Detailed information for compound 1735650

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 292.369 | Formula: C14H28O6
  • H donors: 4 H acceptors: 4 LogP: 0.81 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCOC[C@H]1O[C@H](O)[C@@H]([C@H]([C@H]1O)O)O
  • InChi: 1S/C14H28O6/c1-2-3-4-5-6-7-8-19-9-10-11(15)12(16)13(17)14(18)20-10/h10-18H,2-9H2,1H3/t10-,11+,12+,13-,14+/m1/s1
  • InChiKey: PYAARBHPGPQQKU-HTOAHKCRSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Furin-like cysteine rich region family protein 0.0424 0.1237 0.1237
Echinococcus multilocularis neuroendocrine convertase 2 0.2073 0.6292 0.786
Brugia malayi hypothetical protein 0.0248 0.07 0.07
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0144 0.038 0.8922
Echinococcus granulosus biogenic amine 5HT receptor 0.0248 0.07 0.069
Echinococcus multilocularis insulin receptor 0.0093 0.0224 0.0267
Schistosoma mansoni tyrosine kinase 0.0038 0.0055 0.0045
Schistosoma mansoni amine oxidase 0.0068 0.0148 0.0137
Echinococcus multilocularis integrin alpha ps 0.013 0.0337 0.0409
Schistosoma mansoni neuropeptide F-like receptor 0.0248 0.07 0.069
Loa Loa (eye worm) hypothetical protein 0.0132 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0141 0.0371 0.0371
Toxoplasma gondii subtilisin SUB11 0.0144 0.038 1
Schistosoma mansoni hypothetical protein 0.013 0.0337 0.0327
Toxoplasma gondii subtilisin SUB7 0.0144 0.038 1
Onchocerca volvulus 0.0248 0.07 0.6643
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0248 0.07 0.07
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0026 0.0018 0.0407
Brugia malayi G-protein coupled receptor 0.0248 0.07 0.07
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0248 0.07 0.07
Brugia malayi AKH receptor 0.0248 0.07 0.07
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0055 0.0056
Echinococcus granulosus glutamate NMDA receptor subunit 0.0272 0.0772 0.0762
Echinococcus multilocularis integrin alpha ps 0.0271 0.077 0.095
Plasmodium falciparum subtilisin-like protease 1 0.0144 0.038 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0131 0.0131
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0083 0.0192 0.5
Echinococcus granulosus integrin alpha ps 0.013 0.0337 0.0327
Echinococcus granulosus fibrillin 1 0.005 0.0092 0.0081
Onchocerca volvulus 0.0098 0.0238 0.2257
Echinococcus multilocularis glutamate receptor 2 0.0049 0.0088 0.0097
Schistosoma mansoni neuropeptide receptor 0.0248 0.07 0.069
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0038 0.0055 0.0056
Echinococcus granulosus Furin 1 0.0796 0.2378 0.237
Onchocerca volvulus 0.0248 0.07 0.6643
Loa Loa (eye worm) hypothetical protein 0.3283 1 1
Echinococcus granulosus integrin alpha 3 0.0463 0.1359 0.135
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0248 0.07 0.07
Giardia lamblia Furin precursor putative serine protease 0.0652 0.1937 0.5277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0248 0.07 0.069
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0705 0.2098 0.209
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Brugia malayi Serotonin receptor 0.0248 0.07 0.07
Schistosoma mansoni tyrosine kinase 0.0093 0.0224 0.0214
Brugia malayi Dopamine receptor protein 2 0.0248 0.07 0.07
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0055 0.0056
Echinococcus granulosus somatostatin receptor 0.0248 0.07 0.069
Echinococcus granulosus g-protein coupled receptor 0.0248 0.07 0.069
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0018 0.0363
Mycobacterium leprae Polyketide synthase Pks13 0.0038 0.0057 0.1436
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0156 0.0417 0.0406
Onchocerca volvulus 0.0248 0.07 0.6643
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0652 0.1937 0.3153
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0026
Schistosoma mansoni integrin alpha 0.0605 0.1792 0.1783
Echinococcus multilocularis rhodopsin orphan GPCR 0.0248 0.07 0.0863
Loa Loa (eye worm) fatty acid synthase 0.0025 0.0017 0.0017
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0457 0.134 0.134
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0025 0.0025
Onchocerca volvulus 0.0028 0.0026 0.0236
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0049 0.0088 0.0087
Echinococcus granulosus insulin receptor 0.0093 0.0224 0.0214
Echinococcus granulosus G protein coupled receptor 139 0.0248 0.07 0.069
Mycobacterium ulcerans polyketide synthase 0.0026 0.0018 0.0363
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0144 0.038 0.4241
Mycobacterium ulcerans dehydrogenase 0.0068 0.0148 0.3436
Onchocerca volvulus 0.0248 0.07 0.6643
Onchocerca volvulus 0.0248 0.07 0.6643
Echinococcus granulosus tyrosine protein kinase Src42A 0.0038 0.0055 0.0045
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0023 0.0455
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0028 0.0026 0.0019
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0083 0.0192 1
Brugia malayi RE15519p 0.0248 0.07 0.07
Loa Loa (eye worm) hypothetical protein 0.0399 0.1161 0.1161
Schistosoma mansoni hypothetical protein 0.0067 0.0146 0.0135
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0248 0.07 0.0863
Schistosoma mansoni biogenic amine receptor 0.0248 0.07 0.069
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0018 0.0339
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0038 0.0055 0.0056
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0038 0.0057 0.126
Brugia malayi Integrin beta pat-3 precursor 0.2589 0.7874 0.7874
