugia malayi Latrophilin receptor protein 2 0.003 0.003 0.04
Loa Loa (eye worm) beta-lactamase 0.0035 0.0039 0.0522
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0408 0.0752 0.0751
Loa Loa (eye worm) hypothetical protein 0.0058 0.0083 0.111
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0067 0.0888
Trypanosoma cruzi polo-like protein kinase, putative 0.0088 0.0142 1
Schistosoma mansoni nuclear hormone receptor 0.0408 0.0752 0.0751
Brugia malayi nuclear hormone receptor 0.0193 0.034 0.453
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0408 0.0752 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.0186 0.0452
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0216 0.0384 0.0384
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0091 0.0332
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0408 0.0752 1
Schistosoma mansoni caspase-7 (C14 family) 0.0058 0.0083 0.0083
Brugia malayi conserved hypotetical protein 0.0193 0.034 0.453
Brugia malayi Cytochrome P450 family protein 0.002 0.0012 0.0155
Echinococcus granulosus thyroid hormone receptor alpha 0.0193 0.034 0.1273
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0088 0.0142 0.5665
Brugia malayi Nuclear hormone receptor E75 0.0193 0.034 0.453
Loa Loa (eye worm) hypothetical protein 0.0181 0.0318 0.4229
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0157 0.0272 0.0272
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0061 0.433
Brugia malayi N-terminal motif family protein 0.0181 0.0318 0.4229
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0408 0.0752 0.2824
Brugia malayi orphan nuclear receptor NR2E1 0.0193 0.034 0.453
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0045 0.3162
Trichomonas vaginalis antibiotic synthetase, putative 0.0043 0.0055 0.3858
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0254 0.3386
Brugia malayi hypothetical protein 0.0018 0.0008 0.011
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0006 0.0407
Echinococcus granulosus ecdysone induced protein 78C 0.0408 0.0752 0.2824
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0043 0.0055 0.0122
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.0239 0.0891
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0055 0.0122
Loa Loa (eye worm) hypothetical protein 0.0193 0.034 0.453
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0145 0.025 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0145 0.025 0.0612
Trypanosoma cruzi peter pan protein, putative 0.0061 0.0089 0.6273
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0008 0.0005
Leishmania major acetyl-CoA synthetase, putative 0.0043 0.0055 0.2185
Toxoplasma gondii brix domain-containing protein 0.0061 0.0089 0.9705
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0006 0.0077
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0045 0.3162
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0043 0.0055 0.0727
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0106 0.0389
Brugia malayi Nuclear hormone receptor-like 1 0.0216 0.0384 0.5116
Entamoeba histolytica fatty acid elongase, putative 0.0274 0.0496 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0088 0.0206
Onchocerca volvulus Serine\/threonine kinase homolog 0.0088 0.0142 0.1884
Loa Loa (eye worm) hypothetical protein 0.0193 0.034 0.453
Loa Loa (eye worm) hypothetical protein 0.0193 0.034 0.453
Echinococcus multilocularis CREB binding protein 0.0016 0.0004 0.0002
Mycobacterium tuberculosis Possible penicillin-binding protein 0.022 0.0394 0.0972
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0088 0.032
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0043 0.0055 0.0122
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0012 0.0155
Toxoplasma gondii exonuclease III APE 0.0018 0.0008 0.0256
Plasmodium vivax glutathione reductase, putative 0.0049 0.0067 0.0153
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0043 0.0055 0.0727
Brugia malayi TAZ zinc finger family protein 0.0103 0.0171 0.2269
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0043 0.0055 0.0122
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0055 0.0727
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0408 0.0752 1
Echinococcus granulosus GPCR family 2 0.003 0.003 0.0101
Mycobacterium ulcerans lipase LipD 0.0035 0.0039 0.0084
Trichomonas vaginalis esterase, putative 0.0035 0.0039 0.277
Loa Loa (eye worm) hypothetical protein 0.0108 0.018 0.2396
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.021 0.0512
Schistosoma mansoni thyroid hormone receptor 0.0408 0.0752 0.0751
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.0408 0.1527
Loa Loa (eye worm) hypothetical protein 0.0046 0.0061 0.0816
Brugia malayi AMP-binding enzyme family protein 0.0145 0.025 0.3326
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0408 0.0752 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0408 0.0752 0.2824
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0142 1
Giardia lamblia Kinase, PLK 0.0088 0.0142 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0522
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0045 0.0156
Loa Loa (eye worm) brix domain-containing protein 0.0061 0.0089 0.1182
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.2111 0.3998 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.003 0.003 0.0101
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0067 0.4713
Entamoeba histolytica fatty acid elongase, putative 0.0274 0.0496 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0088 0.0088
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0193 0.034 0.1273
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0193 0.034 0.453
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0193 0.034 0.1273
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0055 0.3858
Leishmania major peter pan protein, putative 0.0061 0.0089 0.3553
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0295 0.1101
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.0186 0.0452
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0039 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0408 0.0752 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0043 0.0055 0.0122
Onchocerca volvulus 0.0058 0.0083 0.111
Loa Loa (eye worm) hypothetical protein 0.0145 0.025 0.3326
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0193 0.034 0.453
Onchocerca volvulus 0.0098 0.0159 0.212
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0088 0.0142 0.1884
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0193 0.034 0.1273
