TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 426.161 | Formula: C12H15IN2O7
H donors: 3 H acceptors: 5 LogP: -1.15 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCC(=O)OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1c(I)cc(=O)[nH]c1=O
InChi: 1S/C12H15IN2O7/c1-2-8(17)21-4-5-9(18)10(19)11(22-5)15-6(13)3-7(16)14-12(15)20/h3,5,9-11,18-19H,2,4H2,1H3,(H,14,16,20)/t5-,9-,10-,11-/m1/s1
InChiKey: OUSIHZBGWCRYGL-VVFBATEQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0003	0.0003
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.1992	0.6425
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.1992	0.6425
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0003	0.0003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0003	0.0003
Brugia malayi	Carboxylesterase family protein	0.0133	0.1575	0.1587
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0003	0.0016
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0003	0.0003
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0133	0.1575	0.5079
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0173	0.1099
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0003	0.0003
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0173	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0173	0.1099
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0479	0.0479
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.2106	0.6792
Loa Loa (eye worm)	hypothetical protein	0.001	0.0003	0.0003
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0112	0.0113
Echinococcus granulosus	acetylcholinesterase	0.0785	0.9926	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0003	0.0003
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1575	0.1587
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0133	0.1575	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0133	0.1575	0.1587
Loa Loa (eye worm)	carboxylesterase	0.0785	0.9926	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.1125	0.1134
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0003	0.0003
Brugia malayi	Carboxylesterase family protein	0.0133	0.1575	0.1587
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0785	0.9926	1
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0252	0.3101	0.3124
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0003	0.0003
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0133	0.1575	1
Echinococcus multilocularis	acetylcholinesterase	0.0785	0.9926	0.9926
Loa Loa (eye worm)	hypothetical protein	0.001	0.0003	0.0003
Brugia malayi	ecdysteroid receptor	0.001	0.0003	0.0003
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0098	0.8782
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1575	0.1587
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0003	0.0003
Schistosoma mansoni	patched 1	0.0041	0.0405	0.0408
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.00000034704	0.0000011191
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0098	0.0099
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0098	0.0099
Brugia malayi	Carboxylesterase family protein	0.0133	0.1575	0.1587
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0133	0.1575	0.1587
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0112	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0003	0.0003
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3101	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0173	0.1565
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0003	0.0003
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0252	0.3101	0.3124
Brugia malayi	steroid hormone receptor	0.001	0.0003	0.0003
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.1106	0.1114
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0405	0.0408
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0173	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0003	0.0003
Schistosoma mansoni	ap endonuclease	0.0018	0.0112	0.0113
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0003	0.0003
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0173	0.1565
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0003	0.0003
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.1106	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0098	0.0081
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0112	0.0112
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0173	0.1099
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0003	0.0003
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0405	0.0408
Mycobacterium ulcerans	carboxylesterase, LipT	0.0133	0.1575	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1106	0.1114
Schistosoma mansoni	acetylcholinesterase	0.0133	0.1575	0.1587
Toxoplasma gondii	exonuclease III APE	0.0018	0.0112	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0112	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0003	0.0003
Echinococcus granulosus	BC026374 protein S09 family	0.0133	0.1575	0.1587
Schistosoma mansoni	hypothetical protein	0.004	0.0386	0.0388
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0405	0.1304
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0173	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0098	0.0099
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0003	0.0003
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0133	0.1575	0.1575
Echinococcus multilocularis	para nitrobenzyl esterase	0.0133	0.1575	0.1575
Schistosoma mansoni	coup transcription factor	0.001	0.0003	0.0003
Trichomonas vaginalis	spcc417.12 protein, putative	0.0133	0.1575	0.5079
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0003	0.0003
Loa Loa (eye worm)	carboxylesterase	0.0133	0.1575	0.1587
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.1106	0.1114
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0405	0.0408
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0173	0.1565
Echinococcus multilocularis	neuroligin	0.0133	0.1575	0.1575
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0003	0.0003
Schistosoma mansoni	gliotactin	0.0133	0.1575	0.1587
Schistosoma mansoni	hypothetical protein	0.004	0.0386	0.0388
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0405	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0785	0.9926	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0133	0.1575	0.1587
Loa Loa (eye worm)	acetylcholinesterase 1	0.0785	0.9926	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0003	0.0003
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.1992	0.6425
Brugia malayi	nuclear receptor NHR-88	0.001	0.0003	0.0003
Brugia malayi	nuclear hormone receptor	0.001	0.0003	0.0003
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0112	1
Brugia malayi	Carboxylesterase family protein	0.0785	0.9926	1
Schistosoma mansoni	hypothetical protein	0.004	0.0386	0.0388
Onchocerca volvulus		0.0133	0.1575	0.7905
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0003	0.0003
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0003	0.0003
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0098	0.0099
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.001	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0173	0.0174
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0003	0.0003
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.00000034704	0.00000034963
Echinococcus multilocularis	Niemann Pick C1 protein	0.0137	0.1634	0.1634
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0112	0.0113
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0133	0.1575	0.1587