Schistosoma mansoni growth hormone secretagogue receptor 0.0248 0.07 0.069
Schistosoma mansoni SWI/SNF complex-related 0.0028 0.0026 0.0015
Schistosoma mansoni hypothetical protein 0.0056 0.0111 0.0101
Schistosoma mansoni biogenic amine (5HT) receptor 0.0248 0.07 0.069
Schistosoma mansoni hypothetical protein 0.0056 0.0111 0.0101
Echinococcus granulosus integrin alpha ps 0.0271 0.077 0.076
Schistosoma mansoni hypothetical protein 0.0056 0.0111 0.0101
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Plasmodium falciparum subtilisin-like protease 3 0.0144 0.038 1
Toxoplasma gondii subtilisin SUB9 0.0144 0.038 1
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0038 0.0027
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0027 0.0023 0.0536
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0032 0.0038 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Echinococcus multilocularis neuropeptide receptor 0.0248 0.07 0.0863
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0083 0.0192 0.5
Echinococcus granulosus sex peptide receptor 0.0248 0.07 0.069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0248 0.07 0.0863
Schistosoma mansoni apoptosis regulator bax 0.0056 0.0111 0.0101
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0144 0.038 0.8922
Trypanosoma cruzi UDP-galactopyranose mutase 0.0068 0.0148 0.1469
Schistosoma mansoni furin-1 (S08 family) 0.1421 0.4294 0.4288
Schistosoma mansoni integrin alpha-ps 0.0141 0.0371 0.0361
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0154 0.0412 0.4619
Echinococcus granulosus epidermal growth factor receptor 0.0156 0.0417 0.0406
Giardia lamblia Neurogenic locus Notch protein precursor 0.0049 0.009 0.0176
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0248 0.07 0.069
Echinococcus multilocularis tyrosine protein kinase HCK 0.0031 0.0033 0.0029
Onchocerca volvulus 0.0248 0.07 0.6643
Onchocerca volvulus 0.0248 0.07 0.6643
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0069 0.0529
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Echinococcus granulosus adam 17 protease 0.0094 0.0227 0.0216
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0238 0.0228
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Loa Loa (eye worm) hypothetical protein 0.013 0.0337 0.0337
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0056 0.0111 0.0101
Echinococcus multilocularis g protein coupled receptor 0.0248 0.07 0.0863
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0068 0.0148 0.0137
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0226 0.0633 0.0779
Loa Loa (eye worm) hypothetical protein 0.1277 0.3853 0.3853
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0248 0.07 0.0863
Echinococcus multilocularis nmda type glutamate receptor 0.0115 0.0291 0.0351
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Onchocerca volvulus 0.0248 0.07 0.6643
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0248 0.07 0.069
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Echinococcus multilocularis fmrfamide receptor 0.0248 0.07 0.0863
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0038 0.0057 0.126
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0248 0.07 0.0863
Schistosoma mansoni integrin alpha-ps 0.0271 0.077 0.076
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0248 0.07 0.0863
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0409 0.1193 0.1193
Echinococcus granulosus rhodopsin orphan GPCR 0.0248 0.07 0.069
Plasmodium falciparum plasmepsin V 0.0129 0.0334 0.8017
Brugia malayi hypothetical protein 0.0248 0.07 0.07
Echinococcus granulosus biogenic amine 5HT receptor 0.0248 0.07 0.069
Echinococcus multilocularis tyrosine protein kinase Blk 0.0034 0.0045 0.0043
Echinococcus multilocularis orexin receptor type 2 0.0248 0.07 0.0863
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0034 0.0045 0.0034
Brugia malayi hypothetical protein 0.0248 0.07 0.07
Echinococcus granulosus disintegrin and metalloproteinase 0.0094 0.0227 0.0216
Schistosoma mansoni opsin-like receptor 0.0248 0.07 0.069
Schistosoma mansoni tyrosine kinase 0.0038 0.0055 0.0045
Loa Loa (eye worm) hypothetical protein 0.0068 0.0148 0.0148
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0083 0.0192 0.4466
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0248 0.07 0.069
Echinococcus granulosus neuropeptide Y receptor 0.0248 0.07 0.069
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0144 0.038 0.8924
Loa Loa (eye worm) TK protein kinase 0.0031 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0248 0.07 0.069
Trichomonas vaginalis conserved hypothetical protein 0.0652 0.1937 0.3153
Schistosoma mansoni adenoreceptor 0.0248 0.07 0.069
Schistosoma mansoni ATP-binding cassette transporter 0.0032 0.0038 0.0027
Brugia malayi hypothetical protein 0.0296 0.0847 0.0846
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0056 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0049 0.0088 0.0078
Loa Loa (eye worm) hypothetical protein 0.0043 0.0071 0.0071
Entamoeba histolytica hypothetical protein 0.0037 0.0052 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Onchocerca volvulus 0.0248 0.07 0.6643
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0248 0.07 0.069
Schistosoma mansoni site-1 peptidase (S08 family) 0.0144 0.038 0.037
Brugia malayi metalloprotease 0.0063 0.0131 0.013
Echinococcus granulosus rhodopsin orphan GPCR 0.0248 0.07 0.069
Trichomonas vaginalis conserved hypothetical protein 0.0652 0.1937 0.3153
