Detailed information for compound 1735506

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 262.344 | Formula: C16H22O3
  • H donors: 0 H acceptors: 2 LogP: 2.44 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)[C@]1(C)[C@H]2[C@H]1CC/C(=C/CC/C(=C\2)/C=O)/C
  • InChi: 1S/C16H22O3/c1-11-5-4-6-12(10-17)9-14-13(8-7-11)16(14,2)15(18)19-3/h5,9-10,13-14H,4,6-8H2,1-3H3/b11-5+,12-9+/t13-,14-,16+/m1/s1
  • InChiKey: NRZFMXMBODNUGB-ZTFMBOIGSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major GTP-binding protein, putative 0.0015 0.0046 0.0043
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0022 0.0019
Trypanosoma brucei glucosamine-6-phosphate isomerase, putative 0.0009 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0106 0.0103
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0106 0.1233
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1756 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0022 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0106 0.1233
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0111 0.0584 0.0581
Echinococcus granulosus cpg binding protein 0.0033 0.0147 0.0144
Echinococcus multilocularis 6 phosphogluconolactonase 0.0009 0.0011 0.0008
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0057 0.0282 0.0279
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0102 0.0533 0.053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0022 0.0019
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0028 0.0118 0.0115
Trypanosoma brucei dynamin-1-like protein 0.0015 0.0046 0.0043
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0069 0.0066
Mycobacterium leprae Probable 6-phosphogluconolactonase DevB (6PGL) 0.0009 0.0011 0.0099
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0034 0.015 0.0147
Brugia malayi Hexokinase family protein 0.1116 0.6259 0.6258
Schistosoma mansoni dynamin 0.0016 0.0053 0.005
Schistosoma mansoni hypothetical protein 0.0017 0.0057 0.0054
Echinococcus granulosus fatty acid binding protein FABP2 0.1148 0.6438 0.6437
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0022 0.0019
Toxoplasma gondii MAPEG family protein 0.0083 0.0428 0.0426
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0022 0.0019
Loa Loa (eye worm) 6-phosphogluconolactonase 0.0009 0.0011 0.0008
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0102 0.0533 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0057 0.0054
Loa Loa (eye worm) hexokinase type II 0.1779 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0054
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0102 0.0533 0.053
Loa Loa (eye worm) DRP-1 protein 0.0015 0.0046 0.0043
Treponema pallidum fructose-bisphosphate aldolase 0.0318 0.1756 0.1747
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0009 0.0011 0.0008
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0883 0.4943 0.4942
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.0015 0.0046 0.0262
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0083 0.0428 0.0426
Echinococcus multilocularis dynamin 1 protein 0.0015 0.0046 0.0043
Loa Loa (eye worm) hypothetical protein 0.1214 0.6808 0.6807
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0181 0.0178
Schistosoma mansoni hypothetical protein 0.0009 0.0009 0.0006
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0022 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0022 0.0019
Echinococcus granulosus neuropeptide s receptor 0.0504 0.2802 0.28
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0022 0.0019
Echinococcus granulosus 6 phosphogluconolactonase 0.0009 0.0011 0.0008
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0057 0.0054
Echinococcus granulosus neuropeptide receptor A26 0.0504 0.2802 0.28
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0063 0.0721
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0241 0.0238
Loa Loa (eye worm) hypothetical protein 0.0566 0.3152 0.315
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0022 0.0019
Giardia lamblia Dynamin 0.0015 0.0046 0.0201
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0106 0.1233
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0022 0.0019
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0014 0.0011
Trichomonas vaginalis dynamin, putative 0.0015 0.0046 0.0262
Plasmodium falciparum hexokinase 0.1779 1 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0057 0.0054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1756 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0003 0.0016
Echinococcus multilocularis hexokinase 0.1779 1 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0155 0.0837 1
Echinococcus granulosus glutamate NMDA receptor subunit 0.0024 0.0093 0.009
Schistosoma mansoni dynamin 0.0016 0.0053 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0022 0.0019
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0102 0.0533 0.053
Schistosoma mansoni glutamate receptor NMDA 0.0028 0.0118 0.0115
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0063 0.0721
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0022 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0022 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0106 0.0103
Brugia malayi CXXC zinc finger family protein 0.0031 0.0136 0.0134
Echinococcus multilocularis neuropeptide receptor A26 0.0504 0.2802 0.28
Echinococcus multilocularis dnaJ subfamily B 0.0445 0.2474 0.2471
Plasmodium vivax dynamin-like protein, putative 0.0015 0.0046 0.0043
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0004 0.0001
Echinococcus multilocularis hexokinase type 2 0.1779 1 1
Echinococcus multilocularis hexokinase 0.1779 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0057 0.0054
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0106 0.1233
Brugia malayi Dynamin central region family protein 0.0015 0.0046 0.0043
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0102 0.0533 0.053
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0009 0.0011 0.0008
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0057 0.0054
Mycobacterium ulcerans 6-phosphogluconolactonase 0.0009 0.0011 0.0099
Schistosoma mansoni cpg binding protein 0.0033 0.0147 0.0144
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0169 0.0167
