Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 1 | 1 |
Schistosoma mansoni | notch | 0.0282 | 0.0323 | 0.0323 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0497 | 0.1783 | 0.1783 |
Echinococcus multilocularis | neural cadherin | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1705 | 1 | 1 |
Echinococcus multilocularis | fibropellin Ia | 0.0282 | 0.0323 | 0.0323 |
Schistosoma mansoni | coup transcription factor | 0.0497 | 0.1783 | 0.1783 |
Echinococcus granulosus | notch | 0.0282 | 0.0323 | 0.0323 |
Brugia malayi | ecdysteroid receptor | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0282 | 0.0323 | 0.0323 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | Notch2 | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0497 | 0.1783 | 0.1783 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0497 | 0.1783 | 0.1783 |
Onchocerca volvulus | Dual oxidase homolog | 0.1705 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.1705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0497 | 0.1783 | 0.1783 |
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Brugia malayi | EGF-like domain containing protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | Muscle positioning protein 4 | 0.0282 | 0.0323 | 0.0323 |
Brugia malayi | nuclear receptor RXR | 0.0262 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0262 | 0.0191 | 0.0191 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0282 | 0.0323 | 0.0323 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0262 | 0.0191 | 0.0191 |
Echinococcus granulosus | delta-like protein 1 | 0.0282 | 0.0323 | 0.0323 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | Animal haem peroxidase family protein | 0.1705 | 1 | 1 |
Onchocerca volvulus | 0.1705 | 1 | 1 | |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0282 | 0.0323 | 0.0323 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0497 | 0.1783 | 0.1783 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0497 | 0.1783 | 0.1783 |
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Onchocerca volvulus | 0.0282 | 0.0323 | 0.0323 | |
Brugia malayi | steroid hormone receptor | 0.0497 | 0.1783 | 0.1783 |
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 1 | 1 |
Schistosoma mansoni | septate junction protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1705 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0497 | 0.1783 | 0.1783 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0282 | 0.0323 | 0.0323 |
Brugia malayi | nuclear hormone receptor | 0.0497 | 0.1783 | 0.1783 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0497 | 0.1783 | 0.1783 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Schistosoma mansoni | cell polarity protein | 0.0282 | 0.0323 | 0.0323 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0262 | 0.0191 | 0.0191 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0497 | 0.1783 | 0.1783 |
Onchocerca volvulus | Slit protein homolog | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0282 | 0.0323 | 0.0323 |
Brugia malayi | notch-like transmembrane receptor | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0497 | 0.1783 | 0.1783 |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 0.1783 | 0.1783 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1705 | 1 | 1 |
Onchocerca volvulus | Putative cubilin | 0.0282 | 0.0323 | 0.0323 |
Schistosoma mansoni | notch | 0.0282 | 0.0323 | 0.0323 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0497 | 0.1783 | 0.1783 |
Echinococcus multilocularis | notch | 0.0282 | 0.0323 | 0.0323 |
Schistosoma mansoni | thyroid hormone receptor | 0.0497 | 0.1783 | 0.1783 |
Onchocerca volvulus | 0.0497 | 0.1783 | 0.1783 | |
Brugia malayi | EGF-like domain containing protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Schistosoma mansoni | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0497 | 0.1783 | 0.1783 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0497 | 0.1783 | 0.1783 |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | EGF-like domain containing protein | 0.0282 | 0.0323 | 0.0323 |
Onchocerca volvulus | Peroxidasin homolog | 0.1705 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1705 | 1 | 1 |
Schistosoma mansoni | notch | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0191 | 0.0191 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0262 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0262 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 1 | 1 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0497 | 0.1783 | 0.1783 |
Schistosoma mansoni | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Echinococcus multilocularis | protein jagged 1 | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0497 | 0.1783 | 0.1783 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0497 | 0.1783 | 0.1783 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0282 | 0.0323 | 0.5 |
Onchocerca volvulus | 0.1705 | 1 | 1 | |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0497 | 0.1783 | 0.1783 |
Schistosoma mansoni | notch | 0.0282 | 0.0323 | 0.0323 |
Echinococcus granulosus | slit 2 protein | 0.0282 | 0.0323 | 0.0323 |
Brugia malayi | EGF-like domain containing protein | 0.0282 | 0.0323 | 0.0323 |
Echinococcus granulosus | fibropellin Ia | 0.0282 | 0.0323 | 0.0323 |
Onchocerca volvulus | Peroxidase homolog | 0.1705 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0282 | 0.0323 | 0.0323 |
Brugia malayi | hypothetical protein | 0.0262 | 0.0191 | 0.0191 |
Schistosoma mansoni | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0191 | 0.0191 |
Schistosoma mansoni | nuclear hormone receptor | 0.0497 | 0.1783 | 0.1783 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0282 | 0.0323 | 0.0323 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | Cadherin domain containing protein | 0.0282 | 0.0323 | 0.0323 |