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Echinococcus multilocularis serotonin receptor 0.0248 0.07 0.0863
Echinococcus multilocularis protein jagged 2 0.0049 0.009 0.0099
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0055 0.0056
Onchocerca volvulus 0.0248 0.07 0.6643
Echinococcus multilocularis rhodopsin orphan GPCR 0.0248 0.07 0.0863
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0032 0.0038 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) TK/INSR protein kinase 0.0093 0.0224 0.0224
Echinococcus granulosus neuropeptide FF receptor 2 0.0248 0.07 0.069
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Echinococcus granulosus g protein coupled receptor 0.0248 0.07 0.069
Echinococcus multilocularis protoporphyrinogen oxidase 0.0068 0.0148 0.0172
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0248 0.07 0.069
Echinococcus granulosus rhodopsin orphan GPCR 0.0248 0.07 0.069
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.0013 0.0217
Echinococcus granulosus membrane bound transcription factor site 1 0.0144 0.038 0.037
Brugia malayi hypothetical protein 0.0037 0.0052 0.0052
Plasmodium vivax subtilisin-like protease 2, putative 0.0144 0.038 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0248 0.07 0.069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0025 0.0025
Echinococcus multilocularis tyrosine protein kinase Srms 0.0034 0.0045 0.0043
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0242 0.068 0.0837
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0144 0.038 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0052 0.0042
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0023 0.0478
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0796 0.2378 0.3882
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0055 0.0045
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0248 0.07 0.0863
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0097 0.0868
Brugia malayi putative neuropeptide receptor 0.0248 0.07 0.07
Echinococcus multilocularis dro:myosuppressin receptor 0.0248 0.07 0.0863
Onchocerca volvulus 0.0045 0.0076 0.0714
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0023 0.0478
Echinococcus granulosus hypothetical protein 0.0248 0.07 0.069
Loa Loa (eye worm) glutamate receptor 1 0.0032 0.0038 0.0038
Toxoplasma gondii subtilisin SUB5 0.0144 0.038 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0248 0.07 0.069
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0144 0.038 0.8922
Echinococcus multilocularis rhodopsin orphan GPCR 0.0248 0.07 0.0863
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0248 0.07 0.069
Loa Loa (eye worm) hypothetical protein 0.0049 0.009 0.009
Echinococcus granulosus glutamate receptor 2 0.0049 0.0088 0.0078
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0144 0.038 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0248 0.07 0.069
Brugia malayi G protein-coupled receptor F59B2.13 0.0248 0.07 0.07
Echinococcus multilocularis G protein coupled receptor 139 0.0248 0.07 0.0863
Brugia malayi ORL1-like opioid receptor 0.0248 0.07 0.07
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0088 0.0078
Onchocerca volvulus 0.0248 0.07 0.6643
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0115 0.0291 0.0351
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0018 0.0363
Mycobacterium ulcerans thioesterase 0.0021 0.0005 0.0053
Echinococcus multilocularis g-protein coupled receptor 0.0248 0.07 0.0863
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0248 0.07 0.0863
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0796 0.2378 0.3882
Echinococcus multilocularis membrane bound transcription factor site 1 0.0144 0.038 0.0463
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0032 0.0038 0.0027
Schistosoma mansoni biogenic amine receptor 0.0248 0.07 0.069
Brugia malayi EGF-like domain containing protein 0.0049 0.009 0.0089
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0248 0.07 0.0863
Schistosoma mansoni hypothetical protein 0.0248 0.07 0.069
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0144 0.038 0.038
Schistosoma mansoni neuropeptide f receptor 76f 0.0248 0.07 0.069
Schistosoma mansoni tyrosine kinase 0.0156 0.0417 0.0406
Toxoplasma gondii hypothetical protein 0.0049 0.0088 0.1832
Brugia malayi Cytochrome P450 family protein 0.0028 0.0025 0.0024
Trypanosoma cruzi UDP-galactopyranose mutase 0.0068 0.0148 0.1469
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Schistosoma mansoni opsin-like receptor 0.0248 0.07 0.069
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.038 0.0585
Giardia lamblia High cysteine protein 0.0049 0.009 0.0176
Onchocerca volvulus 0.0144 0.038 0.3605
Echinococcus granulosus nmda type glutamate receptor 0.0115 0.0291 0.0281
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Echinococcus multilocularis neuropeptide receptor A26 0.0248 0.07 0.0863
Echinococcus multilocularis neuropeptides capa receptor 0.0248 0.07 0.0863
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0248 0.07 0.07
Echinococcus multilocularis serotonin receptor 0.0248 0.07 0.0863
Mycobacterium leprae Possible secreted protease 0.0144 0.038 1
Onchocerca volvulus 0.0248 0.07 0.6643
Brugia malayi Reprolysin 0.0133 0.0345 0.0345
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0248 0.07 0.0863
Plasmodium falciparum subtilisin-like protease 2 0.0144 0.038 1
Echinococcus granulosus tumor protein p63 0.0668 0.1985 0.1976
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0049 0.009 0.0105