Schistosoma mansoni glutamate receptor NMDA 0.0024 0.0093 0.009
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0066 0.0334 0.3972
Plasmodium vivax hexokinase, putative 0.1779 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0057 0.0054
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0057 0.0651
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0019
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0022 0.0019
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein 0.1148 0.6438 0.6437
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0181 0.0178
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0266 0.0264
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0241 0.0238
Leishmania major hexokinase, putative 0.1779 1 1
Echinococcus multilocularis glutamate receptor 2 0.0019 0.0069 0.0066
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0022 0.0019
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0009 0.0009 0.0006
Trypanosoma cruzi dynamin-1-like protein 0.0015 0.0046 0.0043
Schistosoma mansoni hexokinase 0.1779 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0241 0.0238
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0069 0.0066
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0057 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0019
Brugia malayi Dynamin 0.0016 0.0053 0.005
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0022 0.0019
Entamoeba histolytica hexokinase 1 0.1779 1 1
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0038 0.0173 0.017
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0022 0.0019
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0024 0.0093 0.009
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0057 0.0282 0.0279
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0022 0.0019
Echinococcus multilocularis dynamin 1 0.0016 0.0053 0.005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0022 0.0019
Schistosoma mansoni hypothetical protein 0.0037 0.0169 0.0167
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0241 0.0238
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0106 0.1233
Brugia malayi Lipocalin / cytosolic fatty-acid binding protein family protein 0.1148 0.6438 0.6437
Trichomonas vaginalis mgm1, putative 0.0015 0.0046 0.0262
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0057 0.0054
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0022 0.0019
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0004 0.0001
Schistosoma mansoni glutamate receptor AMPA 0.0024 0.0093 0.009
Echinococcus multilocularis dynamin 0.0015 0.0046 0.0043
Onchocerca volvulus 0.1779 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0106 0.1233
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0038 0.0173 0.017
Schistosoma mansoni hypothetical protein 0.0185 0.1001 0.0999
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0004 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1756 1
Echinococcus granulosus glutamate receptor subunit protein glur 0.0009 0.0009 0.0006
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0022 0.0019
Trypanosoma brucei dynamin-1-like protein 0.0015 0.0046 0.0043
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0266 0.0264
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0026 0.0106 0.0103
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0111 0.0584 0.3326
Plasmodium vivax dynamin protein, putative 0.0015 0.0046 0.0043
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0111 0.0584 0.0581
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1756 1
Entamoeba histolytica hypothetical protein 0.0039 0.0181 0.0178
Entamoeba histolytica dynamin-1-like protein, putative 0.0015 0.0046 0.0043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0241 0.0238
Entamoeba histolytica hypothetical protein 0.0039 0.0181 0.0178
Onchocerca volvulus 0.1779 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0022 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0022 0.0019
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0057 0.0054
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0057 0.0054
Loa Loa (eye worm) hypothetical protein 0.0054 0.0266 0.0264
Schistosoma mansoni fatty acid binding protein 0.1148 0.6438 0.6437
Entamoeba histolytica hypothetical protein 0.0039 0.0181 0.0178
Echinococcus multilocularis fatty acid binding protein FABP2 0.1148 0.6438 0.6437
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0019
Entamoeba histolytica dynamin-like protein 0.0015 0.0046 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0022 0.0019
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0111 0.0584 0.0581
Echinococcus granulosus microsomal glutathione S transferase 3 0.0083 0.0428 0.0426
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0106 0.1233
Loa Loa (eye worm) hexokinase 0.1779 1 1
Brugia malayi hypothetical protein 0.0039 0.0181 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0022 0.0019
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0009 0.0011 0.0008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0106 0.0103
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0106 0.0103
Giardia lamblia Fructose-bisphosphate aldolase 0.0318 0.1756 1
Schistosoma mansoni glutamate receptor kainate 0.0024 0.0093 0.009
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0106 0.0103
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0022 0.0019
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0106 0.0103
Mycobacterium ulcerans hypothetical protein 0.0026 0.0106 0.1233
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0022 0.0019
Loa Loa (eye worm) glutamate receptor 2 0.0024 0.0093 0.009
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0022 0.0019
Echinococcus granulosus hexokinase 0.1779 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0066
Echinococcus multilocularis neuropeptide s receptor 0.0504 0.2802 0.28
Brugia malayi Glutamate receptor 2 precursor 0.0024 0.0093 0.009
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0035 0.0159 0.1869
Echinococcus multilocularis GPCR, family 2 0.0017 0.0057 0.0054
Trypanosoma cruzi hexokinase, putative 0.1779 1 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0155 0.0837 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0057 0.0054