Echinococcus multilocularis | slit 2 protein | 0.0282 | 0.0323 | 0.0323 |
Schistosoma mansoni | thyroid hormone receptor | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0497 | 0.1783 | 0.1783 |
Onchocerca volvulus | 0.0282 | 0.0323 | 0.0323 | |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0262 | 0.0191 | 0.0191 |
Brugia malayi | hypothetical protein | 0.0262 | 0.0191 | 0.0191 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0497 | 0.1783 | 0.1783 |
Echinococcus granulosus | protein jagged 2 | 0.0282 | 0.0323 | 0.0323 |
Echinococcus granulosus | protein jagged 1 | 0.0282 | 0.0323 | 0.0323 |
Schistosoma mansoni | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Brugia malayi | Peroxidasin | 0.1705 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0497 | 0.1783 | 0.1783 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0282 | 0.0323 | 0.0323 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0497 | 0.1783 | 0.1783 |
Schistosoma mansoni | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 0.1783 | 0.1783 |
Echinococcus granulosus | neural cadherin | 0.0282 | 0.0323 | 0.0323 |
Onchocerca volvulus | 0.0282 | 0.0323 | 0.0323 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0497 | 0.1783 | 0.1783 |
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0497 | 0.1783 | 0.1783 |
Onchocerca volvulus | 0.1705 | 1 | 1 | |
Schistosoma mansoni | notch | 0.0282 | 0.0323 | 0.0323 |
Onchocerca volvulus | 0.0282 | 0.0323 | 0.0323 | |
Schistosoma mansoni | peroxidasin | 0.1705 | 1 | 1 |
Brugia malayi | Delta serrate ligand family protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | notch protein | 0.0282 | 0.0323 | 0.0323 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0497 | 0.1783 | 0.1783 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0497 | 0.1783 | 0.1783 |
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 0.1783 | 0.1783 |
Schistosoma mansoni | slit | 0.0282 | 0.0323 | 0.0323 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0262 | 0.0191 | 0.0191 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0282 | 0.0323 | 0.0323 |
Onchocerca volvulus | Peroxidase homolog | 0.1705 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.1705 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0497 | 0.1783 | 0.1783 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0497 | 0.1783 | 0.1783 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.1705 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0497 | 0.1783 | 0.1783 |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 0.1783 | 0.1783 |
Echinococcus granulosus | protein jagged 2 | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.1705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | EGF-like domain containing protein | 0.0282 | 0.0323 | 0.0323 |
Brugia malayi | Animal haem peroxidase family protein | 0.1705 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0497 | 0.1783 | 0.1783 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Onchocerca volvulus | Peroxidasin homolog | 0.1705 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0497 | 0.1783 | 0.1783 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | EGF-like domain containing protein | 0.0282 | 0.0323 | 0.0323 |
Echinococcus multilocularis | peroxidasin | 0.1705 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Brugia malayi | Animal haem peroxidase family protein | 0.1705 | 1 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0282 | 0.0323 | 0.0323 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0497 | 0.1783 | 0.1783 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0282 | 0.0323 | 0.0323 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | Cadherin domain containing protein | 0.0282 | 0.0323 | 0.0323 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0497 | 0.1783 | 0.1783 |
Echinococcus granulosus | protein jagged 1 | 0.0282 | 0.0323 | 0.0323 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | Animal haem peroxidase family protein | 0.1705 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0282 | 0.0323 | 0.0323 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0497 | 0.1783 | 0.1783 |
Schistosoma mansoni | notch | 0.0282 | 0.0323 | 0.0323 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0497 | 0.1783 | 0.1783 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0497 | 0.1783 | 0.1783 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0497 | 0.1783 | 0.1783 |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0497 | 0.1783 | 0.1783 |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 0.1783 | 0.1783 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0497 | 0.1783 | 0.1783 |
Giardia lamblia | High cysteine protein | 0.0282 | 0.0323 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0497 | 0.1783 | 0.1783 |
Brugia malayi | Animal haem peroxidase family protein | 0.1705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0497 | 0.1783 | 0.1783 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.0191 | 0.0191 |
Onchocerca volvulus | 0.0282 | 0.0323 | 0.0323 | |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Schistosoma mansoni | hypothetical protein | 0.0282 | 0.0323 | 0.0323 |
Echinococcus multilocularis | protein jagged 2 | 0.0282 | 0.0323 | 0.0323 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0497 | 0.1783 | 0.1783 |
Schistosoma mansoni | peroxidasin | 0.1705 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 170 uM | Cytostatic activity against mouse L1210 cells assessed as inhibition of cell proliferation after 48 hrs by Coulter counter analysis | ChEMBL. | 23380474 |
IC50 (functional) | > 250 uM | Cytostatic activity against human HeLa cells assessed as inhibition of cell proliferation after 72 hrs by Coulter counter analysis | ChEMBL. | 23380474 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.