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0248 0.07 0.069
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Echinococcus granulosus tm gpcr rhodopsin 0.0248 0.07 0.069
Echinococcus granulosus tyrosine protein kinase Src42A 0.0032 0.0036 0.0026
Brugia malayi hypothetical protein 0.0248 0.07 0.07
Loa Loa (eye worm) hypothetical protein 0.0098 0.0238 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0652 0.1937 0.3153
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0705 0.2098 0.2612
Toxoplasma gondii subtilisin SUB8 0.0144 0.038 1
Echinococcus granulosus neuropeptide receptor 0.0248 0.07 0.069
Brugia malayi SWIRM domain containing protein 0.0028 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0335 0.0967 0.0967
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0027 0.0023 0.0536
Brugia malayi ADAMTS-like protease 0.0132 0.0345 0.0344
Brugia malayi hypothetical protein 0.0248 0.07 0.07
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0652 0.1937 0.3153
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0248 0.07 0.0863
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0049 0.0088 0.0097
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0248 0.07 0.069
Brugia malayi amine oxidase, flavin-containing family protein 0.0097 0.0235 0.0234
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.0864 1
Brugia malayi putative neuropeptide receptor NPR1 0.0248 0.07 0.07
Loa Loa (eye worm) G-protein coupled receptor 0.0248 0.07 0.07
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Onchocerca volvulus 0.0024 0.0013 0.0112
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Toxoplasma gondii subtilisin SUB6 0.0144 0.038 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0377 0.4195
Brugia malayi Glutamate receptor 1 precursor 0.0032 0.0038 0.0037
Toxoplasma gondii subtilisin SUB10 0.0144 0.038 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0248 0.07 0.07
Echinococcus granulosus rhodopsin orphan GPCR 0.0248 0.07 0.069
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0652 0.1937 0.3153
Brugia malayi GnHR receptor homolog 0.0248 0.07 0.07
Trichomonas vaginalis conserved hypothetical protein 0.0652 0.1937 0.3153
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0377 0.4195
Trichomonas vaginalis WD repeat domain, putative 0.0067 0.0146 0.0197
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0248 0.07 0.069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0069 0.0529
Echinococcus granulosus dro:myosuppressin receptor 0.0248 0.07 0.069
Echinococcus granulosus neuropeptides capa receptor 0.0248 0.07 0.069
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0025 0.0015 0.0282
Loa Loa (eye worm) neuropeptide F receptor 0.0248 0.07 0.07
Brugia malayi Kelch motif family protein 0.0409 0.1193 0.1192
Loa Loa (eye worm) hypothetical protein 0.0226 0.0633 0.0633
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0032 0.0036 0.0032
Loa Loa (eye worm) TK protein kinase 0.0034 0.0045 0.0045
Brugia malayi sulfakinin receptor protein 0.0248 0.07 0.07
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0248 0.07 0.0863
Echinococcus multilocularis 0.0089 0.0212 0.0252
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Loa Loa (eye worm) hypothetical protein 0.0335 0.0967 0.0967
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0045 0.0043
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0018 0.0363
Echinococcus granulosus tachykinin peptides receptor 99D 0.0248 0.07 0.069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Giardia lamblia Tenascin precursor 0.0049 0.009 0.0176
Brugia malayi Subtilase family protein 0.0144 0.038 0.038
Echinococcus multilocularis epidermal growth factor receptor 0.0424 0.1237 0.1535
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0796 0.2378 0.3882
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0025 0.0015 0.0282
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0248 0.07 0.069
Echinococcus multilocularis fmrfamide receptor 0.0248 0.07 0.0863
Brugia malayi ADAM-TS Spacer 1 family protein 0.0132 0.0345 0.0344
Echinococcus multilocularis somatostatin receptor 0.0248 0.07 0.0863
Echinococcus granulosus tm gpcr rhodopsin 0.0248 0.07 0.069
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0038 0.0055 0.0045
Mycobacterium tuberculosis Conserved hypothetical protein 0.0068 0.0148 0.342
Trichomonas vaginalis hypothetical protein 0.0049 0.009 0.0105
Echinococcus granulosus neuropeptide receptor 0.0248 0.07 0.069
Onchocerca volvulus Neuropeptide F receptor homolog 0.0248 0.07 0.6643
Brugia malayi SRC-1 0.0038 0.0055 0.0055
Schistosoma mansoni integrin beta subunit 0.151 0.4567 0.4561
Onchocerca volvulus Fatty acid synthase homolog 0.0046 0.0081 0.0761
Loa Loa (eye worm) TYRA-2 protein 0.0248 0.07 0.07
Entamoeba histolytica protein kinase, putative 0.0031 0.0033 0.2847
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0018 0.0363
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0038 0.0055 0.0056
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0056 0.0111 0.0101
Brugia malayi Melatonin receptor type 1A 0.0248 0.07 0.07
Schistosoma mansoni hypothetical protein 0.0248 0.07 0.069
Trichomonas vaginalis hypothetical protein 0.0652 0.1937 0.3153
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0038 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Brugia malayi hypothetical protein 0.0248 0.07 0.07
Echinococcus multilocularis G-protein coupled receptor, putative 0.0248 0.07 0.0863
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0248 0.07 0.0863