Echinococcus multilocularis hexokinase 0.1779 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0106 0.0103
Echinococcus granulosus hexokinase 0.1779 1 1
Trypanosoma brucei hexokinase 0.1779 1 1
Echinococcus granulosus glutamate receptor 2 0.0019 0.0069 0.0066
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0155 0.0837 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0106 0.1233
Schistosoma mansoni dynamin 0.0015 0.0046 0.0043
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0106 0.0103
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0136 0.0134
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0022 0.0019
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0102 0.0533 0.053
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0266 0.0264
Schistosoma mansoni microsomal glutathione s-transferase 0.0083 0.0428 0.0426
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0022 0.0019
Echinococcus granulosus dynamin 1 0.0016 0.0053 0.005
Schistosoma mansoni glutamate receptor kainate 0.0053 0.0257 0.0254
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0009 0.0009 0.0006
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0102 0.0533 0.6353
Toxoplasma gondii dynamin-related protein DRPA 0.0015 0.0046 0.0043
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0057 0.0282 0.0279
Brugia malayi 6-phosphogluconolactonase family protein 0.0009 0.0011 0.0008
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0057 0.0054
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0241 0.0238
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0294 0.0292
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0057 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.0167
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0106 0.0103
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0318 0.1756 0.1754
Schistosoma mansoni hypothetical protein 0.0445 0.2474 0.2471
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0022 0.0019
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0111 0.0584 0.3326
Schistosoma mansoni hypothetical protein 0.0039 0.0181 0.0178
Toxoplasma gondii dynamin-related protein DRPB 0.0015 0.0046 0.0043
Echinococcus granulosus dynamin 1 protein 0.0015 0.0046 0.0043
Brugia malayi hexokinase type II 0.0566 0.3152 0.315
Brugia malayi Hexokinase family protein 0.1779 1 1
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0009 0.0011 0.0063
Trypanosoma brucei 6-phosphogluconolactonase 0.0009 0.0011 0.0008
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0057 0.0054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1756 1
Loa Loa (eye worm) hypothetical protein 0.0566 0.3152 0.315
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0111 0.0584 0.3284
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0066 0.0334 0.0332
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0004 0.0001
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0057 0.0054
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.005
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0022 0.0019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0022 0.0019
Loa Loa (eye worm) glutamate receptor 1 0.0024 0.0093 0.009
Schistosoma mansoni ATP-binding cassette transporter 0.0024 0.0093 0.009
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0022 0.0019
Echinococcus multilocularis cpg binding protein 0.0033 0.0147 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0022 0.0019
Echinococcus granulosus glutamate receptor 2 0.0028 0.0118 0.0115
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0028 0.0118 0.0115
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0019
Leishmania major hexokinase, putative 0.1779 1 1
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0102 0.0533 0.053
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0022 0.0019
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0069 0.1108
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0057 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0022 0.0019
Echinococcus multilocularis glutamate receptor 2 0.0028 0.0118 0.0115
Trichomonas vaginalis dynamin, putative 0.0015 0.0046 0.0262
Plasmodium falciparum dynamin-like protein 0.0015 0.0046 0.0043
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0022 0.0019
Brugia malayi isocitrate dehydrogenase 0.0017 0.0057 0.0054
Echinococcus multilocularis nmda type glutamate receptor 0.0009 0.0009 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0019
Onchocerca volvulus 0.1779 1 1
Schistosoma mansoni hypothetical protein 0.0017 0.0057 0.0054
Brugia malayi steroid hormone receptor 0.0011 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0019
Schistosoma mansoni hypothetical protein 0.0185 0.1001 0.0999
Echinococcus multilocularis fatty acid binding protein FABP2 0.1148 0.6438 0.6437
Onchocerca volvulus 0.0011 0.0022 0.0019
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0022 0.0019
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0057 0.0282 0.0279
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0241 0.0238
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0022 0.0019
Trypanosoma brucei hexokinase 0.1779 1 1
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0038 0.0173 0.017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0066
Echinococcus granulosus hexokinase type 2 0.1779 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1756 1
Trypanosoma brucei hexokinase, putative 0.1779 1 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0057 0.0054
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0063 0.0721
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0102 0.0533 0.0523
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0009 0.0011 0.0008
Leishmania major glucosamine-6-phosphate isomerase, putative 0.0009 0.0011 0.0008
Treponema pallidum hexokinase (hxk) 0.1779 1 1
Leishmania major 6-phosphogluconolactonase 0.0009 0.0011 0.0008
Echinococcus granulosus GPCR family 2 0.0017 0.0057 0.0054
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0111 0.0584 0.3326
Brugia malayi ecdysteroid receptor 0.0011 0.0022 0.0019