Loa Loa (eye worm)	hypothetical protein	0.0785	0.9926	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3101	1
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1575	0.1587
Echinococcus multilocularis	carboxylesterase 5A	0.0785	0.9926	0.9926
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0003	0.0003
Echinococcus multilocularis	expressed conserved protein	0.009	0.1032	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0523	0.0527
Onchocerca volvulus		0.0133	0.1575	0.7905
Echinococcus granulosus	expressed conserved protein	0.009	0.1032	0.1039
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0133	0.1575	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0112	0.071
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0173	0.0584
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0098	0.8782
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0112	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0112	0.0113
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.1992	0.6425
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0133	0.1575	0.1587
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0003	0.0003
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0003	0.0003
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0003	0.0003
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3101	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0003	0.0003
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.00000034704	0.0000031374
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0133	0.1575	0.1575
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0173	1
Schistosoma mansoni	hypothetical protein	0.004	0.0386	0.0388
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0003	0.0003
Schistosoma mansoni	ap endonuclease	0.0018	0.0112	0.0113
Echinococcus multilocularis	acetylcholinesterase	0.0785	0.9926	0.9926
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1575	0.1587
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1575	0.1587
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0003	0.0016
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0003	0.0003
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.1992	0.6425
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0003	0.0003
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.2106	0.6792
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.00000034704	0.00000034704
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0003	0.0003
Echinococcus granulosus	carboxylesterase 5A	0.0785	0.9926	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.1992	0.6425
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.1106	0.1106
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0003	0.0003
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0003	0.0016
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0173	1
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.00000034704	0.0000011191
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0098	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3101	1
Onchocerca volvulus		0.0133	0.1575	0.7905
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0003	0.0003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0003	0.0003
Brugia malayi	Carboxylesterase family protein	0.0133	0.1575	0.1587
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0112	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0003	0.0003
Onchocerca volvulus		0.0133	0.1575	0.7905
Loa Loa (eye worm)	hypothetical protein	0.001	0.0003	0.0003
Brugia malayi	Carboxylesterase family protein	0.0785	0.9926	1
Echinococcus multilocularis	protein patched	0.0041	0.0405	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0173	0.0174
Brugia malayi	CHE-14 protein	0.0041	0.0405	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0173	0.0174
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0003	0.0003
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0003	0.0003
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0098	0.0099
Onchocerca volvulus		0.001	0.0003	0.0016
Echinococcus granulosus	Niemann Pick C1 protein	0.0137	0.1634	0.1646
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0003	0.0003
Schistosoma mansoni	BC026374 protein (S09 family)	0.0133	0.1575	0.1587
Loa Loa (eye worm)	hypothetical protein	0.001	0.0003	0.0003
Onchocerca volvulus	Glucosylceramidase homolog	0.0165	0.1992	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0112	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0173	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0003	0.0003
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0173	0.1099
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3101	1
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0003	0.0003
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0003	0.0003
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0112	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0173	0.1099
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0003	0.0003
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0003	0.0003
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0173	0.1099
Loa Loa (eye worm)	carboxylesterase	0.0133	0.1575	0.1587
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0173	0.0584
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0112	1
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0003	0.0003
Echinococcus granulosus	acetylcholinesterase	0.0785	0.9926	1
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0173	0.1099
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0112	0.0361
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0133	0.1575	0.1587
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3101	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0405	0.0405
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0003	0.0003
Brugia malayi	hypothetical protein	0.0133	0.1575	0.1587
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.1992	0.6425
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.00000034704	0.0000011191
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0003	0.0003
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0173	0.0174
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0173	0.1099
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0003	0.0003
Echinococcus granulosus	neuroligin	0.0133	0.1575	0.1587
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0173	0.0174
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0098	0.0624
Onchocerca volvulus		0.0023	0.0173	0.0869
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0003	0.0003
Echinococcus granulosus	replication factor c subunit 1	0.001	0.00000034704	0.00000034963
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0112	0.1011
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0112	0.0173
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0112	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1575	0.1587
Onchocerca volvulus		0.0133	0.1575	0.7905
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1575	0.1587
Loa Loa (eye worm)	hypothetical protein	0.001	0.0003	0.0003

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Antimalarial activity against Plasmodium chabaudi chabaudi infected in mouse assessed as reduction in parasitemia at 7.1 mg/day administered as infusion on days 4 to 6	ChEMBL.	23410043

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2337295

Bibliographic References

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Detailed information for compound 1735611