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.07 0.07
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0248 0.07 0.069
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0068 0.0148 0.3436
Trypanosoma brucei subtilisin peptidase 0.0144 0.038 0.4241
Loa Loa (eye worm) hypothetical protein 0.0049 0.009 0.009
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0018 0.0339
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Schistosoma mansoni tyrosine kinase 0.0153 0.0408 0.0398
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0248 0.07 0.07
Schistosoma mansoni alpha-1 adrenergic receptor 0.0248 0.07 0.069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0038 0.0055 0.0045
Echinococcus granulosus neuroendocrine convertase 2 0.2073 0.6292 0.6288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0248 0.07 0.069
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0248 0.07 0.069
Echinococcus granulosus alpha 1A adrenergic receptor 0.0248 0.07 0.069
Loa Loa (eye worm) angiogenesis inhibito 0.0063 0.0131 0.0131
Toxoplasma gondii subtilisin SUB12 0.0144 0.038 1
Echinococcus multilocularis neuropeptide Y receptor 0.0248 0.07 0.0863
Brugia malayi hypothetical protein 0.0248 0.07 0.07
Echinococcus granulosus tyrosine protein kinase Blk 0.0034 0.0045 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Echinococcus multilocularis fibrillin 2 0.0049 0.009 0.0099
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0055 0.0045
Schistosoma mansoni tyrosine kinase 0.0093 0.0224 0.0214
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0094 0.0227 0.027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0796 0.2378 0.3882
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0144 0.038 0.037
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0248 0.07 0.069
Schistosoma mansoni glutamate receptor NMDA 0.0049 0.0088 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0652 0.1937 0.3153
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0272 0.0772 0.0952
Schistosoma mansoni glutamate receptor NMDA 0.0272 0.0772 0.0762
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Echinococcus granulosus neuropeptides capa receptor 0.0248 0.07 0.069
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0069 0.0529
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0069 0.0529
Toxoplasma gondii histone lysine-specific demethylase 0.0068 0.0148 0.3502
Echinococcus granulosus epidermal growth factor receptor 0.0424 0.1237 0.1228
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.038 0.0585
Entamoeba histolytica hypothetical protein 0.0037 0.0052 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0026 0.0018 0.0017
Schistosoma mansoni tyrosine kinase 0.0156 0.0417 0.0406
Onchocerca volvulus 0.0248 0.07 0.6643
Giardia lamblia Tenascin-like 0.0049 0.009 0.0176
Onchocerca volvulus 0.0067 0.0146 0.1376
Mycobacterium tuberculosis Possible oxidoreductase 0.0068 0.0148 0.342
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Brugia malayi neuropeptide F receptor 0.0248 0.07 0.07
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0068 0.0148 0.3436
Brugia malayi EGF-like domain containing protein 0.0049 0.009 0.0089
Brugia malayi Will die slowly protein 0.0067 0.0146 0.0145
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0027
Echinococcus multilocularis fibrillin 1 0.005 0.0092 0.0102
Loa Loa (eye worm) apoptosis regulator protein 0.0056 0.0111 0.0111
Brugia malayi Stress-activated protein kinase jnk-1 0.0242 0.068 0.0679
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0032 0.0038 0.0027
Schistosoma mansoni histamine h1 receptor 0.0248 0.07 0.069
Schistosoma mansoni neuropeptide F-like receptor 0.0248 0.07 0.069
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0248 0.07 0.069
Plasmodium vivax subtilisin-like protease 1 0.0144 0.038 1
Brugia malayi hypothetical protein 0.0023 0.0011 0.001
Schistosoma mansoni tyrosine kinase 0.0153 0.0408 0.0398
Loa Loa (eye worm) hypothetical protein 0.0049 0.009 0.009
Toxoplasma gondii subtilisin SUB4 0.0144 0.038 1
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.2006 0.6086 0.6082
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Schistosoma mansoni amine oxidase 0.0068 0.0148 0.0137
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0005 0.0029
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Trichomonas vaginalis conserved hypothetical protein 0.0652 0.1937 0.3153
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Echinococcus multilocularis integrin beta 2 0.1909 0.5789 0.7231
Brugia malayi follicle stimulating hormone receptor 0.0248 0.07 0.07
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0094 0.0227 0.0216
Brugia malayi G-protein coupled receptor 0.0248 0.07 0.07
Brugia malayi larval opioid receptor 0.0248 0.07 0.07
Loa Loa (eye worm) SRC-1 0.0038 0.0055 0.0055
Schistosoma mansoni amine GPCR 0.0248 0.07 0.069
Mycobacterium ulcerans hypothetical protein 0.0159 0.0426 1
Echinococcus granulosus g protein coupled receptor 0.0248 0.07 0.069
Echinococcus granulosus fibrillin 2 0.0049 0.009 0.0079
Loa Loa (eye worm) melatonin receptor type 1A 0.0248 0.07 0.07
Onchocerca volvulus 0.0364 0.1054 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0038 0.0057 0.0046
Echinococcus multilocularis disintegrin and metalloproteinase 0.0094 0.0227 0.027
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0144 0.038 0.0463
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.0426 1