Schistosoma mansoni coup transcription factor 0.0011 0.0022 0.0019
Schistosoma mansoni cpg binding protein 0.0033 0.0147 0.0144
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0069 0.0792
Brugia malayi Glutamate receptor 1 precursor 0.0024 0.0093 0.009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1756 1
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0009 0.0009 0.0006
Brugia malayi Hexokinase family protein 0.0551 0.3067 0.3065
Trichomonas vaginalis dynamin, putative 0.0015 0.0046 0.0262
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0022 0.0019
Onchocerca volvulus 0.0026 0.0106 0.0103
Onchocerca volvulus 0.1116 0.6259 0.6258
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0106 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0022 0.0019
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0057 0.0054
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0022 0.0019
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0181 0.0178
Schistosoma mansoni fatty acid binding protein 0.1148 0.6438 0.6437
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.0009 0.0011 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0022 0.0019
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0057 0.0054
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0241 0.0238
Schistosoma mansoni hypothetical protein 0.0017 0.0057 0.0054
Loa Loa (eye worm) hexokinase 0.0551 0.3067 0.3065
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0003 0.0016
Schistosoma mansoni glutamate receptor kainate 0.0053 0.0257 0.0254
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0019
Loa Loa (eye worm) histone methyltransferase 0.001 0.0015 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0022 0.0019
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0022 0.0019
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0102 0.0533 0.053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0022 0.0019
Echinococcus granulosus geminin 0.0185 0.1001 0.0999
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0022 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0022 0.0019
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0057 0.0054
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0334 0.0332
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0009 0.0011 0.0008
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0057 0.0054
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0038 0.0173 0.017
Echinococcus multilocularis NMDA receptor 0.0038 0.0173 0.017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1756 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0063 0.0721
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0057 0.0054
Echinococcus granulosus nmda type glutamate receptor 0.0009 0.0009 0.0006
Schistosoma mansoni 6-phosphogluconolactonase 0.0009 0.0011 0.0008
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0022 0.0019
Onchocerca volvulus 0.0031 0.0136 0.0134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0241 0.0238
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0069 0.0792
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0318 0.1756 0.1754
Trichomonas vaginalis dynamin, putative 0.0015 0.0046 0.0262
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0033 0.0144 0.0142
Entamoeba histolytica hypothetical protein 0.0039 0.0181 0.0178
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0066
Loa Loa (eye worm) hexokinase 0.1116 0.6259 0.6258
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0066
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0106 0.0103
Echinococcus granulosus hexokinase 0.1779 1 1
Entamoeba histolytica hexokinase 2 0.1779 1 1
Loa Loa (eye worm) hexokinase 0.1779 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0057 0.0054
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0004 0.0001
Brugia malayi nuclear hormone receptor 0.0011 0.0022 0.0019
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0022 0.0019
Schistosoma mansoni 6-phosphogluconolactonase 0.0009 0.0011 0.0008
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0362 0.2004 0.2002
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0057 0.0282 0.0279
Echinococcus multilocularis geminin 0.0185 0.1001 0.0999
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0022 0.0019
Schistosoma mansoni hypothetical protein 0.0017 0.0057 0.0054
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0106 0.1233
Onchocerca volvulus Hexokinase homolog 0.1116 0.6259 0.6258
Trichomonas vaginalis dynamin, putative 0.0015 0.0046 0.0262
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0106 0.1233
Toxoplasma gondii hexokinase 0.1779 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0022 0.0019
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0022 0.0019
Schistosoma mansoni cpg binding protein 0.0031 0.0136 0.0134
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0019
Echinococcus granulosus dnaJ subfamily B 0.0445 0.2474 0.2471
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0057 0.0054
Toxoplasma gondii dynamin gtpase 0.001 0.0017 0.0014
Brugia malayi glucose-6-phosphate dehydrogenase 0.0102 0.0533 0.053
Brugia malayi Dynamin 0.0016 0.0053 0.005
Trypanosoma cruzi hexokinase, putative 0.1779 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0066
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0015 0.0012
Brugia malayi nuclear receptor NHR-88 0.0011 0.0022 0.0019
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0057 0.0054
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0057 0.0282 0.0279
Schistosoma mansoni glutamate receptor AMPA 0.0024 0.0093 0.009
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0015 0.0012
Echinococcus multilocularis glutamate receptor 2 0.0024 0.0093 0.009
Echinococcus granulosus fatty acid binding protein FABP2 0.1148 0.6438 0.6437
Plasmodium falciparum dynamin-like protein 0.0015 0.0046 0.0043
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0022 0.0019
Trichomonas vaginalis dynamin, putative 0.0015 0.0046 0.0262
Echinococcus granulosus dynamin 0.0015 0.0046 0.0043
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0106 0.1233

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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