Onchocerca volvulus 0.0043 0.0055 0.0727
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.0838 0.315
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0006 0.0231
Trypanosoma brucei cytochrome P450, putative 0.002 0.0012 0.0824
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0106 0.0389
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0039 0.0135
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0045 0.0902
Loa Loa (eye worm) hypothetical protein 0.0216 0.0384 0.5116
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0091 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0008 0.0318
Schistosoma mansoni alpha glucosidase 0.0037 0.0045 0.0045
Brugia malayi steroid hormone receptor 0.0408 0.0752 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0088 0.0206
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0045 0.3162
Loa Loa (eye worm) hypothetical protein 0.0046 0.0061 0.081
Schistosoma mansoni hypothetical protein 0.0019 0.001 0.0009
Brugia malayi hypothetical protein 0.0145 0.0251 0.3337
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0408 0.0752 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0055 0.0122
Leishmania major 4-coumarate:coa ligase-like protein 0.0145 0.025 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0039 0.0084
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0193 0.034 0.453
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0027 0.0054
Onchocerca volvulus 0.0157 0.0272 0.3616
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0089 0.0208
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0108 0.018 0.0437
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0008 0.0562
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0008 0.0005
Trypanosoma cruzi peter pan protein, putative 0.0061 0.0089 0.6273
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0006 0.0407
Echinococcus granulosus Nuclear hormone receptor HR96 0.0193 0.034 0.1273
Schistosoma mansoni hypothetical protein 0.003 0.003 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0142 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0043 0.0055 0.0122
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0216 0.0384 0.1439
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.021 0.0512
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0408 0.0752 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0006 0.0006
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.0186 0.0452
Brugia malayi hypothetical protein 0.0193 0.034 0.453
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.0186 0.6977
Brugia malayi follicle stimulating hormone receptor 0.0224 0.04 0.5318
Trypanosoma cruzi ISWI complex protein 0.0014 0 0.0018
Schistosoma mansoni hypothetical protein 0.007 0.0106 0.0106
Echinococcus granulosus peter pan 0.0061 0.0089 0.0323
Brugia malayi hypothetical protein 0.0058 0.0083 0.111
Plasmodium falciparum BRIX domain, putative 0.0061 0.0089 0.0208
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0055 0.0727
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.0186 0.0452
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0067 0.0153
Brugia malayi tailless protein 0.0193 0.034 0.453
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0043 0.0055 0.0731
Loa Loa (eye worm) hypothetical protein 0.0193 0.034 0.453
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0407
Leishmania major hypothetical protein, conserved 0.0028 0.0027 0.1097
Brugia malayi Brix domain containing protein 0.0061 0.0089 0.1182
Brugia malayi AMP-binding enzyme family protein 0.0145 0.025 0.3326
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0055 0.0727
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0407
Brugia malayi Nuclear hormone receptor-like 1 0.0408 0.0752 1
Loa Loa (eye worm) DR-78 0.0193 0.034 0.453
Schistosoma mansoni alpha-glucosidase 0.0145 0.025 0.025
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.2111 0.3998 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0522
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0008 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0039 0.0084
Brugia malayi nuclear hormone receptor family member nhr-6 0.0193 0.034 0.453
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0408 0.0752 1
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0142 1
Trypanosoma brucei polo-like protein kinase 0.0088 0.0142 1
Schistosoma mansoni hypothetical protein 0.003 0.003 0.003
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0008 0.0562
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0006 0.0009
Trypanosoma cruzi polo-like protein kinase, putative 0.0088 0.0142 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0027 0.1937
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0012 0.0015
Brugia malayi latrophilin 2 splice variant baaae 0.0064 0.0096 0.1274
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0408 0.0752 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0061 0.433
Loa Loa (eye worm) hypothetical protein 0.0216 0.0384 0.5116
Brugia malayi hypothetical protein 0.0028 0.0027 0.0365
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0067 0.0239
Loa Loa (eye worm) hypothetical protein 0.0043 0.0055 0.0727
Loa Loa (eye worm) hypothetical protein 0.0408 0.0752 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0145 0.025 0.5038
Plasmodium falciparum glutathione reductase 0.0049 0.0067 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0408 0.0752 1
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0027 0.2531
Loa Loa (eye worm) hypothetical protein 0.0145 0.025 0.3326
Schistosoma mansoni hypothetical protein 0.003 0.003 0.003
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0193 0.034 0.1273
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0193 0.034 0.1273
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0045 0.0902
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0142 1
Echinococcus multilocularis caspase 2 0.0058 0.0083 0.0302
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0231
Loa Loa (eye worm) hypothetical protein 0.0408 0.0752 1
Echinococcus multilocularis CREB binding protein 0.0016 0.0004 0.0002
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0157 0.0272 0.3616

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 2 ug ml-1 Antibacterial activity against Escherichia coli assessed as growth inhibition at 37 degC after overnight incubation by agar well diffusion method ChEMBL. 23416192

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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