Trichomonas vaginalis conserved hypothetical protein 0.0652 0.1937 0.3153
Brugia malayi Glutamate receptor 2 precursor 0.0032 0.0038 0.0037
Loa Loa (eye worm) endoprotease bli-4 0.3283 1 1
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0248 0.07 0.069
Schistosoma mansoni site-1 peptidase (S08 family) 0.0144 0.038 0.037
Loa Loa (eye worm) WD40 repeat protein 0.0067 0.0146 0.0146
Schistosoma mansoni myosin xvIII 0.0248 0.07 0.069
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0028 0.0026 0.0015
Echinococcus multilocularis sex peptide receptor 0.0248 0.07 0.0863
Echinococcus granulosus c-Jun N-terminal kinases 0.0242 0.068 0.067
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2006 0.6086 1
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Toxoplasma gondii subtilisin SUB1 0.0144 0.038 1
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0038 0.0027
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0038 0.0027
Echinococcus multilocularis neuropeptides capa receptor 0.0248 0.07 0.0863
Echinococcus granulosus lysine specific histone demethylase 1A 0.0335 0.0967 0.0957
Brugia malayi EGF-like domain containing protein 0.0049 0.009 0.0089
Echinococcus multilocularis NMDA receptor 0.0032 0.0038 0.0034
Echinococcus multilocularis integrin alpha ps 0.0271 0.077 0.095
Brugia malayi proprotein convertase 2 0.2073 0.6292 0.6292
Echinococcus granulosus integrin beta 2 0.1909 0.5789 0.5784
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.0864 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Schistosoma mansoni neuropeptide receptor 0.0248 0.07 0.069
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Echinococcus multilocularis tumor protein p63 0.0668 0.1985 0.247
Echinococcus granulosus rhodopsin orphan GPCR 0.0248 0.07 0.069
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.038 0.0585
Brugia malayi hypothetical protein 0.0248 0.07 0.07
Schistosoma mansoni hypothetical protein 0.0652 0.1937 0.1928
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Loa Loa (eye worm) neuropeptide F receptor 0.0248 0.07 0.07
Schistosoma mansoni neuropeptide receptor 0.0248 0.07 0.069
Onchocerca volvulus 0.0248 0.07 0.6643
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0093 0.0224 0.0267
Echinococcus granulosus rhodopsin orphan GPCR 0.0248 0.07 0.069
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0027 0.0023 0.0455
Giardia lamblia hypothetical protein 0.0049 0.009 0.0176
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Echinococcus multilocularis rhodopsin orphan GPCR 0.0248 0.07 0.0863
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0068 0.0148 0.3502
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0226 0.0633 0.0623
Loa Loa (eye worm) hypothetical protein 0.0132 0.0345 0.0345
Echinococcus multilocularis neuropeptide s receptor 0.0248 0.07 0.0863
Echinococcus multilocularis allatostatin A receptor 0.0248 0.07 0.0863
Loa Loa (eye worm) TK/EGFR protein kinase 0.0424 0.1237 0.1237
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0248 0.07 0.07
Mycobacterium ulcerans polyketide synthase 0.0027 0.0023 0.0478
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0248 0.07 0.069
Echinococcus granulosus neuropeptide receptor A26 0.0248 0.07 0.069
Brugia malayi SWIRM domain containing protein 0.0364 0.1054 0.1053
Trichomonas vaginalis conserved hypothetical protein 0.0652 0.1937 0.3153
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0093 0.0224 0.0214
Onchocerca volvulus 0.0248 0.07 0.6643
Schistosoma mansoni biogenic amine receptor 0.0248 0.07 0.069
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0248 0.07 0.0863
Loa Loa (eye worm) hypothetical protein 0.0049 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0377 0.4195
Echinococcus granulosus rhodopsin orphan GPCR 0.0248 0.07 0.069
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0025 0.0527
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0068 0.0148 0.3436
Brugia malayi protein-tyrosine kinase 0.0034 0.0045 0.0044
Loa Loa (eye worm) proprotein convertase 2 0.0796 0.2378 0.2378
Echinococcus granulosus tyrosine kinase 0.0034 0.0045 0.0034
Brugia malayi Dopamine receptor protein 1 0.0248 0.07 0.07
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0248 0.07 0.069
Loa Loa (eye worm) hypothetical protein 0.0056 0.0111 0.0111
Onchocerca volvulus 0.0023 0.0011 0.0094
Loa Loa (eye worm) integrin beta-2 0.2589 0.7874 0.7874
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0088 0.0097
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0055 0.0045
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0226 0.0633 0.0623
Trichomonas vaginalis conserved hypothetical protein 0.0652 0.1937 0.3153
Echinococcus multilocularis adam 0.0345 0.0998 0.1235
Loa Loa (eye worm) hypothetical protein 0.0097 0.0235 0.0235
Onchocerca volvulus 0.0248 0.07 0.6643
Echinococcus multilocularis glutamate receptor 2 0.0032 0.0038 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.038 0.0585
Loa Loa (eye worm) subtilase 0.0144 0.038 0.038
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0088 0.0078
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.3283 1 1
Brugia malayi Dopamine receptor 0.0248 0.07 0.07
Plasmodium vivax subtilisin-like serine protease, putative 0.0144 0.038 1
Echinococcus granulosus orexin receptor type 2 0.0248 0.07 0.069
Schistosoma mansoni tyrosine kinase 0.0153 0.0408 0.0398
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Giardia lamblia High cysteine protein 0.0049 0.009 0.0176
Loa Loa (eye worm) hypothetical protein 0.0094 0.0227 0.0227
Loa Loa (eye worm) integrin alpha pat-2 0.0932 0.2795 0.2795
Schistosoma mansoni amine GPCR 0.0248 0.07 0.069
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Loa Loa (eye worm) hypothetical protein 0.0457 0.134 0.134
Brugia malayi Integrin alpha pat-2 precursor 0.0605 0.1792 0.1791
Echinococcus granulosus peptide allatostatin:somatostatin 0.0248 0.07 0.069
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0144 0.038 0.8924
Echinococcus multilocularis rhodopsin orphan GPCR 0.0248 0.07 0.0863
Echinococcus multilocularis protein will die slowly 0.0067 0.0146 0.0169
Toxoplasma gondii hypothetical protein 0.0049 0.009 0.1878
Loa Loa (eye worm) reprolysin 0.0226 0.0633 0.0633
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0144 0.038 0.037
Toxoplasma gondii SWIRM domain-containing protein 0.0028 0.0026 0.0094
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0068 0.0148 0.385
Toxoplasma gondii subtilisin SUB2 0.0144 0.038 1
Echinococcus multilocularis 0.0068 0.0148 0.0172
Echinococcus multilocularis neuropeptide receptor 0.0248 0.07 0.0863
Echinococcus multilocularis g protein coupled receptor 0.0248 0.07 0.0863
Brugia malayi G protein-coupled receptor 0.0248 0.07 0.07
Leishmania major UDP-galactopyranose mutase 0.0068 0.0148 0.1469
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0335 0.0967 0.1197
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Echinococcus multilocularis 0.2631 0.8002 1
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Plasmodium vivax plasmepsin V, putative 0.0129 0.0334 0.8017
Echinococcus granulosus lysine specific histone demethylase 1A 0.0068 0.0148 0.0137
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0026 0.0018 0.0339
Loa Loa (eye worm) glutamate receptor 2 0.0032 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0144 0.038 0.038
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0154 0.0412 0.4619
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0088 0.0078
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Mycobacterium ulcerans oxidoreductase 0.0068 0.0148 0.3436
Echinococcus granulosus serotonin receptor 0.0248 0.07 0.069
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0032 0.0038 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2006 0.6086 1
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0027 0.0023 0.0455
Brugia malayi hypothetical protein 0.0068 0.0148 0.0147
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0056 0.0111 0.0126
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Echinococcus granulosus glutamate receptor subunit protein glur 0.0032 0.0038 0.0027
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Onchocerca volvulus 0.0248 0.07 0.6643
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0088 0.0097
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0248 0.07 0.0863
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0248 0.07 0.069
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0248 0.07 0.6643
Echinococcus multilocularis g protein coupled receptor 0.0248 0.07 0.0863
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0335 0.0967 0.0957
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0005 0.006
Brugia malayi EGF-like domain containing protein 0.0049 0.009 0.0089
Echinococcus granulosus fmrfamide receptor 0.0248 0.07 0.069
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0248 0.07 0.07
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0038 0.0055 0.0056
Loa Loa (eye worm) metalloprotease 0.0063 0.0131 0.0131
Schistosoma mansoni neuropeptide receptor 0.0248 0.07 0.069
Echinococcus granulosus neuropeptide s receptor 0.0248 0.07 0.069
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0026 0.0018 0.0407
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0248 0.07 0.069
Brugia malayi Protein kinase domain containing protein 0.0026 0.0019 0.0018
Brugia malayi Tachykinin-like peptides receptor 99D 0.0248 0.07 0.07
Entamoeba histolytica hypothetical protein 0.0037 0.0052 1
Loa Loa (eye worm) hypothetical protein 0.0364 0.1054 0.1054
Schistosoma mansoni amine GPCR 0.0248 0.07 0.069
Loa Loa (eye worm) hypothetical protein 0.0334 0.0961 0.0961
Giardia lamblia High cysteine membrane protein Group 2 0.121 0.3647 1
Brugia malayi neuroendocrine convertase 1 precursor 0.2073 0.6292 0.6292
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0248 0.07 0.069
Brugia malayi hypothetical protein 0.0248 0.07 0.07
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0248 0.07 0.069
Echinococcus granulosus adam 0.0345 0.0998 0.0988
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0248 0.07 0.07
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Schistosoma mansoni hypothetical protein 0.0248 0.07 0.069
Brugia malayi Cytochrome P450 family protein 0.0028 0.0025 0.0024
Echinococcus granulosus neuropeptide Y receptor 0.0248 0.07 0.069
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.0864 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0248 0.07 0.0863
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0144 0.038 0.8924
Trichomonas vaginalis conserved hypothetical protein 0.0652 0.1937 0.3153
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.0864 1
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0224 0.0626 0.0616
Echinococcus multilocularis neuropeptide Y receptor 0.0248 0.07 0.0863
Brugia malayi Serotonin receptor 0.0248 0.07 0.07
Toxoplasma gondii aspartyl protease ASP5 0.0118 0.0299 0.773
Loa Loa (eye worm) TK/ALK protein kinase 0.0026 0.0019 0.0019
Giardia lamblia Tenascin-X 0.0049 0.009 0.0176
Leishmania major subtilisin-like serine peptidase 0.0144 0.038 0.4241
Entamoeba histolytica hypothetical protein 0.0037 0.0052 1
Trichomonas vaginalis conserved hypothetical protein 0.0652 0.1937 0.3153
Echinococcus multilocularis epidermal growth factor receptor 0.0156 0.0417 0.0508
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0796 0.2378 0.3882
Onchocerca volvulus 0.0049 0.009 0.0845
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Echinococcus multilocularis rhodopsin orphan GPCR 0.0248 0.07 0.0863
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0154 0.0412 0.4619
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0144 0.038 0.037
Brugia malayi angiogenesis inhibito 0.0132 0.0345 0.0344
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0296 0.0847 0.0837
Onchocerca volvulus 0.0023 0.0011 0.0094
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0038 0.0055 0.0056
Echinococcus granulosus tm gpcr rhodopsin 0.0248 0.07 0.069
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Echinococcus multilocularis neuropeptide FF receptor 2 0.0248 0.07 0.0863
Brugia malayi Disintegrin family protein 0.0094 0.0227 0.0226
Schistosoma mansoni amine GPCR 0.0248 0.07 0.069
Mycobacterium leprae Probable polyketide synthase Pks1 0.0027 0.0023 0.0536
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.2006 0.6086 0.7602
Chlamydia trachomatis glutamine binding protein 0.0083 0.0192 1
Mycobacterium ulcerans monoamine oxidase 0.0068 0.0148 0.3436
Loa Loa (eye worm) G-protein coupled receptor 0.0248 0.07 0.07
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0063 0.0131 0.012
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0038 0.0027
Mycobacterium ulcerans polyketide synthase Pks13 0.0038 0.0057 0.1282
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0052 0.0042
Echinococcus granulosus allatostatin A receptor 0.0248 0.07 0.069
Echinococcus granulosus protein will die slowly 0.0067 0.0146 0.0135
Loa Loa (eye worm) hypothetical protein 0.007 0.0153 0.0153
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Schistosoma mansoni hypothetical protein 0.0037 0.0052 0.0042
Brugia malayi hypothetical protein 0.0248 0.07 0.07
Schistosoma mansoni biogenic amine (5HT) receptor 0.0248 0.07 0.069
Brugia malayi hypothetical protein 0.0399 0.1161 0.116
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0013 0.0012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0796 0.2378 0.3882
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0025 0.0025
Giardia lamblia Neurogenic locus notch-like protein 0.0049 0.009 0.0176
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0248 0.07 0.0863
Echinococcus multilocularis Furin 1 0.0796 0.2378 0.2963
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Schistosoma mansoni tyrosine kinase 0.0424 0.1237 0.1228
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0248 0.07 0.069
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1233 0.3717 0.371
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0248 0.07 0.069
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0248 0.07 0.069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0083 0.0192 0.448
Echinococcus multilocularis integrin alpha 3 0.0463 0.1359 0.1688
Schistosoma mansoni serine/threonine protein kinase 0.0242 0.068 0.067
Giardia lamblia Tenascin-37 0.0049 0.009 0.0176
Loa Loa (eye worm) hypothetical protein 0.0068 0.0148 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.038 0.0585
Brugia malayi neuropeptide F receptor 0.0248 0.07 0.07
Schistosoma mansoni amine GPCR 0.0248 0.07 0.069
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0242 0.068 0.068
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0038 0.0055 0.0056
Loa Loa (eye worm) hypothetical protein 0.0248 0.07 0.07
Echinococcus granulosus furin 0.3283 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.038 0.0585
Schistosoma mansoni dihydroceramide desaturase 0.0094 0.0227 0.0216
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0088 0.0097
Brugia malayi celfurPC protein 0.2631 0.8002 0.8002
Echinococcus granulosus g protein coupled receptor 0.0248 0.07 0.069
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0013 0.0013
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0144 0.038 0.8922
Echinococcus granulosus tyrosine protein kinase Src64B 0.0038 0.0055 0.0045
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0475 0.1394 0.1394
Schistosoma mansoni opsin-like receptor 0.0248 0.07 0.069
Echinococcus granulosus 7tm_1 domain containing protein 0.0248 0.07 0.069
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0226 0.0633 0.0623
Echinococcus granulosus tyrosine protein kinase HCK 0.0031 0.0033 0.0023
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0144 0.038 0.038
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0032 0.0038 0.0034
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0796 0.2378 0.237
Trypanosoma cruzi subtilisin peptidase 0.0144 0.038 0.4241
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0005 0.0053
Brugia malayi Protein kinase domain containing protein 0.0093 0.0224 0.0224

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) >= 250 ug ml-1 Antibacterial activity against Escherichia coli ATCC 10536 assessed as growth inhibition at 30 degC after 24 hrs by liquid broth dilution method ChEMBL. 23353739

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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